Napoli were denied victory on Monday as Genoa loanee Emanuele Calaio sensationally scored against his parent club to secure a 1-1 draw.
Gonzalo Higuain's 18th-minute strike looked set to prove decisive for Rafael Benitez's side, who sit third in Serie A.
However, substitute Calaio provided a stunning twist to an entertaining match with seven minutes remaining, beating Pepe Reina with a curling free-kick from 30 yards.
Calaio was understandably restrained in celebration after his wonderful left-footed strike punished the hosts for not putting the game to bed.
Napoli now sit six points behind second-placed Roma having played a game more, while Genoa remain 11th.
After Higuain had fired wide on the turn early on, the lively Dries Mertens twice looked to find the top-right corner, narrowly missing the target with his second attempt after Mattia Perin had saved his initial effort.
The home side's early dominance was rewarded when Higuain latched on to a perfectly-weighted throughball from Marek Hamsik before lifting the ball over Perin to take his Serie A tally this season to 13 goals.
Genoa responded well, with Luca Antonelli heading over from a free-kick and Moussa Konate seeing a goalbound shot cleared by Federico Fernandez with Reina beaten.
Higuain then sent a driven strike just past Perin's right-hand post before Matuzalem escaped with just a yellow card after appearing to jump into a challenge with Fernandez.
There were further chances at either end before the interval, Mertens threatening for Napoli on two further occasions either side of Konate seeing a free header saved by Reina.
Konate dribbled into a promising position three minutes into the second half, but was unable to capitalise as Fernandez got back to make a crucial intervention.
A similarly fine challenge from Luca Antonini shut out Napoli's Jose Callejon before Genoa saw another opportunity go begging through Giuseppe Sculli, who was unable to hit the target after good work from Konate.
Sculli also brought a save from Reina with Benitez's side looking vulnerable, yet it was Calaio who had the final say.
Fiorentina twice came from behind to rescue a 2-2 draw at Parma in an ill-tempered match featuring three second-half dismissals.
Parma moved ahead through Antonio Cassano in the 39th minute, but that strike was cancelled out two minutes later by Juan Cuadrado.
An Amauri penalty restored the hosts' lead early in the second half and hopes of a second Fiorentina comeback were dented by the 53rd-minute dismissal of Modibo Diakite for a second bookable offence.
However, Vincenzo Montella's men made light of their numerical disadvantage and snatched a point courtesy of Matias Fernandez's goal with five minutes remaining.
There was still time for two further red cards as Gianni Munari and Borja Valero were sent off following an injury-time brawl.
|Brighton and Hove Albion 2 Stoke City 2: Gross, Izquierdo extend home unbeaten run|
|Rose in contention to face Dortmund as Pochettino denies ´issue´ with defender|
|Benzema knows he can give more – Zidane|
|I´ve fulfilled my dreams already – Klopp has no plans to coach Barcelona|
|Aubameyang will face Tottenham, Bosz confirms|
|Klopp expects Matip to face Chelsea, Lallana return getting ´nearer´|
|Berizzo looking to former Red Aspas to provide lessons for Sevilla|
|Mangala ready to pounce, but realistic on Man City playing time|
|Mendy injury means Aguero or Jesus for Guardiola|
|Guardiola sends ´big hug´ to ´amazing, so gentle´ Pulis|
|Tavecchio quits as head of FIGC, claims board have refused to resign|
|Benedetto facing Argentina World Cup KO with cruciate injury|
|Shape up! Heynckes reveals demand to Bayern star Vidal|
|Ramos sits out Madrid trip to APOEL|
|West Brom sack Pulis after wretched run|
|Lloris wants Spurs to forget title and focus on top four|
|Pogba no Gerrard yet, says Benitez|
|Guardiola will ´kill´ City stars if they get complacent|
|Ibrahimovic: My injury was worse than people know|
|Icardi like a ´raptor pouncing on its prey´, says Spalletti|
|City style suits me and thrills neutrals, says De Bruyne|
|Guardiola ready to risk Kompany for Man City after Stones´ injury|
|Stones can bounce back stronger - Kompany|
|In-form Chelsea have regained hunger - Conte|
|Inter 2 Atalanta 0: Icardi brace sends Spalletti´s side second|
|Giampaolo promises more from ´extraordinary´ Sampdoria|
|Record-breaking Valencia tee up blockbuster Barcelona clash|
|Poor West Ham performance at Watford was to be expected - Moyes|
|We will see what happens in the future - Silva non-committal on Everton rumours|
|Stones can bounce back stronger - Kompany|
|Football needs to do more to combat racism - Boateng|
|Watford 2 West Ham 0: Misery for Moyes on Hammers bow|
|Unlucky 13: Benevento suffer record-breaking defeat|
|Juventus lost composure amid Sampdoria onslaught - Allegri|
|Sampdoria 3 Juventus 2: Champions slip further off the pace after thriller|
|Coleman confirmed as Sunderland boss|
|I was just injured - Belgium´s Nainggolan blasts ´stupid´ claims of feigned ailment|
|Leeds United 2 Middlesbrough 1: Losing streak snapped to ease pressure on Christiansen|
|Hughes backs Giggs for Wales job|
|Madrid confirm Ramos´ broken nose after derby clash|
|Kane wants to retire with Tottenham|
|Mourinho: Man United lacked balance with attacking line-up|
|Pastore not considering PSG exit to help World Cup chances|
|Wenger, Ozil & Sanchez uncertainty affecting Arsenal, says Seaman|
|Silva not surprised by Chelsea, Spurs interest in Richarlison|
|Ancelotti, Conte, Allegri on shortlist to replace Ventura|
|Perth Glory 0 Melbourne Victory 2: Visitors claim first A-League win of season|
|Marcelo unaware of Ramos-Ronaldo rift at Real Madrid|
|Neymar will take PSG´s next penalty - Cavani|
|Ranieri would consider coaching Italy|
|Postecoglou set for decision on Socceroos future|
|Championship Review: Millwall deny sloppy Sunderland, Wolves back on top|
|Simeone rallies around under-fire Griezmann|
|It´s a growth process - Montella optimistic despite Napoli loss|
|Spalletti happy at Inter, tips Ancelotti for Italy job|
|Sarri defends sacked Ventura over Insigne´s Italy snub|