Bayer Leverkusen and Real Sociedad will be seeking their first UEFA Champions League points of the season when they meet on Wednesday.
The Liga outfit were beaten 2-0 by Shakhtar Donetsk in their group stage opener, while Leverkusen went down 4-2 against Premier League champions Manchester United.
However, the Bundesliga side have won all three matches in the league since their defeat at Old Trafford, scoring eight goals and conceding just once in the process.
Sami Hyypia's side third in the German top flight after their 2-0 win over Hannover on Saturday and face champions Bayern Munich on Saturday.
However, Hyypia is focused on Wednesday's game, rather than the meeting with Pep Guardiola's men.
"The next game is the most important," he told the Bundesliga website. "We play Real first. It's not a problem.
"Spanish teams are always very strong technically and play attractive football.
"That won't be any different against Real Sociedad. Of course we're at home and want to win. Otherwise we won't go any further."
Leverkusen have enjoyed 100 per cent records in the group stages of the competition in their past two campaigns, with Hyypia unsure on whether he will rotate his squad for the clash with Jagoba Arrasate's men.
Sociedad have never recorded a European win on German soil, losing two and drawing one of their three encounters in the country.
Arrasate's charges have not won since their Champions League qualifier against Lyon in August, losing two and drawing three of their last five league games.
The 35-year-old was pleased with the performance of his side during their 1-1 draw with Sevilla on Saturday but feels that they are in need of a win to boost confidence.
"I'm happy with the effort that we put in (against Sevilla)," he said.
"But we need a win to recover that joy, that confidence that victories bring."
Xabi Prieto is unlikely to feature for the visitors, having suffered a thigh tear in his side's 4-1 defeat against Barcelona, while loanee Esteban Granero will miss out.
The midfielder suffered an anterior cruciate ligament injury during the defeat against Shakhtar.
In what will be the sides' first meeting, defeat would see the losers cast three points adrift at the bottom of Group A.
|Coach: S. Hyypiä|
for Heung-Min Son 68'
for S. Boenisch 69'
for S. Sam 85'
|Adler ´aged three years´, Labbadia ´extremely proud´ of Hamburg|
|Colombia squad settles in Argentina|
|Balotelli ´a target´ because of Liverpool form - Richards|
|Bosnich: If I´d listened to Terry I would have avoided drugs|
|Luiz Gustavo ruled out of Brazil´s Copa America squad|
|Mexico confirm Copa squad|
|Pogba ´very happy´ at Juve|
|Pogba can be Europe´s greatest - Pirlo|
|Pinedo stays in Argentina, Bolivia captain Raldes in Copa America squad|
|Quinteros cuts Banguera, Hidalgo for Chile showpiece|
|Injured Gonzalez misses Copa America, Venezuela finalise youthful squad|
|Champions League Final: Buffon plays down Juve hopes, Iniesta doubtful|
|Karlsruher 1 Hamburg 2 (2-3 agg): Muller strike ensures survival|
|CONCACAF official Sanz banned by FIFA|
|Gourvennec shuns admirers with Guingamp extension|
|Pastore signs PSG extension|
|Morel swaps Marseille for Lyon|
|Watford sign Austria defender Prodl|
|Monaco confirm Berbatov departure|
|Peru v Mexico: Herrera confident as Copa preparations continue|
|Injury rules Dost out of Netherlands friendlies|
|Koeman must strengthen attack for Europa League challenge - McMenemy|
|Wilshere apologises for Spurs taunts|
|Marchisio: No fear ahead of Barcelona clash|
|Klopp to take break after leaving Dortmund|
|Champions League win would be ´more than extraordinary´ - Allegri|
|Charity calls for education after Leicester ´racist orgy´ claims|
|Taylor agrees Swansea deal|
|Sevilla snare Krohn-Dehli|
|Coloccini hails Gutierrez after ´perfect´ Newcastle finale|
|Benitez excited by Madrid opportunity|
|Sampaoli confirms final Chile squad for Copa America|
|Clement ready to go it alone at Derby|
|Mihajlovic confirms Sampdoria exit|
|Brentford turn to Dijkhuizen|
|Usami, Moto to lead Japan qualifying threat|
|Vieira ´the best bet´ for Newcastle - Bernard|
|´We´ll see what happens with my future´ - De Gea|
|Klinsmann: Guzan will start at Gold Cup|
|Alves wants Barca extension not PSG - Blanc|
|Derby appoint Paul Clement as head coach|
|Karlsruher ´can only win´ - Kauczinski|
|Ronaldinho causes stir with disallowed goal|
|Szczesny plans Arsenal stay|
|Pioli: Lazio deserve Champions League qualification|
|Pablo Aimar makes River Plate return|
|MLS Review: Seattle leave it late against Red Bulls|
|Wenger: Arsenal won´t spend big|
|Police to investigate Rangers-Motherwell fight|
|´I will definitely stay´ at City - Toure|
|Champagne backs Blatter to reform FIFA|
|Honduras 2 El Salvador 0: Penalty, goal and red card to Lozano|
|Mancini wants Icardi to stay|
|Sampdoria set to speak on Mihajlovic future|
|Serie A Review: Napoli miss Champions League in Benitez send-off|
|O´Neill: Fitness of players will determine selection against Romania|
|Inter 4 Empoli 3: Icardi brace secures victory|
|Northern Ireland 1 Qatar 1: Irish cough up lead|
|Eredivisie Review: Five-star Vitesse seal Europa berth, NAC Breda relegated|
|Motherwell 3 Rangers 0 (6-1 agg): Miserable return for McCall|
|Wilshere taunts Spurs during FA Cup parade|
|Di Francesco pens Sassuolo extension|
|Klopp thanks Dortmund for emotional farewell|
|Italy call up uncapped duo|
|Walcott expects Arsenal deal|
|Luiz dreaming of Champions League glory|
|Leicester trio issue apology as club investigate alleged ´racist orgy´|
|Gerrard ´a dream to play with´, says Sturridge|
|Clasie a target if Schneiderlin leaves - Koeman|
|Muller appears to pledge future to Bayern in Instagram post|
|Sheikh Mansour wants Toure at City - agent|
|Real vice-president inadvertently ´confirms´ Benitez appointment|
|Pique targeting Barca ´perfection´|
|Malanda helped us a lot - De Bruyne|
|Falcao not focused on transfer speculation|
|Iniesta in doubt for Champions League final|
|Blanc hoping for FFP boost|
|Willian, Filipe Luis, Cuadrado to miss Premier League start|
|Mourinho: Chelsea not playing Sydney ´for fun´|
|MLS Review: Shipp sinks Montreal, Giovinco stars for Toronto|
|Luis Enrique targets ´exemplary treble´, basks in Messi´s magic|
|Iraola: Neymar ´rainbow´ unsporting|
|Mexico 3 Guatemala 0: Herrera brace ensures farewell victory|
|´I´m not going to change the way I play´ - Neymar|
|PSG motivated by historic opportunity - Douchez|
|Wenger hopes Wembley win convinces Walcott to stay|
|Klopp refuses to dwell on departure after cup heartbreak|