Luca Antonelli's header handed Genoa a 1-0 win against Inter, their first victory over the club since returning to the top flight in 2007.
The defender rose to meet a well-worked corner with seven minutes remaining, ending a run of 16 competive matches for Genoa without a win over Inter.
Walter Mazzarri's men were frustrated by a tenacious performance from the hosts, and saw a number of chances go begging at a sodden Stadio Comunale Luigi Ferraris.
Inter remain winless in 2014, having lost three and drawn one since the turn of the year, scoring just once in the process.
Gian Piero Gasperini, who came into this game having never previously beaten his former team, made six alterations to the Genoa side thumped 4-0 by Roma last weekend, including a return for ex-Milan striker Alberto Gilardino following his suspension.
Former Genoa hitman Diego Milito was the only new face for the visitors as they sought to improve on their recent poor form in front of goal.
Despite the difficult conditions, the visitors made a high-tempo start, with Ricardo Alvarez racing behind Genoa's defence before unleashing a low drive that was smartly saved by Mattia Perin at the near post.
Perin was called into action again to keep out a stinging effort from Jonathan after 10 minutes, as Inter pressed for an early opening.
The Brazilian wasted another good opportunity just before the 20-minute mark, lashing Milito's clipped ball inside the box across goal and wide.
The visitors were dealt a blow when Alvarez limped off injured, but should have been ahead soon after through Rodrigo Palacio, who robbed the ball from Luca Antonini before bursting into the box and firing wide.
Genoa did manage a couple of flashes at goal before the half-hour mark.
Andrea Bertolacci whistled a speculative half-volley just wide, before Stefano Sturaro saw his goalbound effort slowed by a puddle, leaving Samir Handanovic with a simple save.
The Slovenian was tested again five minutes before the break, palming away Giovanni Marchese’s close-range header after Inter struggled to deal with a well-worked corner.
Inter should have taken the lead two minutes after the restart. Water inside the Genoa penalty area helped the ball fall kindly to Palacio, only for the Argentinian to blast over from eight yards.
The home side responded with chances of their own, Gilardino failing to get a shot away after being put clean through and Ioannis Fetfatzidis forcing Handanovic to make a sprawling save with a powerful flick-on.
The Greek was denied again just after the hour mark, cutting in from the right before unleashing a powerful dipping effort that was superbly saved.
Substitute Fredy Guarin almost provided Inter with the breakthrough when he produced a volley that was well kept out by Perrin.
Palacio then saw a deflected effort saved before Inter were made to pay for their wastefulness as Antonelli rose highest from a set-piece to beat Handanovic.
The visitors nearly grabbed a late equaliser through Ruben Botta, whose bouncing header was beaten away by Perrin as Genoa held on for a famous victory.
|4||S. De Maio|
|Coach: G. Gasperini|
for S. Sturaro 72'
for I. Fetfatzidis 76'
for A. Gilardino 86'
|Schneider refuses to ´run away´ from Stuttgart|
|´Loyalty´ means nothing to Hodgson|
|CONCACAF Champions League Preview: Cruz Azul next for Sporting|
|Hoddle: Sherwood should have kept complaints in-house|
|Penalty hero Leno worried about Leverkusen´s ´uncertainty´|
|Keller praises Schalke´s ´right response´|
|AFC Champions League Preview: Evergrande face tricky trip|
|Ancelotti hails Isco as ´the new Seedorf´|
|La Liga Wrap: Barcelona lose again, Atletico go top|
|Simeone applauds ´specialist´ Villa|
|Serie A Wrap: Di Natale condemns Milan to defeat, Catania held by Cagliari|
|Eredivisie Wrap: Vitesse leapfrog Twente, six on the spin for PSV|
|Primeira Liga: Braga 2 Nacional 1|
|Terry rules out England return|
|CAF Champions League Wrap: Raja Casablanca crash out on penalties, Nkana progress|
|Ligue 1 Wrap: Evian, Valenciennes boost survival chances, Ibrahimovic stars for PSG|
|Mourinho: Spurs didn´t scare us|
|CAF Confederation Cup Wrap: Bayelsa United, Zesco advance|
|Bundesliga Wrap: Augsburg win again, Schalke move level with Leverkusen|
|Sherwood slams sorry Spurs|
|Rapids legend Mastroeni hired as coach|
|La Liga: Celta Vigo 0 Atletico Madrid 2|
|Seedorf rues tired Milan performance|
|Di Natale hails ´important´ Udinese win|
|Susic angered by Dzeko criticism|
|Premier League: Chelsea 4 Tottenham 0|
|Hughton bemoans ´soft´ penalty decision|
|Blanc hails Ibrahimovic after Bastia win|
|Hughes laments ´harsh´ Walters red|
