Milan will be without their primary source of goals, Mario Balotelli, when they travel to Sampdoria in Serie A on Sunday.
The Italy striker has scored four of Milan's seven goals since the arrival of Clarence Seedorf as coach in January, but a shoulder injury will force him to miss the trip to the Luigi Ferraris.
Balotelli picked up the problem in Wednesday's 1-0 defeat to Atletico Madrid in the first leg of the sides' UEFA Champions League last-16 tie.
Seedorf's appointment has improved the domestic form of Milan, who have lost just one of five Serie A games since the Dutchman replaced Massimiliano Allegri.
However, their faint hopes of securing European football with a top-five finish could well suffer a blow at a stadium where the 18-time champions have struggled to earn positive results.
Indeed, Milan have not won a league game at Sampdoria since October 2007, Seedorf scoring the final goal in an emphatic 5-0 win on that day.
Injuries at both ends of the pitch may hamper Milan's chances of ending that run, with Mattia De Sciglio (ankle) also having picked up an injury in midweek.
The absence of the right-back and Balotelli will come as a blow to a side already missing several first-team players, including strikers Robinho (thigh) and Stephan El Shaarawy (foot).
Valter Birsa (hamstring), Bryan Cristante (leg) and Matias Silvestre (calf) are also unavailable for Milan, while the suspended pair of defender Daniele Gastaldello and midfielder Lorenzo Di Silvestri miss out for Samp.
Striker Maxi Lopez, scorer of the winning goal in the derby against fierce rivals Genoa earlier this month, is nearing a return from a foot injury, but Gianluca Sansone is a doubt through illness.
Samp were hammered 3-0 by Roma last weekend but are nine points clear of the drop zone despite an inconsistent campaign.
The appointment of Sinisa Mihajlovic in November has proved key to Samp's improving prospects of staying in the top tier, with the Serbian overseeing a handy revival following a dismal start to the campaign under Delio Rossi.
Samp won only two of their first 12 Serie A games this season, but have since claimed victory in five of the next 12 following Mihajlovic's appointment.
Despite their relatively strong form, midfielder Angelo Palombo does not believe Samp can afford to ease off in the closing stages of the season.
"We have to raise our level again on Sunday and return to speed as soon as possible," Palombo said. "Because with 28 points we cannot be relaxed."
|1||Angelo Da Costa|
|Coach: S. Mihajlović|
for P. Wszołek 46'
for Pedro Obiang 56'
for N. Krstičić 81'
|Mignolet wants ´fair´ Karius battle|
|Ancelotti impressed by motivated Bayern|
|West Ham ´unreservedly condemn´ crowd trouble|
|Allegri praises strike duo after win over Sampdoria|
|De Boer praises two-goal Icardi after vital win|
|Chelsea were ´unlucky´ with missed chances, insists Conte|
|Mourinho: I´ve never had fans like these|
|Nacho´s goal better than my Champions League final volley - Zidane|
|Borussia Dortmund 1 Union Berlin 1 (aet, 3-0 pens): Weidenfeller shootout heroics seal progress|
|Bilic: Crowd trouble distracts from great West Ham win|
|Kompany told me he couldn´t play anymore - Guardiola|
|Liverpool and Manchester United handed home quarter-finals|
|Inter 2 Torino 1: Icardi double alleviates pressure on De Boer|
|Manchester United 1 Manchester City 0: Mata extends Guardiola´s winless run|
|West Ham 2 Chelsea 1: Crowd trouble tarnishes Hammers´ route to quarter-finals|
|Cultural Leonesa 1 Real Madrid 7: Morata and Asensio star in BBC´s absence|
|Bayern Munich 3 Augsburg 1: Green´s first goal sends holders through|
|Juventus 4 Sampdoria 1: Rapid start sets champions on their way|
|Crafty Suarez is world´s best striker - Godin|
|Mancini: Balotelli has wasted years but can bounce back|
|Rami rejected ´risky´ PSG move|
|Neymar would have cost PSG €430m, claims father|
|Sacchi warns Bayern players over Ancelotti temper|
|Valencia ´pleased´ with RFEF bottle ruling|
|Mourinho apologises to Utd fans for Chelsea thrashing|
|Barcelona lash out at ´totally reprehensible´ RFEF comments|
|Jacob leaves Marseille amid rumours of Zubizarreta appointment|
