An FA Cup fourth-round replay against Sheffield United on Tuesday will give struggling Fulham an opportunity to restore some pride.
The London club's miserable season reached a new low on Saturday when they dropped to the bottom of the Premier League table with a 3-0 home defeat against Southampton.
Rene Meulensteen's side are without a win in four games and have scored just one goal in those fixtures.
Hugo Rodallega found the back of the net to salvage a replay at Bramall Lane on January 26 after 10-man United looked set to pull off a shock win.
Meulensteen has described the task he faces at Craven Cottage as the biggest challenge of his career to date and the Fulham head coach could really do with a morale-boosting win against Nigel Clough's League One side.
The former Manchester United coach's priority is to keep Fulham in the top flight, but a cup run could provide valuable momentum.
Meulensteen attempted to turn his side's fortunes around by bringing in several new faces during the transfer window.
Greece striker Konstantinos Mitroglou will be expected to add some much-needed firepower following his move from Olympiakos for an undisclosed fee - reported to be £12million.
However, Mitroglou, Larnell Cole, Lewis Holtby, Ryan Tunnicliffe, William Kvist and John Heitinga are not eligible to feature on Tuesday as they were not registered when the original tie was played.
Fulham have doubts over John Arne Riise (hamstring), Fernando Amorebieta (knee) and Matthew Briggs (hernia).
Sheffield United also come into the game on the back of a 3-0 defeat on Saturday, at the hands of Crewe Alexandra.
Clough was puzzled by his side's lacklustre display at Gresty Road against another side battling to avoid relegation.
United, who pulled off a stunning win at Aston Villa in the third round, are now without a win in four games across all competitions, but gave Fulham a real scare when the two sides met last month.
Chris Porter put United in front, but their hopes of reaching the fifth round suffered a major setback when Michael Doyle was sent off early in the second half and Rodallega denied them 15 minutes from time.
Porter has been struggling with a hamstring injury and dropped to the bench at Crewe, but the former Derby County striker could start at Craven Cottage.
Midfielder Doyle serves the second instalment of a three-match ban as a result of his dismissal in the first tie between the two clubs.
|Coach: R. Meulensteen|
for A. Kačaniklić 59'
for H. Rodallega 59'
for S. Parker 69'
|Herrmann pens Gladbach extension|
|Pique calm over Spain defeat|
|Queiroz leaves Iran|
|La Liga Preview: Sevilla working on new Emery deal ahead of Bilbao´s visit|
|Hiddink fumes at booing of Iniesta|
|Santos: Portugal attitude was fine in Cape Verde defeat|
|Bayern face anxious wait over Alaba injury|
|´Title is within reach´ for Marseille - Ocampos|
|Martino hails Argentina performance|
|MLS Preview: DC United, Orlando City battle for top spot|
|Panama 2 Costa Rica 1: Perez, Tejada end visitors´ unbeaten run|
|Kluivert´s Curacao advance to second round|
|Mexico 1 Paraguay 0: Eduardo Herrera´s debut goal secures victory|
|Mexico 1-0 Paraguay: Eduardo Herrera's debut goal secures victory|
|Argentina 2 Ecuador 1: Pastore the hero in Messi´s absence|
|Peru 0 Venezuela 1: Martinez goal settles heated contest|
|Wilmots pleased with Belgium´s response|
|Hodgson satisfied with draw|
|Argentina 2-1 Ecuador: Pastore the hero in Messi's absence|
|Real agree to sign Danilo|
|Turin return evoked ´strong emotions´ for Conte|
|Hiddink looking to build on Spain win|
|Del Bosque frustrated by friendly defeat|
|Bradford City 0 Chesterfield 1: Harrison strike moves visitors into play-off places|
|Portugal 0 Cape Verde 2: Hosts suffer shock friendly defeat|
|Townsend takes swipe at TV pundit Merson|
|Plane issue grounds England squad|
|Israel 0 Belgium 1: Fellaini nets again as Kompany sees red|
|N´Koulou returns to full Marseille training|
|Netherlands 2 Spain 0: Hosts ease pressure on Hiddink|
|Italy 1 England 1: Townsend leveller rescues draw|
|Ghana 1 Mali 1: Sako spot-kick denies Black Stars|
|Luxembourg 1 Turkey 2: Calhanoglu stakes claim with late winner|
