Leon blitzed Santos Laguna in the first half to set up their 4-2 win and stretch their unbeaten run to four matches.
In a pulsating first half of football at the Estadio Leon, both teams missed several chances but the hosts still managed to build a match-winning lead, scoring four times.
While Santos Laguna struck twice after the break, Leon held on for victory, their second in a row in Liga MX.
Leon moved up to seventh spot in the Mexican league table with 11 points, just ahead of Chiapas on goal difference, while Santos Laguna (10 points) dropped out of the Liga MX finals positions to sit ninth.
It took just eight minutes for Leon to hit the front on Saturday with Elias Hernandez cutting inside onto his right foot and curling the ball inside the far post.
Matias Britos scored the home side's second goal in the 19th minute, getting to a long pass first and, despite being upended by a Santos defender, half-volleying the ball into the net.
The game continued in an end-to-end fashion and Carlos Pena struck next for Leon, bursting through the middle of the visiting defence in the 34th minute, evading three opponents and then shooting across Santos goalkeeper Oswaldo Sanchez to score.
Leon completed a brilliant first half when Miguel Sabah side-footed home in the 45th minute after a right-wing cross somehow evaded two Santos defenders.
After a terrible first-half performance, Santos were handed a glimmer of hope two minutes after the break when substitute Mauro Cejas thrashed the ball home from the edge of the area.
But the visitors were unable to score at a regular enough rate to have a chance of getting back into the contest with Oribe Peralta scoring Santos' second goal with 20 minutes remaining.
Santos received another blow in the 90th minute when Jonathan Lacerda was shown his second yellow card and sent off.
Liga MX leaders Cruz Azul continued their unbeaten start to the Clausura season with a 3-1 win at Queretaro on Friday.
Cruz Azul lead the league with 22 points, while Toluca (19 points) are second after their 1-0 win over Guadalajara on Sunday.
Third-placed Pumas UNAM rose to 14 points with a 3-1 win at America, while Pachuca (13 points) moved up to fourth after dispatching with Morelia 3-0.
America's third loss in a row saw them drop to fifth with 12 points, just ahead of Guadalajara on goal difference.
In other Liga MX results, Chiapas won 3-0 at Tijuana, Tigres UANL defeated Veracruz 1-0, Monterrey edged out Atlas by the same scoreline and Atlante were held to a scoreless draw by Puebla.
|Coach: G. Matosas|
for M. Britos 53'
for Elías Hernández 68'
for Edwin Hernández 83'
|De Gea named United´s player of the year|
|Dundee 2 Dundee United 1: Visitors relegated|
|King delighted to crown Leicester rise with title|
|Ranieri: I knew I would win a title eventually!|
|Soccer world reacts to Leicester´s remarkable Premier League title|
|Serie A Review: Strootman starts as Roma fight back again|
|Leicester success a ´good omen´ for Selby|
|Kane: Chelsea celebrated like they won title|
|Thumping Man City, edging Tottenham and five matches that won Leicester the Premier League|
|Vardy marvels at Leicester´s finest hour|
|Ranieri called me to say thanks, reveals Hiddink|
|Leicester did the impossible - Morgan|
|Terry: Leicester title triumph gives hope to smaller sides|
|Pochettino proud as Spurs fall short|
|Savage: Leicester title a key moment in Premier League history|
|Football world reacts to Leicester´s remarkable Premier League title|
|Leicester deserve Premier League title - Hazard|
|Leicester players celebrate Premier League title triumph in style|
|From Tinkerman to champion: Ranieri writes the greatest story ever told|
|Champions Leicester worthy of a film - Heskey|
|The greatest upset: Champions Leicester break new ground for sporting underdogs|
|Chelsea 2 Tottenham 2: Leicester champions as Spurs collapse at Stamford Bridge|
|Leicester crowned Premier League champions|
|Werder Bremen 6 Stuttgart 2: Crushing win lights up survival fight|
|Malaga 3 Levante 1: Late collapse all but relegates Rubi´s men|
|Neuer cites home crowd as advantage for Atleti clash|
|Icardi surprised by Argentina selection|
|Ribery fit to face Atletico in Champions League semi-final|
|FIFA extends Sakho ban worldwide|
|Torres and Atletico ready for war at Bayern|
|Football League Review: Burnley earn promotion back to the Premier League|
|Simeone pledges to chase victory at Allianz Arena|
|´Nothing in life is certain´ - Handanovic on Inter future|
|CAS order FIFA to reconsider Gibraltar membership|
|Trapattoni: I love Simeone and Atletico´s style|
|Balotelli is a changed man, says Galliani|
|Real Madrid job is about politics - Pellegrini|
