Wigan Athletic, Blackburn Rovers and Wolves were among the Championship sides to exit the League Cup on a night of first-round shocks.
Defence was at a premium on an eventful night that saw Brentford beat Dagenham and Redbridge 4-2 on penalties after a staggering 12 goals were shared at 6-6 after extra time.
But cup specialists of Wigan, who won the FA Cup in 2013 before reaching the semi-finals in 2014, were the biggest side to exit the competition at the first stage, losing 2-1 at home to Burton Albion.
Midfielder Neal Bishop's 34th minute strike condemned Blackburn to a 1-0 home loss to Scunthorpe United, while Northampton Town earned a thrilling 3-2 success at Wolves.
But each of those results were dwarfed by events at Victoria Road, where Dagenham suffered spot-kick agony after an astounding encounter despite Ashley Hemmings' double.
Leyton Orient also went through 6-5 on penalties following a 3-3 draw with a spirited Plymouth Argyle side.
Ipswich Town were another second-tier side to exit as Izale McLeod's 111th minute effort sealed a 1-0 win for Crawley Town, and beleaguered Blackpool were defeated 1-0 by Shrewsbury Town.
Managerless Huddersfield Town staged a dramatic comeback to beat Chesterfield 5-3 in their first game since the departure of Mark Robins.
Trailing 3-1 with six minutes remaining, the visitors scored two late goals through Nahki Wells and Jon Stead before the former completed his hat-trick to help cap the turnaround in extra time.
Birmingham City needed extra time to beat Cambridge United 3-1, while Bolton Wanderers came from behind to beat Bury 3-2 in 120 minutes.
Rotherham United required the extra 30 minutes to beat Fleetwood Town 1-0 but the majority of Championship teams all progressed with no such difficulties.
Middlesbrough, Sheffield Wednesday, Nottingham Forest, Brighton and Hove Albion, Bournemouth, Watford and Reading all enjoyed relatively straightforward routes into the next round.
Leeds United were 2-1 winners over Accrington Stanley and Millwall knocked out Wycombe Wanderers 1-0 in outings that each saw the Championship side reduced to 10 men.
Ben Williamson scored a hat-trick as Hartlepool United were hammered 6-2 by Port Vale, whose League One counterparts Preston North End, Crewe Alexandra, Doncaster Rovers, Swindon Town, Charlton Athletic, Gillingham, Walsall and Milton Keynes Dons all emerged victorious.
Bristol City and Peterborough United each suffered surprise losses to Oxford United and Portsmouth respectively, while Bradford City won 1-0 at Morecambe.
|Coach: G. Bowyer|
for D. Dunn 62'
for B. Marshall 63'
for C. Taylor 78'
|Moyes watches Sunderland win, Ibe opens account in six-goal Bournemouth thriller|
|Messi cuts short holiday for Barcelona training camp|
|Ranieri still confident of keeping Mahrez|
|Toure to complete Celtic move on Sunday, says Rodgers|
|Vietto sends Simeone a reminder amid Barcelona links|
|Celtic 1 Leicester City 1 (5-6 on penalties): Mahrez magic the highlight as Ranieri´s side triumph i|
|Ribery, Alaba on target in Bayern win|
|Neymar hails Micale ahead of Olympic tilt|
|Ronaldo wants Real Madrid renewal|
|Ochoa joins Granada from Malaga|
|Heidel quashes Meyer to Liverpool as ´nonsense´|
|Scholes challenges Allardyce to change England mentality|
|Tenerife star Crosas investigated for killing endangered shark|
|De Gea: Manchester United can win title under Mourinho|
|Marseille replace Batshuayi with brother Leya Iseka|
|Cristiano Ronaldo: Best season of my career|
|Scholes: Pogba is not worth £100million|
|Gotze has not forgotten how to play football - Riedle|
|Delph learning more than ever under Guardiola|
|Jovetic ´not worried´ about Juventus|
|Allardyce wants Euro 2016 woes to fire his England|
|Giggs not in a rush to take manager´s job|
|Lopetegui: If not for Spain I would be Wolves boss|
|Shaw one of best left-backs in world - Herrera|
|Injured Sanchez to miss Arsenal tour|
