Free-scoring Liverpool must breach one of the Premier League's sternest defences in order to maintain their title charge at West Ham.
Brendan Rodgers' table-toppers are in line for their first top-flight crown since 1990, and head into the final six games of the season knowing a haul of 18 points will be enough to fend off the challenges of Chelsea and Manchester City.
Liverpool's attacking potency is the primary reason for their unexpected title bid, with the Anfield outfit on course to break Chelsea's record of goals in a Premier League season - 103, set in 2009-10.
They have racked up 88 in their 32 top-flight games so far, with lethal strike duo Luis Suarez and Daniel Sturridge - the division's top two scorers - accounting for 49 of those.
A run of eight consecutive wins, with 30 goals scored in the process, has seen Liverpool surge to the summit of the league - and Rodgers has called on his players to focus solely on themselves as the campaign draws to a close.
"We can't afford to worry about other teams, it would be wasting energy to worry about them," the Northern Irishman said.
"It is now about concentrating on performance. The way we are playing gives us great confidence."
Four of Liverpool's 88 Premier League goals came in their 4-1 hammering of West Ham at Anfield in December and they scored three on their last visit to Upton Park.
However, Sam Allardyce's team have often proved a tough nut to crack this season, with only Chelsea able to better their total of 13 clean sheets - although they have failed to shut out their opponents since a 2-0 win over Norwich City on February 11.
West Ham have won six of their last nine top-flight matches, including their last two, meaning they sit 11 points clear of the bottom three and all but safe from relegation with six games to spare.
Andy Carroll, who moved to Upton Park from Liverpool for a club-record fee last June, opened the scoring in West Ham's 2-1 win at Sunderland last Monday, and Allardyce believes the striker - along with fellow ex-Anfield man Stewart Downing - will be eager to prove a point this weekend.
"Those two lads in particularly will want to show how good they are on Sunday. Let's hope they play very, very well on Sunday, because we need them to," he said.
Allardyce looks set to be without George McCartney (hamstring), while James Collins (calf) and Marco Borriello (hamstring) are doubtful.
Rodgers, meanwhile, has a full complement of players to choose from, with the exception of long-term absentee Jose Enrique (knee).
|Coach: S. Allardyce|
for K. Nolan 68'
for M. Taylor 78'
for M. Diamé 84'
|Montenegro-Russia abandoned after scuffle|
|Euro 2016 Qualifying Review: Montenegro-Russia abandoned, Spain and England win|
|Accrington Stanley 0 Newport County 2: Visitors up to sixth|
|Kane delighted with ´dream´ start|
|England 4 Lithuania 0: Kane enjoys dream debut|
|Spain 1 Ukraine 0: Morata settles tight contest|
|Akinfeev struck by flare as Montenegro-Russia game suspended after 30 seconds|
|Brazil v Chile: Winning is ´our only option´ - Dunga|
|Northern Ireland v Finland: Controversial fixture met with religious protests|
|Scotland v Gibraltar: Wilson out to dent countrymen´s hopes|
|Republic of Ireland v Poland: Pressure is on, says O´Neill|
|Georgia v Germany: Schneider warns world champions|
|PSV agree permament Guardado deal|
|France v Denmark: Olsen hits out at training facilities|
|Pienaar to return to Everton training|
|Hughes eyes silverware at Stoke after signing new deal|
|Portugal v Serbia: Carvalho vows to attack|
|Dynamo Kiev stadium partially closed after racism probe|
|Hull City fined £30,000 for misconduct|
|Balotelli must work hard for Italy return – Bonucci|
|Marchisio suffers knee ligament injury|
