Rafa and Ivan Cavaleiro could make their Portugal debuts against Cameroon after being included in Paulo Bento's 23-man squad.
The duo form part of an otherwise experienced contingent for Wednesday's friendly, as preparations for the 2014 FIFA World Cup step up a gear.
Rafa has displayed impressive form since joining Braga from Feirense in the close season, scoring three goals in 18 league appearances.
Cavaleiro, meanwhile, has come through the ranks at Benfica and broke into the first team earlier this season.
Edinho is included among Portugal's forwards following his recent loan switch from Braga to Kayseri Erciyesspor in Turkey, while Lyon's Miguel Lopes and Inter loanee Rolando are among those returning to the fold.
A hamstring injury rules out Manchester United's Nani, while Real Madrid's Cristiano Ronaldo will once again lead the side.
Portugal have been drawn in Group G alongside Germany, Ghana and the United States for the World Cup in June and July.
Squad in full:
Goalkeepers: Eduardo (Sporting Braga), Beto (Sevilla), Anthony Lopes (Lyon)
Defenders: Miguel Lopes (Lyon), Joao Pereira (Valencia), Ricardo Costa (Valencia), Pepe (Real Madrid), Fabio Coentrao (Real Madrid), Rolando (Inter), Luis Neto (Zenit), Antunes (Malaga).
Midfielders: Raul Meireles (Fenerbahce), Joao Moutinho (Monaco), Miguel Veloso (Dynamo Kiev), William Carvalho (Sporting), Ruben Amorim (Benfica), Josue (Porto).
Forwards: Rafa (Braga), Ivan Cavaleiro (Benfica), Edinho (Kayseri Erciyesspor), Hugo Almeida (Besiktas), Cristiano Ronaldo (Real Madrid), Silvestre Varela (Porto).
|5||Fábio Coentrão||34' 67'|
|7||Cristiano Ronaldo||21' 83'|
|Coach: Paulo Bento|
for Rafa Silva 46'
for Beto 46'
for Ivan Cavaleiro 69'
for William Carvalho 76'
for Edinho 81'
for Cristiano Ronaldo 87'
for C. Itandje 46'
for N. N'Koulou 46'
for V. Aboubakar 63'
for A. Chedjou 71'
for J. Makoun 72'
for E. Choupo-Moting 84'
|Falcao scores as Monaco return ends in defeat to Fenerbahce|
|Southampton overcome Twente, Asoro stars for Sunderland|
|Man City must adapt to Guardiola tactics quickly - Denayer|
|Chelsea and Leicester to play in EFL Trophy as five Premier League clubs refuse|
|Tolisso pulls plug on €37.5m Napoli move to stay at Lyon|
|Ancelotti shrugging off Guardiola´s shadow|
|Uruguay international Lodeiro swaps Boca for Seattle|
|Ibrahimovic will bring United back to where they belong - Larsson|
|Transfer speculation frustrates Aubameyang|
|Willian ready for ´toughest Premier League season in history´|
|Astana 1 Celtic 1: Griffiths hits late equaliser|
|De Laurentiis feels betrayed by Higuain swapping Napoli for Juventus|
|Costa: Chelsea cannot be any worse than last season|
|Wilshere: Xhaka can hold Arsenal midfield together|
|Pato signs four-year deal with Villarreal|
|Higuain sets sights on Champions League after Juventus move|
|Lazio snap up Immobile from Sevilla|
|Batshuayi worth the money, insists Cahill|
|Arnautovic signs new Stoke deal|
|Smith leaves Liverpool for Bournemouth|
|Barcelona insist Arda Turan will stay|
|Andre Gomes: Barcelona suit my identity better than Real Madrid|
|Niersbach to appeal FIFA ban|
|Barcelona agree Mascherano renewal|
|Fernandinho can play in 10 positions - Guardiola|
|Reading´s kit launch is out of this world|
|Ben Arfa: I do not want to be PSG´s star player|
|FA Cup to trial fourth substitute|
|We want Balotelli and he wants us, says Besiktas chief|
|Crowd welcomes Higuain as he arrives for Juventus medical|
|Guardiola warns Man City stars: If you´re not fit, danger is coming|
|Mkhitaryan prepares to prove himself at United|
|Cavani: No pressure replacing Ibrahimovic|
|Wenger vows to keep transfer plans ´secret´ after Lacazette snub|
|Brannagan open to Championship loan move|
|Wenger wants to sign Mertesacker replacement|
|Ancelotti: Bayern´s transfer business done|
|Brisbane Roar sign former Danish international Kristensen|
|Verratti, Luiz missing for PSG|
|Sounders part ways with foundation coach Schmid|
|Mane turned down Manchester United for Liverpool|
|Zidane on Pogba: Until August 31, anything can happen|
|Mkhitaryan driven by father´s death|
|Inter rejected Napoli offer for Icardi, says president|
|Clichy: City fighting fit after Guardiola pizza ban|
|Everton and Burnley win as Hull are held|
|Ajax held by PAOK after Cillessen howler|
|Conte left frustrated by ´crazy´ money in transfer market|
|Neymar makes Barcelona case to Gabriel Jesus|
|Rostov comeback twice for Champions League draw with Anderlecht.|
|Arsenal defender Mertesacker set for lengthy lay-off|
|Conte not selling ´fantastic´ Matic|
|Ibrahimovic keen on MLS and Beckham´s Miami project|
|Neymar: I play for Messi, he´s the man|
|Barcelona reveal details of Andre Gomes deal|
|Suarez bullish over Barcelona prospects|
|Ajax claim Napoli keen on Milik to replace Higuain|
|Totti labels Higuain´s Juventus move ´a disaster´|
|Juventus confirm Higuain deal|
|Pato to Villarreal ´in the final stage´|
|PSG sign Lo Celso|
|Muller: Beating Dortmund will be more fun this season|
|Juventus sign Higuain from Napoli for €90m|
|Pastore: I´m like God in Paris|
|Injured Lanzini out of Olympics|
|Allegri unperturbed by Higuain fee|
|Menezes replaces Bento at Cruzeiro|
|Sporting rejected major bids from Inter and Liverpool for Joao Mario, claims father|
|Pochettino pleased by Tottenham despite Juventus defeat|
|Eriksson: Allardyce the right man for England|
|Mourinho makes United train after stepping off plane from China|
|Hazard can still match Messi, says Pedro|
|Pjanic shows there is life at Juve, with or without Pogba|
|Juventus 2 Tottenham 1: Benatia bags win for Serie A champions|
|Dembele: I am not the Bundesliga´s next superstar|
|Lyon claim €35m Arsenal offer for Lacazette rejected|
|Donnarumma dreaming of Milan captaincy as he eyes long-term stay|
|Robson: Ibrahimovic can match Van Persie´s first year at United|
|Rooney should remain England captain - Eriksson|
|Emery wants new striker at PSG|
|Santos accept Juventus bid for Gabriel|
|Eriksson expects Sweden to try and tempt Ibrahimovic out of retirement|
|Spurs signing Janssen almost quit|
|Leicester stay best for Mahrez - Ranieri|
|Allardyce to take Mourinho cue on Rooney|
|Ings ready to outdo big-money signings|
|Henderson optimistic over Liverpool campaign|
|Allardyce hardened to the challenge of England post|