MK Dons hosts AFC Wimbledon in an emotionally charged League Cup round one clash on Tuesday.
League Two AFC Wimbledon were formed when their League One opponents relocated from London to Milton Keynes in 2002.
It will be the second meeting between the two sides, with MK Dons coming out on top in a December 2012 FA Cup clash.
MK Dons started the season in emphatic fashion with a 4-2 comeback win at home to Gillingham on Saturday, while AFC Wimbledon shared the spoils in a 2-2 draw with Shrewsbury Town
Huddersfield Town begin life without Mark Robins with a trip to Chesterfield.
Robins parted company with Town after their 4-0 opening day defeat to Bournemouth - who travel to face League Two Exeter City - and Chesterfield will hold hopes of claiming a Championship scalp, having begun life back in League One with a 2-1 win over last season's beaten play-off finalists Leyton Orient.
Orient's Wembley conquerors from last May Rotherham United host League Two play-off final winners Fleetwood Town, while the 2013 finalists in the competition, Bradford City, are in another trans-Pennine clash as they make the trip to the Lancashire coast to face Morecambe.
There are all-Lancashire clashes between Bolton Wanderers and Bury and Rochdale and Preston North End, while York and Doncaster Rovers will contest Yorkshire bragging rights.
Leeds United will be dearly hoping to avoid any slip ups against Accrington Stanley after Dave Hockaday's unlikely reign as manager got off to a lacklustre start with a 2-0 loss at Millwall, who also entertain League Two opposition in the form of Wycombe Wanderers.
Cambridge United and Luton Town sealed their returns to the Football League last term and look to build on opening day wins with ties against Birmingham City and Swindon Town respectively.
Shrewsbury Town will have designs on a Championship scalp when crisis club Blackpool travel to Greenhous Meadow, while the latter's 2-0 weekend conquerors Nottingham Forest head to Merseyside to take on Tranmere Rovers.
Forest’s local rivals Derby County get the 2014-15 competition under way at Carlisle United on Monday night, while the two other teams that fell short in the Championship play-offs last season - Brighton and Wigan Athletic - face Cheltenham Town and Burton Albion respectively.
Ipswich Town and Watford are on the road at Crawley Town and Stevenage following impressive weekend showings in the second tier, with Middlesbrough and Cardiff City also travelling Oldham Athletic and Coventry City.
The remaining Championship sides in the draw are Blackburn Rovers, Sheffield Wednesday, Charlton Athletic and Reading and the quartet will enjoy home advantage against Scunthorpe United, Notts County, Colchester United and Newport County respectively.
Elsewhere, Barnsley host Crewe Alexandra, Bristol City face Oxford United, Dagenham and Redbridge welcome Brentford, Plymouth Argyle entertain Leyton Orient, Hartlepool United travel to Port Vale, Portsmouth tackle Peterborough United, Wolves host Northampton Town, Gillingham head to Yeovil Town and Sheffield United play Mansfield Town.
|23||B. Afobe||64' 76'|
|Coach: K. Robinson|
for B. Reeves 61'
for D. Alli 68'
for D. Green 81'
|Tottenham deal for Son not complete, say Leverkusen|
|Tuchel thrilled with aggressive Dortmund display|
|Midtjylland 1 Southampton 0 (2-1 agg): Premier League side crash out|
|Borussia Dortmund 7 Odd 2 (11-5 agg): Reus hat-trick highlights hammering|
|Cudicini tips Mourinho to avoid Porto upset|
|Anything is possible with Neymar´s future - Belletti|
|Burnley bring in Barton|
|Bayern Munich v Bayer Leverkusen: Vidal putting friendships on hold|
|De Bruyne edges closer to City move after further Wolfsburg talks|
|Real Madrid v Real Betis: Benzema back as Real look to hit the goal trail|
|Barcelona v Malaga: Rosales hopes for another upset|
|West Brom hit out at Tottenham´s Berahino pursuit|
|Stoke City v West Brom: Pulis set for Britannia return|
|Tottenham v Everton: Pochettino´s men eye first win|
