Lyon will need to become the first team in a year to win at Juventus if they are to reach the semi-finals of the UEFA Europa League.
Juve hold a 1-0 advantage from the first leg at the Stade de Gerland, which saw the Serie A leaders net a crucial away goal in the 84th minute through Leonardo Bonucci.
Bouncci's strike puts Antonio Conte's men in command of the tie, and the Turin club should be clear favourties to qualify for the last four considering their magnificent home record.
Indeed, the second leg takes place a year to the day since Conte's side last suffered a home defeat, which came at the hands of Bayern Munich in the second leg of last season's UEFA Champions League quarter-finals.
The likes of Real Madrid, Napoli and Roma have all failed to win in Turin since that day, and Lyon coach Remi Garde, who said Lyon had a "mountain" to climb before the first leg, accepted his side needed a "miracle" following its conclusion.
"It was a great experience for the young players (playing against Juve)," he said. "It will be tough in Turin and we will need a miracle to win in the second leg."
The clash marks the start of an exciting run of fixtures for Lyon, who face Ligue 1 champions-elect Paris Saint-Germain on Sunday before taking on Laurent Blanc's men again in the Coupe de la Ligue final the following Saturday at the Stade de France.
But the seven-time French champions will approach that daunting triumvirate of fixtures with a number of injury concerns.
Clement Grenier is out with a groin problem, and fellow midfielder Gueida Fofana will also miss out with a similar injury.
Playmaker Yoann Gourcuff remains unavailable with an ankle problem, and Jordan Ferri - scorer of a spectacular long-range strike in Sunday's 2-1 win at Valenciennes - will likely be selected to fill the void again in a depleted midfield.
At the back, Mouhamadou Dabo has yet to recover from a hamstring issue and Miguel Lopes is out for the rest of the season with a broken leg.
Meanwhile, Juventus will be boosted by the return of Arturo Vidal after he missed the 2-0 Serie A win over Livorno at the weekend through suspension.
Defender Andrea Barzagli (calf) is still struggling for fitness, but Carlos Tevez shook off a thigh injury to play against Livorno on Monday and defender Angelo Ogbonna is available to feature for the first time in nearly a month.
|Coach: A. Conte|
for M. Vučinić 60'
for A. Vidal 75'
for C. Tevez 78'
|Sporting Lisbon 2 Roma 0: Slimani, Mane inspire Portuguese hosts|
|Rodgers feeling ready for new campaign|
|Khedira to miss Supercoppa|
|Paris Saint-Germain 2 Lyon 0: Aurier and Cavani seal more silverware|
|Wolfsburg 1 Bayern Munich 1 (5-4 on penalties): Super-sub Bendtner nicks it for Pokal champions|
|Lampard´s long-awaited New York City debut ends in defeat|
|Casillas the spot-kick hero for Porto|
|Monk bullish ahead of season opener at champions|
|Marseille 2-0 Juventus: Night to forget for Serie A champions|
|Swansea end pre-season with yet another draw|
|HJK 0 Liverpool 2: Origi and Coutinho on target|
|Juventus rocked by Khedira injury scare|
|Lens and Pantilimon star as Sunderland beat Hannover|
|Pardew hopeful of concluding Wickham deal|
|Martinez allays Lukaku fears|
|Stuttgart 4 Manchester City 2: Cause for concern for Pellegrini|
|Wasteful Bournemouth held by Hoffenheim|
|Jerome seals Norwich win|
|Souare´s first goal ensures Palace draw|
|Sinclair hits hat-trick in Villa draw|
|Leicester end pre-season with thrilling Birmingham win|
|Wood and Mowatt condemn Everton to friendly defeat|
|Coloccini not involved as Newcastle lose to Gladbach|
|Borussia Dortmund 2 Real Betis 0: Ramos scores on return from injury|
|Stoke lose to Cologne on Afellay debut|
|Norwich capture goalkeeper Kean|
|Jovetic hits out at Pellegrini following City exit|
|Jones backing new boys to spark United revival|
|Scottish Premiership Review: Celtic up and running, Dundee hammer Kilmarnock|
|Can keen to learn from Milner|
|Immobile on the mend following friendly scare|
|Sagan Tosu 1 Atletico Madrid 1 (1-4 on penalties): Simeone´s men need spot-kicks|
|Cahill: Big-spending rivals will make title race tougher|
|Roberto happy to play full-back for Barca|
|Gestede eager to make his mark at Villa|
|I want to play more and score more - Remy|
|Lambert influence important, says Pulis|
|Benteke a ´bargain´ buy - Rodgers|
|Zola: Qatar would be ideal for Balotelli, Cassano|
|Suarez: I´m not among world´s best|
|PSG ready despite ´chaotic´ pre-season - Blanc|
|Arsenal thumping still hurts - Fournier|
|Aubameyang targets Champions League success|
|Rooney set for Everton return|
|Cech can match Van der Sar - Wenger|
|Mourinho ponders Wenger´s losing record against him|
|CBF confirm Fred failed a doping test|
|Bournemouth beaten by battling Cardiff|
|Immobile injury overshadows Sevilla win at Vicarage Road|
|Lambert at the double on West Brom bow|
|Real sign up Spain starlet Vallejo|
|Valencia blow for West Ham|
|Elche cleared to play in Segunda Division|
|Baker pens a new Villa deal|
|Lambert makes Albion switch|
|Gillingham and Scally found guilty of ´race victimisation´|
|Inter complete Jovetic signing|
|Arsenal v Chelsea: Mourinho cools Wenger rivalry ahead of Wembley meeting|
|Villa snap up Gestede|
|Villa land Veretout|
|Mourinho coy on fresh Stones bid|
|Aubameyang commits to Dortmund|
|Torres on the hunt for trophies with Atletico|
|Cazorla and Walcott sign new Arsenal deals|
|Quick start vital in Arsenal title bid - Wilshere|
|I have received no offers - Guardiola|
|Barcelona to monitor Turan injury|
|Zorc ´surprised´ by Grosskreutz-Tuchel row|
|Phil Neville could be England manager - Moyes|
|UEFA to investigate Shakhtar´s Fred selection|
|City loan Unal to Genk|
|China v South Korea: Stielike looking for new options|
|North Korea v Japan: Halilhodzic to unearth new faces|
|Drogba: I want to be ready, not a burden|
|Hamstrung Clasie in doubt for Southampton league opener|
|West Ham goalscorer Zarate bemoans Astra comeback|
|Negredo quashes Valencia exit rumours|
|´This is not my Sampdoria´ - president Ferrero|
|Criscito could join Inter - agent|
|CBF endorse Zico´s FIFA presidency campaign|
|Hawit to handle CONCACAF´s referee review|
|Falcao is a ´top, top player´ - Terry|
|Tuchel pleased by Dortmund fighting qualities|
|Premier League rules out schedule changes for Champions League clubs|
|UEFA Europa League Review: Southampton stroll as Sampdoria are humiliated|