Valencia will write themselves into the history books if they can progress to the UEFA Europa League semi-finals against Basel on Thursday.
No side has ever come back from a three-goal first-leg deficit in the Europa League but that is the task that faces Juan Antonio Pizzi's men this week after a disastrous showing in Switzerland.
Matias Delgado's brace and a late Valentin Stocker goal would have had St Jakob-Park in raucous mood last week, had it not been played behind closed doors due to crowd trouble in a previous tie.
It did, however, lay the foundations for Basel's likely progression, with the record books pointing to an exit for Valencia - UEFA Cup winners under Rafael Benitez in 2004.
Basel coach Murat Yakin captained the club on their last visit to the Mestalla when the Swiss side were routed by one of the best Valencia teams in recent years.
John Carew, playing alongside the likes of Santiago Canizares, Roberto Ayala and Pablo Aimar, struck a brace in a 6-2 victory and the class of 2014 require a similarly dominant showing to move into the final four of this year's competition.
As well their Europa League campaign looking likely to come to an end this week, Pizzi's Valencia have also lost ground on the top six in La Liga.
Without a win in their last four matches in all competitions, Valencia's hopes of qualifying for Europe next season look all but over, although they will take heart from their strong home form this term.
Pizzi has only tasted defeat once at home during his tenure, which began late last year, but Basel have conceded only one goal in five Europa League fixtures this term.
After their defeat in Basel, Pizzi - whose side were 3-0 first-leg winners over Ludogorets in the previous round - said he was "ashamed" at how his charges performed in the first half, but added: "I didn't think the game with Ludogorets was over and I don’t think this one is, but it will be difficult.
"We will do everything possible to get through in this tie."
After Sunday's goalless draw with Real Valladolid, he reaffirmed his belief that Valencia are in with a shout of progression, saying: "The last thing we lose is hope."
Basel's Stocker (adductor) and Philipp Degen (calf) are ruled out of the trip, while Marek Suchy is suspended.
Pizzi has injury concerns too, having called up a host of youth players to deal with the absences of squad members such as Diego Alves, Philippe Senderos and Victor Ruiz.
Captain Ricardo Costa has returned to training following an ankle knock but Thursday's game could come too soon for him.
|14||Juan Bernat||115' 118'|
|17||E. Vargas||42' 104'|
|16||Paco Alcácer||38' 70' 113' 114'|
for F. Cartabia 76'
for J. Mathieu 81'
for João Pereira 109'
|Eredvisie Review: Vitesse denied by late Uth goal, NAC Breda boost survival hopes|
|Rangers 1 Motherwell 3: McCall´s men facing uphill struggle|
|Hamburg 1 Karlsruher 1: Bundesliga side escape with draw|
|Blatter vows to lead FIFA clear of trouble as corruption scandal rolls on|
|Bundesliga: Bayern Munich season review - League crown not enough to signal successful campaign|
|Genoa forced to wait for UEFA licence|
|Injured Cardozo out of Paraguay squad|
|CONCACAF provisionally dismisses Webb and Li|
|Klopp: Career highlights of a charismatic coach|
|Verona v Juventus: Ogbonna seeks strong Champions League warm-up|
|FA charges Demetriou over betting breaches|
|Atalanta v Milan: Inzaghi faces last chance to prove worth|
|King joins Bournemouth as QPR rebuild begins|
|Plymouth part ways with Sheridan|
|Hernandez banned for three matches|
|Chelsea star Fabregas has nose surgery|
|Blatter: More bad news may follow|
|Galliani hopeful over Ancelotti deal|
|Frontzeck to continue as Hannover coach|
|Tremmel released as Tate waves goodbye to Swansea|
|Arsenal v Aston Villa: Sherwood out to upset holders|
