Liverpool host Manchester City on Sunday with the result likely to be a key factor in who wins the Premier League title.
Leaders Liverpool have enjoyed a remarkable season, based largely on a stellar attacking unit, while City have been just as impressive, despite their fall to third due to their commitments in various cup competitions.
Despite having two games in hand on Brendan Rodgers' men, the gap of four points between the sides means City can ill-afford defeat at Anfield.
With Chelsea lurking in second, two points off the top and hoping for slip-ups from both their rivals, Liverpool know that a 10th straight Premier League win will put them very much in the driving seat for a first title since 1990.
However, Rodgers has insisted this weekend's clash is not necessarily crucial in deciding the destination of the trophy, calling on his players to relish the run-in.
"It's a significant game. It's two teams who have done extremely well this season but still have a lot of work to do after it," he said.
"It's vitally important we stay calm. We showed that at West Ham (in a hard-fought 2-1 victory) last weekend. People talk about pressure, but for us it's excitement."
Strikers Luis Suarez and Daniel Sturridge have been integral to Liverpool's title tilt, contributing 49 of the club's 90 top-flight goals this term.
Indeed, Suarez needs just three more to overtake the record of 31 goals in a 38-game Premier League season, which is held jointly by Alan Shearer and Cristiano Ronaldo.
The Uruguayan's efforts have helped Liverpool eclipse City's own impressive goal tally, with Manuel Pellegrini's side having plundered 84 in their 31 outings.
Sergio Aguero has accounted for 15 of those, and Pellegrini has been boosted by the news the Argentinian is fit to play at Anfield following a four-week lay-off with a hamstring problem.
City's Pablo Zabaleta spoke this week of the importance of his compatriot returning to the fold, but the defender also warned that Liverpool's prolific strikeforce will require close attention.
"Liverpool score a lot of goals - we know they have great players in front with Suarez, (Raheem) Sterling and Sturridge. They are in a great, great moment," Zabaleta told City's official website.
"I think we must work really hard not to concede any goal. But we have defended well for a few weeks - not conceding many goals - so we have to be confident."
City have conceded just twice in their last seven Premier League games, and are unbeaten on the road since a shock 1-0 reverse at Sunderland in November.
Liverpool, though, have lost just once at Anfield this season, and if they can make it six home wins in a row on Sunday, the destiny of the title will remain in their hands.
Both managers have only one major absentee apiece to deal with, as Liverpool's Jose Enrique and City's Matija Nastasic (both knee) remain sidelined.
|Coach: B. Rodgers|
for D. Sturridge 66'
for Philippe Coutinho 89'
for R. Sterling 90+5'
|Hamsik thrilled to reach 100 Napoli goals|
|Zabaleta warns Man City over Celtic backlash|
|MLS Review: Red Bulls, Toronto into play-offs|
|´We were unlucky´ - Bale|
|Guardiola keen for Spurs test|
|Rodgers: I never fell out with Sterling|
|Wenger hails ´different´ Walcott|
|Mazzarri backs Deeney for England call-up|
|Mamelodi Sundowns and Zamalek reach CAF Champions League final|
|Benzema and Morata can play together - Zidane|
|Hummels plays down injury fears|
|Las Palmas 2 Real Madrid 2: Zidane´s men held again|
|Stones benefited from Moyes´ Everton exit, says Duffy|
|Allegri unconcerned by scrappy win|
|Montella demands Milan improvement|
|Ancelotti praises Thiago after Hamburg victory|
|Conte demands better attitude from Chelsea|
|Wenger hails stylish Arsenal display|
|Moreno the unlikely subject of Klopp´s praise|
|Walcott: We wanted it more than Chelsea|
|Phelan has ´no qualms´ over another handball red card|
|Arsenal 3 Chelsea 0: Sanchez, Walcott and Ozil pile on misery for Conte|
|That was how football should be - Klopp on Hull thrashing|
|Luis Enrique plans to keep Sergi Roberto on his toes|
|Karanka draws hope from Middlesbrough´s second half|
|Stoke is stitched into my body – Pulis|
|Palermo 0 Juventus 1: Own goal helps champions stay top|
|Hughes laments two ´stolen´ points|
|Wilshere can be a brilliant player for Bournemouth, says Howe|
|Defoe rues Sunderland collapse against Palace|
|Tottenham must be more clinical - Pochettino|
|Everton were second best, says Koeman|
|Benteke: I knew a chance was coming|
|Ranieri wants answers from Leicester players after Old Trafford thrashing|
|Board can call me if they want to talk - Guidolin|
|Sterling hails Guardiola´s impact|
|Sergi Roberto revelling in new role|
|Guardiola wants Aguero improvement despite scoring streak|
|Mourinho demands more from star man Pogba|
|Sporting Gijon 0 Barcelona 5: No Messi, no problem for ruthless champions|
