Leaders Roma travel to meet Sampdoria on Wednesday aiming to maintain Rudi Garcia's winning start as manager.
Garcia has turned the club around after taking over in June and they have a 100 per cent record, including an impressive 2-0 victory in the Rome derby last time out.
However, they were unable to beat Sampdoria last season, and have only won once in their last seven meetings.
Sampdoria have yet to win this season – in fact the two points they have collected have come away from home – so they will be hoping to collect their first points of the season at the Luigi Ferraris.
Napoli welcome Sassuolo to the San Paolo and they will be confident of recording a big victory.
Eusebio Di Francesco's side are competing in the top flight for the first time but have found it tough going, and were beaten 7-0 by Inter on Sunday.
Rafael Benitez's side could pile more misery on Sassuolo if they can match Sunday's performance against Milan, when they beat them at San Siro for the first time in 27 years.
Close-season arrival Gonzalo Higuain has filled the void left by Edinson Cavani well and has scored four in five for his new club in all competitions.
Two of the top four go head-to-head when Inter face Fiorentina at San Siro.
Walter Mazzarri has revamped the Inter squad and they look likely to improve on their ninth-place finish last season.
Fiorentina should pose a much harder test than Sassuolo did on Sunday, given that Vincenzo Montella's side are also yet to lose in the league.
However, without injured duo Josip Ilicic and Mario Gomez, they could find it hard to add to their 10 goals against Inter's miserly defence, which has only conceded once.
Defending champions Juventus travel to Chievo on Wednesday looking to maintain their impressive record against Giuseppe Sannino's side.
Juventus have only lost once in their 20 meetings and did the double over them last season.
Antonio Conte is set to be without Simone Pepe (thigh) and Martin Caceres (knee) as they prepare to face opposition from Verona for the second time in four days.
Catania – fresh from their first point of the season against Parma – face Lazio, who will be keen to put their derby defeat behind them.
Vladimir Petkovic will be without Andre Dias after his dismissal against Roma, and he also has Diego Novaretti (foot), Lucas Biglia (calf), Stefan Radu (knee) and Giuseppe Biava (foot) on the sidelines.
Milan will face Bologna without Mario Balotelli after the striker was shown a red card after the final whistle following the 2-1 defeat to Napoli.
The striker will serve a three-game ban after having two games added to his initial suspension for intimidating the referee.
Massimiliano Allegri's side have made a stuttering start to the season with just one win so far, but they will be confident of getting their second against a side that they have not lost to since 2008.
Like Milan, Udinese have made a low-key start to the campaign and they will be looking to bounce back from Saturday's defeat to Chievo when they face Genoa on Tuesday.
Elsewhere, Livorno will aim to continue their good start to the season when they face Cagliari, while Verona travel to Torino for their second game in Turin in four days.
The final game of the round sees struggling Parma host Atalanta as they try to collect their first win of the term.
|1||Angelo Da Costa|
|29||L. De Silvestri|
|Coach: D. Rossi|
for P. Wszołek 62'
for L. De Silvestri 74'
for A. Costa 81'
|Atalanta 1 Milan 3: Bergamo old-boys win it for Rossoneri|
|Auxerre 0 Paris Saint-Germain 1: Cavani header seals historic treble|
|´Chelsea target´ Muto makes Mainz move|
|Sherwood eager to change ´losing mentality´|
|Borussia Dortmund 1 Wolfsburg 3: No triumphant send-off for Klopp|
|Allegri admits lack of focus|
|Cup success proves Arsenal´s big-game mentality - Wenger|
|Turkish Super Lig Review: Istanbul Basaksehir clinch European football for the first time|
|Arsenal 4 Aston Villa 0: Wenger´s men make history in one-sided final|
|Verona 2 Juventus 2: Juanito dents Champions League preparations|
|Solanke leads Chelsea to All-Stars victory|
|Indonesian Football Association suspended by FIFA|
|Randolph agrees West Ham switch|
|Mancini vows to rebuild Inter|
|Russian Premier League Review: Torpedo Moscow and Arsenal Tula suffer relegation|
|Kane the difference again as Tottenham see off Sydney|
|Garcia proud of resilient Roma|
|Rio Ferdinand retires from football|
|World Cup allocation to remain unchanged, Blatter confirms|
|Blatter defiant after re-election|
|Barkley break to benefit Everton - Jones|
|Bilic proud of Besiktas achievements following his final game in charge|
|Vietto encourages Atletico bid|
|Di Santo in demand, claims agent|
|Arteta: Arsenal harbour high ambitions for next season|
|Northern Ireland - Qatar Preview: O'Neill sees friendly as perfect preparation for Romania|
|Wilmots considering Schalke offer|
|McCall: Rangers need a miracle|
