Valencia will have to stage another stunning fightback when they face Sevilla on Thursday if they are to reach the UEFA Europa League final.
Juan Antonio Pizzi's men looked to be crashing out after the first leg of their quarter-final tie with Basel following a 3-0 defeat in Switzerland, but mounted an incredible comeback in the Mestalla.
Paco Alcacer scored a hat-trick as the La Liga side secured a stunning 5-0 win as Basel crumbled, but Valencia have again left themselves with a lot to do in the return leg against their Spanish rivals.
Quickfire goals from Stephane M'Bia and Carlos Bacca in the first half earned Sevilla a 2-0 advantage in the first game, with former Valencia boss Unai Emery getting one over on his ex-employers.
Both sides have enjoyed success in this competition in recent years.
Valencia lifted the trophy in 2004 under Rafael Benitez, while Sevilla are the only side to have defended their title since the tournament switched to a one-off final in 1998 - with wins in 2005 and 2006 against Middlesbrough and Espanyol respectively.
The prize for progressing to another final will be a clash with Italian giants Juventus or Portuguese champions Benfica in Turin on May 14.
The hosts go into the game on the back of a 1-0 defeat to title-chasing Atletico Madrid, a result which leaves them eighth in La Liga table and unable to qualify for next year's competition through their league placing.
Valencia have had the better of the two league meetings this season, winning 3-1 at the Mestalla and then securing a goalless draw in Sevilla - and they will need to make the most of home advantage again on Thursday.
Sevilla are enjoying a strong season under Emery, having won 13 of their last 17 games in all competitions.
They were beaten 3-1 at Athletic Bilbao last time out, though, in a game which put a huge dent in their UEFA Champions League qualification hopes.
Emery's men are now six points behind Bilbao in the race for fourth place, with only three matches remaining, and an inferior head-to-head record with the Basque outfit.
Sevilla also had to come from behind in their quarter-final, losing the first leg 1-0 in Porto, before hammering Luis Castro's men 4-1 in the return game in the Estadio Ramon Sanchez Pizjuan.
They will be hopeful Bacca - who has seven goals in this year's tournament and 21 in all competitions - can net them a crucial away goal that could put the tie beyond their hosts, but will be wary of the threat of Alcacer, whose treble in the comeback win over Basel moved him level with Bacca on seven goals in the competition.
Valencia duo Diego Alves and Philippe Senderos (both hamstring) are doubts, while Victor Ruiz (thigh) is definitely out.
The visitors are without Sebastian Cristoforo (knee) and Denis Cheryshev (foot), while defender Daniel Carrico is a doubt with an ankle problem.
|22||J. Mathieu||70' 90+3'|
|8||S. Feghouli||14' 73'|
for P. Piatti 62'
for Dani Parejo 79'
for Jonas 85'
|Cech reveals work permit prevented past Arsenal move|
|Ivory Coast cut coaching shortlist down to five|
|McCarthy satisfied with Mings sale|
|Heaton commits to Burnley|
|Bowyer: Rhodes and Gestede will not come cheap|
|Burton and Day depart West Brom|
|Mendilibar makes Eibar return|
|Milan agree to terminate Muntari contract|
|Copa final a dream come true for Sampaoli|
|CSKA Sofia demoted due to financial crisis|
|Wolfsburg warn off De Bruyne suitors|
|Kone: I want to prove I can cut it at Everton|
|West Ham v Lusitans: Bilic set for first game in charge|
|Millennium Stadium to host 2017 UEFA Champions League final|
|Ronaldo a ´possibility´ for Portugal´s Olympics squad|
|Liverpool should get rid of Sterling - Grobbelaar|
|Miranda arrives for Inter medical|
|Arsenal can challenge the best - Cech|
|Real star Bale can be better than Ronaldo, says Keegan|
|UEFA approves changes to FFP rules|
|Honduras v Mexico: Moreno´s injury may force Mexican rethink pre-Gold Cup|
|Hiddink was the wrong man for Netherlands - De Boer|
