Sheffield United boss Nigel Clough played down the importance of making a strong start to the League One season, with Bristol City first up.
A poor opening to the 2013-14 campaign saw predecessor David Weir lose his job in October after taking just one win from 13 matches.
United subsequently turned to Clough as the man to lead the club out of the third tier of English football and a strong end to the term saw them narrowly miss out on the play-offs in seventh.
Clough also guided the side to the FA Cup semi-finals, with a 5-3 defeat to Hull City at Wembley ending their dreams, and that promising form has raised the already high expectation levels at a club who were in the Premier League just seven years ago.
Saturday's curtain-raiser sees United face another team who have been placed among the favourites for promotion, as Steve Cotterill's City outfit head north looking to put the disappointment of last season - when they finished 12th - firmly behind them.
The encounter promises to be a gripping contest, but Clough will not place too much stock in the result.
"It would be lovely to get off to a great start and be in the top few, but if we're not it's not the end of the world," he said.
"You're talking about a whole new team coming in. Some will settle quicker than others. If things don't go too brilliantly in the first three games we're not going to get too down about it because we'll have 43 to go."
United are joined in League One this season by South Yorkshire rivals Barnsley and Doncaster Rovers, who were both relegated from the Championship last season.
Danny Wilson has had a tough pre-season at Oakwell with Barnsley, as the likes of Luke Steele and Chris O'Grady have departed for pastures new.
However, Wilson is an experienced manager at League One level and will look to make a strong statement at home to Crawley Town.
Doncaster - who were subject to a failed takeover bid from former chairman John Ryan and One Direction star Louis Tomlinson in the close-season - start at Yeovil Town, who are also looking to bounce straight back to the Championship.
Leyton Orient are aiming to recover from May's play-off final defeat to Rotherham United, but face a tricky task on the opening day against a Chesterfield side buoyed by winning the League Two title last season.
Rochdale and Scunthorpe United both achieved automatic promotion to League One last term, with the former hosting last season's play-off semi-finalists Peterborough United, while the latter visit Swindon Town.
Fleetwood Town - who triumphed in the League Two play-off final - welcome Crewe Alexandra to Highbury.
Preston North End finished in the play-off positions in the 2013-14 campaign and start their attempt to reach the Championship at home to Notts County, while MK Dons welcome Gillingham.
Other matches see Bradford City take on Coventry City, Colchester United host Oldham Athletic and Walsall travel to Port Vale.
|Coach: N. Clough|
for R. Flynn 64'
for S. Scougall 76'
for C. Basham 86'
|We can handle the pressure, says Postecoglou|
|Cheyrou joins Toronto|
|AFC boss rejects Australia expulsion claims|
|Australia v South Korea: Socceroos eyeing maiden Asian Cup|
|Wolfsburg plan Malanda tribute|
|Blanc: Ibrahimovic, Cavani need to improve partnership|
|NBA´s Kings invest in Sacramento Republic|
|Djukic slams Ronaldo as ´ugly and conceited´|
|Marcelino hails Villarreal´s historic achievement|
|Destro: I want to show Milan are great|
|Copa del Rey Review: Aduriz breaks drought to send Bilbao through|
|Blaszczykowski to miss Leverkusen clash|
|Villarreal swoop for Bailly|
|CAF to consider alternatives to drawing lots|
|Ginola ´not giving up´ on FIFA presidency bid|
|Eto´o backs Sampdoria´s European dream|
|Chelsea v Manchester City: Doubts over Costa and Fabregas for title showdown|
|Sunderland v Burnley: Poyet calls for change in mentality|
|Serie A Preview: Crisis clubs meet as Parma head to Milan|
|West Brom v Tottenham: Pulis excited by McManaman arrival|
|Ginola campaign cancels crowdfunding page|
|Stoke City v QPR: Hughes hopeful of Diouf boost|
|Manchester United v Leicester City: Pearson has no time for fond memories|
|Thai consortium completes Wednesday purchase|
