Real Madrid moved three points clear in La Liga thanks to a 3-0 win over Elche and Barcelona losing to Real Sociedad.
Real were never in any problems at the Santiago Bernabeu once they opened the scoring through Asier Illarramendi, the midfielder netting his first league goal for the club via a deflection.
Gareth Bale added the second with a long-range strike that crashed off the crossbar on its way in, and Isco completed the win with a low shot past Manu Herrera with nine minutes remaining
Four hours later their lead at the top was confirmed as Barcelona were beaten 3-1 in San Sebastian.
Gorka Elustondo's header deflected off Alex Song to give Sociedad the lead at Anoeta, but Barca soon responded with an equaliser through Lionel Messi - his sixth goal in five matches against Sociedad.
However, that was not enough and Barcelona fell to a shock defeat as the hosts scored twice in five second-half minutes to seal the three points and extend their unbeaten home record against the Catalan giants to five games.
Antoine Griezmann, who was impressive throughout, put Jagoba Arrasate's side back in front with a sliding finish following a square pass from Carlos Vela and the Frenchman turned provider for David Zurutuza to complete the victory.
The defeat is a huge blow to Barcelona's title hopes, while Sociedad move above Villarreal and into fifth.
Celta extended their unbeaten run in the league to five games as they came from a goal behind to rescue a point in a 1-1 draw against Getafe in Vigo.
The visitors opened the scoring in the 20th minute through Lafita, but eight minutes into the second half they were reduced to 10 men as Lisandro Lopez was given a second yellow card.
Celta used their man advantage almost immediately as Rafinha levelled in the 59th minute, and Luis Enrique's side nearly won it in stoppage time but Nolito's strike hit the woodwork.
Meanwhile, at the bottom of the table, an inspired performance from Wily Caballero helped earn Malaga a 0-0 draw against Almeria.
The goalkeeper made a string of saves to deny the hosts as both sides ended winless runs with a much-needed point.
Both sides creep away from the bottom three with the point, with Malaga now three points ahead of Valladolid.
|22||Á. di María|
|Coach: C. Ancelotti|
for Jesé 74'
for K. Benzema 81'
for Xabi Alonso 83'
|UEFA Europa League Preview: Brondby and Slovan to protect handsome leads|
|Bentaleb pens new long-term deal at Tottenham|
|Barca agree Turan deal|
|FIFA bans Mayne-Nicholls|
|United States v Honduras: Klinsmann demands improvement ahead of Gold Cup opener|
|CONCACAF institutes extensive reforms in wake of FIFA corruption scandal|
|Mauri completes Milan move|
|City sign Turkey striker|
|Women´s World Cup final draws huge US TV ratings|
|My first Chelsea team better than current crop - Drogba|
|Bertrand set for lay-off after knee surgery|
|New five-year Juve deal for Marchisio|
|Allegri extends Juve contract|
|Koeman reiterates Alderweireld interest|
|Valencia bag Bakkali|
|New York City FC complete Pirlo capture|
|Panama v Haiti: Collat ready to challenge the best of CONCACAF|
|UEFA Champions League Preview: Harrison eyes TNS progression|
|FIFA sanctions Yemen for fielding ineligible player|
|Toulouse rubbish Ben Yedder exit reports|
|Mourinho ´knows what he´s doing´ with Falcao signing|
|Watford shell out club-record fee for Capoue|
|Braafheid signs Lazio extension|
|Nani finalises Fenerbahce move|
|Liverpool confirm O´Driscoll appointment|
|Liverpool have to start better - Lucas|
|USA simply too good - Sasaki|
|Portland Timbers 1 San Jose Earthquakes 0: Jewsbury wins it in stoppage time|
|No move yet for Van Persie|
|Lloyd wins Golden Ball, Silver Boot awards|
|Mascherano: I never grabbed Banega|
|Dunga requested Brazil not appeal Neymar´s suspension|
|United States 5 Japan 2: Lloyd stars with hat-trick|
|Fiorentina deny Inter criticism|
|Nani relishing Fenerbahce opportunity|
|Newcastle hold talks over Northampton youngster|
|Cuadrado´s agent plays down Chelsea exit rumours|
|Liverpool´s Alberto set for Deportivo loan|
|Leverkusen suffer surprise defeat, Stuttgart hit six|
|Inter ´dismayed´ at Fiorentina vice-president´s Salah Twitter outburst|
|Blaszczykowski ruled out of Dortmund´s Asia tour|
|Gerrard gets the beers in for LA Galaxy fans|
|De Gea coy over Real links|
|Former Brazil star Carlos handed Delhi reins|
|Ciftci will not push through Celtic switch – agent|
|In-demand Mitrovic considering Roma offer|
|Lehmann calls on Cech to ´get over´ Chelsea|
|Marlos double sinks Monaco|
|Mauritius 0 South Africa 2 (agg 0-5): Bafana set up Angola qualifier|
|Keane relishing Gerrard arrival|
|Palace confirm Cabaye interest|
|Hamburg bring in Spahic after head-butt ban|
|Blatter hits out at France and Germany over World Cup votes|
|Sanchez: World Cup exit spurred Chile to Copa glory|
|Jojic makes Cologne switch, Santana move falls through|
|Carrillo keen to get going at Monaco|
|Micronesia thrashed 38-0 as Fiji triumph in Olympic qualifier|
|Schalke stunned by ´machine´ Caicara|
|MLS Review: Keane shines at Gerrard´s Galaxy unveiling|
|Counter-attacking the key for Japan|
|Jimenez happy at Atletico|
|Gerrard predicts ´successful future´ with Galaxy|
|Iniesta can´t see Real selling Ramos|
|Keshi sacked as Nigeria coach|
|Three finals, three defeats for Messi, Mascherano|
|Nani close to Fenerbahce move|
|Sampaoli revels in ´unbelievable joy´|
|Bravo: Copa victory a dream|
|Martino: Argentina should have won|
|Chile 0 Argentina 0 (4-1 on penalties): Hosts end trophy drought|
|Germany 0 England 1 (after extra time): England make World Cup history|