Manchester United held Bayern Munich in midweek and will fancy their chances of following that up with a win at injury-hit Newcastle United.
Defending champions Bayern dominated Tuesday's UEFA Champions League quarter-final first leg, but Nemanja Vidic's header 13 minutes into the second half gave United a shock lead.
Bastian Schweinsteiger's clinical finish nine minutes later ensured the Bavarian giants secured a 1-1 draw, but a spirited display from United - who had been widely tipped to be beaten comfortably - gave manager David Moyes heart.
Moyes vowed to go "toe-to-toe" with the Bundesliga champions in the second leg at the Allianz Arena next Wednesday, but he must first turn his attention to Saturday's Premier League trip to St James' Park.
United suffered a 1-0 defeat against Alan Pardew's side at Old Trafford back in December to pile more pressure on Moyes, after his former club Everton had consigned them to another home loss three days earlier.
But the Premier League champions will be up against a very different Newcastle side to the one that gave the north-east club their first win at United since 1972.
Match-winner Yohan Cabaye moved on to Paris Saint-Germain in the January transfer window, while Pardew this week bemoaned an injury crisis that has hit the club.
Goalkeeper Tim Krul (shoulder), right-back Mathieu Debuchy (groin), midfielder Moussa Sissoko (thigh) and striker Loic Remy (ankle) are all unavailable, hampering Newcastle's chances of turning their fortunes around following heavy defeats against Everton and Southampton.
A 4-0 hammering at his former club Southampton last Saturday inflicted more woe on Pardew, who will have to watch from the stands once again as he continues to serve a touchline ban for headbutting Hull City midfielder David Meyler.
And the Newcastle manager knows his side could be up against it once again this weekend.
He said: "It's difficult because Man United have had a little upsurge.
"They were terrific against Munich and will bring that bounce to our place.
"We're coming off a very poor performance.
"Everything points to them being favourites to win this game, but we have to prove that wrong."
While United have endured some miserable results at Old Trafford, they have a good record on their travels in the top flight this season.
No side can boast more league victories on the road in the this term than United's total of nine and they have come out on top in their last three away games without conceding a goal.
Left-back Patrice Evra will be back in contention after sitting out the clash with Bayern due to suspension, but Ryan Giggs (groin) and Rafael da Silva (hamstring) could miss out.
Robin van Persie (knee) will definitely not feature, but Moyes will be hoping Jonny Evans (calf) and Chris Smalling (hamstring) are available to return.
|18||L. de Jong|
|Coach: A. Pardew|
for L. de Jong 61'
for Y. Gouffran 85'
|Pochettino planning Tottenham transfer talks|
|Wenger confident of top-four finish|
|Hughes sweating on Bojan fitness|
|Hectic schedule caught up with United - Van Gaal|
|Capello: Wenger shunned Lopez advice|
|PSG aim for improvement in Morocco|
|Jones: United could have scored four|
|Mignolet: Getting dropped helped me|
|A-League Preview: No concerns for Finkler ahead of Victory blockbuster|
|Milan, Atletico working on Torres-Cerci swap|
|Garbutt: Crisis talk premature|
|Zurich pair key for Tunisia|
|Uchida ruled out of Asian Cup|
|Lemina rejects Gabon call-up|
|Toure a doubt for Sunderland clash|
|Millen ´ready´ to manage Palace|
|Carver urges Newcastle to kick on|
|Bellarabi extends Leverkusen deal|
|Wenger hails ´committed´ Arsenal|
|Diouf will be missed - Hughes|
|Millen elated at resolute Palace performance|
|Lambert: Big point for Villa|
