Juventus begin their Serie A title defence under new coach Massimiliano Allegri at Chievo on Saturday.
A tumultuous close-season saw adored head coach Antonio Conte surprisingly leave the Turin club, having guided Juve to three successive Scudetti.
Conte has since taken the Italy job, paving the way for Allegri - whose four-year spell at Milan ended in January - to take the reins.
The 47-year-old's tenure will begin at Stadio Marc'Antonio Bentegodi this weekend in the opening game of the 2014-15 season, with big-money striker Alvaro Morata and former Manchester United defender Patrice Evra both poised to make their debuts.
Allegri's former club, Milan, will also be led by a new coach as Filippo Inzaghi takes charge for the first time against Lazio on Sunday.
Inzaghi was appointed to replace the sacked Clarence Seedorf, who filled in at the end of last season following Allegri's departure, and will be desperate to get off to a winning start.
Like Juve, Inter are likely to give a former United stalwart his first Serie A outing as high-profile recruit Nemanja Vidic is set to start at Torino.
Inter will be targeting a good beginning to a crucial campaign as they attempt to challenge Juve and Roma for the title following a fifth-placed finish last term. A Champions League return is also in Inter's sights.
Roma, meanwhile, get under way versus Fiorentina.
Last year's runners-up have a trio of new faces at their disposal in Ashley Cole, Juan Iturbe and Kostas Manolas.
However, those arrivals have been offset by the loss of star centre-back Mehdi Benatia, who has joined Bayern Munich.
The nearest challengers to the top two last season, Napoli, start with a trip to Genoa.
Two of the promoted sides, Cesena and Palermo, play host to Parma and Sampdoria respectively, while the third, Empoli, travel to Udinese.
Palermo went up as champions of Serie B, with Empoli finishing second and Cesena emerging triumphant from the six-team play-off.
Elsewhere, Atalanta take on Verona and Sassuolo tackle Cagliari.
|Berardi will get Italy call when system changes - Ventura|
|Lucas Vazquez delighted by ´dream´ Madrid deal|
|Scottish FA chief backs cross-border competition|
|Dortmund need Reus - Aubameyang|
|Lamela eyeing new Spurs deal|
|Tighter Watford matches are a coincidence, says Mazzarri|
|Karanka: We saved Boro from League One|
|Police investigate homophobic leaflet at West Ham|
|Spain could recall Villa, reveals Lopetegui|
|Hughes backs Bony to break Stoke duck|
|Sarri will greet Higuain ´like a son who made him angry´|
|Robben receives Netherlands recall|
|Dyche considering Gray recall for Burnley|
|Zidane was behind one of my best seasons, says Ronaldo|
|Schweinsteiger absent from United squad photo|
|Emery emphasises Thiago Silva´s importance amid Juve links|
|Ferguson: Leicester will make deep Champions League run|
|Ranieri hails ´special´ Ballon d´Or nominations for Vardy and Mahrez|
|Emery: PSG cannot rely solely on Cavani goals|
|Mourinho can match Guardiola, insists Ferguson|
|Ferguson hails Klopp: Liverpool are strong title contenders now|
|Bayern optimistic over Lewandowski renewal|
|Zubizarreta appointment confirmed by Marseille|
|Clichy: Things will click into place for Manchester City|
|Chiellini: Juventus wanted to send a message|
|Gabigol´s time will come - De Boer|
|Ronaldo: Messi and I are not friends - but we respect each other|
|Earthquake halts play in Serie A game between Pescara and Atalanta|
|Mourinho charged over Taylor comments|
|Ronaldo: I need my haters|
|Badstuber hopeful injury woes behind him|
|Kroos did not want to be rested, insists Zidane|
|Rojo was phenomenal - Mourinho|
|Seven arrests made after West Ham - Chelsea fan clashes|
|Florenzi injury blow for Roma|
|MLS Review: Galaxy, Toronto into semis|
|Beister: Victory move surprised people|
|Bilic: Cup run will help in Premier League|
|Pjaca out for up to three weeks|
|Trophies still the focus for Guardiola|
|Mignolet wants ´fair´ Karius battle|
|Ancelotti impressed by motivated Bayern|
|West Ham ´unreservedly condemn´ crowd trouble|
|Allegri praises strike duo after win over Sampdoria|
|De Boer praises two-goal Icardi after vital win|
|Chelsea were ´unlucky´ with missed chances, insists Conte|
|Mourinho: I´ve never had fans like these|
|Nacho´s goal better than my Champions League final volley - Zidane|
|Borussia Dortmund 1 Union Berlin 1 (aet, 3-0 pens): Weidenfeller shootout heroics seal progress|
|Bilic: Crowd trouble distracts from great West Ham win|
|Kompany told me he couldn´t play anymore - Guardiola|
|Liverpool and Manchester United handed home quarter-finals|
|Inter 2 Torino 1: Icardi double alleviates pressure on De Boer|
|Manchester United 1 Manchester City 0: Mata extends Guardiola´s winless run|
|West Ham 2 Chelsea 1: Crowd trouble tarnishes Hammers´ route to quarter-finals|
|Cultural Leonesa 1 Real Madrid 7: Morata and Asensio star in BBC´s absence|
|Bayern Munich 3 Augsburg 1: Green´s first goal sends holders through|
|Juventus 4 Sampdoria 1: Rapid start sets champions on their way|
|Crafty Suarez is world´s best striker - Godin|
|Mancini: Balotelli has wasted years but can bounce back|
|Rami rejected ´risky´ PSG move|
|Neymar would have cost PSG €430m, claims father|
|Sacchi warns Bayern players over Ancelotti temper|
|Valencia ´pleased´ with RFEF bottle ruling|
|Mourinho apologises to Utd fans for Chelsea thrashing|
|Barcelona lash out at ´totally reprehensible´ RFEF comments|
|Jacob leaves Marseille amid rumours of Zubizarreta appointment|
|Lavezzi added to Argentina squad as Dybala drops out|
|Del Bosque: Mourinho had a point on Conte|
|N´Zonzi in talks over Sevilla extension|
|Allardyce successor ´will not be a mercenary´ - Glenn|
|Aubameyang like a rocket, Lewandowski perfect - Riedle|
|RFEF fines Valencia, warns Barca over bottle incident|
|Wenger tells Iwobi to improve his finishing|
|Barcelona without Mathieu for three weeks|
|Kimmich draws inspiration from Xavi|
|Vazquez signs new Madrid deal|
|Higuain the best striker in the world - Nedved|
|Wolfsburg regret De Bruyne, Perisic sales|
|Parejo slams Neymar for ´inciting´ Valencia fans|
|Gundogan predicts ´very lively´ Manchester derby|
|Luis Enrique satisfied with Supercopa workout|
|Messi could join Newell´s after World Cup - Maxi Rodriguez|
|Ibrahimovic wants United to be the boss of City|
|Schmidt on the bus as Lotte book ticket for next round|
|Pogba still adapting to Premier League, says Mourinho|
|Southgate hails influence of demoted Rooney|
|Lille ready to heap more pressure on PSG as Corchia dreams big|
|I´m among top 20 LaLiga coaches, jokes Luis Enrique|
|Brattan earns Socceroos call-up|
|Pochettino pleased with Janssen|
|Klopp never questioned Sturridge quality|
|Barcelona downed by Espanyol in Supercopa|
|Heavy Milan defeat ´just a bump in the road´ - Montella|
|Pochettino wanted Liverpool debutant sent off|
|Klopp happy to entertain as Liverpool youngsters earn their spurs|
|Leverkusen dumped out by 10-man minnows|