An FA Cup fourth-round replay against Sheffield United on Tuesday will give struggling Fulham an opportunity to restore some pride.
The London club's miserable season reached a new low on Saturday when they dropped to the bottom of the Premier League table with a 3-0 home defeat against Southampton.
Rene Meulensteen's side are without a win in four games and have scored just one goal in those fixtures.
Hugo Rodallega found the back of the net to salvage a replay at Bramall Lane on January 26 after 10-man United looked set to pull off a shock win.
Meulensteen has described the task he faces at Craven Cottage as the biggest challenge of his career to date and the Fulham head coach could really do with a morale-boosting win against Nigel Clough's League One side.
The former Manchester United coach's priority is to keep Fulham in the top flight, but a cup run could provide valuable momentum.
Meulensteen attempted to turn his side's fortunes around by bringing in several new faces during the transfer window.
Greece striker Konstantinos Mitroglou will be expected to add some much-needed firepower following his move from Olympiakos for an undisclosed fee - reported to be £12million.
However, Mitroglou, Larnell Cole, Lewis Holtby, Ryan Tunnicliffe, William Kvist and John Heitinga are not eligible to feature on Tuesday as they were not registered when the original tie was played.
Fulham have doubts over John Arne Riise (hamstring), Fernando Amorebieta (knee) and Matthew Briggs (hernia).
Sheffield United also come into the game on the back of a 3-0 defeat on Saturday, at the hands of Crewe Alexandra.
Clough was puzzled by his side's lacklustre display at Gresty Road against another side battling to avoid relegation.
United, who pulled off a stunning win at Aston Villa in the third round, are now without a win in four games across all competitions, but gave Fulham a real scare when the two sides met last month.
Chris Porter put United in front, but their hopes of reaching the fifth round suffered a major setback when Michael Doyle was sent off early in the second half and Rodallega denied them 15 minutes from time.
Porter has been struggling with a hamstring injury and dropped to the bench at Crewe, but the former Derby County striker could start at Craven Cottage.
Midfielder Doyle serves the second instalment of a three-match ban as a result of his dismissal in the first tie between the two clubs.
|Coach: R. Meulensteen|
for A. Kačaniklić 59'
for H. Rodallega 59'
for S. Parker 69'
|Donnarumma dreams of being Milan captain|
|Koke: History, not revenge motivating Atletico|
|Costa Rica v Venezuela: Hosts ramp up preparations for maiden Copa America tilt|
|Argentina v Honduras: Messi and co warm up for Copa America|
|USA will win a World Cup, says Donovan|
|Pumas UNAM 2 Independiente del Valle 1 (3-3 agg, 3-5 on penalties): Hosts suffer shoot-out heartbrea|
|Gracia leaves Malaga as Rubin Kazan loom|
|Messi: Argentina deserve to be Copa America champions|
|Dybala included in Argentina´s preliminary Olympics squad|
|Mourinho and United a ´good wedding´ - Ancelotti|
|Klinsmann: Copa America better than Euros|
|Messi: Joining Barcelona not an easy decision|
|Carrico receives four-game ban for homophobic slur|
|Dani Alves wants Atletico to win Champions League|
|McNair out to impress ´world-class´ Mourinho|
|Ranieri: Premier League survival is Leicester´s priority next season|
|Argentina forward Lavezzi suffers hamstring scare|
|Koeman talks ´very positive´, say Southampton|
|Rami replaces injured Varane in France´s Euro 2016 squad|
|Matthaus applauds Gotze for rejecting ´easy solution´ of Liverpool|
|Suarez silenced his doubters - De Boer|
|AFC Champions League Review: Jeonbuk, Shanghai SIPG progress|
|Klopp can take Liverpool right to the top, says McAllister|
|Lindelof happy at Benfica amid Real Madrid, Barcelona links|
|Zidane is perfect on and off the pitch - Lippi|
|Bale: Zidane has brought the best out of Real Madrid|
|Favre takes over as Puel and Nice part ways|
|Liverpool complete Karius deal|
|Van Gaal was treated poorly by United, but Mourinho will be a success - De Boer|
|Dani Alves: I have won more titles than Pele|
|I know who I´m taking - Conte sure on Euro 2016 selection|
|Xavi backs Guardiola to ´change the face of English football´|
|Lucescu appointed Zenit boss|
|Manchester United and Liverpool hit with €40,000 fines|
|Weinzierl: I have nothing to lose at Schalke|
|Rangers complete Barton signing|
|Italy better placed as underdogs ahead of Euro´s - Motta|
|Cantona: I love Mourinho, but he is not Manchester United|
|Ben Arfa wants Lyon move - Aulas|
