Gareth Bale is expected to make his home Real Madrid debut in the derby clash with Atletico on Saturday after overcoming a thigh injury.
The world record signing has missed Real's last two matches with the problem after pulling up in the warm-up ahead of the 4-1 victory over Getafe, but he returned to training on Thursday.
Bale rejoins a squad that will be full of confidence following their controversial victory over Elche on Wednesday, although they will likely still have the words of coach Carlo Ancelotti ringing in their ears.
Ancelotti's side needed a highly debatable last-gasp penalty from Cristiano Ronaldo to secure the points with the last kick of the game in midweek, and the Italian admitted that his players must do more if they are to overcome their arch-rivals at the Bernabeu this weekend.
"Playing the way we did (against Elche), we are not going to win the derby," he said. "We need to play better, with more intensity and more personality."
Atletico made it six wins out of six with their 2-1 win over Osasuna on Tuesday and they will be hoping to maintain their perfect record in the first derby of the season.
They won their last meeting with Real in extra time in last season's Copa del Rey final but they have not tasted league success against their capital counterparts since 1999.
Coach Diego Simeone will be hoping to break that run of 23 league games without a win and they will be brimming with confidence after their perfect start to the Liga campaign.
Goalkeeper Thibaut Courtois believes they have what it takes to extend that run, and has reassured the fans that they are going all out for the win.
"We have a great team," he said. "We know how to beat them.
"As a player you never play to draw, always to win."
Real are also unbeaten in the league, but they did drop points in a 2-2 draw with Villarreal that leaves them two points behind their city neighbours and champions Barcelona.
They will need to stop striker Diego Costa if they are to take all three points on Saturday, with the 24-year-old Brazilian having netted his sixth and seventh goals of the season in the midweek win.
Xabi Alonso is definitely out for the hosts with a foot injury, while Adrian will be missing for the visitors with a fractured cheekbone.
|22||Á. di María|
|Coach: C. Ancelotti|
for Á. di María 46'
for Illarramendi 46'
for Isco 73'
|Copa del Rey Wrap: Valencia scrape through, Bilbao thrash Celta|
|Primeira Liga: Maritimo 2 Braga 2|
|Galliani to stay at Milan|
|Klopp plays down Club World Cup|
|Schalke coach Keller not fearing the sack|
|Wilshere loses appeal against two-match ban|
|Zaha on Pardew´s radar|
|Milan will be my final club, says Abbiati|
|Anigo to remain at Marseille helm for time being|
|Premier League Preview: West Brom v Hull City|
|No Bankia involvement in Bale deal, says Perez|
|Galliani wants stronger Milan youth system|
|Rafinha extends Bayern contract|
|Premier League Preview: Stoke City v Aston Villa|
|Poyet: No excuse not to perform|
|Vanishing spray to be used at World Cup|
|Gabbidon praises Palace strike pair|
|Premier League Preview: Manchester United v West Ham|
|Hughton calls for Norwich City to show character|
|Premier League Preview: Fulham v Manchester City|
|Samaras attracting Lazio interest|
|Premier League Preview: Liverpool v Cardiff City|
|Rodgers backs Mackay at Cardiff|
|Foster back fit and raring for West Brom recall|
|De Boer agent denies Tottenham contact|
|Premier League Preview: Crystal Palace v Newcastle United|
|Hungary appoint Pinter as new coach|
|Iniesta signs new Barca contract|
|Rodgers coy over Suarez talks|
|Jagielka hopes for fresh faces at Everton to help top-four push|
|A-League: Central Coast 1 Wellington 0|
|Spain end top of FIFA rankings for sixth year running|
|Allardyce disappointed to draw Manchester City|
|Pascoe hails ´unbelievable´ Suarez|
|Vorm knee surgery brought forward|
|Blanc hails Cavani brace|
|Michu wants Aspas to join Swansea City|
|Hoeness plays down Bayern treble suggestions|
|Dzeko confident he can fill Aguero void|
|Moyes: No loan offers for Zaha|
|Kiessling calls for Leverkusen response|
|Matuidi: Cavani on par with Ibrahimovic|
|Yeboah set to join Borussia Monchengladbach|
|Rooney a ´chance´ to face West Ham|
|FIFA Club World Cup Preview: Bayern Munich v Raja Casablanca|
|Benzarti praises ´extremely talented´ Raja Casablanca|
|Ranieri unsure over Falcao return|
|Coupe de La Ligue Wrap: Cavani leads PSG to dramatic win|
|Copa del Rey Wrap: Real Madrid through as Sevilla crash out|
|Tottenham job appeals to Sherwood|
|Sherwood gutted after defeat|
|Hughes: United worthy winners|
|Moyes pleased to see United weather storm|
|Allardyce hails West Ham fight|
|Coppa Italia: Juventus 3 Avellino 0|
|Manchester clubs kept apart in League Cup semi draw|
|League Cup: Tottenham 1 West Ham 2|
|League Cup: Stoke City 0 Manchester United 2|
|FIFA Club World Cup: Raja Casablanca 3 Atletico Mineiro 1|
|Sheffield Wednesday, Wigan abandoned due to heavy rain|
|United face anxious Rooney wait over injury|
|Messi making good progress|
|Ramos ban overturned|
|Osvaldo charged by FA|
|In-demand Ince offered new Blackpool deal|
|Molde confirm Solskjaer approaches|
|Kramer keen to continue home record|
|Rodgers: Henderson has potential to get even better|
|Ruiz on Anderlecht´s radar|
|Swansea, Hull fined by FA over player behaviour|
|Leeds keen on re-signing Gradel|
|Leverkusen announce Ryu deal|
|Ribery named Bundesliga Player of the Year|
|Moyes: No Zaha interest|
|Barcelona, Real Madrid in European Commission investigation|
|Basel: No Tottenham approach for Yakin|
|Chelsea set for Guarin bid, agent claims|
|Lewandowski has Dortmund goal concerns|
|Pogba, Pirlo will not sign before Christmas, says Marotta|
|Guardiola convinced to join Bayern after ´meat´ and greet|
|Martinez: Everton seen as a ´perfect´ loan destination|
|Anderlecht ´perfect´ for Defour, says Van Holsbeeck|
|Watford appoint Sannino|
|Sakho feels ´lucky´ to play with Suarez|
|Lippi: Too many teams competing in Club World Cup|
|Moyes ´told Welbeck to learn from Rooney´|
|I would kill myself over match-fixing, says Gattuso|
|Hughes dismisses calls for Januzaj protection|
|Aguero ´could miss up to two months´|
|Guardiola lauds Ballon d´Or nominee Ribery|
|Liverpool open Suarez contract talks|
|Copa del Rey Wrap: Barcelona, Levante cruise through|
|A-League Preview: Derby date beckons for winless Heart|
|Pearson upbeat despite Leicester defeat|
|Poyet urges Sunderland to build on Chelsea win|
|Mourinho rues missed chances|