Two of Serie A's in-form sides collide at the Stadio Olimpico on Friday as a rampant Roma host the resurgent Milan.
Roma have kept the pressure on league leaders Juventus with an outstanding run of eight successive wins that has seen them clinch second position in the table.
They have secured a berth in the group stages of next season's UEFA Champions League as a result, and although they are unlikely to catch Juve - who lead by eight points with just four matches left - Rudi Garcia has still done a tremendous job in his first campaign in charge.
Roma have lost just twice in the league this season, and beat fourth-placed Fiorentina 1-0 away last time out.
Radja Nainggolan's first-half goal was enough for the capital club, who have had 10 different players score during their winning streak.
Mattia Destro scored seven in six games before getting suspended following a 3-1 win at Cagliari earlier this month and he remains on the sidelines.
They have found other avenues to goal in his absence, though, and Garcia will be calling on the likes of Gervinho and veteran captain Francesco Totti to fill the void again.
However, Milan have every reason to feel confident of pulling off an upset after five Serie A wins in a row lifted them to seventh.
Key to Milan's run has been defensive stability, with Clarence Seedorf's side conceding just once in their winning streak.
Mario Balotelli has returned to form, while Brazilian Kaka is showing the sort of class that made him such a hit in his first spell at the club.
Milan have a tricky fortnight ahead, with the trip to Roma followed by a derby against Inter - who sit just five points ahead of them in fifth.
But despite the potential stakes in the cross-town clash in terms of a European berth, midfielder Sulley Muntari says all their energy is going into stopping Roma.
"The whole squad is doing well and we hope to continue this run until the end of the season," Muntari told Milan Channel.
"These next two games are going to be difficult, but we can't get ahead of ourselves - we must focus first on Roma. Only after that game can we think about the derby.
"We'll go to the Olimpico and do what Mr (Clarence) Seedorf (Milan coach) tells us. Thankfully, everything is going well for us at the moment. We're going match by match."
Muntari returned from a calf injury to make an appearance off the bench in the club's 3-0 win over Livorno on Saturday.
Nigel De Jong will be suspended for Milan, while Keisuke Honda (ankle), Mattia De Sciglio (ankle) and Michael Essien (thigh) are doubtful.
Young striker Stephan El Shaarawy could also feature off the bench for his first Milan appearance since December after recovering from a foot injury.
Roma - who fielded an all-Brazilian back four last week in the absence of Mehdi Benatia (thigh) and Federico Balzaretti (hernia) - will continue to be without midfielder Kevin Strootman (knee).
|26||M. De Sanctis|
|16||D. De Rossi|
|15||M. Pjanić||43' 44'|
|Coach: R. Garcia|
for F. Totti 77'
for Maicon 83'
for M. Pjanić 86'
|´I´m blessed with golden genes´ - Adebayor insists he is ready for new Premier League chance|
|Messi renewal progressing ´very, very well´ - Robert|
|Neuer expects Clement success at Swansea|
|Klopp calls for Liverpool enjoyment|
|Mustafi talks up Arsenal belief|
|Van Basten still against offside, slams ´nonsense in the media´|
|Rakitic dreaming of career-long Barcelona stay|
|Toure inspired by Ibrahimovic as he explains Chinese Super League snub|
|Kasperczak committed to attacking approach as Tunisia reach AFCON quarters|
|Slimani wants Algeria youngsters to learn from AFCON humiliation|
|Senegal 2 Algeria 2: Slimani at the double as Desert Warriors bow out|
|Zimbabwe 2 Tunisia 4: First-half glut seals progression|
|Adrian: I always wanted to return to Villarreal|
|Togo v DR Congo: Agassa could miss crucial game after vandals hit home|
|Extended Southampton stay on the cards for Sims|
|Bayern hoping for speedy Vidal return|
|Hull sign Markovic on loan from Liverpool|
|Wenger charged with misconduct by FA|
|Deulofeu joins AC Milan - and this time the deal is definitely done!|
|Henderson still playing through pain, reveals Klopp|
|Record-breaking Rooney reveals secret to longevity|
