Santos Laguna will have a chance to pounce on their fellow top-four clubs in Liga MX when they travel to lowly Monterrey on Saturday.
League leaders Cruz Azul will travel to fourth-placed America, while Toluca - who sit second - face one of the toughest trips in Mexican football as the trek north to Tijuana's Estadio Caliente.
Those fixtures could see all three of Cruz Azul, Toluca and America drop points in round 14, providing Santos Laguna with the opportunity to gain ground on their rivals for the Clausura championship.
Pedro Caixinha's Santos Laguna have not lost in four Liga MX games, while their unbeaten run stretches to seven in all competitions.
That should give them plenty of confidence as they head east to local rivals Monterrey, despite the home side having experienced some resurgence over the past fortnight.
Monterrey have won their past two matches, winning 2-1 at Pumas UNAM before a 3-2 triumph over Atlante.
But with Mexico international Oribe Peralta in fine goal-scoring touch, Santos Laguna should be too strong for their hosts.
Peralta has scored four goals in his side's past four league games to move to 16 across both the Apertura and Clausura seasons.
If Santos Laguna win in Monterrey they will rise to 23 points, which could take them within six of leaders Cruz Azul and five of second-placed Toluca.
America and Pachuca will also start the round on 20 points ahead of their games against Cruz Azul and Guadalajara respectively.
Cruz Azul will take on America after their CONCACAF Champions League semi-final first leg against Tijuana, while Toluca also have continental commitments before they visit the Estadio Caliente with a trip to Costa Rica to play Alajuelense.
Tijuana's home record is formidable - just one defeat in all competitions in 21 games - and will give Toluca something to worry about on Friday.
Pachuca will have to be wary of Guadalajara, who will be desperate to bounce back after losing 4-0 to arch-rivals America last week.
Morelia will host Veracruz in the other game on Friday, while Leon face Queretaro and in-form Atlas will entertain Puebla on Saturday.
The round will finish on Sunday with Chiapas heading to Pumas UNAM, while Atlante clash with Tigres UANL.
|Coach: C. Barra|
for C. Ramírez 60'
for C. Delgado 75'
for N. Cardozo 75'
|Fofana completes Bastia loan|
|Deila delighted that Gordon pledges future to Celtic|
|Grenier ruled out for four months|
|Rooney: United squad ready for title challenge|
|Messi and Neymar available for start of season|
|Szczesny seals Roma switch|
|Benitez cools Mourinho war of words|
|Filipe Luis vows to win back Atletico fans|
|Besiktas in negotiations over Gomez switch|
|Kishna seals Lazio switch|
|Diaby completes Marseille move|
|Platini is bad for FIFA - Prince Ali|
|Bilic keen to make further additions|
|Brady makes Norwich move|
|Southampton complete Caulker loan|
|Rummenigge feels Muller ´will never leave´ Bayern|
|Platini to stand in FIFA presidential election|
|Howedes to remain Schalke skipper|
|Albion sign Hull defender Chester|
|Lucescu defends Fred selection amid doping allegations|
|Fabregas still in love with Arsenal|
|Luis Enrique ´happy´ with Barca´s US trip|
|Mourinho optimistic over Cahill and Costa|
|River owe Tigres´ Esqueda - Mercado|
|Van Gaal expecting big season from Shaw|
|Begovic keen to challenge Courtois|
|Mourinho launches attack on Benitez|
|CONMEBOL ´knocked on a lot of doors´ to keep half-spot - president|
|America 0 Benfica 0 (3-4 on penalties): Primeira Liga champions finally win|
|Napoli striker Higuain ´untouchable´ - Gabbiadini|
|Arsenal´s friendly form will boost confidence - Wenger|
|Nagatomo-Melo swap possible, says agent|
|Chelsea 2 Barcelona 2 (4-2 on penalties): Courtois stars for Premier League champions|
|Eriksen calls for ruthless Spurs|
|Pulis praises Berahino attitude|
|Alderweireld confident of top-four finish|
|Villa ready for tough Spurs clash|
|West Ham edge win on Carrow Road anniversary|
|Kozak scores twice as Villa draw at Wolves|
