Cruzeiro are poised to progress to the quarter-finals of the Copa do Brasil after routing Santa Rita 5-0 on Wednesday.
Bolivian attacker Marcelo Moreno bagged a brace as the Brazilian Serie A champions produced a masterclass in the first leg of their last-16 clash at the Estadio Governador Magalhaes Pinto.
Cruzeiro - seven points clear in Brazil's top flight - went into Wednesday's fixture against Campeonato Alagoana opponents Santa Rita in the midst of a 10-game unbeaten streak in all competitions.
And Marcelo Oliveira's men extended that run thanks to a dominant first half that yielded three goals.
Moreno opened the scoring after eight minutes in Belo Horizonte, looping a header over goalkeeper Jeferson from Alisson's cross.
Centre-back Dede doubled Cruzeiro's lead in the 18th minute, when he headed home from a corner.
Former Arsenal and Real Madrid man Julio Baptista made it three with a header across goal in the 35th minute before Moreno doubled his tally nine minutes after the interval.
Henrique capped the lopsided win with three minutes remaining, firing a half-volley past Jeferson.
It was a different story for Serie A rivals Corinthians, who must overturn a one-goal deficit in the return leg after losing 1-0 at Bragantino on Wednesday.
Sandro Mendonca's 56th-minute goal gave the second-tier side a surprise 1-0 win in Cuiaba, while it condemned Corinthians to back-to-back defeats.
Corinthians' woes were compounded in the third minute of injury time, when midfielder Ferrugem received his marching orders.
Atletico Mineiro, Santos, Coritiba, America RN and Ceara were also among the first-leg winners midweek.
Mineiro were 1-0 victors at Palmeiras on Wednesday, with Luan's glancing header in the 71st minute the difference after Henrique missed a penalty for the home side in the first half.
David Braz and Milan loanee Robinho were both on target in the opening half as Santos upstaged Luiz Felipe Scolari's Gremio 2-0 away from home on Thursday.
Coritiba will take a three-goal advantage into the second leg after accounting for visitors Flamengo 3-0 on Wednesday.
The defeat ended Flamengo's four-game winning streak.
Serie B's America RN were 3-0 winners at home to top-flight outfit Atletico PR on Wednesday.
Rodrigo Pimpao, Max and Thiago Cristian found the back of the net for America RN.
Ceara netted two crucial away goals as they prevailed 2-1 at Botafogo on the same day.
Meanwhile, hosts Vasco da Gama were held to a 1-1 draw by ABC on Tuesday.
|M. Martins||8' 54'|
|Coach: Marcelo Oliveira|
for M. Martins 60'
for Alisson 61'
for Lucas Silva 73'
|Zidane backs Navas and defends Benzema as Madrid aim to bounce back|
|Deportivo bring in Kakuta from Hebei after CSL rule changes|
|Matip could miss eight games without doing anything wrong - Klopp|
|United trigger Valencia´s contract extension|
|Ronaldo returns to Real Madrid´s Copa squad|
|FA fine Sagna for Instagram post|
|Nedved does not foresee more January business for Juventus|
|Rafinha injury blow for Barcelona|
|Villas-Boas fumes at CSL foreign player crackdown|
|Ibrahimovic invaluable to Manchester United youngsters - Rashford|
|Robben rejected China move|
|A-League review: Phoenix rise to the occasion to end Victory´s streak|
|Van Gaal slams English media over treatment at Manchester United|
|Mignolet: Liverpool in better position to win title than in 2013-14|
|Giroud wants Premier League title but understands China temptations|
|Tianjin forced to scrap moves for Costa, Benzema, Cavani and Falcao|
|My goal was better than Mkhitaryan´s - Giroud|
|Pochettino not interested in Argentina job|
|Kane: Tottenham can win Premier League|
|Corinthians dreaming of Drogba - Paulo Roberto|
|Coutinho calls for Liverpool focus|
|Chiellini compares Pogba to LeBron and Bolt|
|Maradona to become Napoli ambassador|
|Mihajlovic furious after Torino collapse|
|Icardi has offers from China - Wanda Nara|
|Pogba can cope with pressure - Ibrahimovic|
|´My half-time words will stay in the dressing room´ - Montella annoyed with AC Milan|
|Juventus unveil dramatic change to club logo - but not everyone´s a fan|
|´I do not think I will return to coaching´ - Van Gaal set to call it quits|