|Hughes agrees new Stoke City deal until 2018|
|Martinez hopeful over injured Everton trio|
|South Korea 1-1 Uzbekistan: Kuziboyev's debut strike denies hosts|
|South Korea 1 Uzbekistan 1: Kuziboyev´s debut strike denies hosts|
|Japan 2 Tunisia 0: Kagawa and Honda shine as Halilhodzic starts with a win|
|South Africa v Nigeria: Mashaba wary of bitter opponents|
|Japan 2-0 Tunisia: Kagawa & Honda shine in Halilhodzic's first game|
|Parma captain Lucarelli welcomes FIGC reforms|
|Di Francesco ignoring Milan rumours|
|Melbourne Victory 2 Central Coast Mariners 1: Finkler leads fightback|
|Bale would be ´perfect´ for United - Scholes|
|Badstuber and Bellarabi out of Georgia clash|
|Rooney KOs boxing celebration|
|Allen thrilled with Welsh ´hunger´|
|Kovacic to miss Euro 2016 qualifier|
|Costa Rica 0 Paraguay 0: Dour draw marks Diaz debut|
|Reid ruled out of South Korea friendly|
|Deschamps talks up France despite defeat|
|Rooney chasing England goalscoring record|
|Brazil ´superior´ admit French veterans|
|Reeves sidelined for Finland clash|
|Confidence critical for rampaging Brazil - Dunga|
|France 1 Brazil 3: Dunga´s men maintain winning run|
|Chile 0 Iran 2: Nekounam and Amiri down Copa America hosts|
|Premier League to share over £1bn from record TV deal|
|Morocco v Uruguay: Last chance to impress Tabarez for Copa champions|
|Iran 2-0 Chile: Nekounam and Amiri down Copa America hosts|
|Ivanovic braced for Ronaldo test|
|El Salvador - Argentina Preview: Messi set for Roca reunion|
|Bahrain 0 Colombia 6: Falcao stars in comfortable victory|
|Jones to Bournemouth leads loan deadline day moves in Championship|
|Bahrain 0-6 Colombia: Falcao stars in resounding victory|
|Malmo fined for poor pitch by UEFA|
|League Two Preview: Hartlepool aim to continue great escape, leaders Burton host Stevenage|
|France 1-3 Brazil: Neymar on target as Selecao triumph in Paris|
|Bulgaria v Italy: Verratti vows to be Azzurri´s midfield general|
|Kane primed for full England debut|
|Kone receives positive news over knee injury|
|Terry pens new Chelsea deal|
|PSG tie down Marquinhos|
|De Gea stamp was accidental - Skrtel|
|Villa hopeful over Xavi reunion|
|El Salvador v Argentina: Messi set for Roca reunion|
|Ghana v Senegal: Grant´s side looking to rebuild after AFCON disappointment|
|Ferdinand to serve extended touchline ban|
|League One Preview: Duo aiming to inspire Notts County revival, Alexander back at Preston|
|Hodgson keeps an eye on Sterling and Milner|
|Filipe Luis cools talk of Atleti return|
|West Brom to wear retro kit for Leicester clash|
|Netherlands v Turkey: Sneijder unconcerned by key absentees|
|Del Bosque wary of Ukraine threat|
|Israel v Wales: Pivotal fixture for both sides in chase for Euro dream|
|Bosnich backs Villa to beat drop|
|Walcott denies Wenger ´bust-up´|
|Hart: Aguero more difficult to face than Messi|
|Williams: I can´t see myself playing for anyone else|
|Coutinho eager to add more goals to his game|
|Khedira confirms Real exit|
|Messi attends NBA match with Argentina squad|
|United will qualify for Champions League - Bosnich|
|Mexico v Ecuador: Hernandez desperate to play|
|Podolski plays down Germany cameo|
|Bendtner: I could have scored four|
|Leverock family adds to World Cup exploits for Bermuda|
|Pele: ´Impossible´ for Neymar to replace me|
|MLS Preview: New England hoping to end drought|
|A-League Preview: Phoenix without stars for Sydney showdown|
|Klinsmann laments late collapse|
|Premier League clubs post first pre-tax profit for 15 years|
|Vokes relishing chance to link up with Bale|
|Dunga encourages Brazil to entertain|
|Dyke: FA to discuss Hodgson extension|
|Janko eyes history with Austria|
|Wilson urges Begovic to stay put|
|Strachan: Scotland have work to do|