Lyon will need to come from behind if they are to advance past Astra in the UEFA Europa League play-offs on Thursday.
The Ligue 1 outfit fell to a surprise 2-1 defeat on home soil last week, putting the Romanians firmly in the driving seat.
Steed Malbranque's 25th-minute opener gave Hubert Fournier's men an encouraging start, but Kehinde Fatai levelled for the visitors in the 72nd minute and Lindsay Rose received a costly second yellow card a few minutes later.
Constantin Budescu fired in a penalty in the final 10 minutes to earn a precious away win, but Astra coach Daniel Isaila knows the tie is not won just yet.
"We are really well prepared both physically and mentally," he said. "If you don't have self-confidence, it's impossible to achieve targets.
"Obviously the second leg will be very tough, because the mentality of the French players is to attack and to impose their game.
"But we have a psychological advantage and we will do our best."
Astra - bidding for a first appearance in the group stage of a continental competition - lost in this round to Maccabi Haifa last season, while Lyon made it to the quarter-finals.
Fellow French club Saint-Etienne host Karabukspor a goal down from the first leg, while Astra's compatriots Petrolul Ploiesti trail Dinamo Zagreb 3-1 ahead of their trip to Croatia.
Inter, who are - along with Juventus - the most successful team in Europe's secondary club competition, hold a sizeable 3-0 advantage over Icelandic minnows Stjarnan, but Serie A rivals Torino were held to a goalless draw by Split in their opening encounter.
Tottenham came from behind to get the better of AEL 2-1 in Cyprus and should be full of confidence following a 4-0 demolition of QPR in the Premier League but compatriots Hull City must overturn a 1-0 deficit against Lokeren of Belgium if their maiden European campaign is to go on.
There was success for the competition's Spanish clubs last Thursday.
Villarreal have one foot in the group stage after winning 3-0 at Astana, while Real Sociedad are a goal to the good against Krasnodar.
Borussia Monchengladbach will be hoping for a more straightforward home tie after beating Sarajevo 3-2 in the first leg, and Europa League involvement hangs in the balance for a trio of Dutch outfits.
Feyenoord, Twente and PEC Zwolle were held to first-leg draws by Zorya, Qarabag and Sparta Prague respectively last week.
PSV are a goal up against Shakhtyor ahead of the away leg.
Elsewhere, Apollon's match against Lokomotiv Moscow and Omonia Nicosia's tie with Dinamo Moscow are all square following draws in the first legs of the two Cyprus-versus-Russia encounters, while Swiss duo Young Boys and Zurich are 3-1 up in their respective fixtures with Debrecen and Spartak Trnava.
Metalist host Ruch Chorzow, Neftci are in action against Partizan, Zimbru travel to PAOK and Trabzonspor take a 2-0 advantage to Rostov.
Dnipro, Rijeka, Asteras Tripolis, Panathinaikos and HJK are all on the road against Hajduk Split, Sheriff, Maccabi Tel Aviv, Midtjylland and Rapid Vienna respectively.
In the round's remaining fixtures Nacional host Dinamo Minsk, Club Brugge are at home to Grasshopper, Aktobe head to Legia Warsaw, and Rio Ave welcome Elfsborg.
|Benteke: Villa transfer request was a mistake|
|Gerrard urges Sterling to stay put|
|Pardew calls for calm ahead of derby clash|
|Kerala Blasters v Atletico de Kolkata: Luis Garcia talks up team ahead of final|
|Monk wants three new Swansea signings|
|Koeman plays down Sneijder link|
|Howard targets another World Cup|
|Inzaghi prepared for Stadio Olimpico atmosphere|
|Toronto expect Defoe to return|
|Rodriguez suffers injury setback|
|Klopp denies Dortmund departure plans|
|Copa del Rey Review: Bilbao and Elche edge through, Madrid derby beckons|
|Simeone refuses to criticise Atleti display|
|Serie A Review: Juventus and Napoli brush aside lowly opponents|
|Allegri and Juve ride through unusual Cagliari approach|
|Agent - Hernandez not giving up at Real|
|Atletico Madrid 2 L´Hospitalet 2 (5-2 agg): Spectacular Alcaraz double seals draw for minnows|
|Bruce: Ben Arfa has played his last game for Hull|
|Cagliari 1 Juventus 3: Juve ease into mid-season lead|
|Howard: Mignolet fighting for his Anfield career|
|Aston Villa v Manchester United: Visitors aim to stretch impressive run|
|QPR v West Brom: Irvine enjoying fruits of his labour|
|Balotelli banned for one match over controversial image|
|West Ham v Leicester City: Allardyce wary of fatigue|
|Hull City v Swansea City: Monk dismisses one-man-team tag|
|Dawson set to miss up to five weeks|
|De Boer coy on Ajax exit rumours|
|Hughes keen for Crouch stay|
