Barcelona’s dismal week took another turn for the worse as they crashed to a shock 1-0 La Liga defeat at Granada on Saturday.
Yacine Brahimi's third goal of the season in the first half gave the Andalucian outfit their first win over the champions since they returned to the top flight in the 2011-12 campaign.
Barca were dumped out of the UEFA Champions League at the quarter-final stage by Liga title rivals Atletico Madrid in midweek, and the pressure on coach Gerardo Martino was ramped up again at Estadio Nuevo Los Carmenes.
Neymar cut a frustated figure as he spurned several chances, and defeat ensured Barca missed the chance to replace Atletico - who play on Sunday - at the top of the table, while victory for Granada eased their relegation fears.
Martino stated in the build-up to this game that Barca's season would be deemed a failure following their Champions League exit, and he must now hope his side respond by winning the Copa del Rey final against Real Madrid on Wednesday.
Xavi, Jordi Alba and Dani Alves dropped to the bench as Martino rang the changes following the loss at Atletico and, probably, with one eye on the Copa final.
Barca made a bright start, but they were stunned when the home side took the lead just 16 minutes in.
Midfielder Fran Rico was the architect, with a pass that pierced the Barca defence, and Brahimi raced away from Martin Montoya before beating Jose Pinto with a right-foot finish inside the near post.
Granada wanted a penalty when Youssef El-Arabi went down under a challenge from Javier Mascherano, but referee Carlos Delgado saw nothing untoward.
Neymar should have done better when he headed Montoya's inviting cross over the crossbar, before the Brazil forward tried his luck with a measured right-foot strike from outside the area that was palmed away by Orestis Karnezis.
Former Santos man Neymar was becoming increasingly tetchy, and he was somewhat fortunate to escape with only a yellow card when he kicked out at Allan Nyom just before half-time.
Barca got straight back on the front foot after the break and Granada were indebted to a fine save from Karnezis to keep out a Cesc Fabregas strike that looked destined for the back of the net.
Neymar was wasteful once again when he fired a left-foot strike wide of the far post 12 minutes into the second half as the home side came under yet more pressure.
Karnezis then thwarted Barca again with an outstanding reflex save from a Lionel Messi free-kick, before smothering Sergio Busquets' strike from close range.
Neymar's misery continued 17 minutes from time when he volleyed wide at the far post, and Andres Iniesta then flashed a shot just wide of the far post.
El-Arabi could have sealed the points three minutes from time when he raced through on goal, but Pinto denied him.
That miss was not to prove costly, though, as the home side held on for three precious points in their battle to avoid the drop and dealt a big blow to Barca's title hopes.
|Coach: Lucas Alcaraz|
|Paraguay to change tack against Argentina|
|Sampaoli thrilled with substitutes´ influence, applauds Peru|
|Martino rues Copa America date with former side Paraguay|
|Former Birmingham City player Thwaites among Tunisia victims|
|Chile 2 Peru 1: Zambrano´s red card helps hosts into Copa final|
|Thiago Silva: ´I didn´t even know the ball had hit my hand´|
|Ronaldinho set to sign for Antalyaspor|
|Jara ban reduced on appeal by one match|
|Hiddink leaves Netherlands post|
|Cresswell pens new five-year deal at West Ham|
|Koeman: No serious United bid for Schneiderlin|
|Barbados eliminated from World Cup qualifying after fielding ineligible player|
|Former Catania president admits buying matches|
|Jones agrees Manchester United deal|
|Argentina v Paraguay: Valdez hoping not to need another comeback|
|Milan seal Bertolacci signing|
|Cech grateful to Abramovich and Chelsea fans|
|UEFA Champions League Preview: Brotherly pride at stake as B36 play TNS|
|UEFA Europa League Preview: Tommasi set to aid La Fiorita qualifying bid|
|Cech leaves Chelsea to join Arsenal|
|Paulinho ends Spurs frustration with Guangzhou move|
|Sampdoria confirm Eto´o exit amid Antalyaspor talk|
|Garcia departs Espanyol ahead of expected Qatar move|
|Watford to delay Doyley decision|
|Schlupp agrees new Leicester deal|
|Schweinsteiger hints at Bayern stay amid United links|
|Bertolacci thrilled ahead of Milan move|
|Langerak leaves Dortmund for Stuttgart|
|Muniain extends Athletic contract|
|Youngsters to get chance on US tour - Van Gaal|
|La Liga chief hits out at Real Madrid over TV rights opposition|
|Villa confirm Wilkins as assistant manager|
|Dicks joins West Ham coaching staff|
|Heldt enters to jeers, exits to cheers|
|Paraguay pride has grown at Copa America - Aguilar|
|Van Gaal tight-lipped on De Gea|
|Bacca confirms Milan agreement|
|Weight of expectation on hosts Chile to benefit Peru - Gareca|
|MLS Review: Timbers thump Sounders thanks to Adi´s double|
|Dzeko ´would run to Roma´ - Pjanic|
|Peru won´t sit back - Sampaoli|
|Zenga: Cassano, Balotelli will not be joining Sampdoria|
|Victory to start A-League defence away to Adelaide|
|I want to play MLS ´at the peak of my career´ - Johannsson|
|Allegri: I like Isco and Oscar|
|CAF Champions League Review: Comeback kings Smouha go top of Group A|
|Pirlo in attendance for New York derby|
|No Bayern deal yet, states Costa|
|Jara handed three-game ban|
|Sunderland striker Defoe sets 20-goal target|
|Leicester offer condolences to Albrighton and family after Tunisia attack|
|Chile v Peru: Potential Jara sanction hangs over semi-final|
|Sweden U21 v Portugal U21: History beckons for Jorge´s men|
|Neville appointed Valencia number two|
|Work halted at Olympic Stadium after fatality|
|Ibrahimovic in the same league as Messi - Sacchi|
|Giggs: United want to add winners|
|Turan sets record straight over transfer talk|
|Low keen for new Germany leaders to emerge|
|Tunisia part company with Leekens|
|Evans: Sterling´s Anfield exit must be a done deal|
|FIFA audit chief urges Blatter to stick by decision|
|Hrubesch urges caution after Germany U21s humbled|
|Taarabt hits out at ´very bad manager´ Redknapp|
|Bruce: I´m lucky I wasn´t sacked after Hull relegation|
|Van Hooijdonk warns Van Gaal over Depay tactics|
|SPFL looking into winter break|
|MLS Review: Earthquakes win California Clasico, Vancouver claim top spot in West|
|Muto must toughen up to succeed at Mainz - Ficcadenti|
|Diaz: Paraguay refuse to lose|
|Tragedy strikes for Paraguay match-winner Gonzalez|
|Robinho rues substitution, wanted to take penalty|
|Dunga: Brazil squad hit by virus|
|Fiorentina make ´insane offer´ to Salah|
|Women´s World Cup Review: England reach maiden semi-final|
|Mexico 2 Costa Rica 2: Herrera´s men recover after half-time|
|ES Setif 1 USM Alger 2: African champions beaten|
|Paraguay 1 Brazil 1 (4-3 on penalties): History repeats as Dunga´s men bow out|