For the second season in a row, Manchester United kick off their Premier League campaign against Swansea City and under a new manager.
After 27 years with Alex Ferguson at the helm, the Old Trafford club dismissed successor David Moyes just 10 months into his contract as they careered towards a seventh-placed finish in the Premier League last term - their lowest in the competition's history.
Ryan Giggs saw out the season in the United hot seat on an interim basis, but the onus now falls on former Netherlands coach Louis van Gaal to lead the club out of what are - by their own exalted standards - dark times.
And the experienced coach, who led his country to the semi-finals of the World Cup in Brazil earlier this year, has brought a new sense of optimism to the 20-time English champions.
"We can't wait to get going against Swansea and look to put right the wrongs from last year," midfielder Tom Cleverley told United's official website.
"This club has always been renowned for bouncing back from sticky patches and that's one of the reasons it's so loved around the world."
Swansea, who claimed their first win at Old Trafford in the FA Cup third round last season, have provided the opposition for a number of significant moments in United's recent history.
Prior to losing 4-1 in Moyes' first league game in charge of United at the Liberty Stadium 12 months ago, the Welsh club were also the opponents for Ferguson's last match at Old Trafford at the end of the 2012-13 campaign.
And, with Van Gaal's Premier League bow set to dominate headlines in the build-up to the latest encounter between the clubs, Swansea manager Garry Monk is happy to deflect the attention onto his opposite number.
"All the focus will be on them, which suits us fine," he said. "We'll just go up there and do the best we can.
"The big clubs attract the most attention - the best players in the world play for these bigger clubs. All the focus is on them and we'll just go about our jobs.
"Everyone is beatable, the best teams in the world are beatable. You always have the chance and we'll be going up there believing we can win the game.
"We don't fear it - we see it as a challenge."
United have refreshed their squad with the acquisitions of Luke Shaw and Ander Herrera during the close-season. But Shaw - a big-money signing from Southampton - has been sidelined for up to four weeks with a hamstring injury.
Jonny Evans, Rafael da Silva, Antonio Valencia and Danny Welbeck all missed United's final pre-season friendly against Valencia last Tuesday and could be injury doubts for Saturday.
Michael Carrick is absent as he continues to recover from ankle surgery.
Swansea, meanwhile, have experienced a sizeable turnover in personnel since the end of last season.
Pablo Hernandez, Chico Flores, Ben Davies and Michel Vorm have all left the club for pastures new, while Michu has gone to Napoli on a season-long loan.
Lukasz Fabianski, Bafetimbi Gomis and Jefferson Montero are all likely to make their debuts against United, and Gylfi Sigurdsson could be in line to kick-start his second stint with the club - this time in a permanent capacity.
Leon Britton, Marvin Emnes and Jay Fulton are all missing for Swansea with knee injuries.
|Coach: L. van Gaal|
for J. Lingard 24'
for J. Hernández 46'
for Ander Herrera 67'
|Hernandez thanks Ferguson after United departure|
|Chung: AFC has compromised FIFA election|
|Wales the new best of British|
|Reus out of Germany qualifiers|
|Chile v Paraguay: Vidal missing for Copa champions|
|Ghedin: Anything is possible for Malta|
|Pogba will be worth €100m - Marotta|
|England can win Euro 2016 - Hodgson tells players|
|Conte unsure over Balotelli future|
|Martial never the same again - Mangala|
|Copa del Rey Review: Racing fall at the first|
|Shelvey dismisses talk of England snub|
|Galatasaray unable to play Grosskreutz|
|Faroe Islands v Northern Ireland: O´Neill preaches patience ahead of Euro double-header|
|Levy slams ´wholly inappropriate´ West Brom after Berahino chase|
|Panama v Uruguay: Visitors without Suarez and Cavani|
|Captaincy won´t change me - Robben|
|Liverpool sign Brazilian youngster Allan|
|PFA expects swift Berahino resolution|
|Argentina v Bolivia: Mascherano backs ´very special´ Messi|
|´I do not know if I´m worth €80million´ - Martial shocked at price-tag|
|Afellay suspension reduced|
|Noble red card rescinded|
|Portugal v France: Deschamps aiming to correct mistakes|
|Bahebeck given the all clear|
|Germany v Poland: Muller out to settle the score|
|Gibraltar v Republic of Ireland: Keane counting on McCarthy and Walters|
