Ligue 1 champions-elect Paris Saint-Germain suffered a shock 1-0 loss at Lyon on Sunday, while Saint-Etienne were held 2-2 at Reims.
Laurent Blanc's PSG were knocked out of the UEFA Champions League on Tuesday, losing on away goals to Chelsea in the last eight, and they delivered another disappointing display five days later.
The Stade de Gerland was the setting of last season's title triumph for the visitors but their march to this year's championship suffered a brief blip, as Lyon recorded a deserved win.
Remi Garde's side also gained a mental advantage in what was essentially a dress rehearsal for the Coupe de la Ligue final next Saturday.
Lyon midfielder Jordan Ferri netted the game's only goal in stunning fashion after 31 minutes, scoring with a magnificent effort from distance to end PSG's 16-game unbeaten run in the league.
Despite the defeat, Blanc's side remain at the top of Ligue 1 by 10 points and they will retain their crown with a win over Evian a week on Wednesday, providing that Monaco lose to Nice next Sunday.
Meanwhile, Saint-Etienne's draw at Reims saw their UEFA Champions League ambitions receive another blow as they sit seven points behind third-placed Lille.
It could have been a lot worse, however, as Saint-Etienne found themselves 2-0 down in the 50th minute - Gaetan Charbonnier and Franck Signorino with the goals as Reims looked set to go seventh.
But just a few moments after Signorino's goal, the visitors hit back.
Brandao netted his fifth Ligue 1 goal of the season and that inspired Christophe Galtier's men to snatch a late point.
France international full-back Francois Clerc struck in second-half stoppage time, but their place in fourth does not look secure, with Lyon now just two points behind them.
Sunday's early kick-off saw Nantes all but secure their top-flight status for another season as they beat struggling Guingamp 1-0.
Serge Gakpe's fourth-minute goal was enough for Nantes, leaving Guingamp five points above the drop zone.
The result also means Ajaccio avoided relegation for another week, but after just three wins all season and five matches to acquire 15 points, their descent to Ligue 2 looks to be a formality.
|MLS Review: Atlanta too good for New York City, Dallas draw|
|Totti could´ve played for any big club – Ramos hails Roma great|
|Wenger: FA Cup win my presentation for new deal|
|I´m crazy about returning to Spain – Nolito eyes City exit|
|Roma defender Emerson suffers anterior cruciate ligament injury|
|Zenit sack Lucescu after missing out on Champions League|
|This was probably my last game for Benfica - Ederson hints at Man City move|
|Empoli relegated as Crotone beat Lazio to secure Serie A survival|
|Lorient 0 Troyes 0 (1-2 agg): Goalless draw sees visitors promoted to Ligue 1|
|Dzeko´s 29 goals claim Serie A Capocannoniere|
|Inter 5 Udinese 2: Perisic stars in crushing victory|
|Ausilio confirms Manchester United interest in Perisic|
|Totti: I´m not ready to say it´s over|
|Totti is not normal - De Rossi emotional after Roma icon´s farewell|
|Twenty-five seasons, 307 goals, one incredible legacy – the numbers behind Totti´s remarkable career|
|Sampdoria 2 Napoli 4: Comprehensive win not enough to snatch second place|
|Roma 3 Genoa 2: Perotti seals Champions League berth in dream farewell for Totti|
|Leave him alone! - Montella shrugs off Donnarumma error|
|I didn´t want to leave Real Madrid - Ronaldo|
|The offside rule is crazy - Cahill hits out at Sanchez FA Cup goal|
|I think Rooney wants to leave Manchester United, says Robson|
|Cagliari 2 AC Milan 1: Pisacane late show seals fitting Stadio Sant´Elia farewell|
|Inter announce Palacio departure|
|Courtois ready to sign new Chelsea contract|
|Everyone wrote me off - Critics inspired Mertesacker before Arsenal triumph|
|Emery never feared the sack at PSG|
|Barcelona future not in my hands – Paco Alcacer|
|Varane wants to see Mbappe alongside history-maker Ronaldo|
|Iniesta: I needed Busquets´ help to lift the Copa del Rey trophy!|
|Man United capable of anything - Lingard eyes glory next season|
