Defending champions Ajax need only a draw in the penultimate round to win the Eredivisie for a fourth consecutive season.
Frank de Boer's Ajax travel to lowly Heracles on Sunday in the knowledge one point would be enough to clinch silverware and maintain the Amsterdam club's stranglehold of the competition.
Ajax have collected 69 points from 32 games this season, six more than that of rivals Feyenoord, who are at home to Cambuur this weekend.
The Dutch giants are in the midst of a 20-game unbeaten streak, which stretches back to November last year, and are favourites on paper to get the better of a Heracles side who have lost three games on the bounce.
But Heracles and title hopefuls Feyenoord will take heart from Ajax's 5-1 capitulation at the hands of PEC Zwolle in the KNVB Beker (Dutch Cup) final last Sunday.
Regulars Bojan Krkic, Kolbeinn Sigthorsson, Ricardo van Rhijn and Daley Blind were amongst the starters but could not prevent defeat.
And if Ajax fail to claim at least a point against Heracles, it would open the door ever so slightly for Feyenoord.
Feyenoord have been in lethal form since last month's loss to Ajax, winning five games in succession, scoring 15 goals and conceding just one in the process.
Defeat for Ajax and a win for Ronald Koeman's men would keep their slim title hopefuls alive heading into the final weekend of games.
Elsewhere on Sunday, FC Twente can secure a top-three finish if they beat relegation-threatened NEC.
Twente occupy third spot in the standings, five points clear of Vitesse, who entertain Go Ahead Eagles.
A win for the 2009-10 champions would consolidate third, while it could also keep their hopes of finishing second alive depending on results.
Recently crowned cup champions PEC Zwolle host free-falling PSV, who have lost three straight games to slip to fifth in the table.
In other fixtures, Heerenveen - hot on the heels of PSV - are at home to Utrecht, while seventh-placed AZ Alkmaar are on the road against ADO Den Haag.
Basement club Roda JC entertain Groningen knowing a loss could end their stay in the top tier of Dutch football, provided NEC earn a point against Twente.
Meanwhile, third-bottom RKC Waalwijk travel to fellow strugglers NAC Breda, with just three points separating the two teams.
|32||M. te Wierik|
|8||I. Bel Hassani|
|Coach: J. de Jonge|
|Berardi will get Italy call when system changes - Ventura|
|Lucas Vazquez delighted by ´dream´ Madrid deal|
|Scottish FA chief backs cross-border competition|
|Dortmund need Reus - Aubameyang|
|Lamela eyeing new Spurs deal|
|Tighter Watford matches are a coincidence, says Mazzarri|
|Karanka: We saved Boro from League One|
|Police investigate homophobic leaflet at West Ham|
|Spain could recall Villa, reveals Lopetegui|
|Hughes backs Bony to break Stoke duck|
|Sarri will greet Higuain ´like a son who made him angry´|
|Robben receives Netherlands recall|
|Dyche considering Gray recall for Burnley|
|Zidane was behind one of my best seasons, says Ronaldo|
|Schweinsteiger absent from United squad photo|
|Emery emphasises Thiago Silva´s importance amid Juve links|
|Ferguson: Leicester will make deep Champions League run|
|Ranieri hails ´special´ Ballon d´Or nominations for Vardy and Mahrez|
|Emery: PSG cannot rely solely on Cavani goals|
|Mourinho can match Guardiola, insists Ferguson|
|Ferguson hails Klopp: Liverpool are strong title contenders now|
|Bayern optimistic over Lewandowski renewal|
|Zubizarreta appointment confirmed by Marseille|
|Clichy: Things will click into place for Manchester City|
|Chiellini: Juventus wanted to send a message|
|Gabigol´s time will come - De Boer|
