Valencia will have to stage another stunning fightback when they face Sevilla on Thursday if they are to reach the UEFA Europa League final.
Juan Antonio Pizzi's men looked to be crashing out after the first leg of their quarter-final tie with Basel following a 3-0 defeat in Switzerland, but mounted an incredible comeback in the Mestalla.
Paco Alcacer scored a hat-trick as the La Liga side secured a stunning 5-0 win as Basel crumbled, but Valencia have again left themselves with a lot to do in the return leg against their Spanish rivals.
Quickfire goals from Stephane M'Bia and Carlos Bacca in the first half earned Sevilla a 2-0 advantage in the first game, with former Valencia boss Unai Emery getting one over on his ex-employers.
Both sides have enjoyed success in this competition in recent years.
Valencia lifted the trophy in 2004 under Rafael Benitez, while Sevilla are the only side to have defended their title since the tournament switched to a one-off final in 1998 - with wins in 2005 and 2006 against Middlesbrough and Espanyol respectively.
The prize for progressing to another final will be a clash with Italian giants Juventus or Portuguese champions Benfica in Turin on May 14.
The hosts go into the game on the back of a 1-0 defeat to title-chasing Atletico Madrid, a result which leaves them eighth in La Liga table and unable to qualify for next year's competition through their league placing.
Valencia have had the better of the two league meetings this season, winning 3-1 at the Mestalla and then securing a goalless draw in Sevilla - and they will need to make the most of home advantage again on Thursday.
Sevilla are enjoying a strong season under Emery, having won 13 of their last 17 games in all competitions.
They were beaten 3-1 at Athletic Bilbao last time out, though, in a game which put a huge dent in their UEFA Champions League qualification hopes.
Emery's men are now six points behind Bilbao in the race for fourth place, with only three matches remaining, and an inferior head-to-head record with the Basque outfit.
Sevilla also had to come from behind in their quarter-final, losing the first leg 1-0 in Porto, before hammering Luis Castro's men 4-1 in the return game in the Estadio Ramon Sanchez Pizjuan.
They will be hopeful Bacca - who has seven goals in this year's tournament and 21 in all competitions - can net them a crucial away goal that could put the tie beyond their hosts, but will be wary of the threat of Alcacer, whose treble in the comeback win over Basel moved him level with Bacca on seven goals in the competition.
Valencia duo Diego Alves and Philippe Senderos (both hamstring) are doubts, while Victor Ruiz (thigh) is definitely out.
The visitors are without Sebastian Cristoforo (knee) and Denis Cheryshev (foot), while defender Daniel Carrico is a doubt with an ankle problem.
|22||J. Mathieu||70' 90+3'|
|8||S. Feghouli||14' 73'|
for P. Piatti 62'
for Dani Parejo 79'
for Jonas 85'
|Paris Saint-Germain v Ajax: Dutch outfit quietly confident|
|APOEL v Barcelona: Xavi seeks further improvement|
|Gotze basks in Bayern form|
|Tevez wants domestic form replicated in Europe|
|Mixed news on Naismith for Everton|
|Central Coast Mariners 0 Adelaide United 2: Sanchez nets brace for visitors|
|Can full of praise for Gerrard|
|BATE v Porto: Visitors eye top spot|
|CSKA Moscow v Roma: Italians eye qualification|
|Simeone lauds Atletico display|
|Messi the best ever - Luis Enrique|
|Eredivisie Review: Feyenoord make Peersman pay, Ajax beat Heerenveen|
|La Liga Review: Real Madrid, Barcelona win big|
|Allegri lauds Pogba performance|
|Messi pays homage after record-breaking day|
|Messi the record breaker|
|Serie A Review: Top two both victorious|
|Taylor hints that knee injury not as bad as first feared|
|Ligue 1 Review: Lyon stumble against Bastia|
|Van Gaal critical of United despite win|
|Lazio 0 Juventus 3: Pogba and Tevez star as champions dominate|
|Wenger frustrated by wasteful Arsenal defeat|
|Barcelona 5 Sevilla 1: Messi breaks La Liga record as Barca cruise|
|Garcia delighted with Ljajic display|
|League One Review: Swindon close the gap at the top, Yeovil off the bottom|
|Messi breaks La Liga goal record|
|Ancelotti: Isco a ´perfect´ Modric replacement|
|Bundesliga Review: Wolfsburg slip helps move Bayern well clear|
|Rooney revels in success of counter-attack ploy|
|Tiago: Malaga scalp proves we´re great|
|Arsenal 1 Manchester United 2: Rooney seals Van Gaal´s maiden away win|
|Reus injury angers Klopp|
|Schweinsteiger pays tribute to Bayern fans|
|Pellegrini salutes Toure´s attitude|
|Hughes laments Stoke´s slow start|
