Stoke City recorded a first league win over Manchester United since 1984 as Charlie Adam's brace helped them to a 2-1 victory on Saturday.
On a day where none of the top four sides played and Tottenham dropped points, United failed to take advantage, going down to an organised Stoke side at the Britannia Stadium.
In a first half largely dominated by United, Stoke went ahead after 38 minutes thanks to a deflected Charlie Adam free-kick.
The former Liverpool midfielder's effort hit Michael Carrick on the edge of the area, taking the ball beyond the reach of a helpless David de Gea.
United were level just two minutes after the break, Robin van Persie the man on target as he became the first player in Premier League history to score in eight successive appearances against a single opponent.
The visitors' celebrations were cut short however, when Adam unleashed an unstoppable effort past De Gea from outside the area after 52 minutes.
It proved to be the winner as United lost their eighth league game of the season and their third straight match on the road in all competitions.
United boss David Moyes started the attacking trio of Juan Mata, Van Persie and Wayne Rooney for the first time as they looked to claim a third victory over Stoke this season.
While United were able to field a full-strength forward line, Moyes was given a defensive injury headache just 10 minutes in when Jonny Evans was replaced by Rafael Da Silva having suffered what appeared to be a hamstring problem.
Rooney then had the first chance of the game, turning and firing wide inside the area after 14 minutes following Patrice Evra's cross from the left.
From there, United began to pile on the pressure, Van Persie next to go close with an effort that deflected wide past Asmir Begovic's right-hand post.
However, Stoke survived the strong United spell and perhaps should have engineered a shot on goal when Jonathan Walters was slow to react to a loose ball on the edge of the box - Phil Jones producing a well-timed tackle.
Van Persie went close for the visitors when his close-range header took a deflection off Glenn Whelan and crept over the crossbar.
However, seven minutes before the break, Adam's free-kick, with the help of a large slice of luck and an inadvertent Carrick deflection, put the home side ahead.
Things got worse for United before half-time when Jones was taken off injured after a clash of heads in the air with Walters.
However, Van Persie was again the man to haunt Stoke as he angled a finish past Begovic following Mata's carefully-weighted throughball.
The scores were level for just five minutes however, when Adam registered his sixth league goal of the season with a magnificent left-footed strike.
With time running out United threw everything forward, and Begovic produced a stunning save in seven minutes of added time to deny Rooney from a free-kick.
But Stoke, who were in the relegation zone prior to kick-off, held on to move 11th in the table with their first league win since December.
|Coach: M. Hughes|
for J. Walters 60'
for M. Arnautović 72'
for G. Whelan 83'
|Benzema and Morata can play together - Zidane|
|Hummels plays down injury fears|
|Las Palmas 2 Real Madrid 2: Zidane´s men held again|
|Stones benefited from Moyes´ Everton exit, says Duffy|
|Allegri unconcerned by scrappy win|
|Montella demands Milan improvement|
|Ancelotti praises Thiago after Hamburg victory|
|Conte demands better attitude from Chelsea|
|Wenger hails stylish Arsenal display|
|Moreno the unlikely subject of Klopp´s praise|
|Walcott: We wanted it more than Chelsea|
|Phelan has ´no qualms´ over another handball red card|
|Arsenal 3 Chelsea 0: Sanchez, Walcott and Ozil pile on misery for Conte|
|That was how football should be - Klopp on Hull thrashing|
|Luis Enrique plans to keep Sergi Roberto on his toes|
|Karanka draws hope from Middlesbrough´s second half|
|Stoke is stitched into my body – Pulis|
|Palermo 0 Juventus 1: Own goal helps champions stay top|
|Hughes laments two ´stolen´ points|
|Wilshere can be a brilliant player for Bournemouth, says Howe|
|Defoe rues Sunderland collapse against Palace|
|Tottenham must be more clinical - Pochettino|
|Everton were second best, says Koeman|
|Benteke: I knew a chance was coming|
|Ranieri wants answers from Leicester players after Old Trafford thrashing|
|Board can call me if they want to talk - Guidolin|
|Sterling hails Guardiola´s impact|
|Sergi Roberto revelling in new role|
|Guardiola wants Aguero improvement despite scoring streak|
|Mourinho demands more from star man Pogba|
|Sporting Gijon 0 Barcelona 5: No Messi, no problem for ruthless champions|
|Stoke City 1 West Brom 1: Rondon snatches point as Pulis reaches 1000 games|
|Sunderland 2 Crystal Palace 3: Benteke´s late header stuns Black Cats|
