Craig Gardner's superb goal handed Sunderland a 1-0 FA Cup win over Southampton as Rickie Lambert wasted a glorious late chance to equalise.
Gus Poyet's side continued their excellent form in knockout competitions as the League Cup finalists reached the last eight, but only after Lambert somehow contrived to clear the crossbar from two yards in the closing stages.
Gardner's stunning strike five minutes after the break proved decisive, the midfielder turning away from Victor Wanyama before firing home from outside the penalty area.
Sunderland had several chances to make it more comfortable but none as good as the one presented to England man Lambert, whose miss let the hosts off the hook.
Poyet, whose men remain embroiled in relegation trouble, promised to ring the changes ahead of a busy schedule for his side and he duly obliged, making nine alterations as forward Ignacio Scocco was handed his debut.
Mauricio Pochettino has no such problems, with his charges eighth in the table, but he made six changes as both sides struggled to find their rhythm in a frenetic opening.
The visitors had the first opportunity, Adam Lallana finding Lambert with a cross before the striker nodded down for James Ward-Prowse, whose effort was well saved by Oscar Ustari.
Poyet was angered by the officials' decision not to award a penalty when Fabio Borini went down under the challenge of defender Luke Shaw after 12 minutes.
Emanuele Giaccherini then squandered a promising opportunity when he failed to get a shot away after dribbling his way into the Southampton area.
Lambert was denied an excellent chance to put his side ahead eight minutes before the break when Santiago Vergini executed a well-timed tackle in the box.
Gardner sparked the game into life with 50 minutes gone, putting his side ahead with a long-range strike that crashed in off the underside of Kelvin Davis' bar.
It was Gardner's third goal of the season and the visitors struggled to mount a response, with Pochettino opting to introduce Jay Rodriguez and Morgan Schneiderlin just after the hour mark.
Connor Wickham should have made it two 17 minutes from time but he failed to connect with a pass when through on goal, while Lallana could only put Nathaniel Clyne's cross wide from close range.
Pochettino must have realised it was not to be Southampton's day when Lambert spooned Clyne's low cross over the bar with the goal at his mercy as Sunderland sent the visitors crashing out of a second cup competition this season following their 2-1 League Cup win in November.
|Coach: G. Poyet|
for I. Scocco 69'
for A. Dossena 77'
for C. Gardner 83'
|Napoli not interested in selling Higuain - De Laurentiis|
|Wilson agrees Bournemouth extension|
|Messi makes early Barcelona return|
|Ibrahimovic: My next move will be a very big surprise|
|Van Aanholt backs Lens to shine|
|Besiktas complete loan move for Gomez|
|McClaren: No decision on Coloccini future|
|Kane, Kaka hail goalkeeper Rimando|
|Chung eager to become FIFA president|
|Yedlin open to loan move|
|Tigres not scared of River trip - Ferretti|
|MLS Preview: Wright-Phillips, Lampard set to debut|
|´A draw is good for us´ - River´s Gallardo confident of Libertadores success|
|Di Maria poised for PSG switch - Blanc|
|Franjic: Bring on Bangladesh, Tajikistan|
|Van Gaal bemoans De Gea situation|
|MLS All-Stars 2 Tottenham 1: Kane stunner can´t spare Spurs|
|Manchester United 0 Paris Saint-Germain 2: Van Gaal´s defensive frailties exposed|
|Tigres UANL 0 River Plate 0: Visitors lose Gallardo in Copa Libertadores final first leg|
|Penedo parts ways with Galaxy|
|Benitez backs Mihajlovic, Milan to succeed|
|Barnetta joins Union in MLS|
|Allegri critical of Morata´s attitude|
|Franjic targets more A-League glory with City|
|Beto undaunted by Super Cup clash against Barca|
|Advocaat upbeat despite another Sunderland flop|
|McClaren praises Newcastle recruit Mitrovic|
|Payet will improve West Ham - Bilic|
|Pulis confirms interest in Lambert|
|Deila expects tough test in Baku|
|Drogba mobbed by Montreal Impact fans|
|UEFA Champions League Review: Ajax spurn two-goal lead at 10-man Rapid|
