Manchester City can turn up the heat on leaders Liverpool with a victory over in-form Southampton at the Etihad Stadium on Saturday.
Due largely to their League Cup, FA Cup and UEFA Champions League commitments, City have fallen off the pace at the top - with Brendan Rodgers' side taking full advantage to move four points ahead of the 2011-12 champions.
With just the Premier League left to focus on, manager Manuel Pellegrini can ill-afford any more slip-ups following last Saturday's 1-1 draw at Arsenal.
City, who have also dropped below Chelsea but have two games in hand on the sides above them, meet Liverpool next weekend in a crucial fixture at the top, and Pellegrini will want to head into that game with a win behind them.
With Liverpool not in action until Sunday, City have a chance to apply some pressure on the Merseysiders and they boast an impressive home record.
Pellegrini's men have made the Etihad a fortress this season, winning 13 of their 14 league games on home soil.
The solitary defeat came against Chelsea in February, but City's response has been to take 14 points from six league games since then.
Pellegrini could be without leading goalscorer Sergio Aguero this weekend, with the striker not having featured since limping out of their Champions League defeat to Barcelona in March.
However, Southampton boss Mauricio Pochettino insists that he would welcome the Argentina international's return.
"I would like to play against him," he said. "I always want to face the best."
Pochettino's charges - who earned a 1-1 draw at home to City, when Aguro was on target for the visitors - have found their goalscoring touch lately, hitting 10 in the last three games.
English trio Jay Rodriguez, Adam Lallana and Rickie Lambert have been Southampton's main source of inspiration, with all three having found the net in Saturday's 4-0 win over Newcastle as they moved back into eighth.
And defender Luke Shaw - who could join the likes of Lallana, Rodriguez and Lambert in England's World Cup squad - feels that the sky is the limit for Southampton.
"I think in the next year or so we can be challenging the top five teams," he said.
"They've got to get the manager down on a long-term contract, which will probably be the first thing they try and do."
Victor Wanyama could return for Southampton following a calf problem, although Kelvin Davis (back), Nathaniel Clyne (groin) and Maya Yoshida (knee) remain sidelined.
As well as Aguero, Pellegrini also has doubts over Micah Richards and Matija Nastasic (both knee).
|42||Y. Touré||3' 78'|
|Coach: M. Pellegrini|
for Fernandinho 46'
for E. Džeko 65'
for David Silva 77'
|Liverpool´s loss is our gain, says Redknapp on Remy|
|Ferdinand: I would still be at United with Giggs in charge|
|Pepe targets Super Cup glory|
|Martinez prioritising striker signing|
|Perez not looking to leave Benfica|
|Klopp itching to work with full Dortmund squad|
|Mourinho: It feels like Drogba never left|
|FIFA asks for FIGC review into alleged racist remark|
|Hull to review Maguire deal|
|Wenger prepared to gamble on Chambers|
|Atletico agree Griezmann deal|
|Irvine planning further striker addition|
|Campbell: Black professionals scared to talk about racism|
|Mata backs Herrera to star in Premier League|
|Injured Rafael returning to Manchester|
|Schmidt demands more from Leverkusen|
|Copa Libertadores Preview: Defensor Sporting banking on home record|
|Remy´s Liverpool move off, confirms Rodgers|
|Inzaghi demands nastiness from Milan|
|MLS Review: Timbers triumph in Montreal, Dallas thwart Vancouver|
|Jovetic ready to lead City line - Pellegrini|
|Lewandowski impresses Ribery, Alaba|
|Colombian Primera A Review: Three clubs remain perfect, Atletico Nacional get off the mark|
|Rodgers: ´We can score goals´ without Suarez|
|Chilean Primera Division Review: Canales brace powers Universidad Chile|
|Atletico Madrid need penalties to edge past Earthquakes|
|Liga MX Review: Monterrey, America stay perfect|
|Paraguayan Primera Division Review: Capiata set pace|
