Columbus Crew will look to bounce back from their first loss of the MLS season, when they travel to the San Jose Earthquakes on Sunday.
Crew were humbled 2-0 at home to Toronto last week, but remain top of the Eastern Conference on goal difference from their conquerors, with both on nine points.
Earthquakes sit bottom of the Western Conference, with just one point from three matches.
Although Crew will need to snap a six-match winless run in games against San Jose, with the two sides drawing five of those.
On Saturday, Toronto host the Colorado Rapids at BMO Field.
Six of the past seven contests between the two sides have gone the way of the home side, with Toronto beating the Rapids in all six of their meetings in Canada.
Western Conference leaders Dallas welcome the Seattle Sounders to Texas.
Dallas are four points clear at the top of the table, while the Sounders are riding high after stealing a point from their road trip to Portland Timbers last week as Clint Dempsey's late hat-trick saw them pick up a 4-4 draw.
Real Salt Lake are the only unbeaten side in the league, Dallas aside, and can continue their impressive campaign on the road at Philadelphia Union.
Philadelphia are unbeaten in their past two, but conceded goals in the final 10 minutes in each match to give up maximum points.
Salt Lake came out of their MLS Cup final replay unscathed in a 0-0 draw with Sporting Kansas City, and can stretch their run of minutes without concession beyond 235.
Eastern Conference cellar-dwellers the Montreal Impact can build on back-to-back unbeaten matches when they host the Chicago Fire.
The Impact have two draws to their name after three losses to open the season, while Fire have endured four consecutive stalemates.
The Houston Dynamo will be hungry to snap a two-match losing run, when they travel to the New England Revolution.
DC United enjoyed their first win of the season last weekend, and will look to make it two in a row when they host New York Red Bulls, who have drawn their past four.
The two worst defences in MLS this season, Portland and Chivas USA go head-to-head having both shipped 10 goals in five games.
Los Angeles Galaxy welcome the Vancouver Whitecaps to California.
|Coach: M. Watson|
for C. Cato 46'
for B. Barklage 53'
|Schweinsteiger to start Germany qualifier|
|Akinfeev thanks fans after flare incident|
|Injuries offer Kane chance of first England start|
|Russian Football Union to protest following Montenegro abandonment|
|October comeback the target for injured Foster|
|Van der Vaart looks set to leave Hamburg|
|Bale focused on Wales - Coleman|
|Kluivert helps Curacao to victory|
|Hamstrung Alba returns to Barcelona|
|Macedonia v Australia: Confident visitors eye victory|
|Akinfeev to return to Moscow with Russia squad|
|Brnovic: Montenegro have no chance of qualifying|
|Russia had to resume after Akinfeev incident - Capello|
|Terim: Robben absence important|
|Morata keen to keep working|
|Canada 1 Guatemala 0: Haber heads Floro´s men to win|
|Difficult to find a place for Kane in starting XI - Hodgson|
|Difficult to find a place for Kane in starting XI - Hodgson|
|Montenegro-Russia abandoned after scuffle|
|Euro 2016 Qualifying Review: Montenegro-Russia abandoned, Spain and England win|
|Accrington Stanley 0 Newport County 2: Visitors up to sixth|
|Kane delighted with ´dream´ start|
|England 4 Lithuania 0: Kane enjoys dream debut|
|Spain 1 Ukraine 0: Morata settles tight contest|
|Akinfeev struck by flare as Montenegro-Russia game suspended after 30 seconds|
|Brazil v Chile: Winning is ´our only option´ - Dunga|
|Northern Ireland v Finland: Controversial fixture met with religious protests|
|Scotland v Gibraltar: Wilson out to dent countrymen´s hopes|
|Republic of Ireland v Poland: Pressure is on, says O´Neill|
|Georgia v Germany: Schneider warns world champions|
|PSV agree permament Guardado deal|
|France v Denmark: Olsen hits out at training facilities|
|Pienaar to return to Everton training|
|Hughes eyes silverware at Stoke after signing new deal|