|Martinez rues Cisse decision|
|Dyche delighted by Burnley character|
|Allardyce: Officials got it horribly wrong|
|Poyet rues dropped points at Villa|
|Bruce frustrated as dominant display yields no points|
|Pellegrini laments key turning points in Burnley setback|
|Newcastle United 3 Everton 2: Pardew´s men impress at St James´ Park|
|League One Review: Swindon climb into second, MK Dons suffer surprise defeat|
|Championship Review: Bournemouth go four points clear, Boro held|
|Koeman hails Southampton spirit|
|Inverness Caledonian Thistle 0 Aberdeen 1: Pawlett strikes sends McInnes´ men second|
|Mourinho fumes at ´campaign´ against Chelsea|
|Manchester City 2 Burnley 2: Barnes claims a point to deny champions|
|West Ham 1 Arsenal 2: Wenger´s men climb above hosts|
|Hull City 0 Leicester City 1: Mahrez fires Pearson´s men to victory|
|QPR 0 Crystal Palace 0: Millen makes solid start as temporary Palace boss|
|Aston Villa 0 Sunderland 0: Delph sees red in stalemate|
|Stoke 2 West Brom 0: Diouf brace secures back-to-back wins|
|Southampton 1 Chelsea 1: Mourinho´s men end 2014 on top|
|Van Gaal frustrated with wasteful finishing|
|Pochettino content with goalless draw|
|Tottenham 0 Manchester United 0: Honours even at White Hart Lane|
|Klose vows to fight for Lazio place|
|Hughton admits interest in Palace and Brighton roles|
|Injuries not behind retirement plans, says Rolfes|
|Podolski: Arsenal exit not a formality|
|Wellington Phoenix 1 Western Sydney Wanderers 0: Krishna wins it|
|Taylor wary of ´beast´ Lukaku|
|Al Habsi to lead Oman at Asian Cup|
|Lacazette will stay at Lyon - Aulas|
|Southampton like Atletico, says Alderweireld|
|World Cup held PSG back - Blanc|
|Everton facing ´pivotal´ moment - Martinez|
|Zamora urges QPR to tie down Austin|
|Badstuber, Alaba set for New Year return|
|Burgos: Atletico will get the best out of Torres|
|Chelsea to offer Terry new deal - Mourinho|
|Rodgers excited by Sterling development|
|Strinic close to finalising Napoli switch|
|Torres to join Milan on permanent deal|
|Scottish Premiership Review: Celtic held to shock draw, rivals fail to capitalise|
|Wenger sings Song´s praises|
|Pochettino calls for bravery|
|West Ham could lose Allardyce - Sullivan|
|League One Preview: Saunders takes charge for Colchester clash|
|Aguirre denies any involvement in La Liga match-fixing scandal|
|Mourinho impressed by Koeman´s Southampton|
|QPR v Crystal Palace: Millen recast in familiar role|
|West Ham v Arsenal: Allardyce eyes further home comfort|
|Elusive Coppa Italia on Juventus´ wish list - Marotta|
|Jones eyes swift response|
|Millen focused on QPR clash|
|League Two Preview: Shrewsbury, Wycombe and Burton vie for year-end top spot|
|Mancini not expecting big-money signings at Inter|
|Tottenham v Manchester United: Carrick expects tough return|
|Pearson eager to see Leicester resolve|
|Newcastle United v Everton: Martinez demands clinical touch|
|Liverpool v Swansea City: Rodgers backs returning Mignolet|
|Bayern can still improve - Sammer|
|Warnock sacked by Palace|
|Aston Villa v Sunderland: No club too big to go down, says Lambert|
|Hull City v Leicester City: Pearson vows to keep going|
|Stoke City v West Brom: Hughes targets elusive back-to-back wins|
|Rodgers dismisses Balotelli exit rumours|
|Modric will not rush Madrid return|
|Dyche pleased with Vokes return|
|Southampton v Chelsea: Koeman vows to go on the offensive|
|A-League Review: Six-goal Gosford thriller, Victory leave it late|
|Manchester City v Burnley: Pellegrini warns against complacency|
|Dortmund can fight on two fronts - Watzke|
|Sterling hails improved Liverpool belief|
|Rosicky eager to build on QPR winner|
|Wenger: ´We made it hard for ourselves´|
|Kane: Spurs eye top four|
|Di Maria in doubt for Spurs clash|