Osasuna dented Atletico Madrid's title bid with a 3-0 win on Sunday, while Athletic Bilbao remain in pole position for fourth.
Atletico coach Diego Simeone opted to rest numerous key men following their 1-0 UEFA Champions League win over Milan and with Real Madrid up next in La Liga, but that decision backfired.
Alvaro Cejudo fired Osasuna into a sixth-minute lead as he buried Emiliano Armenteros' corner at the back post. Armenteros added a second in the 21st minute and he did so in style as he lashed in a fierce strike from 25 yards.
The visitors found Osasuna particularly difficult to break down and three minutes prior to the break the El Sadar crowd were cheering for a third time as Roberto Torres steered Damia's left-wing cross past the helpless Thibaut Courtois with precise header.
Simeone made changes at half-time and early in the second period, but his efforts were futile as Osasuna held on to the three-goal margin with relative ease, moving them seven points clear of the bottom three, while Atletico end the weekend three points behind leaders Real.
Athletic maintained their three-point lead over bitter rivals Real Sociedad in the race for fourth place with a routine 2-0 win at nine-man Real Betis.
Iker Muniain got the first from the penalty spot after Kike Sola was tripped by Damien Perquis, who received a second yellow card seven minutes later.
Chilean midfielder Lolo Reyes also picked up a second booking in the second half as Betis went down to nine men and Guillermo's first La Liga goal wrapped up the win in the 81st minute with a header at back post.
Valencia came from behind to steal a late 2-1 win over visitors Granada after Piti initially opened the scoring in the 47th minute.
Paco Alcacer guided Sofiane Feghouli's cross in to level the score 64 minutes in and Ruben Vezo netted his first goal for the club with a 91st-minute tap-in.
Unai Emery's Sevilla contested Sunday's early kick-off at Rayo Vallecano and put their six-match winless La Liga run behind them with a 1-0 victory.
The same fixture last season saw Sevilla miss two penalties in a 0-0 draw, but Coke's 57th-minute strike against his former side was enough this time around, despite the injured Vicente Iborra getting controversially sent off for time wasting while being substituted.
|Coach: Javi Gracia|
for Marc Bertrán 46'
for J. Lotiès 79'
for Cejudo 84'
|Mourinho has ´got to grips´ with United - Ferguson|
|Uganda v Mali: A lot at stake for Mali in shot-shy showdown|
|Napoli 1 Fiorentina 0: Callejon heads Partenopei into semi-finals|
|Bordeaux 1 Paris Saint-Germain 4: Cavani, Di Maria secure final berth|
|Watzke: Dortmund would consider €80m for Aubameyang|
|Togo 1 DR Congo 3: Kabananga´s goal streak continues as Ibenge´s men top group|
|Morocco 1 Ivory Coast 0: Alioui stunner sends holders crashing out|
|Romeu earns Southampton extension as Puel targets away goal|
|Sunderland striker Anichebe out for up to 10 weeks|
|Elneny wants to be an Arsenal legend ´like Thierry Henry´|
|Corini leaves Palermo as Ballardini is tipped for fourth return|
|Hernandez leaves Leicester for Malaga|
|Lukas PodGOALski...Gala forward nets five amid J-League links|
|CAS rejects Serbian appeal against Kosovo UEFA membership|
|Thiago back in Bayern training as Arsenal showdown looms|
|Thiago back in Bayern training as Arsenal showdown looms|
|Shearer´s Toon Army ´trump´ the POTUS|
|Rooney´s record may stand forever - Ferguson|
|Carrick expects full-strength United as Wembley return beckons|
|They insulted his mother and then there were monkey noises - Cyprien on Bastia Balotelli abuse|
|No Chelsea regrets for Sampaoli as Sevilla mount title challenge|
|Egypt v Ghana: Cuper backs Elneny to deliver in crucial Group D clash|
|James adds to Zidane´s injury woes at Madrid|
|Zidane wants fans behind Madrid after latest Ronaldo whistles|
|Mason ´continues to make excellent progress´|
|Allegri slams ´stupidity´ surrounding Buffon referee hug|
|Niang in talks over AC Milan exit, confirms Montella|
|Sunderland sign Lescott|
|China-bound Ramos completes loan switch to Granada|
|Rahman to miss ´several months´|
|Leekens quits after Algeria´s AFCON exit|
|Jese has firm Premier League offer, claims Las Palmas president|
|´I´m blessed with golden genes´ - Adebayor insists he is ready for new Premier League chance|
|Messi renewal progressing ´very, very well´ - Robert|
|Neuer expects Clement success at Swansea|
|Klopp calls for Liverpool enjoyment|
|Mustafi talks up Arsenal belief|
|Van Basten still against offside, slams ´nonsense in the media´|
|Rakitic dreaming of career-long Barcelona stay|
|Toure inspired by Ibrahimovic as he explains Chinese Super League snub|
|Kasperczak committed to attacking approach as Tunisia reach AFCON quarters|
|Slimani wants Algeria youngsters to learn from AFCON humiliation|
|Senegal 2 Algeria 2: Slimani at the double as Desert Warriors bow out|
|Zimbabwe 2 Tunisia 4: First-half glut seals progression|
|Adrian: I always wanted to return to Villarreal|
|Togo v DR Congo: Agassa could miss crucial game after vandals hit home|
|Extended Southampton stay on the cards for Sims|
|Bayern hoping for speedy Vidal return|
|Hull sign Markovic on loan from Liverpool|
|Wenger charged with misconduct by FA|
|Deulofeu joins AC Milan - and this time the deal is definitely done!|
|Henderson still playing through pain, reveals Klopp|
|Record-breaking Rooney reveals secret to longevity|
|No ulterior motive behind Van Dijk captaincy call - Puel|
|Carroll ignoring want-away Payet|
|Gerrard´s managerial ambitions ´wonderful news for Liverpool´ - Klopp|
|PSG interested in Guedes, confirms Emery|
|Barca lose Busquets to sprained ankle|
|Pulisic commits to Dortmund until 2020|
|Mason speaking after suffering fractured skull|
|Aubameyang blames poor preparation for Gabon AFCON exit|
|David Beckham returns to PSG|
|Morocco v Ivory Coast: Holders must beat old boss Renard as group reaches thrilling conclusion|
|Djilobodji charged over Fletcher incident|
|Cahill and Terry visit Mason in hospital|
|Allardyce onto second-choice transfer targets|
|Dortmund sign teenager Isak|
|Madrid confirm Modric and Marcelo injury blows|
|Vidal fears longer lay-off, targets return against Arsenal|
|Yaya Toure: Sterling should have dived!|
|Turan wants to see out Barcelona contract despite China talk|
|Impassioned Ibrahimovic attacks Rooney´s critics|
|´He has to lose weight´ – Mihajlovic angry after dropping Maxi Lopez|
|Lack of Liverpool signings frustrates Klopp|
|Suarez: Busquets difficult to replace for Barca|
|Depay impresses Lyon after debut|
|CSL? Rooney committed to United|
|Denis Suarez wants more goals after opening Barca account|
|Simeone bemoans inconsistency but says Atletico are improving|
|Mourinho won´t stand in the way of Rooney and CSL|
|Dzeko on target as Roma stay on Juve´s tail|
|Rakitic ready to cover for injured Busquets|
|Bale and Kane wish Mason well after serious injury|
|Busquets injury less severe than feared - Luis Enrique|