Stoke City recorded a first league win over Manchester United since 1984 as Charlie Adam's brace helped them to a 2-1 victory on Saturday.
On a day where none of the top four sides played and Tottenham dropped points, United failed to take advantage, going down to an organised Stoke side at the Britannia Stadium.
In a first half largely dominated by United, Stoke went ahead after 38 minutes thanks to a deflected Charlie Adam free-kick.
The former Liverpool midfielder's effort hit Michael Carrick on the edge of the area, taking the ball beyond the reach of a helpless David de Gea.
United were level just two minutes after the break, Robin van Persie the man on target as he became the first player in Premier League history to score in eight successive appearances against a single opponent.
The visitors' celebrations were cut short however, when Adam unleashed an unstoppable effort past De Gea from outside the area after 52 minutes.
It proved to be the winner as United lost their eighth league game of the season and their third straight match on the road in all competitions.
United boss David Moyes started the attacking trio of Juan Mata, Van Persie and Wayne Rooney for the first time as they looked to claim a third victory over Stoke this season.
While United were able to field a full-strength forward line, Moyes was given a defensive injury headache just 10 minutes in when Jonny Evans was replaced by Rafael Da Silva having suffered what appeared to be a hamstring problem.
Rooney then had the first chance of the game, turning and firing wide inside the area after 14 minutes following Patrice Evra's cross from the left.
From there, United began to pile on the pressure, Van Persie next to go close with an effort that deflected wide past Asmir Begovic's right-hand post.
However, Stoke survived the strong United spell and perhaps should have engineered a shot on goal when Jonathan Walters was slow to react to a loose ball on the edge of the box - Phil Jones producing a well-timed tackle.
Van Persie went close for the visitors when his close-range header took a deflection off Glenn Whelan and crept over the crossbar.
However, seven minutes before the break, Adam's free-kick, with the help of a large slice of luck and an inadvertent Carrick deflection, put the home side ahead.
Things got worse for United before half-time when Jones was taken off injured after a clash of heads in the air with Walters.
However, Van Persie was again the man to haunt Stoke as he angled a finish past Begovic following Mata's carefully-weighted throughball.
The scores were level for just five minutes however, when Adam registered his sixth league goal of the season with a magnificent left-footed strike.
With time running out United threw everything forward, and Begovic produced a stunning save in seven minutes of added time to deny Rooney from a free-kick.
But Stoke, who were in the relegation zone prior to kick-off, held on to move 11th in the table with their first league win since December.
|Coach: M. Hughes|
for J. Walters 60'
for M. Arnautović 72'
for G. Whelan 83'
|Seattle Sounders 2 Portland Timbers 0: Conference leaders leave it late|
|2014 FIFA World Cup: Tweets of the tournament|
|2014 FIFA World Cup: Best goals|
|2014 FIFA World Cup: Tournament in numbers|
|2014 FIFA World Cup: Gotze glory rounds off captivating spectacle|
|2014 FIFA World Cup: To Russia with love?|
|World Cup win is unbelievable, says Gotze|
|Downing talks up Valencia arrival|
|Kramer: ´I can´t remember very much´|
|Peru Primera Division Review: Inti Gas go top, Universitario lose|
|Klose to decide on Germany future|
|Ecuador Primera A Review: Emelec poised for championship|
|Devastated Messi: Golden Ball not important|
|Messi comparison inspired Gotze, says Low|
|Hummels: I´m on another planet|
|Messi named player of the tournament|
|Sabella proud of players, defends Messi|
|Adebayor contracts malaria, out of US tour|
|Lahm ecstatic after World Cup triumph|
|Newcastle complete Cabella deal|
|Mascherano endures World Cup pain|
|2014 FIFA World Cup Final: Player Ratings|