|Ronaldo: Messi and I are not friends - but we respect each other|
|Earthquake halts play in Serie A game between Pescara and Atalanta|
|Mourinho charged over Taylor comments|
|Ronaldo: I need my haters|
|Badstuber hopeful injury woes behind him|
|Kroos did not want to be rested, insists Zidane|
|Rojo was phenomenal - Mourinho|
|Seven arrests made after West Ham - Chelsea fan clashes|
|Florenzi injury blow for Roma|
|MLS Review: Galaxy, Toronto into semis|
|Beister: Victory move surprised people|
|Bilic: Cup run will help in Premier League|
|Pjaca out for up to three weeks|
|Trophies still the focus for Guardiola|
|Mignolet wants ´fair´ Karius battle|
|Ancelotti impressed by motivated Bayern|
|West Ham ´unreservedly condemn´ crowd trouble|
|Allegri praises strike duo after win over Sampdoria|
|De Boer praises two-goal Icardi after vital win|
|Chelsea were ´unlucky´ with missed chances, insists Conte|
|Mourinho: I´ve never had fans like these|
|Nacho´s goal better than my Champions League final volley - Zidane|
|Borussia Dortmund 1 Union Berlin 1 (aet, 3-0 pens): Weidenfeller shootout heroics seal progress|
|Bilic: Crowd trouble distracts from great West Ham win|
|Kompany told me he couldn´t play anymore - Guardiola|
|Liverpool and Manchester United handed home quarter-finals|
|Inter 2 Torino 1: Icardi double alleviates pressure on De Boer|
|Manchester United 1 Manchester City 0: Mata extends Guardiola´s winless run|
|West Ham 2 Chelsea 1: Crowd trouble tarnishes Hammers´ route to quarter-finals|
|Cultural Leonesa 1 Real Madrid 7: Morata and Asensio star in BBC´s absence|
|Bayern Munich 3 Augsburg 1: Green´s first goal sends holders through|
|Juventus 4 Sampdoria 1: Rapid start sets champions on their way|
|Crafty Suarez is world´s best striker - Godin|
|Mancini: Balotelli has wasted years but can bounce back|
|Rami rejected ´risky´ PSG move|
|Neymar would have cost PSG €430m, claims father|
|Sacchi warns Bayern players over Ancelotti temper|
|Valencia ´pleased´ with RFEF bottle ruling|
|Mourinho apologises to Utd fans for Chelsea thrashing|
|Barcelona lash out at ´totally reprehensible´ RFEF comments|
|Jacob leaves Marseille amid rumours of Zubizarreta appointment|
|Lavezzi added to Argentina squad as Dybala drops out|
|Del Bosque: Mourinho had a point on Conte|
|N´Zonzi in talks over Sevilla extension|
|Allardyce successor ´will not be a mercenary´ - Glenn|
|Aubameyang like a rocket, Lewandowski perfect - Riedle|
|RFEF fines Valencia, warns Barca over bottle incident|
|Wenger tells Iwobi to improve his finishing|
|Barcelona without Mathieu for three weeks|
|Kimmich draws inspiration from Xavi|
|Vazquez signs new Madrid deal|
|Higuain the best striker in the world - Nedved|
|Wolfsburg regret De Bruyne, Perisic sales|
|Parejo slams Neymar for ´inciting´ Valencia fans|
|Gundogan predicts ´very lively´ Manchester derby|
|Luis Enrique satisfied with Supercopa workout|
|Messi could join Newell´s after World Cup - Maxi Rodriguez|
|Ibrahimovic wants United to be the boss of City|
|Schmidt on the bus as Lotte book ticket for next round|
|Pogba still adapting to Premier League, says Mourinho|
|Southgate hails influence of demoted Rooney|
|Lille ready to heap more pressure on PSG as Corchia dreams big|
|I´m among top 20 LaLiga coaches, jokes Luis Enrique|
|Brattan earns Socceroos call-up|
|Pochettino pleased with Janssen|
|Klopp never questioned Sturridge quality|
|Barcelona downed by Espanyol in Supercopa|
|Heavy Milan defeat ´just a bump in the road´ - Montella|
|Pochettino wanted Liverpool debutant sent off|
|Klopp happy to entertain as Liverpool youngsters earn their spurs|
|Leverkusen dumped out by 10-man minnows|