Two of Serie A's in-form sides collide at the Stadio Olimpico on Friday as a rampant Roma host the resurgent Milan.
Roma have kept the pressure on league leaders Juventus with an outstanding run of eight successive wins that has seen them clinch second position in the table.
They have secured a berth in the group stages of next season's UEFA Champions League as a result, and although they are unlikely to catch Juve - who lead by eight points with just four matches left - Rudi Garcia has still done a tremendous job in his first campaign in charge.
Roma have lost just twice in the league this season, and beat fourth-placed Fiorentina 1-0 away last time out.
Radja Nainggolan's first-half goal was enough for the capital club, who have had 10 different players score during their winning streak.
Mattia Destro scored seven in six games before getting suspended following a 3-1 win at Cagliari earlier this month and he remains on the sidelines.
They have found other avenues to goal in his absence, though, and Garcia will be calling on the likes of Gervinho and veteran captain Francesco Totti to fill the void again.
However, Milan have every reason to feel confident of pulling off an upset after five Serie A wins in a row lifted them to seventh.
Key to Milan's run has been defensive stability, with Clarence Seedorf's side conceding just once in their winning streak.
Mario Balotelli has returned to form, while Brazilian Kaka is showing the sort of class that made him such a hit in his first spell at the club.
Milan have a tricky fortnight ahead, with the trip to Roma followed by a derby against Inter - who sit just five points ahead of them in fifth.
But despite the potential stakes in the cross-town clash in terms of a European berth, midfielder Sulley Muntari says all their energy is going into stopping Roma.
"The whole squad is doing well and we hope to continue this run until the end of the season," Muntari told Milan Channel.
"These next two games are going to be difficult, but we can't get ahead of ourselves - we must focus first on Roma. Only after that game can we think about the derby.
"We'll go to the Olimpico and do what Mr (Clarence) Seedorf (Milan coach) tells us. Thankfully, everything is going well for us at the moment. We're going match by match."
Muntari returned from a calf injury to make an appearance off the bench in the club's 3-0 win over Livorno on Saturday.
Nigel De Jong will be suspended for Milan, while Keisuke Honda (ankle), Mattia De Sciglio (ankle) and Michael Essien (thigh) are doubtful.
Young striker Stephan El Shaarawy could also feature off the bench for his first Milan appearance since December after recovering from a foot injury.
Roma - who fielded an all-Brazilian back four last week in the absence of Mehdi Benatia (thigh) and Federico Balzaretti (hernia) - will continue to be without midfielder Kevin Strootman (knee).
|26||M. De Sanctis|
|16||D. De Rossi|
|15||M. Pjanić||43' 44'|
|Coach: R. Garcia|
for F. Totti 77'
for Maicon 83'
for M. Pjanić 86'
|Del Bosque unmoved by calls for two strikers|
|Deschamps praise for beautiful France|
|Fekir ruptures knee ligaments|
|Italy v Bulgaria: Conte warns against complacency|
|Euro 2016 Qualifiers Review: Germany top Group D, Northern Ireland edge closer|
|Low: Three points most important|
|Northern Ireland on the verge of a ´magnificent achievement´ - O´Neill|
|Scotland need something against Germany - Strachan|
|Portugal 0 France 1: Late Valbuena set-piece clinches deserved win|
|Faroe Islands 1 Northern Ireland 3: O´Neill´s men edge closer|
|Germany 3 Poland 1: Gotze sends world champions top|
|Gibraltar 0 Republic of Ireland 4: Irish hopes reignited|
|Djibouti 0 Togo 2: Saintfiet´s side make it two wins from two|
|Cyprus v Belgium: Benteke boost for Wilmots´ men|
|Roma youngster faces lengthy lay-off|
|United hit back at Perez barb over De Gea saga|
|Georgia 1 Scotland 0: Strachan´s men succumb to Tbilisi hoodoo|
|Hodgson prepared to blood new players|
|Porto invite Euro elite to help raise millions for migrants|
|Dortmund legend Dede backs Tuchel to succeed|
|Robben out for four weeks|
|Turkey v Netherlands: Terim expecting hostile atmosphere for crunch clash|
|Portugal 0-1 France: Valbuena strikes late to sink Ronaldo & Co|
|Wales v Israel: Euro 2016 beckons for Coleman´s history boys|
|Gala: No extra payment for Grosskreutz|
|Increase Bundesliga´s TV rights or be left behind - Rummenigge|
|Kane: I´m no flash in the pan|
|Perez: United showed inexperience in De Gea saga|
|Milligan: Socceroos wary of Tajikistan|
|Conte wants more players like Pelle|
|OFC World Cup Qualifying Review: Samoa to meet Tahiti in next round|
|Krychowiak stayed at Sevilla because of Emery|
|I never considered Bayern exit - Gotze|
|Balotelli ´not in good condition´, Milan must improve - Mihajlovic|
|Robben slams ´stupid´ Martins Indi|
|Robben laments injury blow|
|Euro 2016 Qualifiers Review: Bale edges Wales closer, Iceland dent Netherlands´ qualification hopes|
|De Bruyne relieved to ´boss´ Bosnia-Herzegovina|
|Blind furious after nightmare debut|
|Coleman sees shades of Charles in Bale winner|
|Conte only concerned about Italy winning|
|Mauritania v South Africa: SAFA to investigate Masilela no-show|
|AFC World Cup Qualifying Review: Qatar hit 15 in Bhutan rout|
|Belgium 3 Bosnia-Herzegovina 1: De Bruyne shines in straightforward victory|
|Cyprus 0 Wales 1: Bale winner takes Wales one step closer|
|Netherlands 0 Iceland 1: Sigurdsson winner caps difficult first game for Blind|
|Italy 1 Malta 0: Pelle spares wasteful Azzurri|
|Balotelli stars in Milan friendly win|
|Bhutan thrashed 15-0 by Qatar in qualifier|
|Rwanda v Ghana: Gyan doubt gives hosts hope|
|Tanzania v Nigeria: Enyeama out of AFCON qualifier|
|Valdes and Berahino included in Premier League squads|
|Costa Rica v Brazil: Dunga´s men return after Copa disappointment|
|Spain v Slovakia: Azpilicueta eyeing important revenge|
|Adebayor left out of Tottenham squad list for league and Europe|
|San Marino v England: Place in history books beckons for Rooney|
|Germany can cope with Reus absence - Low|
|Bayern offer aid to refugees in ´training camp´|
|BREAKING NEWS: Welbeck ruled out for months after knee surgery|
|South Korea 8 Laos 0: Son leads the way in rout|
|Australia 5 Bangladesh 0: Socceroos surge to emphatic win|
|Japan 3 Cambodia 0: Hosts pick up first qualifying win|
|Rudiger aiming to nail down Euros spot after Roma move|
|Melo happy to join Inter at last|
|Hernandez thanks Ferguson after United departure|
|Chung: AFC has compromised FIFA election|
|Wales the new best of British|
|Reus out of Germany qualifiers|
|Chile v Paraguay: Vidal missing for Copa champions|
|Ghedin: Anything is possible for Malta|
|Pogba will be worth €100m - Marotta|
|England can win Euro 2016 - Hodgson tells players|
|Conte unsure over Balotelli future|
|Argentina - Bolivia Preview: Mascherano backs 'very special' Messi|
|Portugal - France Preview: Deschamps aiming to correct mistakes|