|Swansea City 1 Manchester City 3: Aguero at the double for Guardiola´s perfect 10|
|Bournemouth 1 Everton 0: Stanislas wonder strike ends Koeman´s unbeaten start|
|Liverpool 5 Hull City 1: Coutinho stunner caps easy win|
|Middlesbrough 1 Tottenham 2: Son shines for Spurs|
|Hamburg 0 Bayern Munich 1: Late Kimmich goal maintains Bayern´s perfect start|
|Bayern facing defensive headache after Hummels limps off at Hamburg|
|Pogba and Mata delighted by United response|
|Vardy and Mahrez were rested for Porto, Ranieri admits|
|Mourinho completely trusts dropped Rooney|
|I beat Usain Bolt in a race - Bolasie|
|Juventus still Scudetto favourites - De Boer|
|Manchester United 4 Leicester City 1: Rooney watches on as Pogba inspires Red Devils demolition|
|Robben and Ribery are like Messi, claims Helmer|
|Pochettino hints at Vertonghen renewal|
|Robben´s style makes him an injury risk - Bayern fitness coach|
|Liverpool refuse to comment on Sakho´s social media outburst|
|Rooney dropped for Leicester City clash|
|Messi injury doesn´t matter to Barcelona - Abelardo|
|Thiago Silva worried by PSG form|
|Mourinho describes Wenger relationship as ´civilised´|
|Milito: Inter are no one-man team|
|Bilic delays naming daughter due to West Ham worries|
|Fernandinho hails ´intelligent´ De Bruyne|
|Matuidi: This season toughest for PSG|
|New York City 4 Chicago Fire 1: Villa nets twice in win|
|Pjaca not Morata - Allegri|
|Guardiola keen for Kolarov extension|
|England criticism changed Rooney - Mourinho|
|Gotze detractors don´t surprise Tuchel|
|Wenger laments missing out on Costa|
|Emery deflects blame from PSG players after Toulouse defeat|
|Guidolin: It´s not possible to beat Manchester City if you don´t play well|
|Mourinho prepared to bench Rooney|
|Fitness fears over Aubameyang with Real Madrid looming|
|Balotelli must remain serious, says Favre|
|Conte: Guardiola only better than me because he has it easy|
|No need for Aguero to calm down - Guardiola|
|Toulouse 2 Paris Saint-Germain 0: Aurier sees red as Emery´s side slip to surprise defeat|
|Borussia Dortmund 3 Freiburg 1: Aubameyang marks landmark game with goal|
|Argentina apologise for Bauza´s Barcelona criticism over Messi|
|Young players ´the spirit´ of Manchester United - Ferguson|
|Lack of Manchester United game-time ´frustrating´ for Rashford|
|Mazzarri rues ´bad injury´ for Janmaat|
|Sampaoli slams Messi treatment|
|Gray handed four-match ban for abusive posts|
|Valencia captain Parejo: I´ve been called a dog in the street|
|Leicester fairytale isn´t Ranieri´s best achievement|
|Former Parma chiefs get five-year bans from football|
|Three Burnley players sign new contracts|
|No complaints over Vidal post for Luis Enrique|
|Manchester City have no case to answer in Garre transfer|
|Angry Moyes slams Van Aanholt over shisha pipe photos|
|Van Basten appointed to FIFA role|
|Albiol signs new Napoli deal|
|Barcelona court re-opens Neymar transfer case|
|Barcelona want the best for Messi - Luis Enrique|
|Mourinho grudgingly helps to ´feed the Einsteins´|
|Mourinho defends embattled Rooney|
|Injured Martial to miss Leicester clash|
|Pochettino backs Janssen to fill Kane void|
|Conte admires Wenger´s ´fantastic´ Arsenal career|
|City confirm Kompany´s groin injury - no date for return|
|Allegri considers benching Dybala|
|´Benny V´ nets Tottenham deal|
|Zidane concern over Casemiro and Marcelo absences|
|Pardew backs Townsend for England recall|
|Terry ruled out of Arsenal clash|
|Kane requires second scan - Pochettino|
|Robben must settle for bench role, says Ancelotti|
|Zidane expects Barca to be weaker without Messi|
|Montero hopes to peak after signing new Swansea deal|
|Matuidi has ´no regrets´ over PSG stay|
|O´Neill, Keane sign new Republic of Ireland deals|
|Guardiola: My tactics nothing to do with Clichy goal|
|Real Madrid confirm Marcelo calf strain|
|Phelan no closer to learning Hull future|
|Italy legend Rossi hails Totti as ´the strongest in the last 20 years´|
|Adebayor dismisses whiskey and cigarette story|
|Masuaku injury blow for Hammers|
|Bauza: I don´t want a Messi war with Barcelona|
|Ramsey sidelined until after internationals|
|Walker signs Spurs extension|
|Hughes quashes Bony rift talk|
|Wenger brushes off Mourinho book claims|
|Mourinho wanted to ´break Wenger´s face´, new book alleges|
|Jones appointed as Jets coach|
|Barca the only club for Messi - Fabregas|
|Dyer on track for November return|
|Koeman rules out Everton future for Niasse|
|´Champion´ Rooney not ahead of my players - Ranieri|
|Klopp hints at Karius start|
|I never planned to leave Chelsea - Fabregas|
|Injured Messi thanks Gladbach for get well message|
|Wenger: Demanding society makes 20-year reign hard to repeat|