|2014 FIFA World Cup Final: Where the final was won and lost|
|2014 FIFA World Cup Final: New Germany ready to dominate|
|2014 FIFA World Cup Final: Germany 1 Argentina 0 (after extra time)|
|BREAKING NEWS: Germany win World Cup|
|Rousseff thanks Brazil despite World Cup woe|
|Fred ´finished´ with Brazil|
|Manchester City lose to Dundee in pre-season opener|
|Rami keen to restore Milan glories|
|Thai Premier League Review: Muang Thong win again, BEC Tero Sasana pay penalty|
|In-demand Lovren joins Southampton on tour|
|Adidas to stick with Suarez|
|Cesar accepts Brazil career all but over|
|Rodriguez signs new Fiorentina deal|
|UEFA Champions League Preview: Celtic begin campaign, Steaua in Norway|
|K.League Review: Steelers maintain lead as top four all win|
|Suso eager for Liverpool stay|
|McDonald allays West Ham injury fears|
|Basanta urges Argentina to enjoy the moment|
|Schweinsteiger: Germany have big-match experience|
|Vidal relaxed over future|
|Bartomeu drooling over Barca strikeforce|
|Gerrard should remain captain, says Beckham|
|Cafu throws support behind Scolari|
|Sabella warns Argentina|
|MLS Review: Henry, Defoe star, as late goals rain down|
|Klinsmann: Germany are favourites|
|Robben rejects Van Gaal´s United proposal|
|Blind hopes Dutch youngsters stick together|
|Thiago Silva frustrated by failure|
|Adrian leaves Atletico for Porto|
|Van Gaal proud after Dutch win|
|Scolari leaving future up to CBF|
|Mixed emotions for Robben|
|FIFA World Cup: Brazil 0 Netherlands 3|
|Sabella remains unsure of Di Maria fitness|
|Abdennour pleased with friendly workout|
|Halilhodzic to take charge at Trabzonspor|
|Fenerbahce delighted to finally sign Diego|
|Low and Germany ready for finale|
|Lyon agree Rose deal|
|Neymar´s World Cup delights Bartomeu|
|De Laurentiis: Higuain going nowhere|
|Beckham lauds ´amazing´ Messi|
|PSG beat Videoton in seven-goal thriller|
|Horta makes Malaga switch|
|Southampton seal deal for Pelle|
|Barcelona ´convinced´ of reduction in Suarez ban|
|West Ham held by League Two Stevenage|
|Bianchi makes move to England|
|West Ham must be more clinical, says Allardyce|
|Germany experience will count - Lehmann|
|Berahino and Dorrans strike in Albion win|
|Ince settling quickly at Hull|
|Swansea in talks with Napoli over Michu|
|Dodo eyes Champions League with Inter|
|FIFA World Cup Preview: Germany v Argentina|
|Huddlestone out to hit the ground running|
|Pogba not bound for Chelsea - agent|
|Barry feeling fresh with Everton|
|Arteta plays down transfer talk|
|PSV complete De Jong deal|
|Colback excited for busy pre-season|
|Milan and Orlando in talks over Robinho|
|West Brom bring in Pocognoli|
|Maradona: Messi will define World Cup final|
|Rami seals Milan move|
|Kuyt eager to secure third place|
|Rodriguez talks up Real Madrid move|
|Bebe welcomes Benfica link|
|Koeman admits unsettled Lovren could leave|
|FIFA World Cup Final Preview: Argentina face old foes Germany with Brazil´s party in tatters|
|FIFA World Cup Final Preview: Messi aims to cement legacy|
|FIFA World Cup Final Preview: Sabella on the brink of greatness|
|FIFA World Cup Final Preview: Muller seeks to augment outstanding finals record|
|FIFA World Cup Final Preview: Low´s hard work pays off|
|FIFA World Cup Final Preview: The coaches to have tasted glory|
|FIFA World Cup Final Preview: The five most iconic finals|
|FIFA World Cup Final Preview: The five most iconic finals|
|FIFA World Cup Final Preview: Germany´s route to the final|
|FIFA World Cup Final Preview: Brazil 2014 produces moments to remember|
|SJ Earthquakes 1 DC United 2: Johnson, Silva score as Eastern Conference leaders extend advantage|
|Otamendi unfazed by price tag|
|Sam targeting top three with Schalke|
|Rodriguez out for revenge|
|Bruno Alves could leave Fenerbahce|
|Thiago Silva endured sleepless nights|
|Final on enemy soil ´special´, says Zabaleta|
|Arteta: Sanchez signing highlights Arsenal´s ambition|
|Mertesacker demands repeat performance|
|Scolari gets federation backing|
|Balotelli poses with shotgun|
|Lizarazu lauds Argentina´s craftiness|