Tottenham head coach Tim Sherwood has conceded Erik Lamela and Etienne Capoue are unlikely to play again this season.
The pair arrived at White Hart Lane in the close-season but have struggled to make an impression, with injuries not helping their attempts to settle in England.
Winger Lamela has not featured in 2014, having been troubled by a back problem, while an ankle injury has kept midfielder Capoue out for several weeks.
Assessing the fitness of Lamela, Sherwood is reported as saying in the British media: "He's probably not going to play this season. He's been out a very long time; he's going to need a pre-season before he can play.
"He's been unfortunate with injuries and it's a shame that he's picked up the knocks because, taking the settling-in period aside, how are you meant to settle when you can't go out there and perform because you've had this serious back injury?"
Asked about Capoue, the 45-year-old added: "I am not sure how far he is away, but it is very doubtful whether he will play between now and the end of the season."
Lamela and Capoue were among a host of players brought in by Tottenham prior to the current campaign who had not previously experienced the Premier League.
Sherwood, who only took charge of the club in December, has stated a preference for targeting players familiar with England's top flight, citing Everton's recent business as a good example to follow.
Roberto Martinez significantly bolstered his squad at the beginning of September, agreeing loan deals for Romelu Lukaku and Gareth Barry, who have both impressed, and also capturing midfielder James McCarthy from Wigan Athletic.
"You can buy someone who's never played in the Premier League and he comes over and is a revelation but it's more of a risk doing that," Sherwood added.
"Premier League experience for me would be key. If you want to look at any team you've got to look at Everton and what they've done in the transfer market, it is second to none.
"They got Gareth Barry, with 534 games or whatever it is in the Premier League. Romelu Lukaku was the best young player last season. The acquisition of James McCarthy.
"On deadline day they looked like an average side but all of a sudden they make three signings and it has turned them into what they are now."
|Chelsea 2 Barcelona 2 (4-2 on penalties): Courtois stars for Premier League champions|
|Eriksen calls for ruthless Spurs|
|Pulis praises Berahino attitude|
|Alderweireld confident of top-four finish|
|Villa ready for tough Spurs clash|
|West Ham edge win on Carrow Road anniversary|
|Kozak scores twice as Villa draw at Wolves|
|Stanislas brace leads Bournemouth past Yeovil|
|Watford slip to friendly defeat at Cardiff|
|Lukaku injury sours Everton win at Dundee|
|UEFA Champions League Review: Fenerbahce draw blank as Monaco impress|
|West Brom earn friendly win over Walsall|
|Vardy at the double as Leicester beat Burton|
|Atletico impress in win over Oviedo|
|Herrera sacked by Mexico after ´punch´|
|Gerrard, Keane and Bradley pull out of MLS All-Star squad|
|Marseille reach Diaby agreement|
|Sammer thrilled with Vidal´s winning mentality|
|Platini expected to launch FIFA presidency bid|
|Romanov sacked me over Barca snub - Korobochka|
|Villa complete Crespo capture|
|Wolfsberger v Borussia Dortmund: Bender praises ´fun but exhausting´ training|
|Okaka swaps Sampdoria for Anderlecht|
|Southampton v Vitesse: Fonte excited for ´dream´ sojourn into Europe|
|Bournemouth agree King compensation|
|West Ham v Astra: Kouyate confident West Ham can progress|
|Vidal completes Bayern switch, signs four-year deal|
|Fabregas calls for Champions League improvement|
|BREAKING NEWS: Filipe Luis completes Atletico return|
|Bayern to present Vidal|
|Wenger unfazed by Mourinho´s spending jibe|
|Pellegrini: Sterling will justify price tag|
|Cavani hit with two-match Uruguay ban|
|Bonucci to remain at Juve until 2020|
|No bids for Berahino - West Brom|
|Putin: Blatter deserves a Nobel prize|
|Howe: Swansea a benchmark for Bournemouth|
|New Parma to play in Serie D|
|Mata vows to hit the goal trail at United|
|Drogba ´perfect fit´ for Montreal|
|Berahino ´not yet´ ready for Tottenham - Irvine|
|Romero lauds caring Van Gaal|
|Jese flying at Real under Rafa|
|Sampdoria unwilling to pay €10m for Balotelli|
|Mourinho talks up Arsenal title chances|
|Hull sign Ryan Taylor, Sam Clucas|
|Kane, Pochettino hail MLS All-Star test|
|Di Santo sorry for swift Werder departure|
|Mourinho tells Ronaldo: Team honours come first|
|Khedira returns to Juve training|
|Celtic v Qarabag: Champions League return of utmost importance, says Collins|
|Pellegrini: Jovetic had to go|
|Manquillo completes Marseille move|
|Schalke reject Juve´s Draxler bid|
|Blanc: Di Maria deal ´close´|
|Di Santo debut ends in stalemate|
|Fire sign Drogba, trade him to Montreal Impact|
|FIFA and UEFA welcome ruling on third-party ownership|
|Juve kick off title defence against Udinese|
|Stoke sign free agent Afellay|
|Benitez confident Ramos will stay|
|Fenerbahce issue warning to fans|
|UEFA Champions League Preview: De Boer confident Ajax are ready for Vienna test|
|Bility: I am the favourite for FIFA presidency|
|Pienaar to miss start of season|
|Vietnam 1 Manchester City 8: Sterling shines as tourists run riot|
|All-Star Keane relishing Spurs clash|
|Shaun Wright-Phillips joins brother Bradley at Red Bulls|
|Inter 0 Real Madrid 3: Rodriguez stunner caps comfortable win|
|Villa sign Ayew|
|Watford complete Berghuis transfer|
|Robben returns to Bayern training|
|Pulis anxious to make West Brom additions|
|David Luiz eager to welcome ´fantastic´ Di Maria|
|Fernando injury free ahead of new campaign|
|Hummels blames weight issues for poor season|
|Defoe hoping for early Sunderland goals|
|Depay hints at identity of ´surprise´ United striker|
|Tigres UANL v River Plate: Hosts look to bounce back and make history|
|Crespo set for Villa move|
|Terry: I would never join a Premier League rival|
|Van Gaal coy on United future|
|Romero to cover potential De Gea exit - Van Gaal|
|Uruguay win men´s football gold at Pan Am Games|
|Pirlo thanks New York City fans for ´beautiful´ welcome|
|Mexico capitalised on ´the mistakes we made´ - Schafer|
|Herrera delighted with Mexico display|
|MLS Review: Whitecaps build happy home, Pirlo debuts|
|Guardado wins Golden Ball at Gold Cup|
|NZF confirms Olympics disqualification appeal|
|Jamaica 1 Mexico 3: CONCACAF giants complete form turnaround|
|New York Red Bulls 2 Benfica 1: Another scalp for MLS side|
|Romero signs with United|
|Moghreb Tetouan 1 Al Hilal Omdurman 1: Visitors go top|
|Van Gaal rules out Ronaldo bid|