Leaders Roma travel to meet Sampdoria on Wednesday aiming to maintain Rudi Garcia's winning start as manager.
Garcia has turned the club around after taking over in June and they have a 100 per cent record, including an impressive 2-0 victory in the Rome derby last time out.
However, they were unable to beat Sampdoria last season, and have only won once in their last seven meetings.
Sampdoria have yet to win this season – in fact the two points they have collected have come away from home – so they will be hoping to collect their first points of the season at the Luigi Ferraris.
Napoli welcome Sassuolo to the San Paolo and they will be confident of recording a big victory.
Eusebio Di Francesco's side are competing in the top flight for the first time but have found it tough going, and were beaten 7-0 by Inter on Sunday.
Rafael Benitez's side could pile more misery on Sassuolo if they can match Sunday's performance against Milan, when they beat them at San Siro for the first time in 27 years.
Close-season arrival Gonzalo Higuain has filled the void left by Edinson Cavani well and has scored four in five for his new club in all competitions.
Two of the top four go head-to-head when Inter face Fiorentina at San Siro.
Walter Mazzarri has revamped the Inter squad and they look likely to improve on their ninth-place finish last season.
Fiorentina should pose a much harder test than Sassuolo did on Sunday, given that Vincenzo Montella's side are also yet to lose in the league.
However, without injured duo Josip Ilicic and Mario Gomez, they could find it hard to add to their 10 goals against Inter's miserly defence, which has only conceded once.
Defending champions Juventus travel to Chievo on Wednesday looking to maintain their impressive record against Giuseppe Sannino's side.
Juventus have only lost once in their 20 meetings and did the double over them last season.
Antonio Conte is set to be without Simone Pepe (thigh) and Martin Caceres (knee) as they prepare to face opposition from Verona for the second time in four days.
Catania – fresh from their first point of the season against Parma – face Lazio, who will be keen to put their derby defeat behind them.
Vladimir Petkovic will be without Andre Dias after his dismissal against Roma, and he also has Diego Novaretti (foot), Lucas Biglia (calf), Stefan Radu (knee) and Giuseppe Biava (foot) on the sidelines.
Milan will face Bologna without Mario Balotelli after the striker was shown a red card after the final whistle following the 2-1 defeat to Napoli.
The striker will serve a three-game ban after having two games added to his initial suspension for intimidating the referee.
Massimiliano Allegri's side have made a stuttering start to the season with just one win so far, but they will be confident of getting their second against a side that they have not lost to since 2008.
Like Milan, Udinese have made a low-key start to the campaign and they will be looking to bounce back from Saturday's defeat to Chievo when they face Genoa on Tuesday.
Elsewhere, Livorno will aim to continue their good start to the season when they face Cagliari, while Verona travel to Torino for their second game in Turin in four days.
The final game of the round sees struggling Parma host Atalanta as they try to collect their first win of the term.
|1||Angelo Da Costa|
|29||L. De Silvestri|
|Coach: D. Rossi|
for P. Wszołek 62'
for L. De Silvestri 74'
for A. Costa 81'
|We played more directly than Guardiola´s Bayern - Ancelotti|
|Chelsea and Arsenal want Brozovic, agent says|
|Kane: I want to stay at Tottenham for my whole career|
|Al-Khelaifi pledges new deal for sought-after Matuidi|
|Bayern Munich 6 Werder Bremen 0: Lewandowski hits hat-trick as champions cruise|
|Arda dropped from Turkey squad|
|Swansea agree deal for Barnsley defender Mawson|
|Aquilani leaves Sporting for Pescara|
|Montella excited as AC Milan close in on Pasalic|
|Lopez returns to Espanyol|
|Spalletti: Uncomfortable Roma must improve in Europe|
|Karanka confirms Ayala and Espinosa fit for Middlesbrough|
|United confirm Pereira to Granada on loan|
|Hey Jorrit - Netherlands call up Hendrix|
|Soares signs new four-year Southampton deal|
|Hernandez recovering from ´perfect´ surgery after falling down stairs|
|Gotze continues wait for second Dortmund debut|
|Montella: I will sleep easier without facing Higuain|
|PSV confirm Zinchenko loan signing|
|Schalke complete Stambouli signing|
|Ronaldo omitted from Portugal squad|
|Emery wants Matuidi to stay at PSG amid Juventus links|
|Sule gets first call-up as Schweinsteiger prepares for Germany farewell|
|Montella thrilled to retain ´irreplaceable´ Romagnoli|
|Real Madrid lose Isco to ankle sprain|
|Second Barca return sits easier with Guardiola|
|FIFA proposes two-and-a-half-year ban for Qatar official Al-Mohannadi|
|Inter set to sign Gabriel Barbosa and Joao Mario|
|Arsenal loan Asano to Stuttgart|
|Bonucci out and Higuain to stay on bench for Lazio - Allegri|
|No chance City will sign more players, says Guardiola|
|Conte unsure of Chelsea additions in ´crazy´ market|
|Conte would have no hesitation starting in-form Batshuayi against Burnley|
|Mourinho: We can think we´re in the Champions League|
|Cillessen aiming to make life difficult for Luis Enrique at Barcelona|
|Mourinho aims dig at Bayern over Schweinsteiger|