|Serie A: Udinese 1 Milan 0|
|Pulis calls for ruthlessness|
|Solskjaer delights in ´big result´|
|League Two Wrap: Accrington stun Chesterfield, Northampton hold Scunthorpe|
|Scottish Premiership Wrap: Motherwell, Hibs play out thriller, Kilmarnock overcome lowly Hearts|
|Guardiola not satisfied despite Bayern rout|
|Pochettino talks up Southampton World Cup credentials|
|Magath defends Mitroglou|
|Title race not over, claims defiant Martino|
|League One Wrap: Orient held at bottom club Notts County, Wolves go top|
|Championship Wrap: Derby´s promotion bid dented, Barnsley surprise Forest|
|Mel: Van Persie should have seen red|
|Van Persie substitution was planned, claims Moyes|
|Ligue 1: Bastia 0 Paris Saint-Germain 3|
|Premier League: Norwich City 1 Stoke City 1|
|Premier League: Crystal Palace 0 Southampton 1|
|Premier League: Cardiff City 3 Fulham 1|
|La Liga: Real Valladolid 1 Barcelona 0|
|Bundesliga: Wolfsburg 1 Bayern Munich 6|
|Wenger delighted with Ozil showing|
|Martinez questions ´soft´ Arsenal penalty|
|J.League Wrap: Sanfrecce fight back as top four win again|
|Premier League: West Brom 0 Manchester United 3|
|FA Cup: Arsenal 4 Everton 1|
|Garcia piles pressure on Napoli|
|Barca are not in decline, Xavi insists|
|Arbeloa out of Levante clash|
|Montolivo agent rules out Milan exit|
|A-League Wrap: Sydney FC seal first derby win, Jets end Heart run|
|Pellegrini backs Aguero and Negredo|
|Lucas benefiting from first-team run, says Blanc|
|Moyes: Players are behind me|
|Marchisio not motivated by revenge|
|Magath: Must-win game for Cardiff|
|Sherwood: I´m the right man for Tottenham|
|Colombia Primera A Wrap: Double joy for Atletico Nacional|
|Davids: Del Piero should delay coaching plans|
|Copa Libertadores Preview: Atletico Mineiro, Velez Sarsfield near progression|
|Moyes set to experiment ahead of Vidic departure|
|Watford comeback a lesson for City, claims Pellegrini|
|Primeira Liga: Rio Ave 0 Academica 0|
|League Two: Bury 0 Rochdale 0|
|Ligue 1: Marseille 0 Nice 1|
|CAF Confederation Cup Wrap: Kigali win dramatic shootout, Sahel oust Brazzaville|
|La Liga Preview: Real Madrid v Levante|
|Serie A Preview: Inter v Torino|
|Bundesliga Preview: Freiburg v Borussia Dortmund|
|No room for sentiment for ´emotional´ Rosler|
|Serie A Preview: Juventus v Fiorentina|
|Valero ban reduced to three games|
|Simeone backs Costa´s Spain involvement|
|Serie A Preview: Roma renew Napoli rivalry, Fiorentina look for league double over Juventus|
|Balotelli set for Milan return|
|CAF Champs League: Kabuscorp 0 Zamalek 0 (0-1 agg)|
|Mourinho backs Pardew after FA charge|
|Mourinho hits out at international schedule|
|Hughes keen to extend Ireland deal|
|Costa handed one-match ban after appeal fails|
|Hughes criticises ´flawed´ FA review process|
|FA Cup Preview: Sheffield United v Charlton Athletic|
|Poor record at Chelsea alleviates pressure, says Sherwood|
|Seedorf unconcerned by league position|
|Meier pens new Frankfurt deal|
|FA Cup Preview: Manchester City v Wigan Athletic|
|Moyes condemns Cleverley petition|
|Klopp ´not satisfied´ with second place|
|De Boer calls for focus from Ajax|
|Pellegrini: I did not deserve touchline ban|
|Blanc confirms Cavani will miss Bastia trip|
|Style more important than points to Ranieri|
|FA Cup Preview: Hull City v Sunderland|
|McNaughton pens new Cardiff deal|
|Martino ready to splash the cash|
|Martino ready to splash the cash|
|A-League: Melbourne Victory 3 Central Coast Mariners 1|
|Pochettino wary of improved Palace|
|Lopez: Celta clash crucial for Atletico title challenge|
|Suarez keen to enjoy Liverpool season|
|Guardiola expecting tough Wolfsburg test|
|Benitez will not sacrifice philosophy|
|Silverware vital for City trust, claims Pellegrini|
|Keller urges Schalke to banish negative thoughts|
|Garde targets European football|
|Birmingham owner Yeung jailed for six years|
|Team spirit the key to Juve success for Tevez|
|Brady to miss remainder of season|
|Solskjaer urges positive Cardiff showing|
|Hyypia: Leverkusen can emerge from slump stronger|
|Wenger reveals shock at Wilshere injury|
|Roar dreaming of Totti signing|
|Martinez baffled by Cleverley criticism|
|Thauvin needs time to grow, insists Anigo|
|Casillas praises form of Lopez|
|Moyes keen to make Old Trafford a ´fortress´ again|
|Kehl not giving up on Bundesliga title|
|Duff´s Fulham future uncertain after season ended|
|Argentina Primera Division Wrap: San Lorenzo silence Rosario, Colon held|
|CSL Preview: Shanghai Greenland unearth new name for derby|
|MLS Preview: Sporting KC set for busy schedule, LA Galaxy host Real Salt Lake|