Free-scoring Liverpool must breach one of the Premier League's sternest defences in order to maintain their title charge at West Ham.
Brendan Rodgers' table-toppers are in line for their first top-flight crown since 1990, and head into the final six games of the season knowing a haul of 18 points will be enough to fend off the challenges of Chelsea and Manchester City.
Liverpool's attacking potency is the primary reason for their unexpected title bid, with the Anfield outfit on course to break Chelsea's record of goals in a Premier League season - 103, set in 2009-10.
They have racked up 88 in their 32 top-flight games so far, with lethal strike duo Luis Suarez and Daniel Sturridge - the division's top two scorers - accounting for 49 of those.
A run of eight consecutive wins, with 30 goals scored in the process, has seen Liverpool surge to the summit of the league - and Rodgers has called on his players to focus solely on themselves as the campaign draws to a close.
"We can't afford to worry about other teams, it would be wasting energy to worry about them," the Northern Irishman said.
"It is now about concentrating on performance. The way we are playing gives us great confidence."
Four of Liverpool's 88 Premier League goals came in their 4-1 hammering of West Ham at Anfield in December and they scored three on their last visit to Upton Park.
However, Sam Allardyce's team have often proved a tough nut to crack this season, with only Chelsea able to better their total of 13 clean sheets - although they have failed to shut out their opponents since a 2-0 win over Norwich City on February 11.
West Ham have won six of their last nine top-flight matches, including their last two, meaning they sit 11 points clear of the bottom three and all but safe from relegation with six games to spare.
Andy Carroll, who moved to Upton Park from Liverpool for a club-record fee last June, opened the scoring in West Ham's 2-1 win at Sunderland last Monday, and Allardyce believes the striker - along with fellow ex-Anfield man Stewart Downing - will be eager to prove a point this weekend.
"Those two lads in particularly will want to show how good they are on Sunday. Let's hope they play very, very well on Sunday, because we need them to," he said.
Allardyce looks set to be without George McCartney (hamstring), while James Collins (calf) and Marco Borriello (hamstring) are doubtful.
Rodgers, meanwhile, has a full complement of players to choose from, with the exception of long-term absentee Jose Enrique (knee).
|Coach: S. Allardyce|
for K. Nolan 68'
for M. Taylor 78'
for M. Diamé 84'
|Benitez backs Mihajlovic, Milan to succeed|
|Barnetta joins Union in MLS|
|Allegri critical of Morata´s attitude|
|Franjic targets more A-League glory with City|
|Beto undaunted by Super Cup clash against Barca|
|Advocaat upbeat despite another Sunderland flop|
|McClaren praises Newcastle recruit Mitrovic|
|Payet will improve West Ham - Bilic|
|Pulis confirms interest in Lambert|
|Deila expects tough test in Baku|
|Drogba mobbed by Montreal Impact fans|
|UEFA Champions League Review: Ajax spurn two-goal lead at 10-man Rapid|
|Sunderland´s struggles continue as Doncaster cruise to win|
|Mahrez and Nugent on target in Leicester win|
|Mitrovic tastes debut defeat for Newcastle|
|Celtic 1 Qarabag 0: Boyata snatches crucial win|
|Jablonec 0 Copenhagen 1: Verbic cracker gives Danes the edge|
|Norwich sign Wisdom on loan from Liverpool|
|UEFA Europa League Preview: Koeman plays down importance of Vitesse links|
|Schneiderlin keen to learn from experienced duo|
|Mandzukic´s maiden Juventus goal seals win in Poland|
|Fofana completes Bastia loan|
|Deila delighted that Gordon pledges future to Celtic|
|Grenier ruled out for four months|
|Rooney: United squad ready for title challenge|
|Messi and Neymar available for start of season|
|Szczesny seals Roma switch|
|Benitez cools Mourinho war of words|
|Filipe Luis vows to win back Atletico fans|
|Besiktas in negotiations over Gomez switch|
|Kishna seals Lazio switch|
|Diaby completes Marseille move|
|Platini is bad for FIFA - Prince Ali|
|Bilic keen to make further additions|
|Brady makes Norwich move|
|Southampton complete Caulker loan|
|Rummenigge feels Muller ´will never leave´ Bayern|
|Platini to stand in FIFA presidential election|
|Howedes to remain Schalke skipper|
|Albion sign Hull defender Chester|
|Lucescu defends Fred selection amid doping allegations|
|Fabregas still in love with Arsenal|
|Luis Enrique ´happy´ with Barca´s US trip|
|Mourinho optimistic over Cahill and Costa|
|River owe Tigres´ Esqueda - Mercado|
|Van Gaal expecting big season from Shaw|
|Begovic keen to challenge Courtois|
|Mourinho launches attack on Benitez|
|CONMEBOL ´knocked on a lot of doors´ to keep half-spot - president|
|America 0 Benfica 0 (3-4 on penalties): Primeira Liga champions finally win|
|Napoli striker Higuain ´untouchable´ - Gabbiadini|
|Arsenal´s friendly form will boost confidence - Wenger|
|Nagatomo-Melo swap possible, says agent|
|Chelsea 2 Barcelona 2 (4-2 on penalties): Courtois stars for Premier League champions|
|Eriksen calls for ruthless Spurs|
|Pulis praises Berahino attitude|
|Alderweireld confident of top-four finish|
|Villa ready for tough Spurs clash|
|West Ham edge win on Carrow Road anniversary|
|Kozak scores twice as Villa draw at Wolves|
|Stanislas brace leads Bournemouth past Yeovil|
|Watford slip to friendly defeat at Cardiff|
|Lukaku injury sours Everton win at Dundee|
|UEFA Champions League Review: Fenerbahce draw blank as Monaco impress|
|West Brom earn friendly win over Walsall|
|Vardy at the double as Leicester beat Burton|
|Atletico impress in win over Oviedo|
|Herrera sacked by Mexico after ´punch´|
|Gerrard, Keane and Bradley pull out of MLS All-Star squad|
|Marseille reach Diaby agreement|
|Sammer thrilled with Vidal´s winning mentality|
|Platini expected to launch FIFA presidency bid|
|Romanov sacked me over Barca snub - Korobochka|
|Villa complete Crespo capture|
|Wolfsberger v Borussia Dortmund: Bender praises ´fun but exhausting´ training|
|Okaka swaps Sampdoria for Anderlecht|
|Southampton v Vitesse: Fonte excited for ´dream´ sojourn into Europe|
|Bournemouth agree King compensation|
|West Ham v Astra: Kouyate confident West Ham can progress|
|Vidal completes Bayern switch, signs four-year deal|
|Fabregas calls for Champions League improvement|
|BREAKING NEWS: Filipe Luis completes Atletico return|
|Bayern to present Vidal|
|Wenger unfazed by Mourinho´s spending jibe|
|Pellegrini: Sterling will justify price tag|
|Cavani hit with two-match Uruguay ban|
|Bonucci to remain at Juve until 2020|
|No bids for Berahino - West Brom|
|Putin: Blatter deserves a Nobel prize|
|Howe: Swansea a benchmark for Bournemouth|
|New Parma to play in Serie D|
|Mata vows to hit the goal trail at United|
|Drogba ´perfect fit´ for Montreal|
|Berahino ´not yet´ ready for Tottenham - Irvine|
|Romero lauds caring Van Gaal|
|Jese flying at Real under Rafa|
|Sampdoria unwilling to pay €10m for Balotelli|
|Mourinho talks up Arsenal title chances|
|Hull sign Ryan Taylor, Sam Clucas|
|Kane, Pochettino hail MLS All-Star test|
|Di Santo sorry for swift Werder departure|