Serie A leaders Juventus will take a two-goal cushion into the second leg of their UEFA Europa League last-32 tie with Trabzonspor.
Pablo Daniel Osvaldo's first goal for the club put hosts Juve in front on 16 minutes before a controversial moment 20 minutes from time.
Trabzonspor substitute Henrique had a shot saved by Gianluigi Buffon and Olcan Adin scooped home Yusuf Erdogan's cut-back, but was denied as the officials decided the ball had gone out for a corner.
Paul Pogba's goal in stoppage time then added insult to injury for the Turkish side.
Fiorentina will also be heavy favourites to progress along with Juve into the last 16 after a 3-1 win over Esbjerg in Denmark, while Napoli drew 0-0 with Swansea City at the Liberty Stadium.
Alessandro Matri opened the scoring for Fiorentina, only for Martin Pusic to equalise immediately, before the Italians took control through Josip Ilicic and an Alberto Aquilani penalty.
Dutch giants Ajax were swept aside 3-0 at home by Salzburg, who have now scored in 63 consecutive matches, a run that stretches back to December 2012. Sadio Mane and Jonathan Soriano's brace did the damage in Amsterdam.
A one-minute silence was observed at all games involving Ukrainian sides out of respect to those who have lost their lives during the recent political unrest in the country, with some Shakhtar Donetsk players in tears ahead of their 1-1 draw with Viktoria Plzen.
Back in Ukraine, Yevhen Konoplyanka's late penalty gave Dnipro a 1-0 win over Tottenham, strikes from Eduardo Vargas and Antonio Barragan saw Valencia defeat Dynamo Kiev 2-0 and the game between Chornomorets and Lyon finished goalless.
Last season's runners-up Benfica have the advantage heading into their second leg with PAOK, returning from Greece with a 1-0 victory thanks to a second-half goal from Rodrigo Lima.
Bulgarian outfit Ludogorets shocked Lazio 1-0, Roman Bezjak's strike securing a famous victory in Rome before Luis Pedro Cavanda and Svetoslav Dyakov were dismissed in the second half as both sides finished with 10 men.
Sevilla drew 2-2 in Slovenia against Maribor, while Porto's match with Eintracht Frankfurt finished in the same result after the German outfit came from two goals down to give themselves a healthy chance of progressing.
Nick Viergever's strike a minute from time earned AZ a 1-0 win at Slovan Liberec, while Anzhi and Genk played out a 0-0 draw in Russia.
Elsewhere, Real Betis drew 1-1 at home with Rubin Kazan and Maccabi Tel Aviv's game with Basel ended goalless.
|West Ham 3 Lusitans 0: Sakho nets twice at start of Europa League journey|
|Holebas makes Watford move|
|Milan secure Adriano signing|
|Peru v Paraguay: Diaz counts cost of semi-final loss|
|Bastia hit out at reports of extra debt|
|Hernandez has successful surgery|
|Odemwingie signs one-year Stoke extension|
|Uth signs for Hoffenheim|
|Henen seals Everton return|
|Cattermole pens long-term Sunderland deal|
|United States v Guatemala: Klinsmann backs Dempsey ahead of Gold Cup warm-up|
|West Ham working on Jenkinson return - Gold|
|Milan agree deal for Bacca|
|Real buy back Vazquez from Espanyol|
|Richards leaves Swansea for Fulham|
|McShane signs for Reading|
|Giggs tells youngsters to seize US chance|
|Hammond pens Leicester extension|
|Only Schweinsteiger can decide Bayern future - Guardiola|
|Cech plans to play until he´s 40|
|Montoya arrives in Milan ahead of Inter move|
|Hernandez out of Gold Cup|
|US asks Switzerland to extradite seven FIFA officials|
|MLS Preview: Sounders seek momentum switch|
|Mexico 0 Honduras 0: Hernandez injury sours friendly|
|Hernandez taken to hospital|
|Garay in doubt for Copa America final|
|Wambach: USA peaking for World Cup final|
|Bassett ´an absolute hero´ despite own goal - Sampson|
|Japan 2 England 1: Late own goal breaks English hearts|
|Salvo quits as Valencia president|
|Costa not Ribery cover - Bayern director Sammer|
|Chile, Argentina deserve final spots - Mena|
|Ramos keen on United switch - Calderon|
|B36 1 The New Saints 2: Wilde leaves it late to secure advantage|
|Sevilla agree deal for Rami|
|Celtic snap up United teenager Janko|
|Beauvue passes Lyon medical|
|Roma bring in Falque|
|Coates completes permanent Sunderland switch|
|Vallecano to make charity donations from shirt sales|
|Angella commits to Watford|
|Gundogan pens new Dortmund deal|
|Juve reject €80million Barca offer for Pogba, says Marotta|
|Ruiz seals permanent Villarreal move|
|Mourinho respects Cech´s decision to quit Chelsea|
|Claridge excited by potential Pearson successors|
|Miranda completes Inter switch|
|Blind takes over as Netherlands coach|
|Mourinho: Premier League tougher to win than ever|
|Hamburg make Holtby move permanent|
|Southampton terminate Osvaldo contract|
|BREAKING NEWS: Swansea swoop for Eder|
|Abbiati extends Milan stay|
|Cruyff: Barcelona have lost their values|
|Vydra seals Watford move|
|Ambitious Clyne targets trophy haul with Liverpool|
|Claridge: Off-field incidents cost Pearson his job|
|Clyne becomes Liverpool´s sixth close-season signing|
|Imbula leaves Marseille for Porto|
|FIFA chief Blatter challenges critics to prove corruption claims|
|Distin joins Bournemouth|
|Bayern seal Costa deal|
|Arsenal confirm Diaby departure|
|Blatter to miss Women´s World Cup final|
|Bogdan sets sights on being Liverpool number one|
|Danilo eager to get started at Real Madrid|
|Leicester´s Wood joins Leeds|
|Porto confirm Atletico move for Martinez|
|Lloyd: Repetition key to netting penalty|
|Sheffield Wednesday job a ´dream´ for Carvalhal|
|´We played a complete game´ - Messi|
|Diaz upbeat despite heavy Copa loss to Argentina|
|Martino lauds Messi for selfless performance|
|Viviani makes surprise Verona switch|
|Estonian team wins cup match 31-0|
|No meeting with Arsenal has occurred - Vidal´s agent|
|United States 2 Germany 0: Ellis´ team reach World Cup final|
|Argentina 6 Paraguay 1: Messi leads Martino´s men to Copa final|
|UEFA Europa League Review: FK Zeljeznicar and FC Dacia Chisinau open with wins|
|UEFA Champions League Review: FC Pyunik make winning start|