Miranda and Diego Costa were on target as Atletico Madrid beat plucky Elche 2-0 to go six points clear at the top of La Liga on Friday.
Brazilian defender Miranda grabbed his second goal of the season in the Spanish top flight 18 minutes from time after David Villa had failed to convert a second-half penalty.
Costa, who missed a penalty at Getafe last weekend, then secured the points with his 35th goal of the season from the spot after Cristian Sapunaru had brought him down - and received a second yellow card - in added time.
Diego Simeone's side had been frustrated by relegation-threatened Elche at a packed Vicente Calderon before Miranda and Costa secured an eighth consecutive La Liga victory.
With Barcelona not playing until Sunday and Real Madrid out of action this weekend, Atleti now have an ominous advantage at the summit with four games remaining as they attempt to win their first La Liga title since 1996.
They can head into Tuesday's UEFA Champions League semi-final first leg against Chelsea knowing they are in with a great chance of securing a famous double.
Defeat for Elche, on the other hand, keeps them only four points above the relegation zone.
Costa suffered a leg wound in a collision with a post in the victory at Getafe last weekend, but the striker was passed fit to start.
And the Spain international was soon in the thick of the action when he fired into the side-netting after Adrian Lopez laid the ball off to him five minutes in.
Elche were not content to just make up the numbers, though, and Thibaut Courtois produced a fine save to keep out a left-footed strike from Javi Marquez, then had to be alert to thwart Damian Suarez when the defender was allowed a free header from the resulting corner.
Filipe Luis fluffed his lines at the other end when the ball fell kindly for him in the penalty area before the home side were given another scare just before the half-hour mark, when Carles Gil fired over the crossbar from inside the area.
Atleti were not at their best in the first half, but ought to have been in front four minutes before the break when Costa flicked on Juanfran's cross and Villa prodded wide with the goal gaping.
Villa had appeared to be in an offside position, but the flag failed to go up.
Simeone replaced Adrian with Raul Garcia at the break and the substitute took only four minutes to make an impact, as Sapunaru was adjudged to have bundled him over in the area and Carlos Clos Gomez pointed to the spot.
Villa stepped up to take the resulting penalty after Costa's miss against Getafe, but the former Barcelona man also failed from the spot as Manu Herrera kept out a tame effort diving to his left.
There was more frustration for Villa when he had a goal ruled out for offside and was then substituted to ensure Elche remain the only current top-flight team he has failed to score against.
Costa was booked following his reaction to two strong challenges, which sparked a melee that also saw Alberto Rivera go into the book.
An animated Simeone orchestrated the Atleti faithful and the opening goal they craved eventually arrived when Miranda rose highest to head home Jose Sosa's corner in emphatic fashion.
Costa then raced clear and was denied by Herrera, but made no mistake when he sent the keeper the wrong way from the spot after Sapunaru had upended him in the 90th minute. The defender was shown a second yellow card to compound his misery.
|Clyne: Klopp is making me confident|
|Klopp: We can´t treat Sturridge normally|
|Neymar will re-sign with Barca, promises father|
|Berisha extends Victory stay|
|Arnold backs fans amid A-League boycott|
|Perez happy at Newcastle|
|Klopp can´t forget ´f***ing´ Palace loss|
|Mihajlovic: Milan didn´t expect extra time|
|Carvalhal hopes cup run spurs Wednesday to league success|
|Coppa Italia Review: AC Milan survive scare, Torino thrash Cesena|
|Hughes happy with rotation policy after League Cup win|
|Football League Review: Burton win to go top of League One|
|Atletico still uncomfortable - Simeone|
|AC Milan 3 Crotone 1 (aet): Bonaventura and Niang extra-time strikes send hosts through|
|Leganes 2 Granada 1: Segunda Division side threaten upset|
|Ligue 1 Review: Leaders Paris Saint-Germain held on the road|
|City thrashing cruel on Hull - Bruce|
|City thrashing cruel on Hull - Bruce|
|Pellegrini: Silva brings style back to City|
|Reaching last four is ´terrific´ - Martinez|
|Lukaku urges Everton to push on|
|FIFA sponsors call for ´independent oversight´ of reforms|
|Stoke City 2 Sheffield Wednesday 0: Potters end visitors´ League Cup run|
|Manchester City 4 Hull City 1: De Bruyne double books semi-final spot|
