Barcelona have confirmed the death of former coach Tito Vilanova at the age of 45 following a battle with cancer.
Vilanova – assistant to Pep Guardiola during his successful stint as Barca boss - led the club to the Liga title last season, though his tenure at the club was heavily interrupted by illness.
He was diagnosed with throat cancer for the second time in December 2012 and left Camp Nou after just a season in charge to undergo treatment.
His condition had worsened in recent days, with Spanish media reporting he had been rushed into emergency surgery on Thursday.
And Barca confirmed on Friday that their former coach had lost his battle with the disease.
A statement read: "FC Barcelona regrets to report that Francesc 'Tito' Vilanova i Bayo has left us today, at the age of 45 years.
"The club wishes to express deepest condolences to his family, who shared those moments of pain along with partners, FC Barcelona fans and all of football and sport."
Barca requested that Vilanova's family be shown privacy in their time of mourning, and confirmed that an area of condolence would be opened at Camp Nou in the hours following the announcement.
A midfielder in his playing days, Vilanova progressed through the youth ranks at Barca, though never made an appearance for the first team, subsequently playing for the likes of Celta Vigo and Mallorca.
Moving into off-field roles, he forged a strong partnership with Guardiola as an unprecedented period of Barca success began.
Three La Liga titles, two Copa del Rey triumphs and two UEFA Champions Leagues were secured in a memorable four-year period, and more silverware followed after Guardiola stepped down.
With Vilanova taking over the reins, Barca regained their domestic crown, equalling Real Madrid's record haul of 100 points in the process, despite their coach often being forced from the touchline by his health.
He resigned in July 2013 and was replaced by Argentine Gerardo Martino.
A statement from the Spanish Football Federation (RFEF), which expressed condolences to the family and loved ones of Vilanova, proposed holding a minute of silence before this weekend's matches in Spain.
Players have also been asked to wear black armbands in Vilanova's memory.
|Jojic makes Cologne switch, Santana move falls through|
|Carrillo keen to get going at Monaco|
|Micronesia thrashed 38-0 as Fiji triumph in Olympic qualifier|
|Schalke stunned by ´machine´ Caicara|
|MLS Review: Keane shines at Gerrard´s Galaxy unveiling|
|Counter-attacking the key for Japan|
|Jimenez happy at Atletico|
|Gerrard predicts ´successful future´ with Galaxy|
|Iniesta can´t see Real selling Ramos|
|Keshi sacked as Nigeria coach|
|Three finals, three defeats for Messi, Mascherano|
|Nani close to Fenerbahce move|
|Sampaoli revels in ´unbelievable joy´|
|Bravo: Copa victory a dream|
|Martino: Argentina should have won|
|Chile 0 Argentina 0 (4-1 on penalties): Hosts end trophy drought|
|Germany 0 England 1 (after extra time): England make World Cup history|
|Kenya 0 Ethiopia 0 (agg 0-2): Hosts sent out of CHAN qualifiers after second penalty miss|
|Dortmund put 17 past Olympians, Bremen hand out thrashing|
|Dinamo Zagreb confirm arrests of coach and club president|
|I didn´t know who Wimbledon guest Klopp was - Brown|
|LeBron James backs Liverpool captain Henderson for FIFA 16 cover.|
|Ramos: I am not negotiating with anyone|
|Valencia complete Mina swoop|
|United States v Japan: US seek final redemption|
|Hanousek consigns Celtic to defeat|
|Roma confirm Dzeko interest|
|Arsenal forward Podolski completes Galatasaray switch|
|Warm Dortmund welcome delights Tuchel|
|Silva vows to fight for Madrid place|
|Mancini hints at Shaqiri and Santon departures|
|Bojan raring to go after return from injury|
|Babel backs Firmino to shine at Liverpool|
|Falcao must wait to impress, warns Chelsea favourite|
|Bartomeu: Deal in place for Turan|
|Parejo re-signs with Valencia|
|MLS Review: Sounders return to winning ways|
|Klinsmann unhappy with USA performance|
|High hopes for Paraguay - Diaz|
|Gareca: More to come from Peru|
|Gerrard had European offers|
|Argentina out to spoil Chile´s party - Martino|
|Sampaoli: Chile won´t change style|
|Di Maria will come good at United - Rojo|
|Peru 2 Paraguay 0: Gareca´s men finish third at Copa|
|United States 4 Guatemala 0: Klinsmann´s men win comfortably|
|´I’d prefer no-one to know my name´ - Bassett|
|Matthews completes Sunderland move|
|Podolski set for Galatasaray medical|
|Gundogan inspires Dortmund victory|
|Inter confirm Montoya capture|
|Murillo joins Inter, as Kuzmanovic and Obi depart|
|Falcao signing not a risk, says former Chelsea star|
|Deeney agrees new Watford deal|
|Confidence and service the key to Falcao success at Chelsea|
|No bids for ´Chelsea target´ Baba, claim Augsburg|
|Derby swoop for Ince|
|Fiorentina consider legal action over Salah ´no-show´|
|Chelsea the team to beat in the Premier League, says Neville|
|Storari exits Juve for Cagliari|
|UEFA removes FFP restrictions on Man City and PSG|
|West Brom hope for new owners within the month|
|Chelsea agree loan deal for Falcao|
|Kuyt eyes trophies on Feyenoord return|
|Chile v Argentina: History beckons ahead of Copa America final|
|Wallace extends Monaco loan|
|Mihajlovic wants to instill fear factor at Milan|
|Mignolet improving at Liverpool - Grobbelaar|
|Mumbai City name Anelka player-manager|
|Olivia the parrot predicts Japan to win Women´s World Cup|
|Lusitans coach blasts Bilic´s ´lack of respect´|
|Sakho eyes more Europa League wins|
|Gareca wants Peru to keep building|
|Chile ´no chance´ if Argentina produce their best - Diaz|
|Ocampos joins Marseille permanently|
|Europa League Review: Cloud-nine Brondby ignite opening round|