|Vargas: I was scoring with every shot at training|
|Zambrano red rocked Peru - Gareca|
|Paraguay to change tack against Argentina|
|Sampaoli thrilled with substitutes´ influence, applauds Peru|
|Martino rues Copa America date with former side Paraguay|
|Former Birmingham City player Thwaites among Tunisia victims|
|Chile 2 Peru 1: Zambrano´s red card helps hosts into Copa final|
|Thiago Silva: ´I didn´t even know the ball had hit my hand´|
|Ronaldinho set to sign for Antalyaspor|
|Jara ban reduced on appeal by one match|
|Hiddink leaves Netherlands post|
|Cresswell pens new five-year deal at West Ham|
|Koeman: No serious United bid for Schneiderlin|
|Barbados eliminated from World Cup qualifying after fielding ineligible player|
|Former Catania president admits buying matches|
|Jones agrees Manchester United deal|
|Argentina v Paraguay: Valdez hoping not to need another comeback|
|Milan seal Bertolacci signing|
|Cech grateful to Abramovich and Chelsea fans|
|UEFA Champions League Preview: Brotherly pride at stake as B36 play TNS|
|UEFA Europa League Preview: Tommasi set to aid La Fiorita qualifying bid|
|Cech leaves Chelsea to join Arsenal|
|Paulinho ends Spurs frustration with Guangzhou move|
|Sampdoria confirm Eto´o exit amid Antalyaspor talk|
|Garcia departs Espanyol ahead of expected Qatar move|
|Watford to delay Doyley decision|
|Schlupp agrees new Leicester deal|
|Schweinsteiger hints at Bayern stay amid United links|
|Bertolacci thrilled ahead of Milan move|
|Langerak leaves Dortmund for Stuttgart|
|Muniain extends Athletic contract|
|Youngsters to get chance on US tour - Van Gaal|
|La Liga chief hits out at Real Madrid over TV rights opposition|
|Villa confirm Wilkins as assistant manager|
|Dicks joins West Ham coaching staff|
|Heldt enters to jeers, exits to cheers|
|Paraguay pride has grown at Copa America - Aguilar|
|Van Gaal tight-lipped on De Gea|
|Bacca confirms Milan agreement|
|Weight of expectation on hosts Chile to benefit Peru - Gareca|
|MLS Review: Timbers thump Sounders thanks to Adi´s double|
|Dzeko ´would run to Roma´ - Pjanic|
|Peru won´t sit back - Sampaoli|
|Zenga: Cassano, Balotelli will not be joining Sampdoria|
|Victory to start A-League defence away to Adelaide|
|I want to play MLS ´at the peak of my career´ - Johannsson|
|Allegri: I like Isco and Oscar|
|CAF Champions League Review: Comeback kings Smouha go top of Group A|
|Pirlo in attendance for New York derby|
|No Bayern deal yet, states Costa|
|Jara handed three-game ban|
|Sunderland striker Defoe sets 20-goal target|
|Leicester offer condolences to Albrighton and family after Tunisia attack|
|Chile v Peru: Potential Jara sanction hangs over semi-final|
|Sweden U21 v Portugal U21: History beckons for Jorge´s men|
|Neville appointed Valencia number two|
|Work halted at Olympic Stadium after fatality|
|Ibrahimovic in the same league as Messi - Sacchi|
|Giggs: United want to add winners|
|Turan sets record straight over transfer talk|
|Low keen for new Germany leaders to emerge|
|Tunisia part company with Leekens|
|Evans: Sterling´s Anfield exit must be a done deal|
|FIFA audit chief urges Blatter to stick by decision|
|Hrubesch urges caution after Germany U21s humbled|
|Taarabt hits out at ´very bad manager´ Redknapp|
|Bruce: I´m lucky I wasn´t sacked after Hull relegation|
|Van Hooijdonk warns Van Gaal over Depay tactics|
|SPFL looking into winter break|
|MLS Review: Earthquakes win California Clasico, Vancouver claim top spot in West|
|Muto must toughen up to succeed at Mainz - Ficcadenti|
|Diaz: Paraguay refuse to lose|
|Tragedy strikes for Paraguay match-winner Gonzalez|
|Robinho rues substitution, wanted to take penalty|
|Dunga: Brazil squad hit by virus|
|Fiorentina make ´insane offer´ to Salah|
|Women´s World Cup Review: England reach maiden semi-final|
|Mexico 2 Costa Rica 2: Herrera´s men recover after half-time|
|ES Setif 1 USM Alger 2: African champions beaten|
|Paraguay 1 Brazil 1 (4-3 on penalties): History repeats as Dunga´s men bow out|