Chelsea assistant coach Steve Holland rued injuries to Marco Van Ginkel and Ramires in their 2-0 win over Swindon Town in the English League Cup.
Both Van Ginkel and Ramires are in doubt for Saturday's crunch English Premier League derby with Tottenham at White Hart Lane.
"(The result was) not perfect because we have got an injury to Marco, which is a little bit early to be certain but it doesn't look good," Holland said.
"He will have a scan tomorrow on an injury to his knee and of course his substitute Ramires also had to go off with a muscular injury at the top of his hip in the glut (gluteal) area which was causing him more discomfort as he tried to run it off.
"He will be a major doubt for Saturday... not out for sure yet but a major doubt for the Tottenham game at the weekend."
Juan Mata has been the name on everyone's lips at Stamford Bridge, with manager Jose Mourinho rarely playing the Spanish attacking midfielder.
In Mata's two Premier League appearances this season, he has been subbed off after just 57 and 65 minutes respectively, causing speculation Mourinho does not have the 25-year-old in his grand plans.
Holland defended Mourinho's treatment of the Spaniard, claiming the Portuguese boss is simply sending a message to his all-star line-up that no-one is protected.
"Obviously a lot has been made of the Mata situation, he is a high profile player," Holland said.
"The message to all our attacking players from Jose Mourinho from day one has been they need to contribute offensively in terms of their production not just look a good player but score goals, make chances and be a threat to the opposition goal and of course they have to contribute and defend."
Holland said the packed fixture schedule was beneficial to Chelsea's chances of claiming silverware in the latter half of the season.
"We have four chances (to win a trophy) and we have a squad of 20 outfield players where there is really not a great deal in between the majority of the players," the assistant coach said.
"At this stage of the season it is important we are playing twice a week to give regular games to all of the squad.
"That might change towards the end of the season when you are looking to rest the players.
"But at this stage it is good to have the regular fixtures and it is an opportunity to win a trophy in February/March, it certainly is the first one anyway so that is the target."
|Coach: M. Cooper|
for N. Ranger 46'
for N. Ajose 72'
|UEFA Champions League Preview: Shakhtar ready for Fenerbahce decider|
|Lampard targets MLS play-offs for City|
|MLS Review: Goals galore as DC United win 10-goal thriller|
|Ronaldinho returns and helps Fluminense to win|
|Keane: United won´t overtake Chelsea|
|Casillas has the ´enthusiasm of a 20-year-old´ - Lopetegui|
|Blanc hopeful over Ibrahimovic knee injury|
|Guardiola laments late goal in Supercup defeat|
|Tuchel plans to keep Bender|
|Hecking happy with Wolfsburg discipline after Supercup win|
|Arsenal players too interested in selfies and six-packs - Keane|
|Confusion over Ibrahimovic´s PSG future|
|Sporting Lisbon 2 Roma 0: Slimani, Mane inspire Portuguese hosts|
|Rodgers feeling ready for new campaign|
|Khedira to miss Supercoppa|
|Paris Saint-Germain 2 Lyon 0: Aurier and Cavani seal more silverware|
|Wolfsburg 1 Bayern Munich 1 (5-4 on penalties): Super-sub Bendtner nicks it for Pokal champions|
|Lampard´s long-awaited New York City debut ends in defeat|
|Casillas the spot-kick hero for Porto|
|Monk bullish ahead of season opener at champions|
|Marseille 2-0 Juventus: Night to forget for Serie A champions|
|Swansea end pre-season with yet another draw|
|HJK 0 Liverpool 2: Origi and Coutinho on target|
|Juventus rocked by Khedira injury scare|
|Lens and Pantilimon star as Sunderland beat Hannover|
|Pardew hopeful of concluding Wickham deal|
|Martinez allays Lukaku fears|
|Stuttgart 4 Manchester City 2: Cause for concern for Pellegrini|
|Wasteful Bournemouth held by Hoffenheim|
|Jerome seals Norwich win|
|Souare´s first goal ensures Palace draw|
|Sinclair hits hat-trick in Villa draw|
|Leicester end pre-season with thrilling Birmingham win|
|Wood and Mowatt condemn Everton to friendly defeat|
|Coloccini not involved as Newcastle lose to Gladbach|
|Borussia Dortmund 2 Real Betis 0: Ramos scores on return from injury|
|Stoke lose to Cologne on Afellay debut|
|Norwich capture goalkeeper Kean|
|Jovetic hits out at Pellegrini following City exit|
|Jones backing new boys to spark United revival|
|Scottish Premiership Review: Celtic up and running, Dundee hammer Kilmarnock|
|Can keen to learn from Milner|
|Immobile on the mend following friendly scare|
|Sagan Tosu 1 Atletico Madrid 1 (1-4 on penalties): Simeone´s men need spot-kicks|
|Cahill: Big-spending rivals will make title race tougher|
|Roberto happy to play full-back for Barca|
|Gestede eager to make his mark at Villa|
|I want to play more and score more - Remy|
|Lambert influence important, says Pulis|
|Benteke a ´bargain´ buy - Rodgers|
|Zola: Qatar would be ideal for Balotelli, Cassano|
|Suarez: I´m not among world´s best|
|PSG ready despite ´chaotic´ pre-season - Blanc|
|Arsenal thumping still hurts - Fournier|
|Aubameyang targets Champions League success|
|Rooney set for Everton return|
|Cech can match Van der Sar - Wenger|
|Mourinho ponders Wenger´s losing record against him|
|CBF confirm Fred failed a doping test|
|Bournemouth beaten by battling Cardiff|
|Immobile injury overshadows Sevilla win at Vicarage Road|
|Lambert at the double on West Brom bow|
|Real sign up Spain starlet Vallejo|
|Valencia blow for West Ham|
|Elche cleared to play in Segunda Division|
|Baker pens a new Villa deal|
|Lambert makes Albion switch|
|Gillingham and Scally found guilty of ´race victimisation´|
|Inter complete Jovetic signing|
|Arsenal v Chelsea: Mourinho cools Wenger rivalry ahead of Wembley meeting|
|Villa snap up Gestede|
|Villa land Veretout|
|Mourinho coy on fresh Stones bid|
|Aubameyang commits to Dortmund|
|Torres on the hunt for trophies with Atletico|
|Cazorla and Walcott sign new Arsenal deals|
|Quick start vital in Arsenal title bid - Wilshere|
|I have received no offers - Guardiola|
|Barcelona to monitor Turan injury|
|Zorc ´surprised´ by Grosskreutz-Tuchel row|
|Phil Neville could be England manager - Moyes|
|UEFA to investigate Shakhtar´s Fred selection|
|City loan Unal to Genk|
|China v South Korea: Stielike looking for new options|
|North Korea v Japan: Halilhodzic to unearth new faces|
|Drogba: I want to be ready, not a burden|
|Hamstrung Clasie in doubt for Southampton league opener|
|West Ham goalscorer Zarate bemoans Astra comeback|
|Negredo quashes Valencia exit rumours|
|´This is not my Sampdoria´ - president Ferrero|
|Criscito could join Inter - agent|
|CBF endorse Zico´s FIFA presidency campaign|
|Hawit to handle CONCACAF´s referee review|
|Falcao is a ´top, top player´ - Terry|
|Tuchel pleased by Dortmund fighting qualities|
|Premier League rules out schedule changes for Champions League clubs|
|UEFA Europa League Review: Southampton stroll as Sampdoria are humiliated|