|Torino 2 AC Milan 2: Bacca caps thrilling comeback as hosts pay the penalty|
|DR Congo 1 Morocco 0: Kabananga pounces on blunder to give 10 men the points|
|´Happy and comfortable´ Sanchez dismisses Arsenal exit talk|
|How much?! West Ham flop Simone Zaza could cost Valencia €20m|
|Mali v Egypt: Salah leads Pharaohs´ bid for AFCON glory|
|Sevilla concede they ´cannot force´ sporting director Monchi to stay|
|Ivory Coast 0 Togo 0: Reigning champions held to opening draw by Adebayor and co.|
|Goalkeeping woes, Stones and tactical confusion - How Guardiola is making life difficult for himself|
|Ozil and Sanchez can be persuaded to stay - Cech|
|Pogba: I rejected Barcelona and Real Madrid|
|Ghana v Uganda: Gyan dreams of first trophy since 1982|
|Chiellini: Juventus a work in progress|
|Robben agrees Bayern renewal until 2018|
|Hazard: Goals do not matter to me|
|Bennell pleads not guilty to eight child sex offences|
|Muller fed up with debate over Bayern role|
|Wenger glad Sanchez is not ´a Costa problem´|
|Flick resigns as DFB´s sporting director|
|Gomis ´can´t wait´ to welcome Payet to Marseille|
|Chinese FA changes foreign player rules after ´irrational´ spending|
|Like father, like son: Justin Kluivert follows in dad´s footsteps|
|´No reason to lose him´ - Marotta rubbishes talk of Allegri exit|
|Courtois: We don´t need Costa|
|Kane: Tottenham players won´t go to China|
|Noble ´angry and disappointed´ with Payet|
|Klopp furious over Matip uncertainty|
|Wenger surprised by tight Premier League|
|´Money is not everything´ - Conte issues warning amid China speculation|
|Fiorentina defeat a ´bad setback´ - Allegri|
|´This will elevate this group of players´ - Sampaoli revels in Sevilla late show|
|WATCH: Rio Ferdinand screams and dances in crazy Man Utd celebration|
|Real Madrid relaxed, admits Zidane after Sevilla defeat|
|Monaco go top of Ligue 1 with stunning Marseille victory|
|Ronaldo equals LaLiga penalty record as Real Madrid lose|
|Sevilla 2 Real Madrid 1: Stunning late comeback ends unbeaten run at 40|
|Fiorentina 2 Juventus 1: Brilliant Viola breathe life into Serie A title race|
|Tunisia 0 Senegal 2: Mane on target as favourites start strongly|
|Mourinho explains Klopp confrontation|
|Klopp delights in Alexander-Arnold display|
|Algeria must cut out mistakes against Tunisia - Leekens|
|Long balls led to Man Utd equaliser, says Klopp|
|´We attacked, Liverpool defended´ – Mourinho insists a point flattered Klopp´s men|
|DR Congo v Morocco: ´Confidence´ the Atlas Lions´ biggest hindrance ahead of AFCON opener|
|Ibrahimovic: Direct tactics worked for United|
|Guardiola rues gap to Chelsea after Goodison mauling|
|Algeria 2 Zimbabwe 2: Mahrez double prevents shock defeat|
|Manchester United 1 Liverpool 1: In-form Ibrahimovic saves hosts|
|Ivory Coast v Togo: AFCON champions hope to tame Le Roy´s ´troublemakers´|
|Guardiola lays City´s mental frailties bare after Goodison rout|
|Koeman hails ´perfect´ Everton after City mauling|
|Nice stalemate gives Monaco chance to go top|
|Guardiola suffers heaviest league loss in Everton thrashing|
|Neymar-esque Zaha is England´s loss – Bolasie|
|Everton 4 Manchester City 0: Koeman leaves old pal Guardiola´s title bid in tatters|
|Matip withdrawn from Liverpool selection over eligibility questions|
|Podolski staying at Galatasaray, insists sporting director|
|Cavani wants PSG stay|
|Torino move feels normal now – Hart|
|Chinese FA changes rule on CSL foreign players - reports|
|Bayern complete swoop for Hoffenheim duo Sule and Rudy|
|Aubameyang: Dortmund not really like Barca, Madrid or Bayern|
|Pogba can chance a game in one second - Herrera|
|Newcastle Jets 2 Perth Glory 2: Keogh´s eighth of season seals draw|
|Klopp: Liverpool ready for Old Trafford test|
|Herrera taunts Liverpool ahead of Old Trafford showdown|
|I had to be 100 per cent to stay at Boca - Tevez|
|No player is bigger than the club - Carroll takes swipe at want-away Payet|
|Icardi: I can always move to China at end of career|
|Mkhitaryan: Klopp convinced me not to join Liverpool|
|Mourinho: Pogba can score every game|
|Cameroon´s profligacy frustrates Broos|