Juventus visit Udinese on Monday hoping to become the first away side to win at Stadio Friuli since January.
Udinese may sit 14th in the table but they are unbeaten in their last seven home matches in all competitions.
That run has involved five wins, including triumphs against Fiorentina and Milan, and Juve, who top the league by eight points in their bid for a third successive title, will need to be at their best.
Antonio Conte's men have looked comfortable at the summit for much of the second half of the campaign, but the second-placed Roma have shown no signs of conceding defeat in the title race by going on a run of six consecutive victories.
The top two are scheduled to meet on May 9, but Conte will be keen to wrap up the title before that showdown.
Monday's trip to Udinese is arguably the most difficult of their matches between now and the fixture at the Stadio Olimpico, with Bologna and Atalanta to face at home and a trip to strugglers Sassuolo.
Former Udinese man Mauricio Isla knows the challenge Juve will face against Francesco Guidolin's side.
"It will be a tough match, because even though Udinese are no longer what they were two years ago, they have important players like (Antonio) Di Natale, (Roberto) Pereyra, (Luis) Muriel…and they also give 100 per cent whenever they face Juve," he told JTV.
"We'll have to be on our guard and play in the way we know how, because it's important to win when you're six games from the end."
And Chilean Isla expressed his gratitude to Udinese, whom he left for Juve in 2012.
"I'm grateful to Udinese for all that they gave me. I spent some fantastic years there, it was a happy time and it's thanks to that experience that I'm now part of the best team in Italy," he added.
Juve will be concerned with the fitness of Arturo Vidal, who revealed he was suffering with a knee problem after being withdrawn during Thursday's 2-1 UEFA Europa League win over Lyon, which sealed their place in the semi-finals, where they will face Benfica.
Carlos Tevez is still battling a thigh problem, and has been substituted in his last three games, while defender Andrea Barzagli (calf) continues to struggle. Emmanuel Agyemang-Badu is suspended for Udinese.
|10||A. Di Natale|
|Coach: F. Guidolin|
for H. Yebda 70'
for A. Di Natale 79'
|Chile, Argentina deserve final spots - Mena|
|Ramos keen on United switch - Calderon|
|B36 1 The New Saints 2: Wilde leaves it late to secure advantage|
|Sevilla agree deal for Rami|
|Celtic snap up United teenager Janko|
|Beauvue passes Lyon medical|
|Roma bring in Falque|
|Coates completes permanent Sunderland switch|
|Vallecano to make charity donations from shirt sales|
|Angella commits to Watford|
|Gundogan pens new Dortmund deal|
|Juve reject €80million Barca offer for Pogba, says Marotta|
|Ruiz seals permanent Villarreal move|
|Mourinho respects Cech´s decision to quit Chelsea|
|Claridge excited by potential Pearson successors|
|Miranda completes Inter switch|
|Blind takes over as Netherlands coach|
|Mourinho: Premier League tougher to win than ever|
|Hamburg make Holtby move permanent|
|Southampton terminate Osvaldo contract|
|BREAKING NEWS: Swansea swoop for Eder|
|Abbiati extends Milan stay|
|Cruyff: Barcelona have lost their values|
|Vydra seals Watford move|
|Ambitious Clyne targets trophy haul with Liverpool|
|Claridge: Off-field incidents cost Pearson his job|
|Clyne becomes Liverpool´s sixth close-season signing|
|Imbula leaves Marseille for Porto|
|FIFA chief Blatter challenges critics to prove corruption claims|
|Distin joins Bournemouth|
|Bayern seal Costa deal|
|Arsenal confirm Diaby departure|
|Blatter to miss Women´s World Cup final|
|Bogdan sets sights on being Liverpool number one|
|Danilo eager to get started at Real Madrid|
|Leicester´s Wood joins Leeds|
|Porto confirm Atletico move for Martinez|
|Lloyd: Repetition key to netting penalty|
|Sheffield Wednesday job a ´dream´ for Carvalhal|
|´We played a complete game´ - Messi|
|Diaz upbeat despite heavy Copa loss to Argentina|
|Martino lauds Messi for selfless performance|
|Viviani makes surprise Verona switch|
|Estonian team wins cup match 31-0|
|No meeting with Arsenal has occurred - Vidal´s agent|
|United States 2 Germany 0: Ellis´ team reach World Cup final|
|Argentina 6 Paraguay 1: Messi leads Martino´s men to Copa final|
|UEFA Europa League Review: FK Zeljeznicar and FC Dacia Chisinau open with wins|
|UEFA Champions League Review: FC Pyunik make winning start|
|Sweden U21 0 Portugal U21 0 (aet, 4-3 on penalties): Carlgren the hero as Swedes claim Euro glory|
|Frankfurt capture Castaignos|
|Bastia face relegation over debt|
|Bahlouli makes Monaco switch|
|Pearson sacked by Leicester|
|Rekik set for Marseille switch|
|Ranocchia and Carrizo sign new Inter deals|
|Crespo handed Modena role|
|Cech reveals work permit prevented past Arsenal move|
|Ivory Coast cut coaching shortlist down to five|
|McCarthy satisfied with Mings sale|
|Heaton commits to Burnley|
|Bowyer: Rhodes and Gestede will not come cheap|
|Burton and Day depart West Brom|
|Mendilibar makes Eibar return|
|Milan agree to terminate Muntari contract|
|Copa final a dream come true for Sampaoli|
|CSKA Sofia demoted due to financial crisis|
|Wolfsburg warn off De Bruyne suitors|
|Kone: I want to prove I can cut it at Everton|
|West Ham v Lusitans: Bilic set for first game in charge|
|Millennium Stadium to host 2017 UEFA Champions League final|
|Ronaldo a ´possibility´ for Portugal´s Olympics squad|
|Liverpool should get rid of Sterling - Grobbelaar|
|Miranda arrives for Inter medical|
|Arsenal can challenge the best - Cech|
|Real star Bale can be better than Ronaldo, says Keegan|
|UEFA approves changes to FFP rules|
|Honduras v Mexico: Moreno´s injury may force Mexican rethink pre-Gold Cup|
|Hiddink was the wrong man for Netherlands - De Boer|
|Vargas: I was scoring with every shot at training|
|Zambrano red rocked Peru - Gareca|
|Paraguay to change tack against Argentina|
|Sampaoli thrilled with substitutes´ influence, applauds Peru|
|Martino rues Copa America date with former side Paraguay|
|Former Birmingham City player Thwaites among Tunisia victims|
|Chile 2 Peru 1: Zambrano´s red card helps hosts into Copa final|
|Thiago Silva: ´I didn´t even know the ball had hit my hand´|
|Ronaldinho set to sign for Antalyaspor|