Carlo Ancelotti has announced that Cristiano Ronaldo will not feature for Real Madrid at Real Sociedad on Saturday.
The Portugal international was substituted 10 minutes from the end of Real's UEFA Champions League quarter-final first-leg tie with Borussia Dortmund on Wednesday due to a minor knee problem.
And Ancelotti will give him a weekend off to recover fully.
Ronaldo has scored 45 goals in 41 appearances for Real this season in all competitions and Ancelotti is keen to give him a break ahead of the second leg in Germany against Dortmund on Tuesday.
"Cristiano will rest. He is tired and has a bit of a problem," said the Real head coach. "We prefer him to stay in Madrid, work and get ready for the next game.
"On Tuesday (against Dortmund) he will be fresher and can recover better.
"He has played a lot of games. We just want him to rest.
"I've spoken with Cristiano and together we decided it was better he rested.
"It's normal he wants to play all the game but there's no problem."
The Italian has not decided who will replace the 29-year-old against Sociedad and insisted there are a number of possibilities to choose from.
"We have options," added Ancelotti.
"Alvaro Morata could play, we could change Isco's position or move the other forwards around.
"Gareth Bale is playing well, consistently. He could change positions with Cristiano missing."
Real are third in La Liga heading into the weekend's fixtures, three points behind leaders and city rivals Atletico.
for José Ángel 18'
for Zurutuza 62'
for Mikel González 74'
|Bony: We have to win every game|
|Subotic rejects Serbia call-up|
|Benitez frustrated at refereeing decisions|
|Real Madrid must learn from Villarreal draw - Marcelo|
|QPR announce losses of £9.8m|
|Rutten to leave Feyenoord|
|First trophy for ´new´ Chelsea - Mourinho|
|Icardi the future of Inter, says Ausilio|
|Patience needed from ´brilliant´ United fans - Rooney|
|Allen hails ´next level´ Coutinho|
|Points over milestones for Cisse|
|Hecking ´furious´ with Wolfsburg defence|
|CONCACAF Champions League Preview: DC United face uphill task to reach semis|
|AFC Champions League Preview: Al Ain enhanced, Wanderers prepare for Evergrande reunion|
|Coupe de France Preview: PSG, Monaco to meet again|
|Crouch happy to silence doubters|
|Blanc questions rivals´ mental strength as PSG gain ground|
|Kane: Fortune favoured Chelsea|
|Ancelotti defends Isco substitution|
|Rooney: Di Maria will come good|
|Stubborn Villarreal impress Real´s Pepe|
|PSG could not ´kill off´ Monaco - Van der Wiel|
|Serie A Review: Napoli suffer defeat at Torino, Lazio lurking|
|Ligue 1 Review: Title chasers´ slip-ups go unpunished|
|La Liga Review: Real and Atletico suffer frustrating draws|
|Primeira Liga Review: Porto´s Tello dents Sporting´s title hopes|
|Monaco 0 PSG 0: Champions miss chance to go top|
|Real Madrid 1 Villarreal 1: Moreno leveller ensures stalemate|
|Simeone satisfied with Sevilla point|
|Henry: Chelsea can win a trophy treble this season|
|Mancini frustrated by ´hesitant´ Inter|
|Sevilla 0 Atletico Madrid 0: Simeone´s men in fiery draw|
|Pochettino upbeat despite League Cup defeat|
|Inter 0 Fiorentina 1: Montella´s men end San Siro wait|
|Bundesliga Review: Wolfsburg edge eight-goal thriller, Monchengladbach win|
|Mourinho revels in ´beautiful´ League Cup success|
|Eredivisie Review: PSV lose home record as Ajax close the gap|
|Terry thrilled by ´massive´ League Cup final win|
|Chelsea 2 Tottenham 0: Mourinho´s men seal League Cup success|
|Coquelin sustains broken nose|
|Wenger hails Giroud character after Everton goal|
|Everton not getting what they deserve - Martinez|
|Coutinho is coming of age at Anfield - Rodgers|
|Football League Preview: Wolves in the hunt for back-to-back promotions|
|Norwich City 2 Ipswich Town 0: Neil´s men go third with derby triumph|
|Southampton v Crystal Palace: Fonte focusing on big picture|
|Arsenal 2 Everton 0: Giroud strikes to silence doubters|
|Dynamo Dresden v Borussia Dortmund: Hummels eager to build on derby win|