|Georgia v Scotland: Tbilisi trip has must-win feel for Robertson|
|Juve still the team to beat - Hernanes|
|De Gea will remain professional, says team-mate Mata|
|Berahino given extra time off following strike tweet|
|´No excuses´ as Costa seeks to kick-start season|
|I´m not like Messi or Ronaldo – Hazard|
|United States v Peru: Klinsmann out to ´prove a point´|
|Martinez unsure when Cleverley will return|
|France set for Russia friendly ahead of Euros|
|Former Manchester United forward Berbatov joins PAOK|
|De Gea must play to earn Euro 2016 spot – Del Bosque|
|Cahill thrilled to lead Socceroos|
|Wijnaldum urges patience with new-look Newcastle|
|Reid praises Stones´ professionalism|
|Mexico v Trinidad and Tobago: Islanders hoping to build on Gold Cup display|
|Choosing Brazil over Spain was easiest decision, says Rafinha|
|Galliani hails ´changed´ Balotelli|
|OFC World Cup Qualifying Review: American Samoa notch second competitive win|
|Canada v Belize: Hosts look to stay calm|
|Carragher surprised by ´big´ Martial price|
|No pressure on Rodgers - Rush|
|No Benzema, no Cavani - Arsenal ´can´t compete´ says Sol Campbell|
|FFA muzzle Postecoglou after pay dispute criticism|
|Celtic complete Simunovic signing|
|Joaquin: I´m as happy as a little boy|
|Navas given time off by Costa Rica|
|Martial unfazed by prospect of United pressure|
|Ramos urges De Gea to overcome transfer woe|
|Premier League spending hits £1bn in 2015|
|Italy v Malta: Conte calls for focus|
|De Laurentiis reveals failed Juve bid for Hamsik|
|Schweinsteiger: Manchester not as bad as everybody thinks|
|Galatasaray finalise Grosskreutz deal|
|Ilori agrees season-long loan with Villa|
|Wolfsburg want to ´annoy´ Bayern - Dante|
|Norwich bring in Jarvis on loan|
|Everton sign Lennon on permanent deal|
|United put blame back on Real Madrid over De Gea|
|Premier League Deadline Day: Berahino on strike, United make Martial number nine|
|Peace: West Brom must repair damage caused by Tottenham´s Berahino pursuit|
|Dyer secures loan switch to Leicester|
|Walters mocks deadline-day culture|
|Derby complete Johnson deal|
|Hector signed by Chelsea and loaned back to Reading|
|Watford secure Ibarbo loan|
|United´s Martial offer too good to reject - Monaco chief|
|No regrets over failed Juve move - Draxler|
|Guedioura returns to Watford|
|Berahino tweet casts doubt on West Brom future|
|Yedlin loaned to Sunderland|
|United complete Martial swoop|
|Strootman undergoes surgery again|
|FIFA set to clarify proposed Grosskreutz deal|
|Watford bolster strikeforce with Oulare|
|Belgium v Bosnia-Herzegovina: Time running out for visitors|
|Antonio makes West Ham move|
|I want to feel important at Leverkusen - Hernandez|
|Villa seal deadline-day swoop for Lescott|
|Austin to stay at QPR|
|Everton´s Gibson given driving ban|
|David de Gea: Timeline of Manchester United goalkeeper´s failed Real Madrid move|
|Southampton complete Van Dijk swoop|
|Bournemouth complete Murray deal|
|Real take aim at United over failed De Gea move|
|Premier League Deadline Day: West Ham bring in three, De Gea set for United stay|
|Reports: Real Madrid will not appeal De Gea transfer collapse|
|FIFA quiet on ´confidential´ De Gea paperwork|
|Chelsea sign Nantes defender Djilobodji|
|West Ham land Jelavic|
|Anthony who? Rooney had to ask who Martial was, says Schneiderlin|
|Moses joins West Ham on loan|
|Netherlands v Iceland: Blind era begins in Amsterdam|
|Deportivo snap up Gutierrez|
|Newcastle´s Kemen returns to France|
|Everton wrap up Funes Mori deal|
|Cyprus v Wales: Difficult to overestimate Bale contribution, says Davies|
|Blaszczykowski ´never considered´ Schalke move|
|Di Maria opens up about Van Gaal ´rows´|
|West Ham seal Song loan|
|Australia v Bangladesh: Luongo excited by Rogic partnership|
|Maturity, fitness vital for Shelvey|
|South Korea v Laos: Hwaseong hosts hunting goals|
|Japan v Cambodia: Hosts out to arrest four-match slump|
|Troisi joins Saudi giants Al-Ittihad|
|Casemiro lauds Benitez after re-signing|
|Rojo wants United stay|
|Milan tried for Witsel - Galliani|
|Conte eyes two Italy wins|
|Ligue 1 Deadline Day: Marseille sign three amid Martial saga|
|La Liga Deadline Day: Uncertainty over De Gea future, Joaquin back at Betis|
|Serie A Deadline Day: Juve and Inter busy as window closes|
|Layun swaps Watford for Porto|
|Joaquin makes Betis return alongside Van Wolfswinkel|
|Coventry City 2 Southend United 2: Ricketts salvages point for hosts|
|Real face anxious wait over De Gea as window shuts|
|Milan loan Mastour to Malaga|