Luca Antonelli's header handed Genoa a 1-0 win against Inter, their first victory over the club since returning to the top flight in 2007.
The defender rose to meet a well-worked corner with seven minutes remaining, ending a run of 16 competive matches for Genoa without a win over Inter.
Walter Mazzarri's men were frustrated by a tenacious performance from the hosts, and saw a number of chances go begging at a sodden Stadio Comunale Luigi Ferraris.
Inter remain winless in 2014, having lost three and drawn one since the turn of the year, scoring just once in the process.
Gian Piero Gasperini, who came into this game having never previously beaten his former team, made six alterations to the Genoa side thumped 4-0 by Roma last weekend, including a return for ex-Milan striker Alberto Gilardino following his suspension.
Former Genoa hitman Diego Milito was the only new face for the visitors as they sought to improve on their recent poor form in front of goal.
Despite the difficult conditions, the visitors made a high-tempo start, with Ricardo Alvarez racing behind Genoa's defence before unleashing a low drive that was smartly saved by Mattia Perin at the near post.
Perin was called into action again to keep out a stinging effort from Jonathan after 10 minutes, as Inter pressed for an early opening.
The Brazilian wasted another good opportunity just before the 20-minute mark, lashing Milito's clipped ball inside the box across goal and wide.
The visitors were dealt a blow when Alvarez limped off injured, but should have been ahead soon after through Rodrigo Palacio, who robbed the ball from Luca Antonini before bursting into the box and firing wide.
Genoa did manage a couple of flashes at goal before the half-hour mark.
Andrea Bertolacci whistled a speculative half-volley just wide, before Stefano Sturaro saw his goalbound effort slowed by a puddle, leaving Samir Handanovic with a simple save.
The Slovenian was tested again five minutes before the break, palming away Giovanni Marchese’s close-range header after Inter struggled to deal with a well-worked corner.
Inter should have taken the lead two minutes after the restart. Water inside the Genoa penalty area helped the ball fall kindly to Palacio, only for the Argentinian to blast over from eight yards.
The home side responded with chances of their own, Gilardino failing to get a shot away after being put clean through and Ioannis Fetfatzidis forcing Handanovic to make a sprawling save with a powerful flick-on.
The Greek was denied again just after the hour mark, cutting in from the right before unleashing a powerful dipping effort that was superbly saved.
Substitute Fredy Guarin almost provided Inter with the breakthrough when he produced a volley that was well kept out by Perrin.
Palacio then saw a deflected effort saved before Inter were made to pay for their wastefulness as Antonelli rose highest from a set-piece to beat Handanovic.
The visitors nearly grabbed a late equaliser through Ruben Botta, whose bouncing header was beaten away by Perrin as Genoa held on for a famous victory.
|4||S. De Maio|
|Coach: G. Gasperini|
for S. Sturaro 72'
for I. Fetfatzidis 76'
for A. Gilardino 86'
|Bundesliga Preview: Leaders Bayern and Wolfsburg kick off Ruckrunde|
|Howard boost for Everton|
|Ligue 1 Preview: Jardim plays down Monaco title hopes ahead of Lyon showdown|
|Costa charged by FA for alleged Can stamp|
|O´Keefe joins Cardiff|
|Dons teenager Alli in demand|
|Gabriel seals Arsenal switch|
|Wolfsburg v Bayern Munich: Guardiola eyes ´big step´ to Bundesliga title|
|Paris Saint-Germain v Rennes: Montanier seeks another upset in French capital|
|Martinez rules out panic buys|
|Gilardino targets Fiorentina goals|
|Milan agree Bocchetti loan|
|League Two Preview: Cambridge and Luton prepare to renew rivalries|
|Ronaldo hit with two-match ban|
|West Brom complete McManaman deal|
|Sullivan hits back in Sakho row|
|Richards: Cuadrado suited to Premier League|
|Figo to challenge for FIFA presidency|
|Inzaghi out to freshen up struggling Milan|
|Wigan agree a fee for Mckay|
|Carver eyes strong finish|
|Bowen cools talk of Stoke swoop for Sandro and Traore|
|Lazio-bound Morrison lands in Rome|
|Mourinho fined £25k for ´campaign´ claims|
|Mainz bring in Castillo|
|Villa: Lambert will not be sacked|
|Monk hopeful of adding new faces|
|Sainsbury ready to replace Franjic|
|Beckenbauer hopeful of Guardiola stay|
|Mourinho hits back at Costa critics|
|Rodriguez grateful for ´fundamental´ Ronaldo support|
|La Liga Preview: Real want revenge against Socieded|
|No Dallas move for Essien|
|Bale rubbishes United link, Ronaldo rift|
|Sahin in ´good shape´ for Bundesliga resumption|
|Rodgers slams Costa´s stamp collection|
|Under-fire Inzaghi urges patience|
|Rodgers: Courtois saved Chelsea|
|Mashaba wants lessons to be learnt after AFCON exit|
|Mourinho refuses to wade into Costa incidents after Chelsea win|
