Argentine clubs River Plate and Lanus booked their Copa Sudamericana spots in the next round, with contrasting aggregate victories.
River Plate trailed Ecuadorian outfit LDU Loja 2-1 after their first leg in Ecuador, with their away goal meaning a 1-0 win would have got the Argentines over the line.
And when Teofilo Gutierrez struck on 36 minutes, the game was on the terms of Ramon Diaz River Plate side.
Manuel Lanzini wrapped up the aggregate victory with a well-struck goal in the 71st minute, to win the leg 2-0 for the hosts in Buenos Aires.
Lanus were already virtually assured of a last-eight spot after a 4-0 first leg win over Universidad de Chile, and on their second-leg trip to Santiago, they limited the damage to a 1-0 loss.
Charles Aranguiz scored the winning goal in the leg for Universidad de Chile on 69 minutes.
In this week's first leg encounters, Coritiba blew their home leg against Itagui, slumping to a 1-0 loss.
The Brazilian hosts were trumped by a goal in the first minute after the half-time interval, as Yessi Mena fired the Colombian visitors a valuable away goal.
Fellow Brazil Serie A side Sport Recife were beaten 2-0 away to Libertad, with first-half goals to Gustavo Gomez and Pedro Benitez handing the Paraguayans a handy lead at the tie's midway point.
There was better news for Brazilian club Ponte Preta, who opened up a two-goal advantage late in their 2-0 win over Colombian outfit Deportivo Pasto.
Fellipe Bastos struck deep into second-half injury time, to follow up Uendel's opener on 31 minutes for the hosts in Sao Paulo.
City rivals Sao Paulo were held to a 1-1 home stalemate by Chilean club Universidad Catolica, while an own goal from Bahia midfielder Diones handed a 1-0 win to Colombia's Atletico Nacional in Medellin.
|10||M. Lanzini||64' 71'|
|Coach: R. Díaz|
for C. Ledesma 46'
for A. Rojas 46'
for F. Andrada 80'
|Inzaghi pleads for Milan reprieve|
|Athletic Bilbao 1 Barcelona 3: Messi magic seals domestic double|
|Atalanta 1 Milan 3: Bergamo old-boys win it for Rossoneri|
|Auxerre 0 Paris Saint-Germain 1: Cavani header seals historic treble|
|´Chelsea target´ Muto makes Mainz move|
|Sherwood eager to change ´losing mentality´|
|Borussia Dortmund 1 Wolfsburg 3: No triumphant send-off for Klopp|
|Allegri admits lack of focus|
|Cup success proves Arsenal´s big-game mentality - Wenger|
|Turkish Super Lig Review: Istanbul Basaksehir clinch European football for the first time|
|Arsenal 4 Aston Villa 0: Wenger´s men make history in one-sided final|
|Verona 2 Juventus 2: Juanito dents Champions League preparations|
|Solanke leads Chelsea to All-Stars victory|
|Indonesian Football Association suspended by FIFA|
|Randolph agrees West Ham switch|
|Mancini vows to rebuild Inter|
|Russian Premier League Review: Torpedo Moscow and Arsenal Tula suffer relegation|
|Kane the difference again as Tottenham see off Sydney|
|Garcia proud of resilient Roma|
|Rio Ferdinand retires from football|
|World Cup allocation to remain unchanged, Blatter confirms|
|Blatter defiant after re-election|
|Barkley break to benefit Everton - Jones|
|Bilic proud of Besiktas achievements following his final game in charge|
|Vietto encourages Atletico bid|
|Di Santo in demand, claims agent|
|Arteta: Arsenal harbour high ambitions for next season|
|Northern Ireland - Qatar Preview: O'Neill sees friendly as perfect preparation for Romania|
|Wilmots considering Schalke offer|
|McCall: Rangers need a miracle|
|Sporting Kansas City 4 Dallas 0: Nemeth, Zusi destroy 10-man visitors|
|Geferson replaces Marcelo for Copa America|
|PSG captain Silva in doubt for Coupe de France final|
|Valverde: Bilbao to stick to style in Copa final|
|Youngsters promoted to Australia´s squad to face Kyrgyzstan|
|´Another round of indictments´ expected in FIFA case|
|Disappointed FFA, US Soccer still want change|
|Gutierrez: Ashley abandoned me|
|US senator urges Blatter to release Garcia Report|
|Gutierrez, Taylor released by Newcastle|
|Figo calls on re-elected Blatter to resign after ´dark day´ for football|
|Szczesny blasts father over ´idiotic´ comments|
|Blatter vows to leave ´strong´ FIFA|
|Blatter re-elected as FIFA president|
|BREAKING NEWS: FIFA elections set for second round of voting|
|Atsu wings in for Bournemouth campaign|
|Klopp: Pokal final not about me|
|Clement says Real goodbyes|
|Inter v Empoli: Icardi looking for final flourish|
|BREAKING NEWS: Blatter - I will fix FIFA|
|Northern Ireland v Qatar: O´Neill keen to prepare for Romania test|
|Palestine drop proposal for Israel suspension|
|Suarez will only get better, warns Iniesta|
|Martinez keen to recruit quickly|
|Monk keen to build on successful Swansea campaign|
|Fit-again Suarez set to aid Barca´s treble quest|
|Anonymous ´bomb´ threat received at FIFA Congress|
|Qatar organisers insist World Cup bid met ´highest ethical standards´|
|Wilkinson and Sorensen leave Stoke|
|Blatter: You can´t ask everyone to behave ethically just like that|
|Van Bronckhorst positive about Feyenoord future|
|Australian police to look into FFA-Warner dealings|
|Dardai signs Hertha deal|
|Protester interrupts FIFA Congress|
|Spurs complete Wimmer signing|
|Warner questions charges following release|
|Mexico v Guatemala: Herrera´s men kick off Copa preparations|
|New Zealand no longer supporting Blatter|
|´Post-World Cup trauma´ affected Mertesacker|
|Racing Club 0 Guarani 0 (0-1 agg): Draw sees Paraguayans through|
|Hamburg shocked by Karlsruher attack - Labbadia|
|Serie A Preview: Napoli, Lazio eye Champions League|
|Hodgson will not overstay England welcome|
|Scholes: United must keep Di Maria|
|Leyton Orient appoint Hendon|
|Benteke has a buy-out clause - Sherwood|
|US Soccer will support Prince Ali in FIFA election|
|Dynamo disappointed with officials after City friendly abandoned|
|Calls for Suarez appeal gather momentum|