Sochaux return to the scene of last season's great escape as they visit Bastia in dire need of a win to boost hopes of Ligue 1 safety.
The Stade Auguste Bonal club claimed a 0-0 draw on the final day of last term in Corsica, which proved enough to ensure survival as Nancy, Troyes and Brest fell into the second tier.
Herve Renard's men will be desperate to go one better at the Stade Armand Cesari this time around.
A last-minute equaliser denied Sochaux a crucial victory over Marseille last weekend and the strugglers head into the weekend eight points adrift of 17th-placed Evian.
Valenciennes are three points above Sochaux and host a Lyon side still harbouring slim hopes of qualifying for the UEFA Champions League and keen to atone for a 2-1 derby loss to Saint-Etienne.
Evian's stunning 1-0 win over second-placed Monaco last time out significantly enhanced their prospects of remaining in the top flight.
And Pascal Dupraz's men could take another step towards safety with a victory at Lorient, who are not yet sure of their place in Ligue 1 for next term.
Six points could separate 11th and 18th by the end of the 32nd round of fixtures, but the picture at the top of the table is far clearer.
Paris Saint-Germain appear to have all but secured a second consecutive title and sit 13 points clear of Monaco.
The capital club can edge ever closer to glory by beating Reims, while Monaco will be aware they may yet come under pressure in the race for Champions League places.
Claudio Ranieri's men currently hold a nine-point advantage over fourth-placed Saint-Etienne and host a Nantes side unbeaten in four.
Saint-Etienne's immediate target is overhauling third-placed Lille, with only three points separating the two sides heading into the weekend.
Next up for Saint-Etienne is a home game against Nice, who narrowly missed out on a Champions League berth last season when finishing only three points behind Lyon.
Lille's trip to Toulouse pits two in-form teams against each other as Rene Girard's men look to make it nine league games unbeaten against a home side without a defeat in five.
Elsewhere, Bordeaux host Rennes, Guingamp meet Montpellier and bottom club Ajaccio travel to a Marseille side in the midst of a dreadful slump.
Jose Anigo's side took just two points from five games in March, a run that has left them nine points adrift of a European place and one that forward Andre Ayew attributes to Marseille's lack of experience.
"I think when you buy young players in a club like Marseille, with a lot of pressure, some players can cope with it no problem, and some others need time," Ayew told BeIN Sport.
"That's why there are a lot of ups and downs, and we need to be more consistent."
|Coach: F. Hantz|
for F. Raspentino 46'
for F. Harek 59'
for J. Sablé 87'
|Ba left out of Senegal AFCON squad|
|Redknapp frustrated by penalty call|
|Wenger sees Giroud wrongs|
|Premier League schedule a ´disgrace´, says Poyet|
|Championship Review: Bournemouth stay top, Heskey scores on Bolton debut|
|Hughes lauds Bojan performance|
|Koeman: Saints marching on|
|Pardew rues referee error|
|Arsenal 2 QPR 1: Sublime Alexis secures the spoils|
|Martinez questions Walters decision|
|Poyet laments Sunderland mistakes|
|League One Review: Swindon cruise to win over Walsall|
|Irvine aware of need for improvement|
|United still doing ´very bad things´ - Van Gaal|
|Lambert proud of players despite Swansea defeat|
|Warnock bemoans Palace defence|
|Bruce hails Hull´s spirit|
|Pochettino relieved to come away with victory|
|Dyche: We had our pocket pinched|
|Monk hails Fabianski performance|
|Pearson demands greater concentration from Leicester|
|Kompany set for City return|
|Rodgers hails character after battling win|
|League Two Review: Ainsworth frustrated by Luton, Shrewsbury go top|
|Everton 0 Stoke City 1: Lacklustre Everton slip to defeat|
|Sunderland 1 Hull City 3: Triumphant return for Bruce|
|Burnley 0 Liverpool 1: Sterling wins it at Turf Moor|
|Leicester City 1 Tottenham 2: Eriksen piles misery on Pearson´s men|
|Manchester United 3 Newcastle United 1: Rooney extends hosts´ streak|
|West Brom 1 Manchester City 3: Three and easy for in-form champions|
|Swansea City 1 Aston Villa 0: Hosts break Boxing Day duck|
|Crystal Palace 1 Southampton 3: Mane marks return with star performance|
|Allardyce upbeat despite defeat|
|Van Dijk happy at Celtic - Deila|
|Table-topping Chelsea delight Mourinho|
|Chelsea 2 West Ham 0: Mourinho´s men ease to victory|
|Suarez enjoying Messi, Neymar link-up|
|A-League Review: Garcia rescues point for Perth, Adelaide up to second|
|Poyet calls for mid-season break|
|Van Gaal rules out Januzaj move|
|Rodgers: Balotelli may have to get used to bench|
|Lallana: I was trying too hard|
|Walker juggles music, football careers in Sweden|
|Song to face ´brother from another mother´ Fabregas|
|Adriano announces Le Havre deal|
|Pardew braced for Old Trafford test|
|Lescott unfazed by City reunion|
|Tskhadadze appointed Georgia coach|
|United to finish top three - Ferdinand|
|Allardyce: Stamford Bridge stalemate saved my job|
|Southampton need three January signings, says Watson|
|Liverpool can make Champions League, says fanzine editor|
|Walsh: Hull clash crucial for Leicester|
|Toure, Aubameyang and Enyeama make shortlist for African gong|
|Docherty backs Chelsea to win two-horse race|
|Liverpool could benefit from Hyypia influence - Scales|
|Saudi Arabia name Asian Cup squad|
|Forty-year-old Cahill no problem for Postecoglou|