|Brazilian Serie A Review: Cruzeiro win again, Kaka scores|
|Sterling goal sees Liverpool past Olympiacos|
|Peruvian Primera Division Review: Los Caimanes notch maiden win, Inti Gas claim top spot|
|CAF Champions League Review: Zamalek held, Vita Club leave it late|
|Jovetic at the double as Manchester City thrash Milan|
|Monk thrilled by Sigurdsson contribution|
|Lovren signs for Liverpool|
|Mourinho pleased with Olimpija test|
|Vertonghen eager to remain at Spurs|
|Sigurdsson marks Swansea return with a brace|
|Lewandowski, Rode help Bayern retain Telekom Cup|
|Immobile scores and suffers injury in Dortmund win|
|Costa scores on Chelsea debut|
|CAF Confederation Cup Review: Leopards de Dolisie 1 Real Bamako 2|
|Thai Premier League Review: Buriram pull clear, Police edge away from danger|
|Falcao nears Monaco return|
|CSL Review: Harbin Yiteng produce another upset, Evergrande stretch lead|
|Britton and Emnes to miss season-opener|
|Taylor-Fletcher strike sinks Everton|
|J.League Review: Chasing pack close on Urawa Reds, Tokushima Vortis secure rare win|
|Ancelotti expects fresh Bale to be even better|
|Simeone keen on Griezmann|
|Mazzarri refuses to set Inter targets|
|Lazio director targeted by fans|
|Dyche rules out Deeney move|
|Rummenigge: Bayern will never sack Guardiola|
|BREAKING NEWS: Arsenal to bring in Ospina|
|Pochettino quiet on Schneiderlin link|
|Vidic settling into Inter life|
|Van Gaal hints at Zaha United future|
|Di Maria will report for training - Ancelotti|
|Wilshere vows to answer critics|
|Rodgers expecting titles|
|Deila demands Celtic cutting edge|
|Rodgers: We won´t rush Lallana|
|Wenger: We have to be better against top-level teams|
|FIGC presidential candidate uses racist slur|
|MLS Review: Columbus claim second straight win, Toronto falter|
|Villa battle past Dynamo in Houston|
|United more efficient, says Garcia|
|Pedestrian Tottenham edge past Chicago Fire|
|Van Gaal bemoans display|
|CS Sfaxien 1 ES Tunis 0: Troussier era opens with a win|
|Icardi stars from the spot as Inter overcome Real Madrid|
|Arsenal upstaged by Red Bulls|
|Pre-Season Friendly Review: Rooney stars for United, Bayern reach Telekom final|
|In-form Rooney inspires Manchester United win|
|CAF Confederation Cup Review: Cotonsport on verge of progress|
|Ribery helps Bayern to penalty victory on return|
|Balzaretti suffers another injury blow|
|Puel confirms Ospina departure|
|Beckham backs Rodriguez to be Real hit|
|Bojan fails to inspire Stoke|
|Long on target as Hull held by Barnsley|
|Cardiff issue Medel warning|
|Ferreyra sorry for late Shakhtar return|
|Payet rules out Swansea move|
|Gilchrist nets winner as Burnley edge Accrington|
|Cazorla optimistic for new season|
|Celtic suffer St Pauli defeat|
|QPR lose on Ferdinand debut|
|Mashaba handed Bafana Bafana role|
|Van Aanholt eager to prove himself|
|Areola completes Bastia loan switch|
|Ospina imminent, but Szczesny gets Wenger´s backing|
|Reus happy with progress|
|Alleged spot-fixers released|
|Giuly: Mathieu can be the next Abidal|
|Allardyce hoping to keep hold of Morrison|
|Monk hails quality of Swansea additions|
|Van Gaal orders United players to speak English|
|Allardyce: We must improve|
|Campbell thrilled by Palace switch|
|Bojan drawn by Stoke style|
|Palace were wasteful, says Pulis|
|Van Gaal suits me - Cleverley|
|Newcastle stay perfect in NZ|
|Van Gaal prepared to wait for Strootman|
|West Brom overcome Sacramento|
|Colorado Rapids 3 Chivas USA 0: Hosts rise to third in the West|
|Gameiro brace adds to West Ham woes|
|Villas-Boas: Rodriguez best suited to no.10 role|
|Cazorla: I´m happy at Arsenal|
|Reina respects Liverpool contract|
|Lampard could move to Melbourne on loan|
|Galliani: Balotelli ´99.9 per cent´ staying|
|Own goal helps Palace win in Philadelphia|
|Mourinho: Shaw deal would have ´killed´ Chelsea|
|Al Ahli Benghazi 0 ES Setif 2: Visitors on verge of semi-final spot|
|Julio Cesar returns to QPR|
|Rooney wants to lead United|