|UEFA open to boycott of World Cup - Platini|
|Porto activate release clause for Casemiro|
|Athletic Bilbao v Barcelona: Catalans seeking second leg of treble|
|Auxerre v Paris Saint-Germain: History beckons for Ligue 1 champions|
|Cole confirms West Ham departure|
|UEFA elect not to boycott FIFA Congress|
|Borussia Dortmund v Wolfsburg: Klopp aiming for triumphant farewell|
|Flamini hails Coquelin impact at Arsenal|
|South Africa deny wrongdoing in World Cup bid|
|Benitez confirms Napoli exit|
|McShane among six released by Hull|
|Cerci committed to Milan|
|West Ham expect Collins to return for pre-season|
|Real deny Pogba bid|
|Important to keep Chelsea squad together - Mourinho|
|Alonso: Gerrard was magic|
|Pochettino silent on Ings speculation|
|Visa threatens to ´reassess´ sponsorship amid FIFA scandal|
|Blatter skips FIFA Medical Conference|
|MLS Preview: Revs not out for revenge against Galaxy|
|MLS Review: Sounders go top in West, Timbers and Galaxy win|
|AFC stands by Blatter|
|Matheus ´alright´ after collapse - Markevych|
|Copa Libertadores Review: River, Inter through to semis|
|Signing Toni a ´long shot´ for Adelaide|
|Ramsey good enough for Barca - Coleman|
|Bacuna pushing for Benteke stay|
|Evans stunner settles City friendly in Toronto|
|Banega: Emery a great coach|
|Emery tight-lipped on Sevilla future|
|Argentina finalise Copa America squad|
|Nike issues statement following arrest of FIFA officials|
|Hero Bacca grateful for Europa League triumph|
|Markevych rues defensive errors in Dnipro defeat|
|AFC Champions League Review: Naft Tehran fairytale continues|
|Emery: We deserved Europa League success|
|Dnipro 2 Sevilla 3: Bacca brace sees holders make history|
|South Africa 0 Malawi 0 (4-5 on penalties): Harawa heroics send Bafana Bafana out|
|CONCACAF and CONMEBOL respond to arrests in FIFA scandal|
|FIFA president Blatter welcomes investigations as corruption probe rocks world football|
|UEFA calls for FIFA elections to be postponed|
|BREAKING NEWS: Advocaat exits Sunderland and retires from club management|
|La Liga: Real Madrid season review - Ancelotti pays the price for disappointing season|
|Zambia 3 Ghana 0: First-half spree does the damage|
|Barnes suffers double knee ligament injury|
|Balotelli to stay at Liverpool - agent|
|Kane at the double in friendly win|
|Norwich make Dorrans switch permanent|
|Ings unsure of next move|
|Bournemouth snap up Federici|
|FIFA ´crisis´ cannot continue - Prince Ali|
|Barton headlines QPR exits|
|Juan demands more from Inter|
|Stoke snap up Haugaard|
|Subotic commits to Dortmund|
|Warner pleads innocence after US indictment|
|Napoli to refuse questions on Benitez´s future|
|USDoJ names indicted FIFA officials|
|Wenger coy over Vidal and Benzema moves|
|Suarez back in training ahead of Copa final|
|Pique: I´ll retire at Barca|
|Gerrard ´blown away´ by Liverpool send-off|
|FIFA ´very happy´ with Zurich arrests|
|Liverpool defender Toure targeting trophies|
|Ramsey eyeing title assault|
|Welbeck out of FA Cup final and England matches|
|FIFA the ´injured party´ as Swiss prosecutors open criminal proceedings|
|Prince Ali saddened by FIFA arrests|
|Pellegrini to make City defence a priority|
|Labbadia giving Lasogga, Olic, Jiracek time|
|Ramsey confident on Wembley chances|
|Swiss authorities confirm FIFA arrests|
|El Shaarawy open to Premier League move - agent|
|Reports: FIFA officials set to be arrested|
|Tigres UANL 2 Emelec 0 (2-1 agg): Mexicans through to Libertadores semis|
|Valencia ruled out of Copa America|
|Coleman: Bale being ignored by Real team-mates|
|Ruddy eyes England recall|
|Benteke will strike fear into Arsenal - Westwood|
|Howe named LMA Manager of the Year|
|Casillas reiterates desire to stay in Madrid|
|Dnipro players pay for fans´ tickets, transport|
|Galliani: I want Ancelotti back at Milan|