|Rodgers tips hat to relentless Liverpool|
|City facing uphill challenge to retain title - Pellegrini|
|Celtic 4 Aberdeen 0: Champions dominate top-of-the-table clash|
|Lallana hails ´massive´ win as Liverpool´s top-four charge continues|
|Hull City v Sunderland: Cattermole allowing no excuses against ´bogey team´|
|Liverpool 2 Manchester City 1: Coutinho dents City´s title hopes|
|Sunderland to appeal Brown red card|
|Aston Villa v West Brom: Sherwood looking for confidence boost|
|Allegri not taking risks on Vidal and Pogba|
|Pardew defends Jedinak over Sakho elbow|
|Heldt apologises after Schalke´s derby humbling|
|Milan must give that bit extra - Bocchetti|
|Rooney: Brown red must be rescinded|
|Monk hails Swansea´s versatility|
|Melbourne Victory 2 Wellington Phoenix 3: Hosts miss chance to go top|
|Rodgers: Top-four finish would be bigger than last season´s effort|
|Batman and Robin ´a bit of fun´ - Reus|
|Rakitic feeling better after ending goal drought|
|Copa Libertadores Preview: Well-rested Cruzeiro ready for Universitario|
|Fournier fuming after Lyon loss|
|DFB Pokal Preview: Gladbach visit rusty Offenbach|
|Mourinho: Tottenham approached me|
|Primeira Liga Review: Birthday boys Benfica hit Estoril for six|
|Inzaghi finds positives in lacklustre display|
|Eredivisie Review: AZ move third, Propper fires Vitesse to victory|
|Chievo 0 Milan 0: Pressure back on Inzaghi|
|Bundesliga Review: Derby win for Dortmund superheroes, Leverkusen go fourth|
|Ligue 1 Review: Lyon loss leaves door open for PSG|
|Bueno nets perfect hat-trick in four-goal spree for Rayo|
|Carver impressed with Newcastle´s fighting spirit|
|Van Gaal explains Di Maria decision|
|Luis Enrique angered by Granada pitch|
|Sherwood confident of Villa survival|
|Referee East says ´no mistaken identity´ as Poyet pledges to look again|
|League One Review: Robertson and Johnson off to winning starts, Bristol City go eight clear|
|Bruce angered by missed decision|
|Berahino can be ´top class´ - Pulis|
|Grateful Gutierrez thanks ´special´ fans|
|Monk targets Swansea points record|
|Klopp´s ´perfect´ afternoon|
|Victory soured by Ireland injury, says Hughes|
|Championship Review: Middlesbrough´s opportunity missed as Derby are defeated|
|Koeman: I am realistic on Champions League|
|League Two Review: Burton beaten again, Hartlepool gain welcome lift|
|´Triple punishment´ rule could be scrapped|
|Scottish Premiership Review: Inverness slip up as strugglers prosper|
|Mancini wary of Fiorentina quality|
|Hearts attack hits double figures in Scotland|
|West Brom 1 Southampton 0: Berahino wins it, then limps off|
|Manchester United 2 Sunderland 0: Rooney at the double amid red card controversy|
|Newcastle United 1 Aston Villa 0: Cisse strike downs visitors|
|Stoke City 1 Hull City 0: Super sub Crouch secures win|
|Granada 1 Barcelona 3: Suarez inspires routine win|
|Burnley 0 Swansea City 1: Trippier own goal proves decisive|
|Borussia Dortmund 3 Schalke 0: Late show seals dominant derby win|
|Referee Dowd fails to make it through West Brom, Saints clash|
|Allardyce ´shocked´ after home loss|
|Pardew lauds Murray after ´mixed afternoon´ for striker|
|West Ham 1 Crystal Palace 3: Pardew enjoys more away-day success|
|Blanc: PSG prepared for confident Monaco|
|Ancelotti: Isco place is non-negotiable|
|Pellegrini out to end dismal record at Anfield|
|Roma v Juventus: Matri eyes glory in title tussle|
|Martinez wary of wounded Arsenal|
|A-League Review: Spectacular Sydney derby the highlight|
|Perez to testify in corruption case|
|Bentaleb determined to avoid European hangover|
|Liverpool cannot dwell on Europa exit, says Rodgers|
|Marquinhos welcomes Manchester United interest|
|Tottenham must be ´nearly perfect´ to beat Chelsea - Pochettino|
|Bielsa: I take responsibility|
|League Cup final ´most important´ for Mourinho|
|Rodgers unsure if European exit will be a blessing|
|Vitoria Guimaraes 1 Maritimo 0: Hosts end winless run|