Hugo Rodallega's second-half goal denied 10-man Sheffield United an FA Cup fifth-round spot as Fulham came from behind to force a replay.
League One outfit United, who beat Aston Villa 2-1 in the third round, looked to be on course for a second successive Premier League giant-killing when striker Chris Porter gave them the lead midway through the first half at Bramall Lane.
However, the game turned early in the second period when United captain Michael Doyle was sent-off for violent conduct.
And Fulham, who needed a replay to overcome Norwich City and reach the fourth round, took advantage of the extra man as Colombian striker Rodallega levelled matters with 15 minutes remaining.
Rene Meulensteen's side could not break through a determined home defence in the closing stages, with Darren Bent somehow shooting wide from point-blank range late on as United held on.
The hosts handed a debut to John Brayford, signed on loan from Cardiff on Friday, while 19-year-old Joshua Passley made his first appearance for a Fulham side that featured 11 changes from the 2-0 Premier League defeat to Arsenal.
Fulham made a bright start to proceedings and created the game's first chance after five minutes as Rodallega headed narrowly over the crossbar.
However, the visitors were forced into a change shortly after, Ange-Freddy Plumain replacing John Arne Riise following the Norwegian's collision with an advertising hoarding.
Jose Baxter curled wide from a free-kick for Nigel Clough's men just after the 20-minute mark, as chances proved few and far between in the early stages.
But United took the lead with their first real opportunity of the game after as Porter turned home Harry Maguire's shot across the face of goal.
Fulham were left aggrieved moments later, the London club denied a penalty by referee Andre Marriner despite goalkeeper George Long appearing to bring down Rodallega.
Clough made one change at half-time, with another new recruit Stefan Scougall taking the place of goalscorer Porter.
And United were forced to make a further alteration just minutes into the second half as Robert Harris came on for injured defender Maguire shortly after Pajtim Kasami had curled wide for Fulham.
United were then reduced to 10, Doyle seeing red for an ill-advised kick on Chris David in an off-the-ball altercation.
Still, that dismissal did not impact the hosts' ambition, and midfielder Ryan Flynn - who scored the winner at Villa Park in round three - came close to adding a second when his near-post shot was kept out by David Stockdale.
Fulham dictated possession in the second half as their numerical advantage began to tell, but Meulensteen's men were fortunate not to concede a penalty for Aaron Hughes' apparent trip on Flynn.
Again Marriner dismissed the claims, and Fulham's quality told in the 75th minute, Rodallega finding the bottom corner from the edge of the area with a fierce low finish.
Defender Philippe Senderos hit the bar with a header eight minutes from time before Bent's incredulous miss encapsulated a frustrating afternoon for Fulham.
|Coach: N. Clough|
for C. Porter 46'
for H. Maguire 48'
for J. Baxter 85'
|Irvine backs Ideye to end goal drought|
|Carrick backs Falcao to kick on|
|Dortmund will come back stronger, vows Klopp|
|Bojan senior slams Barcelona|
|Sterling eager to catch Arsenal cold|
|Eredvisie title not won yet - Depay|
|Monk: Ki will be sorely missed|
|Bruce looking to recall Hull duo from loan spells|
|Allardyce: Pearson deserves time|
|Burns double downs Sydney|
|Real Madrid 2 San Lorenzo 0: Spanish giants complete triumphant 2014|
|McCoist: Departures sucking life out of Rangers|
|Hargreaves urges Sterling to stay put|
|Herediano 1 Deportivo Saprissa 1 (agg 3-5): Draw hands visitors consecutive titles|
|Tribulietx basks in Auckland City´s heroics|
|San Lorenzo´s Bauza applauds Ancelotti|
|Wenger: Sanchez a Footballer of the Year candidate|
|Chelsea like United´s treble-winning team - Hargreaves|
|Ancelotti: Copa del Rey victory inspired Real´s stunning run|
|La Liga Review: Catalan clubs triumph|
|Milan on right track - Inzaghi|
|Estoril 1 Vitoria Guimaraes 0: Kleber checks visitors´ momentum|
|Eredivisie Review: PSV in Eagles demolition, AZ downed at home|
|Garcia fumes at missed handball|
|Serie A Review: 10-man Milan frustrate Roma, Cesena rescue point|
|Roma 0 Milan 0: Hosts denied despite Armero red|
|Ligue 1 Review: PSG held at home, Monaco claim fourth win in a row|
|Bundesliga Review: Bremen off bottom with Dortmund win, Augsburg beat Gladbach|
|Blanc frustrated after drab stalemate|
|League Two Review: Moore´s Hartlepool tenure begins with draw|
|Championship Review: Blackpool hit for six, Middlesbrough slip up|
|Luis Enrique enjoying Pedro´s resurgence|
|Scottish Premiership Review: Aberdeen move to second, St Mirren misery continues|