|Lavezzi added to Argentina squad as Dybala drops out|
|Del Bosque: Mourinho had a point on Conte|
|N´Zonzi in talks over Sevilla extension|
|Allardyce successor ´will not be a mercenary´ - Glenn|
|Aubameyang like a rocket, Lewandowski perfect - Riedle|
|RFEF fines Valencia, warns Barca over bottle incident|
|Wenger tells Iwobi to improve his finishing|
|Barcelona without Mathieu for three weeks|
|Kimmich draws inspiration from Xavi|
|Vazquez signs new Madrid deal|
|Higuain the best striker in the world - Nedved|
|Wolfsburg regret De Bruyne, Perisic sales|
|Parejo slams Neymar for ´inciting´ Valencia fans|
|Gundogan predicts ´very lively´ Manchester derby|
|Luis Enrique satisfied with Supercopa workout|
|Messi could join Newell´s after World Cup - Maxi Rodriguez|
|Ibrahimovic wants United to be the boss of City|
|Schmidt on the bus as Lotte book ticket for next round|
|Pogba still adapting to Premier League, says Mourinho|
|Southgate hails influence of demoted Rooney|
|Lille ready to heap more pressure on PSG as Corchia dreams big|
|I´m among top 20 LaLiga coaches, jokes Luis Enrique|
|Brattan earns Socceroos call-up|
|Pochettino pleased with Janssen|
|Klopp never questioned Sturridge quality|
|Barcelona downed by Espanyol in Supercopa|
|Heavy Milan defeat ´just a bump in the road´ - Montella|
|Pochettino wanted Liverpool debutant sent off|
|Klopp happy to entertain as Liverpool youngsters earn their spurs|
|Leverkusen dumped out by 10-man minnows|
|Wenger praises Oxlade-Chamberlain work ethic|
|Wenger praises Oxlade-Chamberlain work ethic|
|Tuchel unaffected by Real Madrid rumours|
|I would like to pick Toure, believe me - Guardiola|
|Genoa 3 AC Milan 0: Unbeaten run comes crashing to an end as Paletta sees red|
|Liverpool 2 Tottenham 1: Sturridge at the double to book quarter-final spot|
|Arsenal 2 Reading 0: Oxlade-Chamberlain brace secures safe passage|
|Football world mourns Carlos Alberto|
|81 per cent win ratio and more goals than Bayern Munich - Two years of Messi, Suarez and Neymar|
|Ridgewell reportedly arrested for drink driving|
|Verratti not leaving PSG - agent|
|Costa competition benefitting Batshuayi, says Conte|
|Pele hails ´friend and brother´ Carlos Alberto|
|Bailly confirms two-month lay-off|
|How Carlos Alberto established his legacy as one of the greats|
|Allegri hints at Marchisio return|
|Lewandowski has not renewed with Bayern - agent|
|Carlos Alberto: Capita´s World Cup triumph in numbers|
|Hull´s Snodgrass out for a month|
|Keita reveals Arsenal, Manchester City, Liverpool snub|
|Mikel not giving up on Chelsea career|
|Former Brazil captain Carlos Alberto dies|
|Guardiola wants to help ´special player´ Aguero|
|Roma welcome back Strootman, Rudiger for Sassuolo clash|
|Wolves confirm Zenga dismissal|
|Bruce lauds Rooney as a world ´great´|
|Raiola made €27m on Pogba move, reveals Juventus director|
|Dortmund injury woes worsen with Aubameyang|
|De Bruyne out of Manchester derby|
|Conte: I always show respect to opponents|
|FIFA fines RFEF over Madrid, Atletico breaches|
|Pedro backs Conte amid Mourinho spat|
|Big clubs would fight for Edwards if he was Brazilian - Pochettino|
|They boo Ronaldo, they booed me as well - Zidane|
|De Boer fed up of sacking talk|
|Neuer: Bayern have no room for error|
|Bilic praises Conte´s ´aggressive´ demeanour|
|Di Maria will bounce back - Motta|
|EFL opens investigation into Watford over ´forged´ bank letter|
|Hummels admits RB Leipzig a serious threat for Bayern|
|Pedro reveals Barcelona talks|
|De Bruyne: I have no problem with Mourinho|
|Casillas: I have not retired from Spain duty|
|Raul backs under-fire Ronaldo for Ballon d´Or glory|
|Mourinho and United must lower expectations - Xavi|
|Hands off! Milan CEO insists Donnarumma will stay|
|Glory coach Lowe accepts ban|
|Scolari extends contract with Guangzhou Evergrande|
|Guardiola eliminated City doubts - De Bruyne|
|Klopp lauds Ings for ´perfect´ response|
|Wenger: Perez needs to take chance|
|Boys to men: Mourinho challenges United players|
|Kompany committed to bargain with City medics|
|´Insipid´ Hazard overlooked for Ballon d´Or|