|Freiburg´s Grifo signs Borussia Monchengladbach deal|
|Verratti expects to be at PSG next season amid Barcelona rumours|
|Coquelin: FA Cup win was for Wenger and we want him to stay|
|Ibrahimovic wanted by ´many clubs´, but he´ll stay in Europe - Raiola|
|Matuidi unsure about PSG future amid Man United links|
|Al-Khelaifi certain Emery will stay at PSG|
|MLS Review: Galaxy win Clasico, Sporting KC beaten|
|He will be at the Wanda Metropolitano – Atletico hint at Griezmann stay|
|Mexico 1 Croatia 2: Hernandez breaks record in surprise loss|
|Mexico 1 Croatia 2: Hernandez breaks record in surprise loss|
|Luis Enrique hails ´extraterrestrial´ Messi|
|Every player wants to play more – Fabregas cagey on Chelsea future after final omission|
|Tuchel hopes to continue as Borussia Dortmund boss|
|Kompany adamant Stones ´has everything´|
|People talk too much about China - Costa would only leave Chelsea for Atletico|
|Conte clear-headed for close season after Chelsea´s Wembley woe|
|Conte: Sanchez´s goal should not have stood|
|Neymar equals Puskas´ record in Copa final|
|Carrick signs new one-year Manchester United deal|
|Barcelona 3 Alaves 1: Messi magic secures Luis Enrique parting gift|
|Angers 0 Paris Saint-Germain 1: Cissokho own goal in stoppage time delivers Coupe de France glory|
|Ridiculous to base my future on one match - Wenger|
|Allegri turns focus to Champions League after ´beautiful´ season|
|Eintracht Frankfurt 1 Borussia Dortmund 2: Audacious Aubameyang penalty seals DFB-Pokal crown in sty|
|Ramsey wants Wenger to stay after scoring FA Cup final winner|
|On Wednesday it will be clearer – Wenger reiterates stance on his future despite FA Cup glory|
|Wenger should bow out in glory after Wembley thriller|
|Silva attracted by Watford´s ambition|
|Arsenal and Wenger set new FA Cup records|
|Teenager Kean makes history with Juve winner|
|Arsenal 2 Chelsea 1: Ramsey the hero again as Gunners win record 13th FA Cup|
|Moses sent off following dive in FA Cup final|
|Bologna 1 Juventus 2: Kean´s first goal secures win|
|Hasenhuttl acknowledges RB Leipzig could lose Keita and Forsberg|
|Making history is not easy! - Rodgers lauds Celtic´s identity after Scottish Cup triumph|
|Celtic 2 Aberdeen 1: Late Rogic moment of magic seals unbeaten domestic treble|
|Montella urges Donnarumma to ´use his head´ amid Milan exit speculation|
|Spalletti not drawn on Inter links as he eyes second place with Roma|
|FA Cup final: Ospina starts for Arsenal with Chelsea stars primed for double|
|Vecchi demands ´blood, sweat and tears´ from Inter players|
|Totti is used by the media - Spalletti frustrated by focus on Roma captain|
|Falcao wants Monaco stay|
|Sergio Ramos is tattooing every week – Varela bemused by Frankfurt banishment|
|Juventus stalwart Tacchinardi ´betting on Higuain´ to settle Champions League|
|Mertens renews Napoli deal|
|Romero wants to become United´s number one|
|El Shaarawy and Montolivo handed Italy recalls|
|Ex-Newcastle boss Pardew not interested in Sunderland job|
|Watford appoint Silva|
|A disgrace I will never forget – Wenger savages Arsenal critics|
|Mourinho: Griezmann? Ask Ed Woodward|
|Raiola denies Donnarumma threat from AC Milan ahead of contract talks|
|Zabaleta challenges West Ham to believe in winning trophies|
|Ajax defender Sanchez would love to play for Barcelona|
|Kane beats Kante to PFA Fans´ Player of the Season prize|
|Kane will stay at Tottenham but others may think we´re ´a nearly club´, says Rose|
|Stopping Messi the main concern for reported Real Madrid target Hernandez|
|Asensio: Rafa Nadal told Real Madrid to sign me|
|Chelsea star Hazard yet to receive new contract offer|
|Emery desperate to win Coupe de France|
|Toronto 5 Columbus Crew 0: Eastern Conference leaders cruise|
|Hazard unfazed by comparisons to ´leaders´ Messi, Ronaldo|
|Zidane hails ´extraordinary´ Buffon|
|Wenger to give away FA Cup medal if Arsenal beat Chelsea|
|Conte eyes Chelsea extension to reward Abramovich faith|
|Gerrard to take on Man Utd again in Carrick´s testimonial|
|Bernardo hoping to learn Silva service from Manchester City star namesake|