|Everton reject Stones´ transfer request|
|Messi named UEFA Player of the Year|
|Pocehttino quiet on Berahino bids|
|Real Madrid to meet PSG in Champions League, Barca drawn with Leverkusen|
|Bournemouth v Leicester City: Howe eager to entertain|
|Ranieri coy on Gray link|
|Newcastle United v Arsenal: Wenger hopes for sharper shooting|
|PSG snap up Kurzawa from Monaco|
|Aston Villa v Sunderland: Sinclair aims to replicate cup form|
|Grabban a silly boy - Neil|
|Chelsea v Crystal Palace: Pardew braced to face stronger champions|
|Manchester City v Watford: Flores heads to Etihad with confidence|
|Marseille loan Real Madrid youngster Lucas Silva|
|Howe surprised by Harte´s retirement|
|Liverpool v West Ham: History counts for nothing, says Bilic|
|Bolasie set for Palace comeback|
|De Bruyne to City not a done deal - Allofs|
|Sevilla complete Llorente swoop|
|Wenger supports video technology|
|Milan v Empoli: Zapata sets sights on ´must-win´ fixture|
|Watford boss Flores ´not happy´ with transfer situation|
|Balotelli: I am no longer a kid|
|Bilic has no issue with Valencia|
|Arsenal ´not close´ to any late deals|
|Balotelli finalises return to Milan on loan|
|West Ham confirm Nolan departure|
|Thiago signs new Bayern deal|
|Schmidt saddened as Son nears exit|
|CONCACAF Champions League Review: Sounders lose in Honduras|
|Van Gaal considered early Herrera substitution|
|MLS Review: Fire stun Red Bulls|
|Carroll nears West Ham return|
|Rodriguez hoping for England recall|
|Leverkusen can challenge best - Schmidt|
|Ozil defends United recruit Schweinsteiger|
|Sporting ´better over two legs´ - Jesus|
|Stoilov revels in historic Astana triumph|
|Pioli: Lazio not ready for Champions League|
|UEFA Champions League Review: Rooney nets treble and Astana make history|
|Everton to reject Stones´ transfer request - Martinez|
|Barnsley 3 Everton 5 (aet): Delightful Deulofeu spares blushes for Martinez´s men|
|Van Gaal lauds Rooney character|
|Rooney delighted to be back in the goals|
|Club Brugge 0 Manchester United 4 (1-7 agg): Rooney ends goal drought with hat-trick|
|Juve striker Llorente undergoing Sevilla medical|
|Blanc confirms imminent Kurzawa switch to PSG|
|AFC Champions League Review: Lima gives Al Ahli the edge, Jeonbuk Motors and Gamba Osaka draw|
|Wanyama out of Euro tie with stomach infection|
|Digne joins Roma on loan from PSG|
|Monaco agree deal for Real´s Coentrao|
|Wolves reject third Norwich bid for Afobe|
|Valencia clarifies West Ham criticism of injury treatment|
|O´Neill hands duo Northern Ireland recalls|
|Illarramendi makes Sociedad return|
|Arsenal a player away from dominance - NBA star Deng|
|Godin ´always wanted´ Atletico stay|
|Schalke reject Roma´s Kolasinac bid|
|Injured Allen omitted from Wales squad|
|Bellerin ready for Debuchy battle|
|Valencia lashes out at West Ham treatment|
|Van Dijk hints at Celtic exit|
|Everton legend Gray resigned to Stones exit|
|Negredo: Suffering is in the past|
|Commons and Gordon reject Deila critcism after Celtic defeat|
|Neil remains defiant on Bournemouth target Grabban|
|Happy Milner optimistic about Liverpool chances|
|CONCACAF Champions League Review: DC United, Saprissa preserve perfect records|
|Tomkins eyes West Ham recall|
|Di Maria, Pastore out of Argentina squad|
|Schmidt unfazed by Lazio injuries|
|Pique hits back at Barca critics|
|Hurt Traore a ´marked man´ - Sherwood|
|Wolves reject second bid for Norwich target Afobe|
|Pardew fears ´long term´ Jedinak injury|
|Hughes thrilled with Bojan return|
|Maccabi´s Europe feat ´the high of highs´ for Ben Haim|
|McClaren expecting big things from Thauvin|
|Lucescu calls for Shakhtar improvement in group stage|
|Watford will learn from loss - Flores|
|Nuno revels in Valencia´s Champions League qualification|
|Advocaat unhappy despite win|
|League Cup Review: Preston claim Watford scalp, Luton lose shoot-out to Stoke|
|UEFA Champions League Review: Valencia make history for Spain, Celtic dumped out|