|Koeman delighted with clinical Southampton|
|Pochettino tips in-form Kane for England call-up|
|Dortmund are ´idiots´ - Klopp|
|Allardyce hails ´outstanding´ Downing|
|Young admitted fault after Agbonlahor dismissal, says Lambert|
|Pearson not concerned with speculation|
|Bruce: Hull simply not good enough|
|Everton must improve - Martinez|
|Irvine rues sloppy defending|
|Cruz Azul 1 Auckland City 1 (2-4 on pens): Plucky New Zealanders claim third|
|Austin an example for young strikers - Redknapp|
|Dyche takes pride in White Hart Lane defeat|
|Arabian Gulf League Review: Al Shabab strike late to sink Al Dhafra, top two win|
|Swansea win vindicated changes, says Monk|
|Van Gaal frustrated by dropped points at Villa|
|Paris Saint-Germain 0 Montpellier 0: Champions frustrated by Courbis´ men|
|League One Review: Wilson gains landmark win as Bristol City and Swindon falter|
|Hull City 0 Swansea City 1: Monk´s men celebrate rare away win|
|Southampton 3 Everton 0: Koeman´s side back to winning ways|
|Aston Villa 1 Manchester United 1: Visitors held despite Agbonlahor dismissal|
|QPR 3 West Brom 2: Austin treble lifts hosts out of drop zone|
|Barcelona 5 Cordoba 0: Suarez opens Liga account in emphatic win|
|Tottenham 2 Burnley 1: Lamela stunner wins it for Spurs|
|West Ham 2 Leicester City 0: Carroll, Downing seal the points|
|Werder Bremen 2 Borussia Dortmund 1: Hosts off the bottom by adding to Klopp´s woes|
|Kerala Blasters 0 Atletico de Kolkata 1: Last-gasp Rafique seals inaugural title|
|Warnock fumes over disallowed goal|
|Pellegrini hails Silva quality|
|Betis announce Mel return|
|Huntelaar signs Schalke extension|
|Juventus v Napoli: Allegri backs Tevez to make difference|
|Stoke City v Chelsea: Mourinho calls for adaptability|
|Manchester City 3 Crystal Palace 0: Silva strikes twice as champions go joint-top|
|A-League Review: City snatch Melbourne derby honours, Glory pull further clear|
|Mancini: Inter can finish third|
|Sterling revels in Golden Boy award|
|Pellegrini: You never win a title in December|
|Rodgers bemoans Sanchez snub|
|Ayew confident Marseille can beat title rivals|
|Mercier: San Lorenzo won´t roll over to Real Madrid|
|Lukaku: I´m still 21|
|Mainz bemoan ´tragic´ loss to Bayern|
|Rojo ruled out for Villa trip|
|Lopetegui thrilled with Porto response|
|Guardiola pays tribute to battling Mainz|
|Orlando City sign Shea|
|Porto 4 Vitoria Setubal 0: Brahimi inspires late drama|
|League Two Review: Burton held, Cambridge snatch late point|
|Millwall 0 Bolton Wanderers 1: Pratley nets winner for visitors|
|Lens 2 Nice 0: Cyprien and Coulibaly lift hosts|
|Celta Vigo 0 Almeria 1: Nolito miss proves costly|
|Heerenveen 0 ADO Den Haag 0: Visitors´ winless streak extended|
|Mainz 1 Bayern Munich 2: Guardiola´s men break Christmas points record|
|Blanc unconcerned by league placing|
|United targeting title - Carrick|
|Soldado ´ashamed´ at not performing for Spurs|
|Ramos to wait and see on fitness for final|
|Garcia wins appeal against two-match ban|
|Hart signs new City contract|
|Hereford United wound up|
|Pearson given touchline ban for fan row|
|FIFA confirms third-party ownership ban|
|Inter v Lazio: Ranocchia wants to build momentum|
|Rodgers hits out at Sterling criticism|
|Pardew backs Colback to shine against Sunderland|
|Minimal recovery time a concern for Bauza|
|Liverpool v Arsenal: Wenger out to avoid repeat performance|
|Newcastle United v Sunderland: Pardew calls for a derby day show|
|Adebayor available for Burnley clash|
|Athletic Bilbao v Atletico Madrid: Simeone´s men eye fitting response|
|Targett commits to Southampton|
|Garcia vows to attack Milan|
|City still without strike trio for Palace test|
|Courtois set for return at Stoke|
|Di Maria set for possible United return at Villa|
|Neymar in frame for Cordoba match|
|FIFA to publish Garcia report|
|Liverpool will not appeal Balotelli ban|
|A-League: Newcastle Jets 2 Adelaide United 1|
|Fournier eyes Fekir stay and attacking reinforcements|
|Abidal announces retirement ahead of potential Barca return|
|Redknapp: Crouch deal not possible|
|Klaassen laments Ajax ´off-day´|
|Wenger not fearful of another Anfield nightmare|
|Whelan wants to extend Stoke stay|
|Kalou eyes Hertha exit|
|Fellaini: Belief growing of title tilt at United|
|Benteke: Villa transfer request was a mistake|
|Gerrard urges Sterling to stay put|
|Pardew calls for calm ahead of derby clash|
|Kerala Blasters v Atletico de Kolkata: Luis Garcia talks up team ahead of final|
|Monk wants three new Swansea signings|
|Koeman plays down Sneijder link|
|Howard targets another World Cup|
|Inzaghi prepared for Stadio Olimpico atmosphere|
|Toronto expect Defoe to return|
|Rodriguez suffers injury setback|
|Klopp denies Dortmund departure plans|
|Copa del Rey Review: Bilbao and Elche edge through, Madrid derby beckons|