|Wigan exodus continues as Ramos joins Levante|
|Crystal Palace v Everton: Martinez hoping to reap Qatar training rewards|
|Liverpool v West Ham: Allardyce backs Carroll to shine on Anfield return|
|Strootman injury ´nothing serious´|
|Pearson backs Kramaric to adapt quickly|
|Hull City v Newcastle United: Carver calls for repeat KC Stadium rout|
|Rodgers not expecting immediate Sturridge impact|
|Palace land free agent Ameobi|
|Guinea progress past Mali in drawing of lots|
|Strootman requires surgery|
|Mathieu reveals details of Luis Enrique-Messi bust-up|
|New Inter signing Brozovic wants to be the next Frank Lampard|
|Bayer Leverkusen v Borussia Dortmund: Visitors aim for fresh start|
|Eibar v Atletico Madrid: Capa up for a fight|
|Whelan and Crouch sign new Stoke deals|
|Mutch joins Palace from QPR|
|Eriksen delighted by League Cup double|
|Real Madrid v Real Sociedad: Moyes´ men out for rare Real double|
|Nolan impressed by Carroll attitude|
|Wenger: Gabriel will adapt to English football|
|Destro says yes to Milan move|
|Allardyce not expecting Sakho ban|
|Ribery sidelined for three Bayern Munich matches|
|Cahill refuses to rule out retirement after Asian Cup final|
|Pogba to leave Juve by end of next season - Agent|
|Martinez not planning Eto´o replacement|
|Blatter formally submits bid to remain FIFA president|
|Puncheon predicts ´great times´ for Palace|
|Donadoni has no plans to leave Parma and criticises Cassano|
|Mangala: My first season at City could have been better|
|UAE v Iraq: Rare podium finish on offer|
|Ryan spurred on by Australia´s 2011 heartbreak|
|Montella will not sell Cuadrado cheap|
|Mali, Guinea furious with tie-breaking procedure|
|Luis Enrique defends Neymar´s behaviour|
|Gabi: Referee lacked personality|
|Chile 3 USA 2: Gonzalez´s brace extends Americans´ pain|
|Franjic cleared of serious injury|
|Our progression was deserved - Pochettino|
|Ivory Coast´s tournament starts now - Renard|
|Allegri rejects Juve criticism|
|Atletico´s Arda Turan escapes red card after throwing boot at assistant referee|
|Atletico Madrid 2 Barcelona 3 (agg 2-4): Neymar double secures semi-final spot|
|Parma 0 Juventus 1: Morata late show wins it for visitors|
|Sheffield United 2 Tottenham 2 (agg 2-3): Pochettino books Wembley final|
|Ecuador dismiss Vizuete|
|Championship Preview: Middlesbrough out to continue run, Bournemouth seek response|
|Guinea 1 Mali 1: Lots to decide Group D runners-up|
|Cameroon 0 Ivory Coast 1: Gradel strike sends Renard´s men through|
|Lots to be drawn to decide AFCON qualifiers|
|Eredivisie Preview: De Boer warning for Ajax, leaders PSV host Willem II|
|Bundesliga Preview: Leaders Bayern and Wolfsburg kick off Ruckrunde|
|Howard boost for Everton|
|Ligue 1 Preview: Jardim plays down Monaco title hopes ahead of Lyon showdown|
|Costa charged by FA for alleged Can stamp|
|O´Keefe joins Cardiff|
|Dons teenager Alli in demand|
|Gabriel seals Arsenal switch|
|Wolfsburg v Bayern Munich: Guardiola eyes ´big step´ to Bundesliga title|
|Paris Saint-Germain v Rennes: Montanier seeks another upset in French capital|
|Martinez rules out panic buys|
|Gilardino targets Fiorentina goals|
|Milan agree Bocchetti loan|
|League Two Preview: Cambridge and Luton prepare to renew rivalries|
|Ronaldo hit with two-match ban|
|West Brom complete McManaman deal|
|Sullivan hits back in Sakho row|
|Richards: Cuadrado suited to Premier League|
|Figo to challenge for FIFA presidency|
|Inzaghi out to freshen up struggling Milan|
|Wigan agree a fee for Mckay|
|Carver eyes strong finish|
|Bowen cools talk of Stoke swoop for Sandro and Traore|
|Lazio-bound Morrison lands in Rome|
|Mourinho fined £25k for ´campaign´ claims|
|Mainz bring in Castillo|
|Villa: Lambert will not be sacked|
|Monk hopeful of adding new faces|
|Sainsbury ready to replace Franjic|
|Beckenbauer hopeful of Guardiola stay|
|Mourinho hits back at Costa critics|
|Rodriguez grateful for ´fundamental´ Ronaldo support|
|La Liga Preview: Real want revenge against Socieded|
|No Dallas move for Essien|
|Bale rubbishes United link, Ronaldo rift|
|Sahin in ´good shape´ for Bundesliga resumption|
|Rodgers slams Costa´s stamp collection|
|Under-fire Inzaghi urges patience|
|Rodgers: Courtois saved Chelsea|