|Allardyce frustrated after Everton defeat|
|We deserved more - Redknapp|
|Irvine: Yacob can have no complaints|
|League Two Review: Luton run ended by Burton, Wycombe go top|
|Eibar 0 Real Madrid 4: Relentless Real win again|
|Poyet defends Cattermole over Cambiasso tackle|
|Dyche hails Burnley resolve|
|Martinez hails ´satisfying´ Everton triumph|
|Pearson sure of Leicester survival|
|Gomis earns Monk forgiveness for late miss|
|Pardew full of praise for Sissoko|
|Mourinho lauds ´beautiful´ Chelsea display|
|Scottish Premiership Review: Guidetti strikes again for Celtic, top four all win|
|Championship Review: Bamford denies Mackay´s Wigan, Derby extend lead|
|Aston Villa v Southampton: Koeman eyes international swagger|
|Newcastle United 1 QPR 0: Skipper Sissoko seals fifth straight win|
|Leicester City 0 Sunderland 0: Hosts´ goal drought continues|
|Stoke City 1 Burnley 2: Ings at the double as visitors hold on|
|Atletico Madrid 3 Malaga 1: Unconvincing champions halt in-form visitors|
|Everton 2 West Ham 1: Osman celebrates landmark with winner|
|Manchester City 2 Swansea 1: Toure seals comeback win for champions|
|Chelsea 2 West Brom 0: Yacob sees red as leaders march on|
|Paderborn 2 Borussia Dortmund 2: Reus injury leads to Dortmund capitulation|
|Bayern Munich 4 Hoffenheim 0: Champions move seven clear|
|Bielsa not concerned by Marseille investigation|
|Mancini buoyed by Inter preparations|
|Benitez rules out Liverpool return|
|Hertha prepared for Kalou absence|
|Montella confident despite Fiorentina pressures|
|Injured Alex out of Milan derby|
|Pochettino wants versatility from Dier|
|Van Gaal will not take risks with Falcao fitness|
|A-League Review: Sydney keep pressure on at top|
|K. League Review: Sangju Sangmu all but down, Gyeongnam remain in danger|
|J.League Review: Gamba deny title-chasing Urawa, Ventforet ensure safety|
|Rabiot thrilled with PSG return|
|Sterling wants long Liverpool stay|
|Poyet: I thought Cattermole would ´shoot´ me|
|Simeone: Cerci interest compliments Atletico|
|Blanc: ´I was confident´ of PSG win|
|Silva sidelined for crucial City-Bayern clash|
|Lambert would ´love´ to keep Vlaar, slams agent|
|Championship Review: Brentford up to fourth, Reading lose again|
|Athletic Bilbao 3 Espanyol 1: Aduriz back with a bang|
|Metz 2 Paris Saint-Germain 3: Lavezzi late show sends Blanc´s men top|
|Four clubs face UEFA investigation regarding overdue payables|
|Icardi can reach the top at Inter, says Milito|
|Klopp open to Premier League interest|
|Marseille sweat on fitness of Gignac and Alessandrini|
|Mansfield part company with Cox|
|Pochettino calls for Tottenham unity|
|Alaba targets January return|
|Milan v Inter: Mancini returns for derby showdown|
|Zidane ban overturned|
|Hughes optimistic on Bardsley and Pieters fitness|
|No room for error against Malaga - Simeone|
|Crystal Palace v Liverpool: Six-goal thriller still fresh in the memory|
|Koeman hopeful on Schneiderlin fitness|
|Khedira or Isco will replace Modric - Ancelotti|
|Costa fully fit after hamstring problems|
|Rodgers rules out early Origi arrival|
|Garcia unsure of Castan timeframe|
|Hull City v Tottenham: Dawson returns as Bruce´s men seek response|
|Luis Enrique: No talks over Messi future|
|Schweinsteiger in line for Bayern return|
|Kompany and Lampard fit for City|
|A-League Review: Zadkovich sees red after just 17 seconds in Glory win|
|FA to investigate Whelan comments|
|Mourinho relishing busy schedule|
|Allegri reveals Lazio talks|
|Caen president steps aside following arrest|
|Moyes sees Everton similarities at Sociedad|
|Whelan not racist - Bruce|
|Balotelli: The goals will come at Liverpool|
|Torres wants to be Milan top scorer|
|Milito backs Martino to lead Argentina to success|
|Gonalons signs new Lyon contract|
|Spurs need to give Pochettino time - Dawson|
|Walcott out of United clash, Welbeck a doubt|
|Poyet targeting cover for Van Aanholt|
|Messi happy at Barcelona - Bartomeu|
|Pardew plays down Perez-Shearer comparisons|
|Werder Bremen suffer Di Santo blow ahead of derby|
|Everton will not rush Stones - Martinez|
|Monk: Swansea will not recall Michu|
|Colombian Primera A Review: Santa Fe, Medellin still perfect in semis|
|Brazilian Serie A Review: Cruzeiro rally to beat Gremio|
|Lallana: ´I´ve got friends´ at Southampton|
|Boca Juniors 0 River Plate 0: Honours even in Superclasico|
|Costa Rican Primera Division Review: Alonso scores 10th goal in Alajuelense win|
|Guarani 3 Cerro Porteno 4: Late Ortigoza goal lifts Astrada´s men to summit|
|Defensa y Justicia 1 Newell´s Old Boys 0: Pellegrino saves late penalty|