|Stoke City 1 West Brom 1: Rondon snatches point as Pulis reaches 1000 games|
|Sunderland 2 Crystal Palace 3: Benteke´s late header stuns Black Cats|
|Swansea City 1 Manchester City 3: Aguero at the double for Guardiola´s perfect 10|
|Bournemouth 1 Everton 0: Stanislas wonder strike ends Koeman´s unbeaten start|
|Liverpool 5 Hull City 1: Coutinho stunner caps easy win|
|Middlesbrough 1 Tottenham 2: Son shines for Spurs|
|Hamburg 0 Bayern Munich 1: Late Kimmich goal maintains Bayern´s perfect start|
|Bayern facing defensive headache after Hummels limps off at Hamburg|
|Pogba and Mata delighted by United response|
|Vardy and Mahrez were rested for Porto, Ranieri admits|
|Mourinho completely trusts dropped Rooney|
|I beat Usain Bolt in a race - Bolasie|
|Juventus still Scudetto favourites - De Boer|
|Manchester United 4 Leicester City 1: Rooney watches on as Pogba inspires Red Devils demolition|
|Robben and Ribery are like Messi, claims Helmer|
|Pochettino hints at Vertonghen renewal|
|Robben´s style makes him an injury risk - Bayern fitness coach|
|Liverpool refuse to comment on Sakho´s social media outburst|
|Rooney dropped for Leicester City clash|
|Messi injury doesn´t matter to Barcelona - Abelardo|
|Thiago Silva worried by PSG form|
|Mourinho describes Wenger relationship as ´civilised´|
|Milito: Inter are no one-man team|
|Bilic delays naming daughter due to West Ham worries|
|Fernandinho hails ´intelligent´ De Bruyne|
|Matuidi: This season toughest for PSG|
|New York City 4 Chicago Fire 1: Villa nets twice in win|
|Pjaca not Morata - Allegri|
|Guardiola keen for Kolarov extension|
|England criticism changed Rooney - Mourinho|
|Gotze detractors don´t surprise Tuchel|
|Wenger laments missing out on Costa|
|Emery deflects blame from PSG players after Toulouse defeat|
|Guidolin: It´s not possible to beat Manchester City if you don´t play well|
|Mourinho prepared to bench Rooney|
|Fitness fears over Aubameyang with Real Madrid looming|
|Balotelli must remain serious, says Favre|
|Conte: Guardiola only better than me because he has it easy|
|No need for Aguero to calm down - Guardiola|
|Toulouse 2 Paris Saint-Germain 0: Aurier sees red as Emery´s side slip to surprise defeat|
|Borussia Dortmund 3 Freiburg 1: Aubameyang marks landmark game with goal|
|Argentina apologise for Bauza´s Barcelona criticism over Messi|
|Young players ´the spirit´ of Manchester United - Ferguson|
|Lack of Manchester United game-time ´frustrating´ for Rashford|
|Mazzarri rues ´bad injury´ for Janmaat|
|Sampaoli slams Messi treatment|
|Gray handed four-match ban for abusive posts|
|Valencia captain Parejo: I´ve been called a dog in the street|
|Leicester fairytale isn´t Ranieri´s best achievement|
|Former Parma chiefs get five-year bans from football|
|Three Burnley players sign new contracts|
|No complaints over Vidal post for Luis Enrique|
|Manchester City have no case to answer in Garre transfer|
|Angry Moyes slams Van Aanholt over shisha pipe photos|
|Van Basten appointed to FIFA role|
|Albiol signs new Napoli deal|
|Barcelona court re-opens Neymar transfer case|
|Barcelona want the best for Messi - Luis Enrique|
|Mourinho grudgingly helps to ´feed the Einsteins´|
|Mourinho defends embattled Rooney|
|Injured Martial to miss Leicester clash|
|Pochettino backs Janssen to fill Kane void|
|Conte admires Wenger´s ´fantastic´ Arsenal career|
|City confirm Kompany´s groin injury - no date for return|
|Allegri considers benching Dybala|
|´Benny V´ nets Tottenham deal|
|Zidane concern over Casemiro and Marcelo absences|
|Pardew backs Townsend for England recall|
|Terry ruled out of Arsenal clash|
|Kane requires second scan - Pochettino|
|Robben must settle for bench role, says Ancelotti|
|Zidane expects Barca to be weaker without Messi|
|Montero hopes to peak after signing new Swansea deal|
|Matuidi has ´no regrets´ over PSG stay|
|O´Neill, Keane sign new Republic of Ireland deals|
|Guardiola: My tactics nothing to do with Clichy goal|
|Real Madrid confirm Marcelo calf strain|
|Phelan no closer to learning Hull future|
|Italy legend Rossi hails Totti as ´the strongest in the last 20 years´|
|Adebayor dismisses whiskey and cigarette story|
|Masuaku injury blow for Hammers|
|Bauza: I don´t want a Messi war with Barcelona|
|Ramsey sidelined until after internationals|
|Walker signs Spurs extension|
|Hughes quashes Bony rift talk|
|Wenger brushes off Mourinho book claims|
|Mourinho wanted to ´break Wenger´s face´, new book alleges|
|Jones appointed as Jets coach|
|Barca the only club for Messi - Fabregas|
|Dyer on track for November return|
|Koeman rules out Everton future for Niasse|
|´Champion´ Rooney not ahead of my players - Ranieri|
|Klopp hints at Karius start|
|I never planned to leave Chelsea - Fabregas|
|Injured Messi thanks Gladbach for get well message|
|Wenger: Demanding society makes 20-year reign hard to repeat|