Serie A leaders Juventus will take a two-goal cushion into the second leg of their UEFA Europa League last-32 tie with Trabzonspor.
Pablo Daniel Osvaldo's first goal for the club put hosts Juve in front on 16 minutes before a controversial moment 20 minutes from time.
Trabzonspor substitute Henrique had a shot saved by Gianluigi Buffon and Olcan Adin scooped home Yusuf Erdogan's cut-back, but was denied as the officials decided the ball had gone out for a corner.
Paul Pogba's goal in stoppage time then added insult to injury for the Turkish side.
Fiorentina will also be heavy favourites to progress along with Juve into the last 16 after a 3-1 win over Esbjerg in Denmark, while Napoli drew 0-0 with Swansea City at the Liberty Stadium.
Alessandro Matri opened the scoring for Fiorentina, only for Martin Pusic to equalise immediately, before the Italians took control through Josip Ilicic and an Alberto Aquilani penalty.
Dutch giants Ajax were swept aside 3-0 at home by Salzburg, who have now scored in 63 consecutive matches, a run that stretches back to December 2012. Sadio Mane and Jonathan Soriano's brace did the damage in Amsterdam.
A one-minute silence was observed at all games involving Ukrainian sides out of respect to those who have lost their lives during the recent political unrest in the country, with some Shakhtar Donetsk players in tears ahead of their 1-1 draw with Viktoria Plzen.
Back in Ukraine, Yevhen Konoplyanka's late penalty gave Dnipro a 1-0 win over Tottenham, strikes from Eduardo Vargas and Antonio Barragan saw Valencia defeat Dynamo Kiev 2-0 and the game between Chornomorets and Lyon finished goalless.
Last season's runners-up Benfica have the advantage heading into their second leg with PAOK, returning from Greece with a 1-0 victory thanks to a second-half goal from Rodrigo Lima.
Bulgarian outfit Ludogorets shocked Lazio 1-0, Roman Bezjak's strike securing a famous victory in Rome before Luis Pedro Cavanda and Svetoslav Dyakov were dismissed in the second half as both sides finished with 10 men.
Sevilla drew 2-2 in Slovenia against Maribor, while Porto's match with Eintracht Frankfurt finished in the same result after the German outfit came from two goals down to give themselves a healthy chance of progressing.
Nick Viergever's strike a minute from time earned AZ a 1-0 win at Slovan Liberec, while Anzhi and Genk played out a 0-0 draw in Russia.
Elsewhere, Real Betis drew 1-1 at home with Rubin Kazan and Maccabi Tel Aviv's game with Basel ended goalless.
|Andre Gomes can play in Busquets role, insists Luis Enrique|
|Aguero´s dangerous tackle scared me, says Conte|
|Guardiola: We are killing the players|
|Bournemouth announce plans for new stadium|
|Former Bayern Munich and Real Madrid star Ze Roberto to play beyond 43rd birthday|
|Barcelona friendly awaits new Chapecoense coach Mancini|
|Arsenal are privileged to have Sanchez and Ozil - Monreal|
|Watzke denies agreement to discuss Aubameyang transfer with Madrid|
|Paris Saint-Germain v Nice: Champions hunting down shock leaders|
|Giggs tells Rashford how to end his goal drought|
|Manchester United without Shaw, Smalling for Tottenham clash|
|Willems inks PSV renewal|
|Costa and Conte scoop Premier League awards|
|Conte detained on suspicion of assault|
|Strootman ban for derby ´simulation´ overturned|
|Mourinho demands more goals from Rooney|
|Bobo preserves Sydney´s unbeaten start in Cup final rematch|
|Luis Enrique: I don´t dare predict if Messi will renew|
|Mourinho admits changing style for United|
|Sanchez talk is disrespectful, says Conte|
|Sassuolo 0 Genk 2: Visitors seal top spot|
|Sterling back for City as Guardiola predicts tough Leicester test|
|Mourinho still the ´Special One´ for Pochettino|
|Matic return leaves Conte with Fabregas dilemma|
|Guardiola expects greater impact from City youngsters next season|
|Klopp defends Karius after Bournemouth blunder|