|David Silva praises Iniesta´s Copa del Rey heroics|
|´It was a little scare´ - Ronaldo plays down injury fears|
|Eder the real deal for Lille|
|Van Gaal treated unfairly during Manchester United spell - Daley Blind|
|Ginola doing ´very well´ after heart surgery|
|Depay rules out Manchester United exit following Van Gaal departure|
|Hojbjerg confirms desire to leave Bayern|
|Ronaldo leaves Madrid training early after knock|
|Abbiati unimpressed with Milan players´ attitude|
|Pepe calls on Madrid to continue making history|
|Ayestaran signs two-year deal with Valencia|
|Montolivo, Antonelli sign new AC Milan contracts|
|Ronaldo ready for UCL final after being rested from practice match|
|Hummels, Sanches deals will not stop Bayern spending - Rummenigge|
|Oblak´s penalty heroics, Griezmann´s Barcelona brace - Atletico Madrid´s route to the Champions Leag|
|Salvio all but confirms Gaitan will join Atletico Madrid|
|Motta warns PSG over Ronaldo, Neymar interest|
|Europa League Mourinho´s best hope for United trophy - Sheringham|
|Injustice if Iniesta never wins a Ballon d´Or - Del Bosque|
|Van Gaal didn´t deserve United sacking - Blind|
|I´ll be happy if we make Euro 2016 semi-finals - Del Bosque|
|Koke: Why would I want to leave Atletico?|
|Fofana could retire aged 25 - Lyon president|
|Sandro set to leave Barcelona|
|Silva plays down injury worries ahead of Euro 2016|
|United would be brave to appoint Mourinho, says Schmeichel|
|Neymar adamant he is happy at Barcelona|
|Wilshere: Arsenal play me out of position|
|Ryan backs former coach Neville|
|Keane talks up Galaxy move for Ronaldo|
|´Free agent´ Diarra wants Mourinho reunion|
|Eintracht Frankfurt beat Nuremberg to secure Bundesliga status|
|Manchester United to turn to Mourinho, the man who most resembles Ferguson|
|Manchester United kids are Van Gaal´s legacy - Ferdinand|
|´Sex-masochism´, ´fat man´ and ´Mr Mike Smalling´ - Van Gaal´s best quotes as Manchester United mana|
|I have fulfilled a long-held ambition - ´Very disappointed´ Van Gaal´s statement in full|
|Van Gaal should call time on career after Manchester United sacking|
|Better than Busby? - The stats behind Van Gaal´s United exit|
|Van Gaal sacked by Manchester United|
|Suarez expected to miss Copa America group stage|
|Herrera wants more trophies with Manchester United|
|FIFA sacks deputy secretary general Kattner|
|Asensio wants to fight for his chance at Real Madrid|
|SFA to investigate Rangers-Hibernian disorder|
|Van der Wiel takes aim at Blanc after PSG exit|
|Halilovic: Missing Euro 2016 would not be a tragedy|
|Van Gaal leaves United training ground as Mourinho speculation goes on|
|Zanetti rules out Inter move for Simeone|
|Rodgers adamant Celtic is not a step down|
|Sanches chose Bayern Munich over Manchester United|
|Rosicky was the perfect player for Arsenal - Wenger|
|Tonelli becomes Napoli´s first close-season signing|
|Thigh injury rules Steffen out of Euro 2016|
|Gotze is a perfect fit for Liverpool - Hitzfeld|
|Hummels completes Bayern move after passing medical|
|Guardiola era has been sensational - Neuer|
|Bayern will never sign a Messi or Ronaldo - Hitzfeld|
|Wilkins backs Mourinho appointment|
|Suarez´s Copa America hopes alive despite hamstring injury|
|Delneri exits Verona following relegation|
|Ireland´s Wilson ruled out of Euro 2016|
|Gotze looking forward to new season with Bayern|
|Pirlo, Giovinco out of Italy Euro 2016 squad|
|Coleman signs new Wales contract|
|Gotze talk intensifies as Bayern Munich forward leaves agent|
|Rami called up by France following Varane injury|
|United States v Ecuador: Klinsmann pins hopes on Yedlin as Copa preparations continue|
|Gabriel, Lucas Lima unsure on Santos futures|
|AC Milan to terminate Mihajlovic deal in June|
|Emery confirms Banega will leave Sevilla|
|Neville still unsure over Valencia future|
|Van Gaal arrives at United training ground amid Mourinho talk|
|Messi: We suffered but we won together|
|Evra confirms two-year Juventus deal|
|Son unfazed by Tottenham exit rumours|
|Argentine footballer dead after being struck in head|
|Arnautovic refuses to commit to Stoke|
|Sirigu: PSG wanted me out|
|MLS Review: Galaxy held by Earthquakes, Timbers end skid|
|Alba: Messi deserves credit for my goal|
|Pique: Barca deserved Copa del Rey title|
|Smalling admits relief after Lingard winner|
|Suarez, Barca unsure on extent of injury|
|Luis Enrique revels in Barca´s spectacular end to season|
|Emery proud in Copa del Rey defeat|
|Rooney hopes FA Cup lifts United - with or without Van Gaal|
|Iniesta: Copa del Rey win caps magnificent season|
|Barcelona 2 Sevilla 0 (AET): Alba and Neymar decide heated Copa del Rey final|