|Stanislas brace leads Bournemouth past Yeovil|
|Watford slip to friendly defeat at Cardiff|
|Lukaku injury sours Everton win at Dundee|
|UEFA Champions League Review: Fenerbahce draw blank as Monaco impress|
|West Brom earn friendly win over Walsall|
|Vardy at the double as Leicester beat Burton|
|Atletico impress in win over Oviedo|
|Herrera sacked by Mexico after ´punch´|
|Gerrard, Keane and Bradley pull out of MLS All-Star squad|
|Marseille reach Diaby agreement|
|Sammer thrilled with Vidal´s winning mentality|
|Platini expected to launch FIFA presidency bid|
|Romanov sacked me over Barca snub - Korobochka|
|Villa complete Crespo capture|
|Wolfsberger v Borussia Dortmund: Bender praises ´fun but exhausting´ training|
|Okaka swaps Sampdoria for Anderlecht|
|Southampton v Vitesse: Fonte excited for ´dream´ sojourn into Europe|
|Bournemouth agree King compensation|
|West Ham v Astra: Kouyate confident West Ham can progress|
|Vidal completes Bayern switch, signs four-year deal|
|Fabregas calls for Champions League improvement|
|BREAKING NEWS: Filipe Luis completes Atletico return|
|Bayern to present Vidal|
|Wenger unfazed by Mourinho´s spending jibe|
|Pellegrini: Sterling will justify price tag|
|Cavani hit with two-match Uruguay ban|
|Bonucci to remain at Juve until 2020|
|No bids for Berahino - West Brom|
|Putin: Blatter deserves a Nobel prize|
|Howe: Swansea a benchmark for Bournemouth|
|New Parma to play in Serie D|
|Mata vows to hit the goal trail at United|
|Drogba ´perfect fit´ for Montreal|
|Berahino ´not yet´ ready for Tottenham - Irvine|
|Romero lauds caring Van Gaal|
|Jese flying at Real under Rafa|
|Sampdoria unwilling to pay €10m for Balotelli|
|Mourinho talks up Arsenal title chances|
|Hull sign Ryan Taylor, Sam Clucas|
|Kane, Pochettino hail MLS All-Star test|
|Di Santo sorry for swift Werder departure|
|Mourinho tells Ronaldo: Team honours come first|
|Khedira returns to Juve training|
|Celtic v Qarabag: Champions League return of utmost importance, says Collins|
|Pellegrini: Jovetic had to go|
|Manquillo completes Marseille move|
|Schalke reject Juve´s Draxler bid|
|Blanc: Di Maria deal ´close´|
|Di Santo debut ends in stalemate|
|Fire sign Drogba, trade him to Montreal Impact|
|FIFA and UEFA welcome ruling on third-party ownership|
|Juve kick off title defence against Udinese|
|Stoke sign free agent Afellay|
|Benitez confident Ramos will stay|
|Fenerbahce issue warning to fans|
|UEFA Champions League Preview: De Boer confident Ajax are ready for Vienna test|
|Bility: I am the favourite for FIFA presidency|
|Pienaar to miss start of season|
|Vietnam 1 Manchester City 8: Sterling shines as tourists run riot|
|All-Star Keane relishing Spurs clash|
|Shaun Wright-Phillips joins brother Bradley at Red Bulls|
|Inter 0 Real Madrid 3: Rodriguez stunner caps comfortable win|
|Villa sign Ayew|
|Watford complete Berghuis transfer|
|Robben returns to Bayern training|
|Pulis anxious to make West Brom additions|
|David Luiz eager to welcome ´fantastic´ Di Maria|
|Fernando injury free ahead of new campaign|
|Hummels blames weight issues for poor season|
|Defoe hoping for early Sunderland goals|
|Depay hints at identity of ´surprise´ United striker|
|Tigres UANL v River Plate: Hosts look to bounce back and make history|
|Crespo set for Villa move|
|Terry: I would never join a Premier League rival|
|Van Gaal coy on United future|
|Romero to cover potential De Gea exit - Van Gaal|
|Uruguay win men´s football gold at Pan Am Games|
|Pirlo thanks New York City fans for ´beautiful´ welcome|
|Mexico capitalised on ´the mistakes we made´ - Schafer|
|Herrera delighted with Mexico display|
|MLS Review: Whitecaps build happy home, Pirlo debuts|
|Guardado wins Golden Ball at Gold Cup|
|NZF confirms Olympics disqualification appeal|
|Jamaica 1 Mexico 3: CONCACAF giants complete form turnaround|
|New York Red Bulls 2 Benfica 1: Another scalp for MLS side|
|Romero signs with United|
|Moghreb Tetouan 1 Al Hilal Omdurman 1: Visitors go top|
|Van Gaal rules out Ronaldo bid|