Lyon coach Hubert Fournier confirmed he will be missing five key players against Rennes in Ligue 1 on Sunday.
Key midfielders Clement Grenier (groin) and Yoann Gourcuff (ankle) are still working their way back to full fitness, while defenders Henri Bedimo (hamstring), Milan Bisevac (back) and Mouhamadou Dabo (suspension) will also be unavailable.
Bedimo and another defender Lindsay Rose (hamstring) both suffered injuries in Lyon's 2-1 win over Mlada Boleslav of Czech Republic in UEFA Europa League qualifying on Thursday but while the former is out for three weeks, Fournier claimed the latter could still play against Rennes.
"Henri Bedimo is out for a minimum three weeks," Lyon's coach said at a media conference on Friday.
"For Lindsay Rose, we will give him until Saturday to see if he can play. Milan Bisevac is out; he will be available for the Toulouse game.
"[Captain] Maxime Gonalons can step into central defence; we spoke about it on Thursday, but I prefer he played in midfield.
"The injuries? There's no miracle solution to always avoid injury.
"It's a difficult moment. I don't know when Clement Grenier will be back, he's improving, he's on the right track … I can't give you a date. He is not looking at surgery.
"Dabo will be back next week. He is out for this game though. Gourcuff is continuing his pre-season."
Lyon learnt on Friday that they will face Romania's Astra in the final play-off round of the Europa League.
Fournier admitted he does not know much about the club from Ploiesti but argued the first leg at Lyon's Stade de Gerland will be critical.
"We never know if it's a good draw before we've played," the 46-year-old said.
"I would have preferred the return leg at the Stade de Gerland.
"We can imagine that they are another step up from Mlada. They [Astra] eliminated [another Czech club] Slovan Liberec. We all know how good Romanian football is.
"We will have to do the job in the first leg. That will help the return. The match at the Stade de Gerland will go a long way to settling the tie."
|Coach: H. Fournier|
for N. Fekir 26'
for M. Yattara 67'
for A. Mvuemba 84'
|Sneijder demands improved display from Netherlands|
|Real Madrid make €1m pledge to help refugees|
|Ings: I can learn from ´fantastic´ Sturridge|
|Ozil: Scotland won´t stop us|
|Portugal will be better than France - Santos|
|Kruse: I am 100 per cent fit|
|Mexico 3 Trinidad and Tobago 3: Herrera the hero for Ferretti´s men|
|FFA expect Tajikistan match to go ahead despite Dushanbe violence|
|Panama 0 Uruguay 1: Stuani´s late header clinches win|
|CONCACAF World Cup Qualifying Review: Jamaica stunned, Canada win|
|Argentina 7 Bolivia 0: Aguero, Messi star in rout|
|Canada 3 Belize 0: Hosts dominate in Toronto|
|Chelsea ´warehousing´ players - PFA chief|
|United States 2 Peru 1: Altidore inspires hosts´ comeback|
|Argentina 7-0 Bolivia: Aguero, Messi & Lavezzi net doubles in rout|
|Del Bosque unmoved by calls for two strikers|
|Deschamps praise for beautiful France|
|Fekir ruptures knee ligaments|
|Italy v Bulgaria: Conte warns against complacency|
|Euro 2016 Qualifiers Review: Germany top Group D, Northern Ireland edge closer|
|Low: Three points most important|
|Northern Ireland on the verge of a ´magnificent achievement´ - O´Neill|
|Scotland need something against Germany - Strachan|
|Portugal 0 France 1: Late Valbuena set-piece clinches deserved win|
|Faroe Islands 1 Northern Ireland 3: O´Neill´s men edge closer|
|Germany 3 Poland 1: Gotze sends world champions top|
|Gibraltar 0 Republic of Ireland 4: Irish hopes reignited|
|Djibouti 0 Togo 2: Saintfiet´s side make it two wins from two|
|Cyprus v Belgium: Benteke boost for Wilmots´ men|
|Roma youngster faces lengthy lay-off|
|United hit back at Perez barb over De Gea saga|
|Georgia 1 Scotland 0: Strachan´s men succumb to Tbilisi hoodoo|
|Hodgson prepared to blood new players|
|Porto invite Euro elite to help raise millions for migrants|
|Dortmund legend Dede backs Tuchel to succeed|
|Robben out for four weeks|
|Turkey v Netherlands: Terim expecting hostile atmosphere for crunch clash|
|Portugal 0-1 France: Valbuena strikes late to sink Ronaldo & Co|
|Wales v Israel: Euro 2016 beckons for Coleman´s history boys|
|Gala: No extra payment for Grosskreutz|
|Increase Bundesliga´s TV rights or be left behind - Rummenigge|
|Kane: I´m no flash in the pan|
|Perez: United showed inexperience in De Gea saga|
|Milligan: Socceroos wary of Tajikistan|
|Conte wants more players like Pelle|
|OFC World Cup Qualifying Review: Samoa to meet Tahiti in next round|
|Krychowiak stayed at Sevilla because of Emery|
|I never considered Bayern exit - Gotze|
|Balotelli ´not in good condition´, Milan must improve - Mihajlovic|
|Robben slams ´stupid´ Martins Indi|
|Robben laments injury blow|
|Euro 2016 Qualifiers Review: Bale edges Wales closer, Iceland dent Netherlands´ qualification hopes|
|De Bruyne relieved to ´boss´ Bosnia-Herzegovina|
|Blind furious after nightmare debut|
|Coleman sees shades of Charles in Bale winner|
|Conte only concerned about Italy winning|
|Mauritania v South Africa: SAFA to investigate Masilela no-show|
|AFC World Cup Qualifying Review: Qatar hit 15 in Bhutan rout|
|Belgium 3 Bosnia-Herzegovina 1: De Bruyne shines in straightforward victory|
|Cyprus 0 Wales 1: Bale winner takes Wales one step closer|
|Netherlands 0 Iceland 1: Sigurdsson winner caps difficult first game for Blind|
|Italy 1 Malta 0: Pelle spares wasteful Azzurri|
|Balotelli stars in Milan friendly win|
|Bhutan thrashed 15-0 by Qatar in qualifier|
|Rwanda v Ghana: Gyan doubt gives hosts hope|
|Tanzania v Nigeria: Enyeama out of AFCON qualifier|
|Valdes and Berahino included in Premier League squads|
|Costa Rica v Brazil: Dunga´s men return after Copa disappointment|
|Spain v Slovakia: Azpilicueta eyeing important revenge|
|Adebayor left out of Tottenham squad list for league and Europe|
|San Marino v England: Place in history books beckons for Rooney|
|Germany can cope with Reus absence - Low|
|Bayern offer aid to refugees in ´training camp´|
|BREAKING NEWS: Welbeck ruled out for months after knee surgery|
|South Korea 8 Laos 0: Son leads the way in rout|
|Australia 5 Bangladesh 0: Socceroos surge to emphatic win|
|Japan 3 Cambodia 0: Hosts pick up first qualifying win|
|Rudiger aiming to nail down Euros spot after Roma move|
|Melo happy to join Inter at last|
|Hernandez thanks Ferguson after United departure|
|Chung: AFC has compromised FIFA election|
|Wales the new best of British|
|Reus out of Germany qualifiers|
|Chile v Paraguay: Vidal missing for Copa champions|
|Ghedin: Anything is possible for Malta|
|Pogba will be worth €100m - Marotta|
|England can win Euro 2016 - Hodgson tells players|
|Conte unsure over Balotelli future|
|Argentina - Bolivia Preview: Mascherano backs 'very special' Messi|
|Portugal - France Preview: Deschamps aiming to correct mistakes|