Raul Jimenez netted a hat-trick as America routed Puebla 4-0 to preserve their 100 per cent record in Liga MX.
Jimenez scored twice in the second half after breaking the deadlock in the first on Saturday to make it three wins from three for America in the Apertura campaign.
Oribe Peralta was also on the scoresheet for America, who defeated Spanish champions Atletico Madrid in the Copa EuroAmericana midweek.
America are the only team with a perfect record in Mexico and remain two points clear of Atlas and Monterrey on nine points after three rounds.
Atlas came from behind twice to defeat Chiapas 4-2 on Saturday, while Monterrey were held to a scoreless draw by Santos Laguna on the same day.
Confidence was high within the America camp after the club shocked Atletico in a penalty shoot-out on Wednesday and it showed as they put Puebla to the sword away from home.
Jimenez - a Mexico international - opened the scoring in the 16th minute after finding himself unmarked at the back post and heading the ball across goal and into the net.
The 23-year-old doubled the visitors' advantage with a 62nd-minute penalty before Peralta fired the ball beyond goalkeeper Rodolfo Cota 11 minutes later.
Jimenez completed the rout in the 76th minute, when he controlled the ball in the air, cut inside his defender and placed the ball into the net with the outside of his boot for his fourth goal in two games.
Defending champions Leon kick-started their season with a 4-0 demolition of Morelia.
Leon had lost their opening two games but they bounced back with a four-goal second half on home soil.
Yamilson Rivera, Carlos Pena, Jose Cardenas and Miguel Sabah were on target during the final 35 minutes against second-bottom Morelia.
In other results, Queretaro are fourth in the standings on six points after accounting for Pachuca 2-0 on Friday.
Friday's only other game saw Tijuana draw 1-1 at home to Tigres UANL.
Strugglers Cruz Azul and Veracruz - both still searching for their first wins of the season - played out a scoreless stalemate.
Meanwhile, Pablo Velazquez netted a brace as Toluca defeated Pumas UNAM 2-1 on Sunday.
|Coach: R. Romano|
for U. Álvarez 46'
for E. Loboa 61'
for W. Cosme 61'
|OFC World Cup Qualifying Review: Samoa to meet Tahiti in next round|
|Krychowiak stayed at Sevilla because of Emery|
|I never considered Bayern exit - Gotze|
|Balotelli ´not in good condition´, Milan must improve - Mihajlovic|
|Robben slams ´stupid´ Martins Indi|
|Robben laments injury blow|
|Euro 2016 Qualifiers Review: Bale edges Wales closer, Iceland dent Netherlands´ qualification hopes|
|De Bruyne relieved to ´boss´ Bosnia-Herzegovina|
|Blind furious after nightmare debut|
|Coleman sees shades of Charles in Bale winner|
|Conte only concerned about Italy winning|
|Mauritania v South Africa: SAFA to investigate Masilela no-show|
|AFC World Cup Qualifying Review: Qatar hit 15 in Bhutan rout|
|Belgium 3 Bosnia-Herzegovina 1: De Bruyne shines in straightforward victory|
|Cyprus 0 Wales 1: Bale winner takes Wales one step closer|
|Netherlands 0 Iceland 1: Sigurdsson winner caps difficult first game for Blind|
|Italy 1 Malta 0: Pelle spares wasteful Azzurri|
|Balotelli stars in Milan friendly win|
|Bhutan thrashed 15-0 by Qatar in qualifier|
|Rwanda v Ghana: Gyan doubt gives hosts hope|
|Tanzania v Nigeria: Enyeama out of AFCON qualifier|
|Valdes and Berahino included in Premier League squads|
|Costa Rica v Brazil: Dunga´s men return after Copa disappointment|
|Spain v Slovakia: Azpilicueta eyeing important revenge|
|Adebayor left out of Tottenham squad list for league and Europe|
|San Marino v England: Place in history books beckons for Rooney|
|Germany can cope with Reus absence - Low|
|Bayern offer aid to refugees in ´training camp´|
|BREAKING NEWS: Welbeck ruled out for months after knee surgery|
|South Korea 8 Laos 0: Son leads the way in rout|
|Australia 5 Bangladesh 0: Socceroos surge to emphatic win|
|Japan 3 Cambodia 0: Hosts pick up first qualifying win|
|Rudiger aiming to nail down Euros spot after Roma move|
|Melo happy to join Inter at last|
|Hernandez thanks Ferguson after United departure|
|Chung: AFC has compromised FIFA election|
|Wales the new best of British|
|Reus out of Germany qualifiers|
|Chile v Paraguay: Vidal missing for Copa champions|
|Ghedin: Anything is possible for Malta|
|Pogba will be worth €100m - Marotta|
|England can win Euro 2016 - Hodgson tells players|
|Conte unsure over Balotelli future|
|Portugal - France Preview: Deschamps aiming to correct mistakes|
|Martial never the same again - Mangala|
|Copa del Rey Review: Racing fall at the first|
|Shelvey dismisses talk of England snub|
|Galatasaray unable to play Grosskreutz|
|Faroe Islands v Northern Ireland: O´Neill preaches patience ahead of Euro double-header|
|Levy slams ´wholly inappropriate´ West Brom after Berahino chase|
|Panama v Uruguay: Visitors without Suarez and Cavani|
|Captaincy won´t change me - Robben|
|Liverpool sign Brazilian youngster Allan|
|PFA expects swift Berahino resolution|
|Argentina v Bolivia: Mascherano backs ´very special´ Messi|
|´I do not know if I´m worth €80million´ - Martial shocked at price-tag|
|Afellay suspension reduced|
|Noble red card rescinded|
|Portugal v France: Deschamps aiming to correct mistakes|
|Bahebeck given the all clear|
|Germany v Poland: Muller out to settle the score|
|Gibraltar v Republic of Ireland: Keane counting on McCarthy and Walters|
|Georgia v Scotland: Tbilisi trip has must-win feel for Robertson|
|Juve still the team to beat - Hernanes|
|De Gea will remain professional, says team-mate Mata|
|Berahino given extra time off following strike tweet|
|´No excuses´ as Costa seeks to kick-start season|
|I´m not like Messi or Ronaldo – Hazard|
|United States v Peru: Klinsmann out to ´prove a point´|
|Martinez unsure when Cleverley will return|
|France set for Russia friendly ahead of Euros|
|Former Manchester United forward Berbatov joins PAOK|
|De Gea must play to earn Euro 2016 spot – Del Bosque|
|Cahill thrilled to lead Socceroos|
|Wijnaldum urges patience with new-look Newcastle|
|Reid praises Stones´ professionalism|
|Mexico v Trinidad and Tobago: Islanders hoping to build on Gold Cup display|
|Choosing Brazil over Spain was easiest decision, says Rafinha|
|Galliani hails ´changed´ Balotelli|
|OFC World Cup Qualifying Review: American Samoa notch second competitive win|
|Canada v Belize: Hosts look to stay calm|
|Carragher surprised by ´big´ Martial price|
|No pressure on Rodgers - Rush|
|No Benzema, no Cavani - Arsenal ´can´t compete´ says Sol Campbell|
|FFA muzzle Postecoglou after pay dispute criticism|
|Celtic complete Simunovic signing|
|Joaquin: I´m as happy as a little boy|
|Navas given time off by Costa Rica|
|Martial unfazed by prospect of United pressure|
|Ramos urges De Gea to overcome transfer woe|