Rene Meulensteen's decision to make eight changes spectacularly backfired as Fulham were dumped out of the FA Cup 1-0 by Sheffield United.
Substitute Shaun Miller popped up in the final minute of extra-time in Tuesday's fourth-round replay at Craven Cottage to head home from close range as the League One strugglers claimed their second Premier League scalp in the competition this season after beating Aston Villa to progress.
United's prize is a home tie against either Preston North End or Nottingham Forest, but for Fulham, who have scored only once in the last five games in all competitions and are bottom of the Premier League, the misery continues.
And Meulensteen will face plenty of scrutiny over his team selection.
With Fulham head coach Meulensteen making wholesale changes to the side that lost 3-0 at home to Southampton on Saturday, it was perhaps unsurprising that it was the visitors who made the brightest start when Jamie Murphy whipped a shot wide from 20 yards that had David Stockdale worried.
Although Meulensteen's men started to see more of the ball, the best Fulham could offer in terms of a threat was a Pajtim Kasami header that sailed harmlessly wide.
Some lovely build-up play involving Scott Parker, Kasami and Hugo Rodallega gave Clint Dempsey a sight of goal, but his effort was a wild swipe that ended a promising team move in disappointing fashion.
Sheffield United are languishing in the League One drop zone, but went close after 35 minutes when Conor Coady's inch-perfect cross found Murphy and he flashed his header just wide.
But it was the Premier League outfit who had the best chance of the half in injury time when Dan Burn headed Kasami's corner wide from six yards out.
Nigel Clough's United side resumed confidently after the restart with Bob Harris curling a free-kick just wide of Stockdale's goal before shooting straight at the goalkeeper moments later.
The game badly needed a goal and almost got one through calamitous circumstances after 65 minutes when Damien Duff's cross was sliced towards his own goal by Neil Collins, but the defender was bailed out by Mark Howard, who made an excellent one-handed save.
Both sides looked short of confidence as extra-time was required. John Brayford almost made a telling contribution when he was given space to drive through the Fulham defence, but his fierce low effort produced a superb save by Stockdale, who clawed the ball away.
Kasami went close twice late on with a crisp shot that went wide and again when Howard tipped wide.
But United won it at the death through Miller, who stooped to head in from close range after Harry Maguire had headed back across goal.
|Coach: R. Meulensteen|
for A. Kačaniklić 59'
for H. Rodallega 59'
for S. Parker 69'
|Lampard welcomes ´perfect´ NYCFC challenge|
|Shamrock Rovers 3 Progres Niederkorn 0: Waters at the double|
|Gerrard keen to emulate ´hero´ Beckham at Galaxy|
|UEFA Champions League Review: Red Imps make history, TNS breeze through|
|Ameobi extends Newcastle deal and heads for Cardiff|
|U.S. women celebrate World Cup victory with LA rally|
|Atletico agree Vietto deal|
|Silva appointed Olympiacos head coach|
|Presidential candidates unsure of Turan´s Barca switch|
|Toure keen to bounce back from ´disappointing´ campaign|
|El Salvador v Canada: Floro targets Gold Cup learning curve|
|Juve complete Zaza swoop|
|Costa Rica v Jamaica: Borges confident Wanchope´s men are ready|
|Marseille snare Sarr|
|Italy coach Conte to stand trial in match-fixing case|
|Castan keen to repay Roma´s faith|
|Rami thrilled to reunite with ´best coach´ Emery at Sevilla|
|Lusitans v West Ham: Tomkins seeks to silence minnows|
|Kagawa shines as Dortmund hit six in Japan|
|Alonso tips Gerrard for Galaxy glory|
|Firmino seeks self-improvement with Liverpool|
|Buffon bids farewell to Pirlo|
|Sterling named Europe´s ´most valuable´ young player|
|Casillas´ agent reveals Porto offer|
|Southampton bring in Martina|
|Dundee United accept Celtic´s Ciftci bid|
|McArthur pens new Palace deal|
|Bartomeu rules out Barca move for Pogba this year|
|Spurs have to be better now - Bentaleb|
|Milner expects central role|
|Micronesia thrashed again, this time 46-0|
|Marchisio: I cannot be Pirlo´s heir|
|Inter aiming for Champions League return - Icardi|
|UEFA Europa League Preview: Brondby and Slovan to protect handsome leads|
|Bentaleb pens new long-term deal at Tottenham|
|Barca agree Turan deal|
|FIFA bans Mayne-Nicholls|
|United States v Honduras: Klinsmann demands improvement ahead of Gold Cup opener|
|CONCACAF institutes extensive reforms in wake of FIFA corruption scandal|
|Mauri completes Milan move|
|City sign Turkey striker|
|Women´s World Cup final draws huge US TV ratings|
|My first Chelsea team better than current crop - Drogba|
|Bertrand set for lay-off after knee surgery|
|New five-year Juve deal for Marchisio|
|Allegri extends Juve contract|
|Koeman reiterates Alderweireld interest|
|Valencia bag Bakkali|
|New York City FC complete Pirlo capture|
|Panama v Haiti: Collat ready to challenge the best of CONCACAF|
|UEFA Champions League Preview: Harrison eyes TNS progression|
|FIFA sanctions Yemen for fielding ineligible player|
|Toulouse rubbish Ben Yedder exit reports|
|Mourinho ´knows what he´s doing´ with Falcao signing|
|Watford shell out club-record fee for Capoue|
|Braafheid signs Lazio extension|
|Nani finalises Fenerbahce move|
|Liverpool confirm O´Driscoll appointment|
|Liverpool have to start better - Lucas|
|USA simply too good - Sasaki|
|Portland Timbers 1 San Jose Earthquakes 0: Jewsbury wins it in stoppage time|
|No move yet for Van Persie|
|Lloyd wins Golden Ball, Silver Boot awards|
|Mascherano: I never grabbed Banega|
|Dunga requested Brazil not appeal Neymar´s suspension|
|United States 5 Japan 2: Lloyd stars with hat-trick|
|Fiorentina deny Inter criticism|
|Nani relishing Fenerbahce opportunity|