|Lambert reiterates no issue with Keane|
|Inzaghi confident of ´great things´ for Milan|
|Barcelona v Cordoba: Catalans aim to end year in style|
|Koeman rules out Sneijder move|
|Southampton v Everton: Martinez ignoring hosts´ slump|
|Roma v Milan: Mexes targeting greater consistency|
|Jardim wary of Monaco fatigue|
|Tottenham v Burnley: Bentaleb sets sights on top four|
|Manchester City v Crystal Palace: Warnock has no fear|
|Wenger hopeful on duo for Liverpool clash|
|Alonso and Lewandowski out of Mainz clash|
|Cruz Azul v Auckland City: Tena wants Real reaction|
|Warnock: Palace have no chance of signing Cole|
|Allardyce in no rush for contract talks|
|Uche signs Villarreal extension|
|League One Preview: Sheffield United and Yeovil back in league action after cup exploits|
|Real Madrid v San Lorenzo: Casillas set for landmark appearance in final|
|Ronaldo more impressive than Messi, says Carlos|
|Poyet desperate for recruitments|
|Palace suffer Chamakh blow|
|Germany end year at top of FIFA rankings|
|Martinez calms Mirallas injury fears|
|Clayton ruled out for the season|
|Cabaye pleased to play full game|
|Klopp upbeat despite late equaliser|
|Cech: We can be best ever Chelsea side|
|Newcastle face goalkeeper crisis ahead of derby|
|Werder Bremen v Borussia Dortmund: Bundesliga stugglers targeting morale-boosting win|
|Medellin 1 Santa Fe 2: Visitors fight back to win|
|Barcelona 1 Emelec 1: Ecuadorian Primera A Third Stage play-off evenly poised|
|Sporting Cristal 0 Juan Aurich 0: Third leg required to decide Peruvian champions|
|Bauza ´delighted´ after San Lorenzo reach final|
|Paris Saint-Germain v Montpellier: PSG look to build|
|Bundesliga Preview: Bayern seeking to extend unbeaten start before winter break|
|Contra, Michel join Guangzhou R&F|
|Naismith signs Everton extension|
|Palestino 3 Santiago Wanderers 1: Title drought almost over for hosts|
|Copa del Rey Review: Finnbogason breaks drought in Sociedad win|
|Coupe de la Ligue Review: PSG scrape into quarters, Lille, Monaco win on penalties|
|Worcester City 1 Scunthorpe United 1 (aet, 13-14 on pens): League side narrowly avoid shock|
|Stambouli hails ´perfect´ Tottenham|
|Goals win games - Pardew|
|Bundesliga Review: Dortmund held by late equaliser, Leverkusen beat Bremen|
|PSV 4 Feyenoord 3: De Jong hat-trick helps settle thriller|
|Rodgers hails ´brilliant´ Liverpool|
|Eredivisie Preview: Leaders PSV take on struggling Eagles|
|Madoui hails second-half display|
|Championship Preview: Reading´s Clarke era begins at Watford|
|Liverpool to meet Chelsea in League Cup semi-finals|
|San Lorenzo 2 Auckland City 1: Extra time required to book Real final|
|AC Ajaccio 1 PSG 3: Late show sends holders through|
|Bournemouth 1 Liverpool 3: Sterling brace helps ease pressure|
|Tottenham 4 Newcastle United 0: Pochettino´s men march into semi-finals|
|Borussia Dortmund 2 Wolfsburg 2: Naldo denies Klopp´s strugglers|
|League Two Preview: Moore looks for fighting spirit, Accrington aim to bounce back|
|Allegri has suspension overturned|
|ES Setif 2 Western Sydney Wanderers 2 (5-4 on pens): Algerians rely on penalties to finish fifth|
|Ligue 1 Preview: Fournier not expecting to claim top spot, Marseille entertain Lille|
|Indian Super League Review: Kerala through to face Kolkata in final|
|Lasogga suffers thigh strain|
|Michael Garcia FIFA resignation notice in full|
|Bayern draw not ideal - Lucescu|
|Garcia resigns from FIFA role|
|Mainz v Bayern Munich: Bavarians on brink of more records|
|Garcia to fight two-match ban|
|Green backs Mignolet to return stronger|
|Mandzukic and Koke to lead inexperienced Atleti XI|
|Fonte apologises to fans after cup defeat|
|Metz suspend Maiga after unauthorised absence|
|Agent: Cole settled at Roma|
|Bayern duo sign new deals|
|Allegri calls for Juve focus ahead of Cagliari trip|
|Pearson accepts FA charge after fan row|
|Mourinho rules out January signings|
|Schaars set for PSV absence after knee surgery|
|Traore wants more Barca chances|
|Hamann hopes Liverpool receive cup boost|
|Lukaku wants Everton to produce Premier League best in Europe|
|La Liga Preview: Barca host Cordoba, Atletico travel to Bilbao|
|A-League Preview: Berisha crucial for Milligan-less Victory|
|Tena: Real ´by far the better team´|
|Blanc avoids Mourinho mind games, hails retiring Henry|
|Hecking convinced Dortmund remain dangerous|
|United´s Jones insists injuries are behind him|
|Henry: Managing Arsenal is my dream|
|Hard to imagine a better performance - Luis Enrique|
|Copa del Rey Review: Goals rain in Spain|
|Benatia to sit out Mainz clash|
|Koeman slams ´disrespectful´ Sheffield United|