Sheffield United boss Nigel Clough played down the importance of making a strong start to the League One season, with Bristol City first up.
A poor opening to the 2013-14 campaign saw predecessor David Weir lose his job in October after taking just one win from 13 matches.
United subsequently turned to Clough as the man to lead the club out of the third tier of English football and a strong end to the term saw them narrowly miss out on the play-offs in seventh.
Clough also guided the side to the FA Cup semi-finals, with a 5-3 defeat to Hull City at Wembley ending their dreams, and that promising form has raised the already high expectation levels at a club who were in the Premier League just seven years ago.
Saturday's curtain-raiser sees United face another team who have been placed among the favourites for promotion, as Steve Cotterill's City outfit head north looking to put the disappointment of last season - when they finished 12th - firmly behind them.
The encounter promises to be a gripping contest, but Clough will not place too much stock in the result.
"It would be lovely to get off to a great start and be in the top few, but if we're not it's not the end of the world," he said.
"You're talking about a whole new team coming in. Some will settle quicker than others. If things don't go too brilliantly in the first three games we're not going to get too down about it because we'll have 43 to go."
United are joined in League One this season by South Yorkshire rivals Barnsley and Doncaster Rovers, who were both relegated from the Championship last season.
Danny Wilson has had a tough pre-season at Oakwell with Barnsley, as the likes of Luke Steele and Chris O'Grady have departed for pastures new.
However, Wilson is an experienced manager at League One level and will look to make a strong statement at home to Crawley Town.
Doncaster - who were subject to a failed takeover bid from former chairman John Ryan and One Direction star Louis Tomlinson in the close-season - start at Yeovil Town, who are also looking to bounce straight back to the Championship.
Leyton Orient are aiming to recover from May's play-off final defeat to Rotherham United, but face a tricky task on the opening day against a Chesterfield side buoyed by winning the League Two title last season.
Rochdale and Scunthorpe United both achieved automatic promotion to League One last term, with the former hosting last season's play-off semi-finalists Peterborough United, while the latter visit Swindon Town.
Fleetwood Town - who triumphed in the League Two play-off final - welcome Crewe Alexandra to Highbury.
Preston North End finished in the play-off positions in the 2013-14 campaign and start their attempt to reach the Championship at home to Notts County, while MK Dons welcome Gillingham.
Other matches see Bradford City take on Coventry City, Colchester United host Oldham Athletic and Walsall travel to Port Vale.
|Coach: N. Clough|
for R. Flynn 64'
for S. Scougall 76'
for C. Basham 86'
|Willian expects Terry to depart Chelsea|
|Mexico 2 Senegal 0: Duenas, Pizarro inspire win|
|Copa Libertadores Review: Sao Paulo, Racing qualify for group stages|
|Liverpool should be transparent with Sturridge injuries - Owen|
|FFA hands Wanderers fine and suspended points deduction|
|Luis Enrique: I had to give my voice a rest|
|Silva: I was not kicked off Marseille team bus|
|Blanc could sign PSG renewal by end of week|
|PSG drawn against familiar foes Saint-Etienne in Coupe de France|
|Neville confident Valencia fans will be back|
|Guardiola praises beaten Bochum|
|Coupe de France Review: Ibrahimovic sends PSG through, Nantes win thriller|
|I love penalties - West Brom´s shootout hero Foster|
|Ross County 0 Hearts 3: Dauda dazzles in valuable victory|
|Bayern Munich avoid Borussia Dortmund in DFB-Pokal semi-finals|
|FC Heidenheim 2 Hertha Berlin 3: Ibisevic at the double in DFB-Pokal|
|Hart: We will fight for Pellegrini all the way|
|Peterborough United 1 West Brom 1 (aet, 3-4 on pens): Foster spares Premier League team´s blushes|
|Paris Saint-Germain 3 Lyon 0: Ibrahimovic fires holders into last eight|
|Valencia 1 Barcelona 1 (1-8 agg): Kaptoum breaks record with late leveller|
|Bochum 0 Bayern Munich 3: Lewandowski double helps book semi-final spot|
|Colour clash forces Stoke to produce new kit|
|Hernandez to miss Darmstadt match with muscle injury|
|Stoichkov backs ´smart guy´ Neymar to stay at Barcelona|