|Football League Review: Bent double sends Derby second, Rotherham triumph|
|Chelsea 1 Liverpool 0 (aet, agg 2-1): Ivanovic settles action-packed League Cup semi-final|
|Milan 0 Lazio 1: Inzaghi future plunged into further doubt|
|Neymar dreaming of ending Brazil´s home hoodoo|
|South Africa 1 Ghana 2: Late Ayew winner seals qualification|
|Senegal 0 Algeria 2: Mahrez and Bentaleb dump Senegal out|
|Bocchetti poised to join Milan on loan|
|De Rossi suffers calf injury|
|Montano accuses Oldham of double standards after Evans saga|
|Bojan out for the season with ruptured cruciate|
|Cameroon v Ivory Coast: Renard defends Yaya Toure|
|Yanga-Mbiwa makes Roma move permanent|
|Guinea v Mali: Quarter-final berth on offer in Mongomo|
|Thohir: Inter not reliant on European football|
|Bremen land Vestergaard|
|Allegri refuses to rule out Cassano move|
|Mexes handed four-game ban after Lazio dismissal|
|Joyce reveals Valdes´ inspirational team-talk|
|CAF announces AFCON venue switches|
|Alcacer commits future to Valencia|
|Postecoglou calls for Aussie ´energy´|
|Everton confirm Eto´o departure to Sampdoria|
|Pochettino to stick with Vorm despite cup error|
|Barcelona are not favourites against Atletico, says Luis Enrique|
|Allegri wary of Parma backlash in Coppa Italia|
|Zidane urges Real to tie Ancelotti down|
|FIFPro: Transfer system failing football|
|Anderlecht condemn Standard´s Defour banner|
|Australia 2 UAE 0: Socceroos ease into home final|
|Barca overhaul youth system|
|FIFPro demands clubs respect contractual obligations|
|Mahmoud targeting World Cup place with Iraq|
|Fabregas wants Chelsea to show winning mentality|
|Rangers borrow £10m from Ashley´s Sports Direct|
|Lyon face anxious wait over Lacazette|
|Undermanned Lazio recall Perea|
|Ki wants South Korea to prove their superiority|
|Ghana´s Gyan wary of South Africa|
|Mashaba urges South Africa to attack|
|Benitez: Napoli deserved to win|
|Pacos de Ferreira 1 Benfica 0: Leaders fail from the spot|
|Serie A Review: Higuain at the double in controversial Napoli win, Udinese see off Empoli|
|I´m glad Rochdale haven´t made the news - Hughes|
|Getafe 2 Celta Vigo 1: Hosts come from behind for first win in 10|
|Real hit back at media reports over transfer dealings|
|Rochdale 1 Stoke City 4: Joy and angst for Bojan as Premier League side progress|
|Turkish Super Lig Review: Kuyt at the double in Fenerbahce win, Besiktas back on track|
|Senegal v Algeria: Morale is high, insists Gourcuff|
|Cassano leaves beleaguered Parma|
|Copa del Rey Preview: Atleti look to overturn Barca advantage, Espanyol wary|
|Atletico Madrid v Barcelona: Griezmann targets second-leg fightback|
|Sheffield United v Tottenham: Clough expects fired-up Spurs for second leg|
|Cape Verde 0 Zambia 0: Stalemate sends both sides out|
|Democratic Republic of Congo 1 Tunisia 1: Both teams qualify for quarter-finals|
|FA Cup fifth round: Middlesbrough handed Arsenal test|
|South Africa v Ghana: Must-win game for Mashaba´s men|
|Parma v Juventus: Serie A leaders strong favourites to reach semi-finals|
|Van Praag planning to stand for FIFA presidency|
|Inter snap up Brozovic|
|Van Persie unsure of long-term United future|
|Broken metatarsal rules El Shaarawy out for at least six weeks|
|FIFA: No disciplinary proceedings against Real|
|No Plan B if Guardiola goes - Rummenigge|
|Millwall take Hooiveld on loan|
|Chile v United States: Klinsmann has high hopes for young stars|
|Carver to lead Newcastle until end of season|
|Shenaishil taking positives from last-four exit|
|Neymar happy with life at Barca and Messi relationship|
|Lucas Silva ready for life at Real|
|Milan ´always with Inzaghi´ - Menez|
|Rodriguez living the dream at Real|
|Stielike expecting Australia in final|
|Mourinho not dwelling on Bradford defeat|
|Schweinsteiger under no pressure to extend Bayern contract|
|Herd heads to Wigan on loan|
|Inter defensive duo suffer hamstring tears|
|UAE coach Ali eyes Asian Cup final|
|Gattuso dreaming of managing Rangers|
|Fiorentina agree return of Gilardino on loan|
|Sakho hits back at critics|
|South Korea 2 Iraq 0: Kim books sixth Asian Cup final place|
|Sturridge could return against Chelsea|
|Zinnbauer backs Drobny as Hamburg first choice|
|Drogba targeting Chelsea stay|
|Postecoglou confident Australia squad can progress|
|UEFA does not have the courage to run against me - Blatter|
|Foster: Anichebe unplayable|
|Australia v UAE: Japan´s absence a boon for Asian Cup hosts|
|Milan v Lazio: Injury-hit visitors aiming for back-to-back wins|
|Trezeguet confirms retirement|
|No ´major problems´ with Nicolas Frey´s head wound|
|Strootman injury not "serious" - Garcia|
|No Paraguay, USA for retiring Riquelme|
|Saint-Etienne did not try to play football - Blanc|
|Primeira Liga Review: Sporting move within one point of Porto|
|La Liga Review: Parejo downs Sevilla, Resino starts with a point|
|Serie A Review: Juve go seven points clear as Roma draw again|