Everton can shift the pressure of expectancy back on to Arsenal in the scramble for a UEFA Champions League spot with a win at Southampton.
Having bounced back from a 3-2 home defeat to Crystal Palace with a 2-0 Premier League win against Manchester United last weekend - a result that prompted the departure of former Goodison Park boss David Moyes - Everton remain a point adrift of fourth-placed Arsenal, who undoubtedly have the easier run-in.
Arsene Wenger's men are due to host Newcastle United on Monday and West Brom before ending the season at Norwich City, while Everton meet Manchester City and Hull City after Saturday's trip to Southampton.
That means Roberto Martinez's side can ill-afford a slip-up this weekend if they are to pip Arsenal to fourth.
One factor that could work in Everton's favour at St Mary's Stadium is that Southampton have little to play for as they close in on a top-half finish.
That lack of incentive could go some way to explaining Southampton's recent run of having won just one of their last five games in the league, but their home record against Everton will be cause for optimism.
The Merseysiders have failed to win in their last four visits to the south coast and have triumphed in just one of their last 12 matches against this weekend's hosts.
If Everton can break that duck at Southampton's current ground, they will win their fourth away league game in a row for the first time since December 1985, but Martinez knows it will not be a straightforward task.
"(In terms of) football concepts they're one of most attractive teams in the league," he said. "There's a bravery about the way they play. Young players have big roles.
"It shows you the incredible progress they've had. We know we're going to face a really difficult team but in our eyes it's another very important game to be as good as we can.
"It's going to be one of the biggest tests we'll face this season."
Jay Rodriguez's season is over for Southampton and Mauricio Pochettino's men have not found the net in two games since the striker picked up a knee ligament injury against Manchester City three weeks ago.
Everton, meanwhile, will be without Kevin Mirallas (groin) for the remainder of 2013-14 and Lacina Traore (hamstring) is another set to miss the club's remaining three fixtures.
The visitors' biggest blow is that Sylvain Distin (hamstring) is unavailable for selection, and Martinez is reluctant to risk fellow centre-back Phil Jagielka (hamstring), meaning John Stones and Antolin Alcaraz will likely be partnered at the back.
|Coach: M. Pochettino|
for S. Gallagher 76'
for A. Lallana 86'
for S. Davis 90'
|Mauritius 0 South Africa 2 (agg 0-5): Bafana set up Angola qualifier|
|Keane relishing Gerrard arrival|
|Palace confirm Cabaye interest|
|Hamburg bring in Spahic after head-butt ban|
|Blatter hits out at France and Germany over World Cup votes|
|Sanchez: World Cup exit spurred Chile to Copa glory|
|Jojic makes Cologne switch, Santana move falls through|
|Carrillo keen to get going at Monaco|
|Micronesia thrashed 38-0 as Fiji triumph in Olympic qualifier|
|Schalke stunned by ´machine´ Caicara|
|MLS Review: Keane shines at Gerrard´s Galaxy unveiling|
|Counter-attacking the key for Japan|
|Jimenez happy at Atletico|
|Gerrard predicts ´successful future´ with Galaxy|
|Iniesta can´t see Real selling Ramos|
|Keshi sacked as Nigeria coach|
|Three finals, three defeats for Messi, Mascherano|
|Nani close to Fenerbahce move|
|Sampaoli revels in ´unbelievable joy´|
|Bravo: Copa victory a dream|
|Martino: Argentina should have won|
|Chile 0 Argentina 0 (4-1 on penalties): Hosts end trophy drought|
|Germany 0 England 1 (after extra time): England make World Cup history|
|Kenya 0 Ethiopia 0 (agg 0-2): Hosts sent out of CHAN qualifiers after second penalty miss|
|Dortmund put 17 past Olympians, Bremen hand out thrashing|
|Dinamo Zagreb confirm arrests of coach and club president|
|I didn´t know who Wimbledon guest Klopp was - Brown|
|LeBron James backs Liverpool captain Henderson for FIFA 16 cover.|
|Ramos: I am not negotiating with anyone|
|Valencia complete Mina swoop|
|United States v Japan: US seek final redemption|
|Hanousek consigns Celtic to defeat|
|Roma confirm Dzeko interest|
|Arsenal forward Podolski completes Galatasaray switch|
|Warm Dortmund welcome delights Tuchel|
|Silva vows to fight for Madrid place|
|Mancini hints at Shaqiri and Santon departures|
|Bojan raring to go after return from injury|
|Babel backs Firmino to shine at Liverpool|
|Falcao must wait to impress, warns Chelsea favourite|
|Bartomeu: Deal in place for Turan|
|Parejo re-signs with Valencia|
|MLS Review: Sounders return to winning ways|
|Klinsmann unhappy with USA performance|
|High hopes for Paraguay - Diaz|
|Gareca: More to come from Peru|
|Gerrard had European offers|
|Argentina out to spoil Chile´s party - Martino|
|Sampaoli: Chile won´t change style|
|Di Maria will come good at United - Rojo|
|Peru 2 Paraguay 0: Gareca´s men finish third at Copa|
|United States 4 Guatemala 0: Klinsmann´s men win comfortably|
|´I’d prefer no-one to know my name´ - Bassett|
|Matthews completes Sunderland move|
|Podolski set for Galatasaray medical|
|Gundogan inspires Dortmund victory|
|Inter confirm Montoya capture|
|Murillo joins Inter, as Kuzmanovic and Obi depart|
|Falcao signing not a risk, says former Chelsea star|
|Deeney agrees new Watford deal|
|Confidence and service the key to Falcao success at Chelsea|
|No bids for ´Chelsea target´ Baba, claim Augsburg|
|Derby swoop for Ince|
|Fiorentina consider legal action over Salah ´no-show´|
|Chelsea the team to beat in the Premier League, says Neville|
|Storari exits Juve for Cagliari|
|UEFA removes FFP restrictions on Man City and PSG|
|West Brom hope for new owners within the month|
|Chelsea agree loan deal for Falcao|
|Kuyt eyes trophies on Feyenoord return|
|Chile v Argentina: History beckons ahead of Copa America final|
|Wallace extends Monaco loan|
|Mihajlovic wants to instill fear factor at Milan|
|Mignolet improving at Liverpool - Grobbelaar|
|Mumbai City name Anelka player-manager|
|Olivia the parrot predicts Japan to win Women´s World Cup|
|Lusitans coach blasts Bilic´s ´lack of respect´|
|Sakho eyes more Europa League wins|
|Gareca wants Peru to keep building|
|Chile ´no chance´ if Argentina produce their best - Diaz|
|Ocampos joins Marseille permanently|
|Europa League Review: Cloud-nine Brondby ignite opening round|