|Sunderland´s struggles continue as Doncaster cruise to win|
|Mahrez and Nugent on target in Leicester win|
|Mitrovic tastes debut defeat for Newcastle|
|Celtic 1 Qarabag 0: Boyata snatches crucial win|
|Jablonec 0 Copenhagen 1: Verbic cracker gives Danes the edge|
|Norwich sign Wisdom on loan from Liverpool|
|UEFA Europa League Preview: Koeman plays down importance of Vitesse links|
|Schneiderlin keen to learn from experienced duo|
|Mandzukic´s maiden Juventus goal seals win in Poland|
|Fofana completes Bastia loan|
|Deila delighted that Gordon pledges future to Celtic|
|Grenier ruled out for four months|
|Rooney: United squad ready for title challenge|
|Messi and Neymar available for start of season|
|Szczesny seals Roma switch|
|Benitez cools Mourinho war of words|
|Filipe Luis vows to win back Atletico fans|
|Besiktas in negotiations over Gomez switch|
|Kishna seals Lazio switch|
|Diaby completes Marseille move|
|Platini is bad for FIFA - Prince Ali|
|Bilic keen to make further additions|
|Brady makes Norwich move|
|Southampton complete Caulker loan|
|Rummenigge feels Muller ´will never leave´ Bayern|
|Platini to stand in FIFA presidential election|
|Howedes to remain Schalke skipper|
|Albion sign Hull defender Chester|
|Lucescu defends Fred selection amid doping allegations|
|Fabregas still in love with Arsenal|
|Luis Enrique ´happy´ with Barca´s US trip|
|Mourinho optimistic over Cahill and Costa|
|River owe Tigres´ Esqueda - Mercado|
|Van Gaal expecting big season from Shaw|
|Begovic keen to challenge Courtois|
|Mourinho launches attack on Benitez|
|CONMEBOL ´knocked on a lot of doors´ to keep half-spot - president|
|America 0 Benfica 0 (3-4 on penalties): Primeira Liga champions finally win|
|Napoli striker Higuain ´untouchable´ - Gabbiadini|
|Arsenal´s friendly form will boost confidence - Wenger|
|Nagatomo-Melo swap possible, says agent|
|Chelsea 2 Barcelona 2 (4-2 on penalties): Courtois stars for Premier League champions|
|Eriksen calls for ruthless Spurs|
|Pulis praises Berahino attitude|
|Alderweireld confident of top-four finish|
|Villa ready for tough Spurs clash|
|West Ham edge win on Carrow Road anniversary|
|Kozak scores twice as Villa draw at Wolves|
|Stanislas brace leads Bournemouth past Yeovil|
|Watford slip to friendly defeat at Cardiff|
|Lukaku injury sours Everton win at Dundee|
|UEFA Champions League Review: Fenerbahce draw blank as Monaco impress|
|West Brom earn friendly win over Walsall|
|Vardy at the double as Leicester beat Burton|
|Atletico impress in win over Oviedo|
|Herrera sacked by Mexico after ´punch´|
|Gerrard, Keane and Bradley pull out of MLS All-Star squad|
|Marseille reach Diaby agreement|
|Sammer thrilled with Vidal´s winning mentality|
|Platini expected to launch FIFA presidency bid|
|Romanov sacked me over Barca snub - Korobochka|
|Villa complete Crespo capture|
|Wolfsberger v Borussia Dortmund: Bender praises ´fun but exhausting´ training|
|Okaka swaps Sampdoria for Anderlecht|
|Southampton v Vitesse: Fonte excited for ´dream´ sojourn into Europe|
|Bournemouth agree King compensation|
|West Ham v Astra: Kouyate confident West Ham can progress|
|Vidal completes Bayern switch, signs four-year deal|
|Fabregas calls for Champions League improvement|
|BREAKING NEWS: Filipe Luis completes Atletico return|
|Bayern to present Vidal|
|Wenger unfazed by Mourinho´s spending jibe|
|Pellegrini: Sterling will justify price tag|
|Cavani hit with two-match Uruguay ban|
|Bonucci to remain at Juve until 2020|
|No bids for Berahino - West Brom|
|Putin: Blatter deserves a Nobel prize|
|Howe: Swansea a benchmark for Bournemouth|
|New Parma to play in Serie D|
|Mata vows to hit the goal trail at United|
|Drogba ´perfect fit´ for Montreal|
|Berahino ´not yet´ ready for Tottenham - Irvine|
|Romero lauds caring Van Gaal|
|Jese flying at Real under Rafa|
|Sampdoria unwilling to pay €10m for Balotelli|
|Mourinho talks up Arsenal title chances|
|Hull sign Ryan Taylor, Sam Clucas|
|Kane, Pochettino hail MLS All-Star test|
|Di Santo sorry for swift Werder departure|