|Melbourne Victory 1 Juventus 1 (Melbourne win 4-3 on pens): Thomas inspires Victory as Juve pay pena|
|Janssen: Ajax and PSV were never going to pay as much as Tottenham|
|Bayern to make Munich shooting tributes|
|Wenger wishes luck to old foe Allardyce|
|United defender Varela joins Frankfurt on loan|
|Sunderland appoint Moyes as Allardyce replacement|
|Javi Martinez devastated by Munich shootings|
|Rooney: I´m desperate to play for Mourinho, just like under Ferguson|
|Godin: Champions League the dream, but LaLiga the focus|
|Klopp hails Wijnaldum´s ´football smartness´|
|Klavan ready to fight for starting spot after completing ´dream´ Liverpool move|
|Real Salt Lake 1 San Jose Earthquakes 1: Mulholland salvages point|
|Madeira airport to be named after Cristiano Ronaldo|
|Villar, Ceferin and Van Praag announce UEFA presidential bid|
|Witsel has offers from England and Italy|
|Tuchel will bring out Gotze´s best - Watzke|
|Swansea confirm interest in Liverpool´s Allen|
|Arsenal´s Coquelin: LeBron v Curry is like Messi v Ronaldo|
|Rooney backs Allardyce appointment|
|Bayern and Ancelotti respond to Munich attacks|
|West Brom friendly cancelled over violence concerns|
|Allardyce ´cannot stop smiling´ after getting England job|
|Rakitic dismisses Barcelona exit talk|
|Oxlade-Chamberlain salvages draw for Arsenal in opening friendly|
|Bruce leaves Hull City by mutual consent|
|Juventus start Serie A title defence against Fiorentina|
|Guardiola already making impact at Manchester City - Clichy|
|Liverpool sign Netherlands international Wijnaldum|
|Ranieri: Chilwell, Ulloa going nowhere|
|Batshuayi: Conte already making me a better player|
|Allardyce determined to be the best - Davies|
|Wolfsburg sign Mayoral from Real Madrid|
|New coaches the attraction in USA/Europe Champions Cup zone|
|´It was like F1 v F3´ - Mourinho not making hasty judgments on United squad|
|Suarez would welcome Vietto with open arms at Barcelona|
|Glenn hails ´ideal candidate´ Allardyce|
|Juventus begin ICC campaign amid Pogba furore|
|Sunderland look to move forward after Allardyce departure|
|Kuyt backs Wijnaldum for Liverpool success|
|No major trophies, fewer goals than Moyes - the stats behind England boss Allardyce´s career|
|Hayden was wasting his career at Arsenal - Wenger|
|New recruits excite Aubameyang after United rout|
|Allardyce the right man to take England back to basics|
|Solve the Rooney puzzle and restore Sterling´s confidence: Five problems for Allardyce to solve|
|England appoint Allardyce as manager|
|Manchester United 1 Borussia Dortmund 4: Classy BVB hand Mourinho first defeat|
|James vows to stay at Real Madrid|
|Caught in a jam - Minnesota ´explain´ goalkeeper gaffe|
|Clarke nominated for FA chairman|
|Gazidis expects more Leicester-style Premier League triumphs|
|Arsenal snap up Bolton defender|
|Alex the Mann for Liverpool as veteran seals Anfield move|
|Dortmund sign Schurrle on five-year deal|
|Balotelli needs right opportunity - Raiola|
|Lukaku undergoes Lazio medical|
|Suarez: Messi better than Ronaldo by far|
|Allegri remains hopeful of Pogba Juve stay|
|Rakitic´s agent questions Barcelona midfield buys|
|Shearer: England players must respect Allardyce or walk|
|Raiola: I don´t give a damn if Pogba costs a world-record fee|
|Mazinho dreams of Thiago-Rafinha reunion at Barca|
|No heart, no gold says ex-Brazil striker Elber|
|There is space for Mata at United - Mourinho|
|Alonso: Guardiola needs time to improve City|
|Argentina approach Bauza to be coach|
|Inter still ´under construction´ - Ranocchia|
|Mourinho: Rooney will be an important player|
|Ganso prepared for the step up to European football|
|Dyke: Brexit could help England|
|Galatasaray confirm Lucas interest|
|Conte targets Champions League with Chelsea|
|Swansea style attracted new owners Kaplan and Levien|
|Mourinho not concerned if United fail to sign Pogba|
|Mourinho teased Ibrahimovic into United move|