Hamburg will move out of the Bundesliga's relegation positions with a win against northern rivals Werder Bremen on Saturday.
A run of five straight defeats in all competitions after the German winter break came to an end last week for Hamburg, as they stunned Borussia Dortmund 3-0 in Mirko Slomka's first match as head coach.
The win took Hamburg to 19 points for the season and into 16th position - the relegation play-off spot.
But if Slomka can lead his new team to a second consecutive win at Bremen's Weserstadion on Saturday in the Nordderby, Hamburg could move as high as 13th by the end of the weekend.
Hamburg are the only club to have played in every season of the Bundesliga.
Slomka took over from Dutchman Bert van Marwijk on February 16 to become Hamburg's fourth head coach this season, including caretaker Rodolfo Esteban Cardoso, who led the team for a week in September following Thorsten Fink's sacking.
Hamburg battled hard against Dortmund last week with striker Pierre-Michel Lasogga leading the way, setting up his team's first goal and converting the second.
The 22-year-old German forward's cross was headed home by Petr Jiracek just before half-time before Lasogga doubled Hamburg's lead in the 58th minute, while Hakan Calhanoglu clinched the win in second-half stoppage time with an improbable long-range free-kick.
If Hamburg overcome their northern rivals, they will leapfrog Bremen (22 points) in the table due to superior goal difference, while Slomka's side could also move above Stuttgart (19) or Eintracht Frankfurt (22).
Stuttgart have lost six straight matches in the German league and travel to Frankfurt on Sunday to play Frankfurt, who drew 0-0 with Bremen last week.
Leaders Bayern Munich will be aiming for a 15th consecutive win on Saturday when they host fourth-placed Schalke, who will be coming off a UEFA Champions League clash with Real Madrid.
Third-placed Dortmund bounced back from their loss to Hamburg with a 4-2 win at Zenit St Petersburg in the Champions League round of 16 on Tuesday and will face Nuremberg next.
Hertha Berlin will begin the weekend's action against 17th-placed Freiburg, who are a point behind Hamburg, while bottom club Eintracht Braunschweig (15 points) host Borussia Monchengladbach.
In other fixtures, Bayer Leverkusen will host Mainz, Hannover will travel to Augsburg and Hoffenheim take on Wolfsburg.
|16||Z. Junuzović||19' 53'|
|9||F. Di Santo||34'|
|Coach: R. Dutt|
for F. Di Santo 58'
for A. Hunt 66'
for P. Bargfrede 78'
|Mustafi eyes Bundesliga switch|
|Klopp laughs off Hummels, Reus speculation|
|Klopp laughs off Hummels, Reus speculation|
|Campana makes Sampdoria switch|
|Leicester seal Ulloa deal|
|Morata sidelined for seven weeks with knee injury|
|Riviere on target in comfortable Newcastle win|
|Advocaat set for Serbia role|
|Wisdom joins West Brom on loan|
|Bundesliga to consider vanishing foam|
|Five-man shortlist for Ivory Coast|
|´Personal issues´ keep Gervinho away from Roma tour|
|Jedinak raring to go|
|Borini set for Liverpool stay, claims agent|
|Koeman: No bids for Lovren|
|Livermore: England hopes shouldn´t hinge on club side|
|MLS Preview: Tough tests for Conference leaders, Revolution still struggling|
|Mathieu not Barca material, says Marquez|
|West Brom claim unimpressive win in Sacramento|
|Neymar: Brazil behind Germany, Spain|
|Vietnamese police confirm match-fixing players|
|Lucescu blames Joorabchian for AWOL players|
|Robinho undecided on future|
|Rush: Still years left in Gerrard|
|Tiago re-signs with Atletico|
|Puyol against Spain overhaul|
|Agger considering his Liverpool future|
|Peruvian Primera Division Review: Juan Aurich bounce back, Melgar draw with Inti Gas|
|Bayern deny interest in Cuadrado|