|FSG´s letter of apology to Liverpool fans in full|
|Huracan bus overturns following Copa Libertadores clash|
|Liverpool scrap ticket price increases following fan backlash|
|Oviedo hopeful of new Everton contract|
|Zoff: Juventus-Napoli a Scudetto match|
|Bolton chairman Phil Gartside dies aged 63|
|Palermo turn to Bosi after Barros Schelotto exit|
|Ben Arfa considered retirement from football during exile|
|Bilic: We paid the price for cup progress|
|Griezmann happy to stay at Atletico|
|Wales to face Sweden in final Euro 2016 warm-up|
|Varela hopeful of long United career|
|Ki: I had ice on my face for two days|
|Niasse settling in well, could face West Brom - Martinez|
|Stevens leaves Hoffenheim on health grounds and retires|
|Diaby nearing return after near 18-month lay-off|
|Nasri would love to finish career at Manchester City|
|Captain Howedes extends Schalke stay|
|M´Vila keen to stay if Sunderland survive|
|Johnson admits child sex and grooming charges|
|Amazing Mahrez is one of Premier League´s best - Ulloa|
|Ronaldo, Messi rivalry good for football - Zidane|
|Barros Schelotto leaves Palermo|
|Age is just a number - Ilori defends Klopp´s team selection|
|Messi, Suarez and Neymar rested for Copa second leg|
|Madrid can dream of trophies under Zidane - Raul|
|Ancelotti: Italy job is a decade away|
|Reus will become a monster, says Dortmund boss Tuchel|
|Young Tottenham stars don´t know their limits - Lloris|
|Niang happy at Milan despite Leicester interest|
|Ticket price rise means more tourist fans, warns football supporters chairman|
|Ogbonna revels in first West Ham goal|
|Copa Libertadores Review: Huracan, River Plate advance to group stages|
|Klopp backs Benteke to rediscover goalscoring form|
|Turan will not leave Barca for China - agent|
|Beating Chelsea more difficult without Mourinho - Motta|
|Tuchel praises Dortmund for ´perfect game´|
|Klopp rues Liverpool wastefulness in FA Cup loss|
|Allegri: Chelsea rumours unfounded|
|Bilic feels weight of history after Liverpool win|
|Coupe de France Review: Second tier Sochaux stun Ligue 1 Monaco|
|West Ham 2 Liverpool 1 (aet): Ogbonna sinks Klopp´s men in cup thriller|
|Football League Review: Rhodes rescues a point to send Boro top|
|Stuttgart 1 Borussia Dortmund 3: Aubameyang helps Tuchel´s men into last four|
|Kyle Allen blames chaotic Texas A&M culture on Johnny Manziel era|
|Dortmund fans stage protest against ticket prices for Stuttgart game|
|Bayer Leverkusen 1 Werder Bremen 3: 10-man hosts dumped out|
|Ferdinand fears title wilderness for United|
|Carvalho lands new Sporting deal with €45m buy-out clause|
|Ben Arfa out for at least four weeks with hamstring injury|
|Neville´s Valencia woes welcomed by Crespo|
|Ozil key to Arsenal´s title hopes - Rosicky|
|Zika threat could keep Solo from Rio Olympics|
|Blanc pleased to have solved David Luiz matter|
|Atletico midfielder Partey suffers thigh strain|
|Dickov: Leicester title run built to last|
|Guardiola not a menace for our players, says Luis Enrique|
|Mexico v Senegal: Osorio believes in youngsters|
|Celta Vigo v Sevilla: Krohn-Dehli not taking Copa del Rey final for granted|
|Madrid confirm Marcelo shoulder dislocation|
|Injury rules Chiellini out of crucial Juve games|
|Oblak extends Atletico deal|
|Blanc hints PSG could move for Ben Arfa|
|Luis Enrique urges Neymar to cope with off-field distractions|
|Carrick: Manchester United not throwing in towel|
|Neville determined to turn things around at Valencia|
|Guardiola hails Lewandowski professionalism amid Real Madrid and PSG rumours|
|Guardiola wary of ´aggressive´ Bochum|
|Premier League reveals new logo|
|West Ham open Payet contract talks|
|I could leave Barcelona for Guardiola, says Busquets|
|Giggs can be Manchester United´s Guardiola - Robson|
|Zidane has everything to become a great coach - Ancelotti|
|Carragher: Liverpool got it wrong on ticket prices|
|Neymar will be at Barcelona for years, claims director|
|Eder talks up Inter´s Scudetto chances|
|Larsson: Watching Barca is like playing FIFA|
|City recruit Wilkinson hoping to debut in Melbourne derby|
|Allegri will join Chelsea, says former coach|
|Zanetti: No need to compare Maradona and Messi|
|Vardy: I never expected Leicester to top Premier League|
|Capello: Ronaldo has at least three years at the top|
|Klopp hoping for Sturridge revival|
|Bilic wants new contract to keep Payet at West Ham|
|Shelvey can be as good as Cabaye - Sissoko|