|Sporting Kansas City 4 Dallas 0: Nemeth, Zusi destroy 10-man visitors|
|Geferson replaces Marcelo for Copa America|
|PSG captain Silva in doubt for Coupe de France final|
|Valverde: Bilbao to stick to style in Copa final|
|Youngsters promoted to Australia´s squad to face Kyrgyzstan|
|´Another round of indictments´ expected in FIFA case|
|Disappointed FFA, US Soccer still want change|
|Gutierrez: Ashley abandoned me|
|US senator urges Blatter to release Garcia Report|
|Gutierrez, Taylor released by Newcastle|
|Figo calls on re-elected Blatter to resign after ´dark day´ for football|
|Szczesny blasts father over ´idiotic´ comments|
|Blatter vows to leave ´strong´ FIFA|
|Blatter re-elected as FIFA president|
|BREAKING NEWS: FIFA elections set for second round of voting|
|Atsu wings in for Bournemouth campaign|
|Klopp: Pokal final not about me|
|Clement says Real goodbyes|
|Inter v Empoli: Icardi looking for final flourish|
|BREAKING NEWS: Blatter - I will fix FIFA|
|Northern Ireland v Qatar: O´Neill keen to prepare for Romania test|
|Palestine drop proposal for Israel suspension|
|Suarez will only get better, warns Iniesta|
|Martinez keen to recruit quickly|
|Monk keen to build on successful Swansea campaign|
|Fit-again Suarez set to aid Barca´s treble quest|
|Anonymous ´bomb´ threat received at FIFA Congress|
|Qatar organisers insist World Cup bid met ´highest ethical standards´|
|Wilkinson and Sorensen leave Stoke|
|Blatter: You can´t ask everyone to behave ethically just like that|
|Van Bronckhorst positive about Feyenoord future|
|Australian police to look into FFA-Warner dealings|
|Dardai signs Hertha deal|
|Protester interrupts FIFA Congress|
|Spurs complete Wimmer signing|
|Warner questions charges following release|
|Mexico v Guatemala: Herrera´s men kick off Copa preparations|
|New Zealand no longer supporting Blatter|
|´Post-World Cup trauma´ affected Mertesacker|
|Racing Club 0 Guarani 0 (0-1 agg): Draw sees Paraguayans through|
|Hamburg shocked by Karlsruher attack - Labbadia|
|Serie A Preview: Napoli, Lazio eye Champions League|
|Hodgson will not overstay England welcome|
|Scholes: United must keep Di Maria|
|Leyton Orient appoint Hendon|
|Benteke has a buy-out clause - Sherwood|
|US Soccer will support Prince Ali in FIFA election|
|Dynamo disappointed with officials after City friendly abandoned|
|Calls for Suarez appeal gather momentum|
|Eredvisie Review: Vitesse denied by late Uth goal, NAC Breda boost survival hopes|
|Rangers 1 Motherwell 3: McCall´s men facing uphill struggle|
|Hamburg 1 Karlsruher 1: Bundesliga side escape with draw|
|Blatter vows to lead FIFA clear of trouble as corruption scandal rolls on|
|Bundesliga: Bayern Munich season review - League crown not enough to signal successful campaign|
|Genoa forced to wait for UEFA licence|
|Injured Cardozo out of Paraguay squad|
|CONCACAF provisionally dismisses Webb and Li|
|Klopp: Career highlights of a charismatic coach|
|Verona v Juventus: Ogbonna seeks strong Champions League warm-up|
|FA charges Demetriou over betting breaches|
|Atalanta v Milan: Inzaghi faces last chance to prove worth|
|King joins Bournemouth as QPR rebuild begins|
|Plymouth part ways with Sheridan|
|Hernandez banned for three matches|
|Chelsea star Fabregas has nose surgery|
|Blatter: More bad news may follow|
|Galliani hopeful over Ancelotti deal|
|Frontzeck to continue as Hannover coach|
|Tremmel released as Tate waves goodbye to Swansea|
|Arsenal v Aston Villa: Sherwood out to upset holders|
|UEFA open to boycott of World Cup - Platini|
|Porto activate release clause for Casemiro|
|Athletic Bilbao v Barcelona: Catalans seeking second leg of treble|
|Auxerre v Paris Saint-Germain: History beckons for Ligue 1 champions|
|Cole confirms West Ham departure|
|UEFA elect not to boycott FIFA Congress|
|Borussia Dortmund v Wolfsburg: Klopp aiming for triumphant farewell|
|Flamini hails Coquelin impact at Arsenal|
|South Africa deny wrongdoing in World Cup bid|
|Benitez confirms Napoli exit|
|McShane among six released by Hull|
|Cerci committed to Milan|
|West Ham expect Collins to return for pre-season|
|Real deny Pogba bid|
|Important to keep Chelsea squad together - Mourinho|
|Alonso: Gerrard was magic|
|Pochettino silent on Ings speculation|
|Visa threatens to ´reassess´ sponsorship amid FIFA scandal|
|Blatter skips FIFA Medical Conference|
|MLS Preview: Revs not out for revenge against Galaxy|
|MLS Review: Sounders go top in West, Timbers and Galaxy win|
|AFC stands by Blatter|
|Matheus ´alright´ after collapse - Markevych|
|Copa Libertadores Review: River, Inter through to semis|
|Signing Toni a ´long shot´ for Adelaide|
|Ramsey good enough for Barca - Coleman|
|Bacuna pushing for Benteke stay|
|Evans stunner settles City friendly in Toronto|
|Banega: Emery a great coach|
|Emery tight-lipped on Sevilla future|
|Argentina finalise Copa America squad|
|Nike issues statement following arrest of FIFA officials|