|Sevilla seal Sirigu loan signing|
|´Alcacer or nobody´ in Barcelona striker hunt|
|Recovering Ronaldo remains absent for Madrid|
|Europa League draw: Man Utd to face Van Persie´s Fenerbahce, Inter get Southampton|
|Europa League draw in full|
|Zidane brushes aside Pique´s Champions League jibe|
|Barcelona flop Douglas joins Sporting Gijon on loan|
|Simeone: Congratulations to Ronaldo, but Griezmann was better last season|
|West Ham can beat Manchester City again, says Bilic|
|Zidane reiterates desire for James to stay at Madrid|
|Granada pull off Samper loan coup|
|Guardiola was in his own world, says Muller|
|Pulis understands fans´ frustrations at West Brom|
|Henry named assistant to new Belgium boss Martinez|
|Casillas, Fabregas left out of Spain squad|
|Phelan targets six new faces before transfer deadline|
|Howe wary of Benteke threat|
|Zaza set to join West Ham, confirms Bilic|
|Sunderland goalkeeper Mannone out for three months|
|PSG favourites for Champions League group - Wenger|
|Wenger ´99 per cent confident´ on Arsenal arrivals as Perez and Mustafi wait in wings|
|Europe´s top four leagues to get four guaranteed Champions League spots|
|Pardew: Zaha not going to Tottenham|
|Bacca relishing life under Montella, aims subtle dig at Mihajlovic|
|Defiant Dortmund emerge from transfer trials in fighting shape|
|Livermore: Positive cocaine test my get out of jail free card|
|Pochettino relishing Champions League bow|
|Ronaldo wants to retire at Madrid at 41|
|CONCACAF Champions League Review: Dragon hold Saprissa, Connection and Progreso draw|
|Herrera: United out to win Europa League|
|Klopp targeting a trophy at Liverpool every year|
|Granada suspend recruit Angulo over failed drugs test|
|City vow to find Hart a new club|
|Palace blast ´ridiculous´ Zaha bid from Tottenham|
|Bravo: Barca will always be in my heart|
|Almost zero chance of Juventus signing James - Marotta|
|Liverpool´s Coutinho could miss Tottenham clash|
|Bilic ´angry and frustrated´ as West Ham crash out of Europe|
|Begiristain confident despite tough group for City|
|West Ham 0 Astra 1 (1-2 agg): Romanian minnows embarrass Hammers again|
|Hammers sign Swiss midfielder Fernandes|
|Humble Ronaldo hails team-mates following UEFA award|
|Krul joins Ajax on loan after signing new Newcastle deal|
|Leicester underdogs again in Champions League - Ranieri|
|Bale gunning for Champions League glory in Cardiff|
|Juventus additions strengthen Champions League bid - Marotta|
|Tuchel relishing ´classic´ Madrid Champions League encounter|
|Changed Burnley determined to survive|
|Ronaldo named UEFA Best Player in Europe for second time|
|Champions League draw in full|
|Guardiola handed Barca return with City in Champions League|
|Guidolin calls on Swansea to avenge Leicester thrashings|
|Eduardo completes Chelsea switch|
|Not easy to see Higuain at Juve - Cannavaro|
|Puel insists Fonte focused on Southampton|
|Ranieri knows Leicester are wanted men in Champions League|
|Puel backs Forster to take England chance|
|Cannavaro questions Juve´s European credentials after Pogba exit|
|Milan: Romagnoli not for sale, despite Chelsea bid|
|´Nobody more exciting than Michail Antonio´ - West Ham chairman|
|Pochettino prioritising transfers over new deals|
|Bravo completes Manchester City switch|
|No Barcelona bid for Mariano, insist Sevilla|
|Rashford drops down to England Under-21 squad|
|Koeman: No Everton interest in Hart|
|Ancelotti has it all - Ballack|
|Nolito eager for Champions League challenge|
|Evra dropped from France squad|
|Oliver Torres agrees Porto return|
|Ancelotti sees no need for Bayern revolution|
|Messi´s Roma goal wins UEFA award|
|Maradona questions Messi U-turn|
|Napoli pledge funds to earthquake victims|
|Hughes confirms Stoke interest in Manchester United defender Jones|
|Bentaleb completes Schalke switch|
|Klopp: Balotelli decision not imminent|
|Manquillo makes Sunderland move|
|Barca complete Cillessen signing|
|Hummels surprised by criticism from Dortmund fans|
|Blatter will accept CAS ruling|
|I do not want Sturridge as a wide player, insists Klopp|
|Schalke close in on Bentaleb and Stambouli|
|Wanted man Sukur denounces coup|
|´Everyone knows my best position´ - Sturridge unhappy at wide role|
|Villa says Alcacer ´knows what to do´ amid Barcelona links|
|Solo ´saddened´ by United States axing|
|Drinkwater signs new Leicester deal|
|Spanish clubs dominate as history beckons for Ancelotti - the Champions League in numbers|
|Lopes sets sights on Lille silverware and Portugal breakthrough|
|´A scholar and a monster´ - Surgeon hails ´unique´ Ronaldo|
|MLS Review: Altidore scores as Toronto move top in east, Galaxy rally|
|CONCACAF Champions League Review: Tigres win, Dallas held|
|Victory lure Rojas back to Melbourne|
|Chaplow suspended two games for verbal abuse, denies homophobia|
|Eduardo farewells Dinamo Zagreb amid Chelsea speculation|
|Zidane shoud give James more respect - Asprilla|
|Solo suspended from USA women´s team for six months|
|Guardiola understands fans unhappiness over Hart situation|
|Burnley and Middlesbrough sent packing from League Cup|
|Coleman baffled by Ramsey´s treatment at Arsenal|
|Six of the best for Gladbach as Rostov rout Ajax|
|Leicester face Chelsea, Northampton host United in League Cup third round|
|Cillessen set to fly out to Barca to complete move|