|Ghana 1-1 Mali: Sako spot-kick denies Black Stars|
|Italy 1-1 England: Townsend rocket earns draw for Three Lions|
|Rummenigge marvels at ´genius´ Guardiola|
|Switzerland 1 United States 1: Stocker seals draw after Altidore red|
|Young players should not need a break, says Dyche|
|Tottenham acquire final piece of land for new stadium|
|Portugal 0-2 Cape Verde Islands: African minnows claim historic victory|
|Netherlands 2-0 Spain: Rejuvenated Dutch ease pressure on Hiddink|
|Switzerland 1-1 USA: Altidore sent off in friendly draw|
|Palestinian FA speaks out against Israel-Belgium venue selection|
|Valdes enjoying football again after injury nightmare|
|Emotional Cha retires ´a happy man´|
|Dortmund´s Kirch suffers knee injury|
|Newcastle need to be mentally prepared, says Williamson|
|Leno ´knows nothing´ of Real interest|
|Tunisia to compete in AFCON after apology|
|Van der Vaart not allowing future to affect his game|
|Vlaar: Sherwood has reduced stress levels|
|Roma hit by Gervinho hamstring blow|
|Jones optimistic over Everton´s strike partnership|
|Milik sustains knee ligament damage|
|Georgia fear stadium closure for Scotland clash|
|Zamparini: Juventus and Arsenal have bid for Dybala|
|South Korea 1 New Zealand 0: Lee nets late winner|
|Japan 5 Uzbekistan 1: Five-star hosts maintain Halilhodzic start|
|European clubs benefit from UEFA agreement|
|Vassell: Sky is the limit for Kane|
|Manchester United move would be an ´honour´ for Coentrao|
|Insigne out to bolster Napoli season after lay-off|
|Rooney warns Kane over ´clever´ Italy defenders|
|Rangers results reveal £500,000 Newcastle clause|
|Southampton announce £33.4m profit|
|´I am a very flexible man´ - Van Gaal|
|A-League Preview: Top spot up for grabs|
|Portugal - Cape Verde Preview: Andre and Oliveira eager for international bows|
|Puerto Rico 0 Canada 3: Floro´s men rout hosts|
|Xavi denies Al Sadd link|
|Fernando´s life ban upheld by CAS|
|Argentina - Ecuador Preview: Messi remains doubtful for friendly|
|Falcao equals Colombia´s all-time scoring record|
|Macedonia trip good learning curve - Postecoglou|
|Macedonia 0 Australia 0: Stalemate in Skopje|
|Del Bosque not out for Netherlands revenge|
|Burton Albion 1 Stevenage 1: Both teams score at wrong end in draw|
|Pekerman: I have no say on Falcao´s Manchester United future|
|Buffon has studied England new boy Kane|
|Conte urges patience from Italy fans|
|Johnson tasked with keeping Cheltenham up|
|Rooney not keen on Serie A switch|
|Kane to make first England start|
|Colombia 3 Kuwait 1: Spot-on Falcao equals Iguaran record|
|Goal-shy Barkley eyes striker´s role|
|UEFA opens disciplinary proceedings against Montenegro and Russia|
|Draxler and Choupo-Moting back in training|
|Ghana v Mali: Last chance to impress before Giresse return|
|Wilson: Gibraltar getting stronger|
|Mata confident of Spain future|
|Armenia coach Challandes resigns|
|Hiddink rubbishes talk of Dutch negativity|
|Portugal v Cape Verde: Santos set to rotate|
|Loren hails Moyes for Sociedad surge|
|Cruyff brands Netherlands ´a disgrace´|
|Kick It Out backs Barnes over race comments|
|Argentina v Ecuador: Messi remains doubtful for friendly|
|Coates backs Hughes ambition at Stoke|
|Atletico able to call on Saul again|
|Italy v England Preview: Kane set to start after dream debut|
|Zidane would accept Real job|
|Hernandez frustrated by lack of Real opportunities|
|Spartak donate money to 102-year-old fan after robbery|
|Clasie pulls out of Netherlands squad|
|Italy´s Bertolacci out of England friendly|
|Newcastle post record profit as Ashley debt stays the same|
|Al Sadd: We want Xavi to bring tiki-taka|
|Lacazette expected frosty Saint-Etienne reception|
|Barnes: I can´t get back into management because I´m black|
|Rooney praises England aggression|
|Southgate tips Kane for return to U21s|
|Mexico v Paraguay: Goals in order for Copa America aspirants|
|Netherlands - Spain Preview: Wijnaldum rallies behind under-fire Hiddink|
|Peru v Venezuela: Sanvicente wants Venezuelan response|
|Carvalho confident of playing Juventus|
|Neymar demands protection after Medel stamp|
|MLS Review: RSL, Fire secure breakthrough wins|
|Firmino firmly on radar - Dunga|