|Portugal v Serbia: Carvalho vows to attack|
|Dynamo Kiev stadium partially closed after racism probe|
|Hull City fined £30,000 for misconduct|
|Balotelli must work hard for Italy return – Bonucci|
|Marchisio suffers knee ligament injury|
|Hughes agrees new Stoke City deal until 2018|
|Martinez hopeful over injured Everton trio|
|South Korea 1-1 Uzbekistan: Kuziboyev's debut strike denies hosts|
|South Korea 1 Uzbekistan 1: Kuziboyev´s debut strike denies hosts|
|Japan 2 Tunisia 0: Kagawa and Honda shine as Halilhodzic starts with a win|
|South Africa v Nigeria: Mashaba wary of bitter opponents|
|Japan 2-0 Tunisia: Kagawa & Honda shine in Halilhodzic's first game|
|Parma captain Lucarelli welcomes FIGC reforms|
|Di Francesco ignoring Milan rumours|
|Melbourne Victory 2 Central Coast Mariners 1: Finkler leads fightback|
|Bale would be ´perfect´ for United - Scholes|
|Badstuber and Bellarabi out of Georgia clash|
|Rooney KOs boxing celebration|
|Allen thrilled with Welsh ´hunger´|
|Kovacic to miss Euro 2016 qualifier|
|Costa Rica 0 Paraguay 0: Dour draw marks Diaz debut|
|Reid ruled out of South Korea friendly|
|Deschamps talks up France despite defeat|
|Rooney chasing England goalscoring record|
|Brazil ´superior´ admit French veterans|
|Reeves sidelined for Finland clash|
|Confidence critical for rampaging Brazil - Dunga|
|France 1 Brazil 3: Dunga´s men maintain winning run|
|Chile 0 Iran 2: Nekounam and Amiri down Copa America hosts|
|Premier League to share over £1bn from record TV deal|
|Morocco v Uruguay: Last chance to impress Tabarez for Copa champions|
|Iran 2-0 Chile: Nekounam and Amiri down Copa America hosts|
|Ivanovic braced for Ronaldo test|
|El Salvador - Argentina Preview: Messi set for Roca reunion|
|Bahrain 0 Colombia 6: Falcao stars in comfortable victory|
|Jones to Bournemouth leads loan deadline day moves in Championship|
|Bahrain 0-6 Colombia: Falcao stars in resounding victory|
|Malmo fined for poor pitch by UEFA|
|League Two Preview: Hartlepool aim to continue great escape, leaders Burton host Stevenage|
|France 1-3 Brazil: Neymar on target as Selecao triumph in Paris|
|Bulgaria v Italy: Verratti vows to be Azzurri´s midfield general|
|Kane primed for full England debut|
|Kone receives positive news over knee injury|
|Terry pens new Chelsea deal|
|PSG tie down Marquinhos|
|De Gea stamp was accidental - Skrtel|
|Villa hopeful over Xavi reunion|
|El Salvador v Argentina: Messi set for Roca reunion|
|Ghana v Senegal: Grant´s side looking to rebuild after AFCON disappointment|
|Ferdinand to serve extended touchline ban|
|League One Preview: Duo aiming to inspire Notts County revival, Alexander back at Preston|
|Hodgson keeps an eye on Sterling and Milner|
|Filipe Luis cools talk of Atleti return|
|West Brom to wear retro kit for Leicester clash|
|Netherlands v Turkey: Sneijder unconcerned by key absentees|
|Del Bosque wary of Ukraine threat|
|Israel v Wales: Pivotal fixture for both sides in chase for Euro dream|
|Bosnich backs Villa to beat drop|
|Walcott denies Wenger ´bust-up´|
|Hart: Aguero more difficult to face than Messi|
|Williams: I can´t see myself playing for anyone else|
|Coutinho eager to add more goals to his game|
|Khedira confirms Real exit|
|Messi attends NBA match with Argentina squad|
|United will qualify for Champions League - Bosnich|
|Mexico v Ecuador: Hernandez desperate to play|
|Podolski plays down Germany cameo|
|Bendtner: I could have scored four|
|Leverock family adds to World Cup exploits for Bermuda|
|Pele: ´Impossible´ for Neymar to replace me|
|MLS Preview: New England hoping to end drought|
|A-League Preview: Phoenix without stars for Sydney showdown|
|Klinsmann laments late collapse|
|Premier League clubs post first pre-tax profit for 15 years|
|Vokes relishing chance to link up with Bale|
|Dunga encourages Brazil to entertain|
|Dyke: FA to discuss Hodgson extension|
|Janko eyes history with Austria|
|Wilson urges Begovic to stay put|
|Strachan: Scotland have work to do|