|No ulterior motive behind Van Dijk captaincy call - Puel|
|Carroll ignoring want-away Payet|
|Gerrard´s managerial ambitions ´wonderful news for Liverpool´ - Klopp|
|PSG interested in Guedes, confirms Emery|
|Barca lose Busquets to sprained ankle|
|Pulisic commits to Dortmund until 2020|
|Mason speaking after suffering fractured skull|
|Aubameyang blames poor preparation for Gabon AFCON exit|
|David Beckham returns to PSG|
|Morocco v Ivory Coast: Holders must beat old boss Renard as group reaches thrilling conclusion|
|Djilobodji charged over Fletcher incident|
|Cahill and Terry visit Mason in hospital|
|Allardyce onto second-choice transfer targets|
|Dortmund sign teenager Isak|
|Madrid confirm Modric and Marcelo injury blows|
|Vidal fears longer lay-off, targets return against Arsenal|
|Yaya Toure: Sterling should have dived!|
|Turan wants to see out Barcelona contract despite China talk|
|Impassioned Ibrahimovic attacks Rooney´s critics|
|´He has to lose weight´ – Mihajlovic angry after dropping Maxi Lopez|
|Lack of Liverpool signings frustrates Klopp|
|Suarez: Busquets difficult to replace for Barca|
|Depay impresses Lyon after debut|
|CSL? Rooney committed to United|
|Denis Suarez wants more goals after opening Barca account|
|Simeone bemoans inconsistency but says Atletico are improving|
|Mourinho won´t stand in the way of Rooney and CSL|
|Dzeko on target as Roma stay on Juve´s tail|
|Rakitic ready to cover for injured Busquets|
|Bale and Kane wish Mason well after serious injury|
|Busquets injury less severe than feared - Luis Enrique|
|Mason in stable condition after skull fracture|
|Senegal v Algeria: Misfiring favourites in last-chance saloon|
|PSV provide perfect finish for darts champ Van Gerwen|
|Broos predicts ´something great´ for Cameroon|
|Eibar 0 Barcelona 4: MSN see Barca to victory after Busquets blow|
|Busquets sustains ankle ligament damage in Eibar v Barcelona|
|Cameroon 0 Gabon 0: Aubameyang miss haunts hosts as AFCON campaign ends|
|Guinea-Bissau 0 Burkina Faso 2: Traore on target as Stallions advance|
|Busquets injury at Eibar compounds Barcelona midfield woes|
|Deulofeu lands in Italy ahead of AC Milan move|
|´I made the best decision´ - Conte basks in Costa recall|
|Wenger urges Xhaka not to ´punish´ Arsenal|
|Ex-Bastia man Palmieri questions Balotelli racial abuse claims|
|Costa reaction hailed by Cahill|
|Manchester City must be mentally strong, says embattled Bravo|
|Chelsea 2 Hull City 0: Costa back with a bang for Blues|
|Koke lauds Griezmann ´stroke of genius´ as Atletico snatch draw|
|Pioli questions Ansaldi dismissal|
|´I should have shut up and I apologise´ - Wenger sorry for ref rant|
|Arsenal can be proud of this red-card record|
|Mustafi: Arsenal never give up|
|Higuain: Lazio posed no threat to Juventus|
|Athletic Bilbao 2 Atletico Madrid 2: Griezmann magic rescues point|
|Puel unsure Van Dijk will be fit for Liverpool clash|
|Free-scoring Monaco return to Ligue 1 summit|
|Arsenal 2 Burnley 1: Sanchez snatches thrilling win for 10-man Gunners|
|Palermo 0 Inter 1: Joao Mario strike extends Inter streak|
|Arsenal fans give Alexis Sanchez paws for thought|
|Costa returns to Chelsea XI to face Hull City|
|Inter cannot delude fans about Messi - Ausilio|
|Allegri admits new Juventus formation was a ´mad idea´|
|Leicester boss Ranieri admits to tactical mistakes|
|Zimbabwe v Tunisia: Kasperczek demands ruthlessness with quarter-final spot on the line|
|Southampton 3 Leicester City 0: Saints end losing streak but suffer potential Van Dijk blow|
|Juventus 2 Lazio 0: Dybala and Higuain strikes see leaders return to form|
|Iborra makes a mark at both ends as Sevilla scrape past Osasuna|
|Pogba hails ´brother´ Griezmann as Manchester United speculation continues|
|Costa fight rumour ´not nice´, says Courtois|
|Henry makes emotional Ozil plea: Stay and become an Arsenal legend|
|Welbeck still has huge promise, says Wenger|
|A-League Review: Wanderers finally end home hoodoo|
|Tevez denies he´s highest-paid player after CSL move|
|Napoli capable of greatness - Sarri|
|Montella proud of Milan display against Napoli|
|Ramos tells Madrid fans: We need support|
|Conte: Costa committed to Chelsea|
|Callejon credits ´Maradona effect´ as Napoli down AC Milan|