|Pirlo visits Chelsea - but Conte is not signing him|
|Ronaldo, Modric rested for Deportivo clash|
|Tuchel hails returning Reus|
|Klopp has ´no idea´ on Sturridge return|
|´My players are intelligent and good people´ - Zidane on Ronaldo´s taxes|
|Atletico to play at ´Wanda Metropolitano´|
|Real Madrid to rest Benzema and start Morata against Deportivo|
|Ancelotti rules out Draxler bid as Bayern prepare for barren transfer window|
|Ighalo calls on Watford to sign Mikel|
|Pardew wants defender and striker to bolster Palace survival push|
|Moyes: M´Vila doesn´t have the fight for Sunderland|
|Leipzig only built to earn Red Bull money - Watzke|
|Shenhua director blasts CSL imports... but desperate for Tevez deal|
|Ribery: Bayern my last club in Europe|
|Hughes targets Arsenal fans to help Stoke end dismal away run|
|83 suspects, 98 clubs ´impacted´ in football abuse probe|
|Fowler pleads with Liverpool to keep ´top quality´ Sturridge|
|Reus ´100 per cent different´ on comeback|
|Ibrahimovic ´super happy´ for rejuvenated Mkhitaryan|
|Vertonghen: Football needs Mourinho|
|Title triumph went to Leicester´s heads, admits Ranieri|
|Conceicao named new Nantes coach|
|LaLiga lead means nothing - Zidane|
|Chapecoense add two stars to badge in wake of air disaster|
|Blatter accuses Infantino of lack of respect|
|Austin injury compounds Puel´s misery|
|Gestifute publishes further evidence of ´Ronaldo tax compliance´|
|Pioli eyes further Inter improvement|
|´I feel s***´ - Van Dijk blasts Southampton after Europa League collapse|
|Mourinho marvels at Mkhitaryan mentality after Zorya stunner|
|Southampton 1 Hapoel Be´er Sheva 1: Late Van Dijk leveller not enough as visitors progress|
|Inter 2 Sparta Prague 1: Eder double sends hosts out on a high|
|Vieira wanted Arsenal coaching opportunity|
|Vieira hopes MLS experience puts him in frame to replace Guardiola|
|Mkhitaryan: I waited a long time for this|
|Zorya 0 Manchester United 2: Mkhitaryan magic sends Mourinho´s men through|
|Ranieri urges Leicester players to fight for their futures|
|Cellino banned for 18 months over McCormack transfer|
|Koeman demands reaction from dropped Barkley|
|Tevez unsure on Boca future amid China speculation|
|Bradley vows to fight for his job at Swansea|
|Koeman speaks out on Depay, Schneiderlin links|
|Wenger unconvinced by World Cup expansion plans|
|Kovac brothers sign new Frankfurt deals|
|Selling Sturridge would be a mistake, says Rush|
|UEFA opens disciplinary proceedings against Besiktas, Dynamo Kiev|
|Filipe Luis suffers thigh tear|
|Kashima Antlers 2 Auckland City 1: Late Kanazaki header the difference|
|Suarez´s Barca renewal already done, says Bartomeu|
|Barcelona invite Chapecoense for Joan Gamper Trophy|
|Arsenal would have a chance against Real Madrid, insists Wenger|
|FIFA chief Infantino calls for zero tolerance on child abuse|
|Sanchez will not leave Arsenal for China - Wenger|
|Dybala delighted with Juventus return|
|Rashford desperate to learn from Ibrahimovic|
|Weigl not ready for Real Madrid - Tuchel|
|Why Zidane must drop Ronaldo at the Club World Cup|
|Barton: They built me up into a Neymar-Messi type|
|Shakhtar aware of Barca interest in Srna - Fonseca|
|Mets hitting coach believes Tebow can make it to MLB|
|Aubameyang reiterates Madrid dream after Bernabeu show|
|Zidane praises Benzema after 50th Champions League goal|
|Aubameyang deserves 99 per cent of credit - Reus|
|Neymar: There´s only one Ballon d´Or winner and it´s Messi, not Ronaldo|
|Magiera hails Legia victory as for ´all of Poland´|
|Tuchel thought Aubameyang had blown chance to equalise|
|Pochettino confident Spurs are back on track|
|Santo hails Porto´s mature performance|
|Lyon proved we can compete with Europe´s best - Genesio|
|Slutsky unsurprised by apparent Premier League interest in Dzagoev|
|Jardim frustrated as Monaco finally lose|