|Middlesbrough 0 Everton 2: Deulofeu and Lukaku on target in routine win|
|Reus Deportiu 1 Atletico Madrid 2: Third-tier hosts make life difficult for Atleti|
|Amnesty International critical of Qatar, FIFA|
|Angers 0 Paris Saint-Germain 0: Cavani fails to make his mark|
|Ramos: Madrid fight for Undecima every day|
|Silver screen awaits for Vardy?|
|Del Bosque noncommittal on Aduritz form|
|Dybala: Juventus´ slow start normal|
|Koeman confident Southampton can match Liverpool|
|Venezuela stars issue quit threat to FA|
|Moreno agent opens door to Real Madrid offer|
|Herrera: I´m very happy at Manchester United|
|Lars Bender undergoes ankle surgery|
|Delneri takes over at Verona|
|Bellerin: I did not know how to defend until I joined Arsenal|
|Panathinaikos hit with three-point penalty after violence|
|Martial and Depay unhappy under ´selfish´ Van Gaal - Parker|
|Injured Carvajal set to miss Cadiz tie|
|Klopp vows to play strongest Liverpool team against Southampton|
|Ronaldo rested for Copa clash|
|Sanchis implies Neymar provoked Isco kick|
|Benitez: I have no problem with James|
|Luis Enrique plays down Suarez Ballon d´Or omission|
|Sergio Ramos is right - football is cyclical, says Luis Enrique|
|Klopp defends Mignolet amid Ter Stegen rumours|
|Boksic backs Mandzukic to get 20 goals for Juve|
|Neymar hails ´great friends´ Messi and Suarez|
|Chelsea submit planning application for new stadium|
|French sports people need to be exemplary - Valls|
|Moyes: Valencia job has come too soon for Neville|
|Napoli loss ´doesn´t change anything´ for Mancini|
|Ronaldo ´uncomfortable´ as a number nine, claims Madrid great Sanchez|
|Manchester City receive $400m Chinese investment|
|Messi: Ronaldo deserves Ballon d´Or nomination, but I´d prefer Suarez|
|Moyes open to another European gig|
|Everton welcome cup pressure - Martinez|
|Casillas open to MLS move|
|Hughes: Butland going nowhere|
|Milner eyes trophies at ´exciting´ Liverpool|
|Napoli became anxious - Sarri|
|Inter did not deserve to lose - Mancini|
|Messi beats Ronaldo to top prize at La Liga awards|
|Bolton Wanderers 1 Brentford 1: Smith watches on as strugglers snatch point|
|Napoli 2 Inter 1: Higuain at the double as hosts go top|
|Lewandowski: Less pressure on me than Aubameyang|
|Defoe, Larsson to miss Arsenal match|
|Sassuolo 1 Fiorentina 1: Di Francesco´s side extend unbeaten home run|
|Barcelona took ´a step forward´ without Messi - Busquets|
|Unfair to blame Garcia for Roma form - Zanetti|
|Southampton v Liverpool: Returning stars have Ibe in buoyant mood|
|Lewandowski´s five-goal haul recognised for four records|
|Barcelona v Villanovense: Holders get second crack at minnows|
|Verona sack Mandorlini|
|Valencia confirm Nuno departure|
|Premier League clubs reveal agent fees|
|Stoke will not underestimate Sheffield Wednesday – Hughes|
|Robben wants Guardiola to stay at Bayern|
|Aguero allays foot injury concerns|
|Cadiz v Real Madrid: Pepe calls for hard work in Andalusia|
|Bolton confirm players have not been paid for November|
|Neville takes Valencia training following Nuno resignation|
|Mihajlovic targets Coppa Italia triumph|
|Garde confident Villa will survive|
|Everton to make late call on Barry and McCarthy|
|Davids: Messi is an anomaly but Ronaldo just an athlete|
|Simeone open to January signings following Tiago injury|
|Messi leads nominees for Puskas Award|
|Hummels defends himself after media criticism|
|Messi, Ronaldo and Neymar nominated for Ballon d´Or|
|Luis Enrique, Guardiola and Sampaoli up for World Coach of the Year|
|Chelsea about the team, not just Costa - Ivanovic|
|Kuyt open to Feyenoord extension|
|Barcelona lodge complaint over ex-Madrid duo´s Neymar comments|
|Davies wants Manchester City quarter-final to get crazy|
|Ribery ordeal is over – Rummenigge|
|Smalling: Vardy run opens door to non-League hopefuls|
|Bender relieved to end Dortmund losing streak|
|Mata: Manchester United have six finals in December|
|Vardy reveals painful road to Premier League record|
|Pardew urges Newcastle to back McClaren|
|Russian clubs banned from signing Turkish players|
|Klopp expects Coutinho to face Southampton|
|Valverde: Let´s hope Barcelona don´t sign Aduriz|
|De Bruyne relishing link-up with Silva|
|´Crazy´ Munich could convince Guardiola to stay|
|Defiant Garcia refuses to resign despite Roma slump|
|Monk confident Swansea can turn the corner|
|Bellerin: Arsenal can cope without Sanchez|
|McClaren: Newcastle not panicking|
|Klopp delighted with Sturridge, Henderson returns|
|I wouldn´t swap Lukaku for Vardy - Martinez|
|MLS Review: Timbers, Crew to meet in final|
|Nuno saddened by Valencia departure|
|Morata will become a key player - Allegri|