|New signings on show in Hull double-header|
|Hooiveld strike sinks Swindon|
|Costa departs Valencia|
|Morata suffers knee injury in training|
|K.League Preview: Seoul, Sangju aim to close gap to sixth, Ulsan host Jeonbuk|
|Lewandowski off the mark on Bayern bow|
|Gerrard retirement will boost Liverpool - Carragher|
|World Cup bidding report due in September|
|Evra bids emotional farewell to United fans|
|J.League Preview: Ventforet Kofu look to escape drop zone, Sagan Tosu battle Kawasaki Frontale|
|Salah spared military service|
|Garcia would welcome Torres return|
|Livermore understands Ince decision|
|Cole happy to get away from English press|
|Evra seals Juve switch|
|Bayern stay was Kroos´ ´priority´|
|Scuffet: Udinese right place to continue developing|
|Gerrard retires from England duty|
|Ambitious Pochettino targets title|
|Aspas eager to put ´bad season´ behind him|
|Atletico Mineiro v Lanus: Visitors out to recover from first-leg loss|
|UEFA Europa League Preview: Sligo, Inter Baku out to finish shocks|
|Hughes expects Bojan decision soon|
|Cech on the mend - Holland|
|Pardew eager to honour crash victims|
|Prandelli hits back at critics|
|Negredo breaks metatarsal|
|Rooney eager to impress Van Gaal|
|Palacios´ Qatar move falls through|
|Wenger rules out striker signing|
|Six Shakhtar players refuse to return|
|Six Vietnamese footballers arrested for match fixing|
|Copa Libertadores Preview: Nacional Asuncion, San Lorenzo to host first legs|
|Mata hopeful of title|
|Napoli bullish about Scudetto chances|
|Colombian Primera A Review: Patriotas Boyaca, Deportes Tolima start with wins|
|Subotic thrilled to be back|
|Germain: Monaco can replace Rodriguez|
|Sullivan confident of Carroll improvement|
|Callejon staying put|
|DC United 3 Chivas USA 1: DC end Chivas´ winning run|
|Liga MX Review: Goalkeeping howler costs champions Leon, Monterrey move top|
|Chilean Primera Division Review: Huachipato, Santiago Wanderers opening-day winners|
|Brazilian Serie A Review: Internacional rout Flamengo, Cruzeiro win again|
|Prosinecki keen on South Korea job|
|Woodward promises new United signings|
|Chelsea´s Omeruo set for Middlesbrough return|
|Africa Cup of Nations Qualifying Review: Lesotho, Congo, Benin take first-leg leads|
|Ecuadorian Primera A Review: Deportivo Cuenco shock leaders Emelec, Independiente held|
|Rodriguez spotted in Madrid|
|Niang and Mastalli earn Milan win|
|Jutkiewicz at the double in Burnley rout|
|Crouch denies Gladbach victory|
|Hertha lead Biermann tributes|
|Vidic makes Inter bow in narrow victory|
|Rodriguez eager to leave Atletico|
|Thai Premier League Review: Buriram fail to close gap on Muang Thong, Chonburi gain ground|
|CSL Review: Guangzhou R&F take advantage as rivals Evergrande are held|
|Juventus and Lazio hold Astori talks|
|Lewandowski and Contento back in training|
|Sunderland target Borini joins Liverpool squad for US tour|
|K.League Review: Jeonbuk hammer Sangmu, Steelers march on|
|UEFA Champions League Preview: Buckley warns St Pat´s, Celtic primed to progress|
|Giaretta reveals Pereyra in demand|
|Kramer confirms Napoli talks|
|Nedved insists Juve key men going nowhere|
|Barton is a manager in the making - Redknapp|
|Monk unfazed from friendly setback|
|Holland: Lukaku not set to leave Chelsea|
|Debut nerves for Lambert|
|Woodward: Van Gaal will make United an attacking force|
|MLS Review: Sporting KC win again, Toronto held|
|Wenger: I´ll talk to Wilshere|
|Redknapp almost retired|
|Allardyce: Home form key for West Ham|
|Luis Enrique: ´We can´t draw conclusions yet´|
|Liverpool agree to sell Borini to Sunderland|
|Late Falque penalty spares Spurs blushes|
|Besler, Zusi agree Sporting KC contracts|