|De Laurentiis wants Sarri at Napoli long term|
|Yarmolenko will not go to Everton or Stoke - Dynamo president|
|Suarez a difference maker - Stoichkov|
|Drinkwater to face no further action from FA|
|Albrighton: Leicester players will watch Chelsea v Tottenham together|
|More to Manchester City than Aguero - Casemiro|
|Boban: Maldini can save Milan|
|Real Madrid v Manchester City: Pellegrini eyes away goal as Zidane hopes for Ronaldo|
|Pellegrini doubts longevity of Leicester´s credentials|
|Portugal unconcerned by Ronaldo fitness|
|Ribery tells Guardiola to play him against Atletico|
|Vardy wins FWA Player of the Year award|
|Hiddink: Title pressure could get to Tottenham|
|Messi never cheats, insists Xavi|
|Dortmund tell Bayern Hummels fee is non-negotiable|
|Welbeck a different animal again - Wenger|
|Xavi: Real Madrid played like a small team in Clasico|
|Bayern can win Champions League - Santa Cruz|
|Reina backs Atletico to win the double|
|Perth Glory lure Herd to A-League|
|England can´t afford Australia loss - Kewell|
|Stankovic: Simeone will coach Inter, but not now|
|I had to rotate squad - Pellegrini|
|Candreva backs Inzaghi for Lazio job|
|I can make fans forget my bad season – Hazard|
|MLS Review: Cole sees red in Galaxy stalemate, Valeri stunner lifts Timbers|
|Pochettino: Deal announcement can convince Tottenham stars to stay|
|Hiddink: Chelsea can´t replace Terry|
|Pulisic, Morris picked by Klinsmann in initial Copa squad|
|Wenger anticipated worse from protests|
|Kante set to have stand named after him|
|Furious Mancini slams Inter´s ´worst ever´ first half against Lazio|
|Serie A Review: Champions League places locked, Milan play out six-goal thriller|
|La Liga Review: Villarreal secure Champions League return|
|Lazio 2 Inter 0: Champions League race comes to a Klose|
|Koeman delivers Pelle warning|
|Morata wants to stay at Juventus, claims Marotta|
|Pellegrini disappointed with City defending in defeat|
|Iheanacho: City will bounce back from Saints defeat|
|´On fire´ Mane salutes Southampton show|
|Angers 0 Marseille 1: Batshuayi strike secures Ligue 1 status|
|Southampton 4 Manchester City 2: Mane hat-trick blows top-four race open|
|Van Gaal calls for video referees after Drinkwater decision|
|Schmeichel: I don´t care how we win it|
|Montella open to Italy role|
|Brocchi pleased with Milan fightback|
|Van Gaal defends ´human´ Fellaini over Huth elbow clash|
|Ronaldo wants Zidane to stay at Madrid|
|Ranieri to miss decisive Tottenham clash|
|Rooney disappointed after Leicester draw dents top-four hopes|
|Bayern Munich v Atletico Madrid: Hosts seek to vent Bundesliga frustration|
|Leicester captain Morgan hails battling Old Trafford point|
|AC Milan 3-3 Frosinone: Menez penalty denies strugglers|
|Klopp not concerned by Sturridge behaviour|
|Manchester United 1 Leicester City 1: Captain Morgan on target as Foxes edge closer to glory|
|Allofs: We do not have the same weapons as Bayern|
|Guidolin coy on Swansea future|
|Allegri happy with win after title celebrations|
|Umtiti flattered by Tottenham interest|
|Klopp frustrated by lacklustre Liverpool|
|Hannover mourn Feierabend|
|Godin, Carrasco fit for Bayern clash|
|Swansea City 3 Liverpool 1: Ayew double punishes wasteful visitors|
|Dybala claims Messi, Ronaldo would score less in Italy|
|Juventus 2 Carpi 0: Hernanes, Zaza on target as champions march on|
|Ronaldo back in training for Madrid|
|Barcelona confirm Bravo calf injury|
|Aulas brands Ligue 1 ´championship of Qatar´|
|Leicester City at Manchester United: Aiming for Hollywood ending to title push|
|I can start for England at Euro 2016 - Sturridge|
|Dybala never doubted Juventus|
|Aguero celebrates brother´s Independiente debut|
|Sturridge rounds on critics, plays down Klopp rift|
|Adelaide United 3 Western Sydney Wanderers 1: Reds seal maiden A-League title|
|Eriksson: Simeone is an example to follow|
|´Where am I?´ - Lovren reveals travel struggles|
|´If I have to leave Bayern, then I will´ - Benatia|
|Walker ´over the moon´ after Pochettino agrees new deal|
|MLS Review: Villa leads City, Impact held|
|We´d probably be relegated without Defoe – Allardyce|
|Koeman: Leicester will do well in Champions League|
|Ronaldo needs rest or could miss Euros - doctor|
|United shaped me as a player - Schlupp|
|Sanchez, Vidal lead Chile´s Copa squad|
|Arsenal´s patience paid off - Cech|
|I will know Madrid´s plans - Pellegrini|
|Granada 3 Las Palmas 2: Superb comeback boosts hosts´ survival hopes|
|Martinez pleased with impact of new faces|
|Ligue 1 Review: Lyon, Monaco continue fight for second|
|Serie A Review: Fiorentina frustrated, Torino hit five|
|Barca keeper Bravo set for tests on calf strain|